Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript varia... See more...

Aliases for CPNE2 Gene

Aliases for CPNE2 Gene

  • Copine 2 2 3 5
  • Copine II 2 3 4
  • Copine-2 3 4
  • COPN2 3
  • CPN2 3

External Ids for CPNE2 Gene

Previous GeneCards Identifiers for CPNE2 Gene

  • GC16P047522
  • GC16P057204
  • GC16P056861
  • GC16P056901
  • GC16P055684
  • GC16P042996

Summaries for CPNE2 Gene

Entrez Gene Summary for CPNE2 Gene

  • Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript variants but their full-length natures could not be determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPNE2 Gene

CPNE2 (Copine 2) is a Protein Coding gene. An important paralog of this gene is CPNE3.

UniProtKB/Swiss-Prot Summary for CPNE2 Gene

  • Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties.

Additional gene information for CPNE2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CPNE2 Gene

Genomics for CPNE2 Gene

GeneHancer (GH) Regulatory Elements for CPNE2 Gene

Promoters and enhancers for CPNE2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J057091 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 506.5 +0.4 398 3.7 HNRNPK CTCF POLR2G PHF8 ZFX ZNF10 POLR2A ZNF423 ZBTB26 TARDBP CPNE2 ENSG00000260148 CIAPIN1 RF00951-047
GH16J057090 Promoter/Enhancer 0.7 Ensembl dbSUPER 500.7 -1.9 -1942 0.4 ZNF146 PRDM10 ZNF140 CPNE2 ENSG00000260148 PSME3IP1 ENSG00000260145
GH16J057123 Enhancer 1 Ensembl ENCODE dbSUPER 26.9 +31.4 31358 2.2 RBM25 NFIC SPI1 FOSL1 BCOR ZNF189 VEZF1 MITF POLR2A ZMYM3 CPNE2 RF00951-047
GH16J057070 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 19.6 -21.6 -21558 4.8 RBAK ZNF10 CTBP1 ZNF316 MAFF MAFK ZFHX2 NR2F1 SUPT5H TAF15 CPNE2 NLRC5 CETP PSME3IP1 RSPRY1 ENSG00000260145 ENSG00000260148
GH16J057138 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.6 +51.5 51538 11.4 CTCF ZIC2 RFX1 CTBP1 NR2F2 NCOR1 RELA TCF12 GABPA RAD21 ENSG00000279019 ENSG00000279803 piR-61945-186 PSME3IP1 PLLP CPNE2 RSPRY1 ARL2BP ENSG00000261114 BBS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CPNE2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CPNE2

Top Transcription factor binding sites by QIAGEN in the CPNE2 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Hlf
  • RP58
  • SRF
  • SRF (504 AA)

Genomic Locations for CPNE2 Gene

Genomic Locations for CPNE2 Gene
chr16:57,092,543-57,148,369
(GRCh38/hg38)
Size:
55,827 bases
Orientation:
Plus strand
chr16:57,126,449-57,181,878
(GRCh37/hg19)
Size:
55,430 bases
Orientation:
Plus strand

Genomic View for CPNE2 Gene

Genes around CPNE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPNE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPNE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPNE2 Gene

Proteins for CPNE2 Gene

  • Protein details for CPNE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FN4-CPNE2_HUMAN
    Recommended name:
    Copine-2
    Protein Accession:
    Q96FN4
    Secondary Accessions:
    • Q68D19
    • Q719H8
    • Q86XP9

    Protein attributes for CPNE2 Gene

    Size:
    548 amino acids
    Molecular mass:
    61190 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CPNE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPNE2 Gene

Post-translational modifications for CPNE2 Gene

  • Ubiquitination at Lys92
  • Modification sites at PhosphoSitePlus

Other Protein References for CPNE2 Gene

No data available for DME Specific Peptides for CPNE2 Gene

Domains & Families for CPNE2 Gene

Gene Families for CPNE2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CPNE2 Gene

Blocks:
  • C2 domain
  • Copine
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CPNE2 Gene

GenScript: Design optimal peptide antigens:
  • Copine II (CPNE2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96FN4

UniProtKB/Swiss-Prot:

CPNE2_HUMAN :
  • The C2 domain 2, but not the C2 domain 1, is necessary for calcium-mediated membrane association. The linker region is necessary for calcium-dependent cell membrane association.
  • Belongs to the copine family.
Domain:
  • The C2 domain 2, but not the C2 domain 1, is necessary for calcium-mediated membrane association. The linker region is necessary for calcium-dependent cell membrane association.
Family:
  • Belongs to the copine family.
genes like me logo Genes that share domains with CPNE2: view

Function for CPNE2 Gene

Molecular function for CPNE2 Gene

UniProtKB/Swiss-Prot Function:
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties.

Phenotypes From GWAS Catalog for CPNE2 Gene

Gene Ontology (GO) - Molecular Function for CPNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
GO:0005544 calcium-dependent phospholipid binding IBA 21873635
genes like me logo Genes that share ontologies with CPNE2: view
genes like me logo Genes that share phenotypes with CPNE2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPNE2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPNE2 Gene

Localization for CPNE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPNE2 Gene

Cytoplasm. Nucleus. Cell membrane. Note=Translocates to the cell membrane and the nucleus in a calcium-dependent manner. Colocalizes with CD2 at the cell membrane. {ECO:0000250 UniProtKB:P59108}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPNE2 gene
Compartment Confidence
plasma membrane 4
nucleus 4
cytosol 2
extracellular 1
cytoskeleton 1
endosome 1
lysosome 1
golgi apparatus 1
mitochondrion 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CPNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with CPNE2: view

Pathways & Interactions for CPNE2 Gene

PathCards logo

SuperPathways for CPNE2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071277 cellular response to calcium ion IBA 21873635
genes like me logo Genes that share ontologies with CPNE2: view

No data available for Pathways by source and SIGNOR curated interactions for CPNE2 Gene

Drugs & Compounds for CPNE2 Gene

No Compound Related Data Available

Transcripts for CPNE2 Gene

mRNA/cDNA for CPNE2 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPNE2

Alternative Splicing Database (ASD) splice patterns (SP) for CPNE2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - - - - -
SP2: - - - - -
SP3:
SP4: - -
SP5: - - -
SP6:
SP7: - - - - - - - - - - - - - - -
SP8: -

Relevant External Links for CPNE2 Gene

GeneLoc Exon Structure for
CPNE2

Expression for CPNE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CPNE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CPNE2 Gene

This gene is overexpressed in Serum (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CPNE2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CPNE2

SOURCE GeneReport for Unigene cluster for CPNE2 Gene:

Hs.339809

mRNA Expression by UniProt/SwissProt for CPNE2 Gene:

Q96FN4-CPNE2_HUMAN
Tissue specificity: Expressed in the brain. Expressed in neutrophil precursors from the bone marrow and peripheral blood (PubMed:12949241).

Evidence on tissue expression from TISSUES for CPNE2 Gene

  • Nervous system(4.5)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with CPNE2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPNE2 Gene

Orthologs for CPNE2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CPNE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPNE2 31 30
  • 99.64 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CPNE2 31 30
  • 92.64 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CPNE2 31 30
  • 92.46 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPNE2 31
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPNE2 31
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpne2 17 31 30
  • 89.29 (n)
rat
(Rattus norvegicus)
Mammalia Cpne2 30
  • 88.72 (n)
chicken
(Gallus gallus)
Aves CPNE2 31 30
  • 83.36 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPNE2 31
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpne2 30
  • 73.31 (n)
zebrafish
(Danio rerio)
Actinopterygii cpne2 31 30
  • 74.32 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13834 30
corn
(Zea mays)
Liliopsida Zm.9280 30
wheat
(Triticum aestivum)
Liliopsida Ta.1560 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 54 (a)
ManyToMany
CSA.7161 31
  • 49 (a)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
Species where no ortholog for CPNE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for CPNE2 Gene

ENSEMBL:
Gene Tree for CPNE2 (if available)
TreeFam:
Gene Tree for CPNE2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CPNE2: view image

Paralogs for CPNE2 Gene

Paralogs for CPNE2 Gene

(8) SIMAP similar genes for CPNE2 Gene using alignment to 5 proteins:

  • CPNE2_HUMAN
  • H3BPR8_HUMAN
  • H3BQQ3_HUMAN
  • H3BUC8_HUMAN
  • Q719H8_HUMAN
genes like me logo Genes that share paralogs with CPNE2: view

Variants for CPNE2 Gene

Additional dbSNP identifiers (rs#s) for CPNE2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CPNE2 Gene

Variant ID Type Subtype PubMed ID
dgv5138n54 CNV gain 21841781
dgv5139n54 CNV loss 21841781
dgv5140n54 CNV gain 21841781
dgv5141n54 CNV gain+loss 21841781
esv22093 CNV loss 19812545
esv3553471 CNV deletion 23714750
nsv1113811 CNV deletion 24896259
nsv522759 CNV loss 19592680
nsv572704 CNV gain 21841781
nsv572716 CNV loss 21841781
nsv827683 CNV loss 20364138

Variation tolerance for CPNE2 Gene

Residual Variation Intolerance Score: 19.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPNE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPNE2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CPNE2 Gene

Disorders for CPNE2 Gene

Additional Disease Information for CPNE2

No disorders were found for CPNE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPNE2 Gene

Publications for CPNE2 Gene

  1. The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans. (PMID: 9430674) Creutz CE … Cohen J (The Journal of biological chemistry 1998) 2 3 23 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Tissue expression of copines and isolation of copines I and III from the cytosol of human neutrophils. (PMID: 12949241) Cowland JB … Lollike K (Journal of leukocyte biology 2003) 3 4 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage. (PMID: 28031328) An H … Sun FL (Molecular and cellular biology 2017) 3 54

Products for CPNE2 Gene

Sources for CPNE2 Gene