Aliases for CPNE7 Gene
External Ids for CPNE7 Gene
- HGNC: 2320
- Entrez Gene: 27132
- Ensembl: ENSG00000178773
- OMIM: 605689
- UniProtKB: Q9UBL6
Previous GeneCards Identifiers for CPNE7 Gene
- GC16P080962
- GC16P090630
- GC16P089345
- GC16P089385
- GC16P088169
- GC16P089643
- GC16P075338
- GC16P089646
- GC16P089652
- GC16P089663
- GC16P089671
Summaries for CPNE7 Gene
-
This gene encodes a member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains and one von Willebrand factor A domain. The encoded protein may be involved in membrane trafficking. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
GeneCards Summary for CPNE7 Gene
CPNE7 (Copine 7) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is CPNE4.
UniProtKB/Swiss-Prot for CPNE7 Gene
-
Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPNE7 Gene
Genomics for CPNE7 Gene
GeneHancer (GH) Regulatory Elements for CPNE7 Gene
Promoters and enhancers for CPNE7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CPNE7 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CPNE7 gene promoter:
-
- LCR-F1
- RFX1
- PPAR-alpha
- E47
- AML1a
- ZID
- RORalpha2
- Pax-5
- POU2F1
- POU2F1a
Regulatory Element Products
Genomic Locations for CPNE7 Gene
Genomic Locations for CPNE7 Gene
- chr16:89,575,768-89,597,246
- (GRCh38/hg38)
- Size:
- 21,479 bases
- Orientation:
- Plus strand
- chr16:89,642,176-89,663,654
- (GRCh37/hg19)
- Size:
- 21,479 bases
- Orientation:
- Plus strand
Genomic View for CPNE7 Gene
Genes around CPNE7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q24.3 by Entrez Gene
- 16q24.3 by HGNC
- 16q24.3 by Ensembl
CPNE7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CPNE7 Gene
Proteins for CPNE7 Gene
-
Protein details for CPNE7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UBL6-CPNE7_HUMAN
- Recommended name:
- Copine-7
- Protein Accession:
- Q9UBL6
Protein attributes for CPNE7 Gene
- Size:
- 633 amino acids
- Molecular mass:
- 70294 Da
- Quaternary structure:
- No Data Available
Protein Expression for CPNE7 Gene
Post-translational modifications for CPNE7 Gene
Other Protein References for CPNE7 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CPNE7
- Novus Biologicals Antibodies for CPNE7
- Invitrogen Antibodies for CPNE7 (AFLGC-CPNE7)
- GeneTex CPNE7 Antibody for CPNE7
-
Boster Bio Antibodies for CPNE7
Protein Products
-
OriGene Purified Proteins for CPNE7
- Search Origene for MassSpec and Protein Over-expression Lysates for CPNE7
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- antibodies-online: Search results for 4 available CPNE7 Proteins ranked by validation data
- Compare Top CPNE7 Proteins
-
Quality Products:
- Search GeneTex for Proteins for CPNE7
-
Abcam proteins for CPNE7
Assay Products
No data available for DME Specific Peptides for CPNE7 Gene
Domains & Families for CPNE7 Gene
Gene Families for CPNE7 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CPNE7 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CPNE7 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UBL6UniProtKB/Swiss-Prot:
CPNE7_HUMAN :- The C2 domain 1 is not necessary for calcium-mediated translocation and association to the plasma membrane. The C2 domain 2 is necessary for calcium-mediated translocation and association to the plasma membrane.
- Belongs to the copine family.
- Domain:
-
- The C2 domain 1 is not necessary for calcium-mediated translocation and association to the plasma membrane. The C2 domain 2 is necessary for calcium-mediated translocation and association to the plasma membrane.
- Family:
-
- Belongs to the copine family.
Function for CPNE7 Gene
Molecular function for CPNE7 Gene
- UniProtKB/Swiss-Prot Function:
- Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.
- GENATLAS Biochemistry:
- copine VII,member of the COPINE family,potential tumor suppressor,but excluded as a candidate gene in breast cancers (TSG16A,TSG16D)
Phenotypes From GWAS Catalog for CPNE7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005215 | transporter activity | TAS | 10534407 |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for CPNE7 Gene
- GenomeRNAi human phenotypes for CPNE7:
Animal Model Products
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- Cyagen custom Knockout/knockin (KOKI) mouse models for CPNE7
-
CRISPR Products
-
OriGene CRISPR knockouts for CPNE7
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- genomics-online: gRNA clones - Search results for 106 available CPNE7 gene related products
- Overview of 106 available CPNE7 gene related products
- Applied Biological Materials CRISPR for CPNE7
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CPNE7
- GenScript: Design CRISPR guide RNA sequences for CPNE7
miRNA for CPNE7 Gene
- miRTarBase miRNAs that target CPNE7
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CPNE7
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- Overview of 106 available CPNE7 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CPNE7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CPNE7
- Applied Biological Materials Clones for CPNE7
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CPNE7
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPNE7 Gene
Localization for CPNE7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CPNE7 Gene
- Cytoplasm. Nucleus. Cell membrane. Note=Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455). {ECO:0000269 PubMed:21087455}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 21087455 |
| GO:0005737 | cytoplasm | IEA,IDA | 21087455 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 23533145 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CPNE7 Gene
Pathways & Interactions for CPNE7 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glycerophospholipid biosynthesis | ||
| 2 | Metabolism |
.37
|
|
Pathways by source for CPNE7 Gene
4 Reactome pathways for CPNE7 Gene
Interacting Proteins for CPNE7 Gene
Selected Interacting proteins:
Q9UBL6-CPNE7_HUMAN
ENSP00000268720
for CPNE7 Gene via
UniProtKB
IID
STRING
MINT
GPS-Prot Interaction Network for CPNE7
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | TAS | 10534407 |
| GO:0046474 | glycerophospholipid biosynthetic process | TAS | -- |
| GO:0071277 | cellular response to calcium ion | IDA | 21087455 |
No data available for SIGNOR curated interactions for CPNE7 Gene
Drugs & Compounds for CPNE7 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Approved | Nutra | 0 |
Drug Products
Transcripts for CPNE7 Gene
mRNA/cDNA for CPNE7 Gene
- (8) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (60) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000268720 2657 bps (uc002fnp.3)
- ENST00000525982 576 bps (uc059ypd.1)
- ENST00000319518 2409 bps (uc002fnq.4)
- ENST00000532500 550 bps (uc059ype.1)
- ENST00000529800 519 bps (uc059ypf.1)
CRISPR Products
-
OriGene CRISPR knockouts for CPNE7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CPNE7
- genomics-online: gRNA clones - Search results for 106 available CPNE7 gene related products
- Overview of 106 available CPNE7 gene related products
- Applied Biological Materials CRISPR for CPNE7
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CPNE7
- GenScript: Design CRISPR guide RNA sequences for CPNE7
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CPNE7
- Browse OriGene Inhibitory RNA Products For CPNE7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPNE7
- genomics-online: shRNA clones - Search results for 106 available CPNE7 gene related products
- Overview of 106 available CPNE7 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CPNE7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CPNE7
- Applied Biological Materials Clones for CPNE7
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CPNE7 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
-
Eye (Sensory Organs)
- Lens Vesicle Cells Lens Vesicle
- Lens
-
Blood (Hematopoietic System)
- Natural Killer Cells Peripheral Blood
-
Stomach (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for CPNE7 Gene
This gene is overexpressed in Brain - Cortex (x5.1), Brain - Anterior cingulate cortex (BA24) (x4.6), and Pituitary (x4.6).
This gene is overexpressed in Lung (42.7), Urine (6.8), and Brain (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CPNE7 Gene
NURSA nuclear receptor signaling pathways regulating expression of CPNE7 Gene:
CPNE7SOURCE GeneReport for Unigene cluster for CPNE7 Gene:
Hs.461775mRNA Expression by UniProt/SwissProt for CPNE7 Gene:
Q9UBL6-CPNE7_HUMAN
Tissue specificity:
Expressed in the brain, testis, thymus and small intestine (PubMed:10534407, PubMed:12949241).
Evidence on tissue expression from TISSUES for CPNE7 Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for CPNE7
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CPNE7 Gene
Orthologs for CPNE7 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CPNE7 33 |
|
||
| cow (Bos Taurus) |
Mammalia | CPNE7 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CPNE7 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Cpne7 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Cpne7 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CPNE7 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CPNE7 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CPNE7 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cpne7 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | CPNE7 34 |
|
OneToOne | |
| LOC564556 33 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | gem-4 34 |
|
ManyToMany | |
| nra-1 34 |
|
ManyToMany | |||
| Y73F8A.19 35 |
|
|
|||
| cpna-5 34 |
|
ManyToMany | |||
| cpna-4 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for CPNE7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for CPNE7 Gene
- ENSEMBL:
- Gene Tree for CPNE7 (if available)
- TreeFam:
- Gene Tree for CPNE7 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CPNE7: view image
Paralogs for CPNE7 Gene
(8) SIMAP similar genes for CPNE7 Gene using alignment to 5 proteins:
- CPNE7_HUMAN
- E9PJ31_HUMAN
- H0YE30_HUMAN
- H0YEH8_HUMAN
- H3BP03_HUMAN
Variants for CPNE7 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000031435 | -- | 89,575,514(+) | C/T | upstream_transcript_variant | |
| rs1000079252 | -- | 89,594,557(+) | C/T | intron_variant | |
| rs1000186637 | -- | 89,579,483(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000243934 | -- | 89,597,519(+) | C/T | downstream_transcript_variant | |
| rs1000326963 | -- | 89,579,303(+) | A/T | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.73;
83.14% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CPNE7 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CPNE7
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPNE7 Gene
Disorders for CPNE7 Gene
Additional Disease Information for CPNE7
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for CPNE7 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPNE7 Gene
Publications for CPNE7 Gene
- Copines-1, -2, -3, -6 and -7 show different calcium-dependent intracellular membrane translocation and targeting. (PMID: 21087455) Perestenko PV … Jeffrey McIlhinney RA (The FEBS journal 2010) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Characterization of copine VII, a new member of the copine family, and its exclusion as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3. (PMID: 10534407) Savino M … Savoia A (Genomics 1999) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 58
Products for CPNE7 Gene
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- Quality Products:
- GeneTex CPNE7 Antibody for CPNE7
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- genomics-online: cdna clones - Search results for 106 available CPNE7 gene related products
- Overview of 106 available CPNE7 gene related products
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- Overview of 106 available CPNE7 gene related products
- genomics-online: gRNA clones - Search results for 106 available CPNE7 gene related products
- Overview of 106 available CPNE7 gene related products
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- Overview of 106 available CPNE7 gene related products
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- Overview of 106 available CPNE7 gene related products
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Sources for CPNE7 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
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