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Aliases for CPN2 Gene

Aliases for CPN2 Gene

  • Carboxypeptidase N Subunit 2 2 3 3 5
  • Carboxypeptidase N, Polypeptide 2, 83kD 2 3
  • Carboxypeptidase N Regulatory Subunit 3 4
  • Carboxypeptidase N Large Subunit 3 4
  • Carboxypeptidase N 83 KDa Chain 3 4
  • ACBP 3 4
  • Carboxypeptidase N, Polypeptide 2 2
  • Carboxypeptidase N Polypeptide 2 4
  • Arginine Carboxypeptidase 3

External Ids for CPN2 Gene

Previous HGNC Symbols for CPN2 Gene

  • ACBP

Previous GeneCards Identifiers for CPN2 Gene

  • GC08U990012
  • GC03M195380
  • GC03M195542
  • GC03U900610
  • GC03M194060
  • GC03M191440

Summaries for CPN2 Gene

GeneCards Summary for CPN2 Gene

CPN2 (Carboxypeptidase N Subunit 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include enzyme regulator activity. An important paralog of this gene is LRRC15.

UniProtKB/Swiss-Prot for CPN2 Gene

  • The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit.

Gene Wiki entry for CPN2 Gene

Additional gene information for CPN2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPN2 Gene

Genomics for CPN2 Gene

GeneHancer (GH) Regulatory Elements for CPN2 Gene

Promoters and enhancers for CPN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J194351 Promoter 1.2 EPDnew 650.7 +0.0 23 0.1 FOXA2 ARID4B DMAP1 ZSCAN9 RARA SLC30A9 ZNF614 EGR1 CREM THAP11 CPN2 GC03P194346 PIR54267 GC03P194349 GC03P194348 GC03P194347 GC03P194345 GC03P194344 GC03P194343 GC03P194342
GH03J194350 Enhancer 0.9 ENCODE 650.7 +0.8 848 0.5 PKNOX1 FEZF1 ZNF2 YY1 ZNF121 GLIS2 ZNF213 KLF7 RXRA REST CPN2 LRRC15 ENSG00000229964 ENSG00000233987 LINC01972 ENSG00000238031 GC03P194343 GC03P194344 PIR54267 GC03P194349
GH03J194571 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -222.5 -222486 5.3 PKNOX1 SMAD1 MLX ARNT ARID4B FEZF1 ZNF2 SLC30A9 ZNF766 E2F8 ATP13A3 TMEM44-AS1 LSG1 ENSG00000244675 LINC00884 RNU6-1101P GP5 RNU6ATAC24P CPN2 ACAP2
GH03J194166 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.7 +184.2 184244 0.6 HDAC1 PKNOX1 FOXA2 RB1 KLF17 FEZF1 ZNF2 ZNF335 GLIS2 SCRT2 HES1 ENSG00000232874 CPN2 RN7SL215P GC03P194205
GH03J194577 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.2 -227.4 -227388 2.3 HDAC1 ELF3 KLF17 ZNF335 GLIS2 FOS CREM EGR2 ZNF362 ZEB2 ATP13A3 ENSG00000244675 LINC00884 RNU6-1101P GP5 CPN2 TMEM44-AS1 RPL23AP93
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CPN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CPN2 gene promoter:
  • GR-alpha
  • GR
  • GR-beta
  • PPAR-gamma2
  • PPAR-gamma1
  • E47
  • Hand1
  • NF-kappaB1

Genomic Locations for CPN2 Gene

Genomic Locations for CPN2 Gene
chr3:194,339,765-194,351,345
(GRCh38/hg38)
Size:
11,581 bases
Orientation:
Minus strand
chr3:194,060,494-194,072,057
(GRCh37/hg19)
Size:
11,564 bases
Orientation:
Minus strand

Genomic View for CPN2 Gene

Genes around CPN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPN2 Gene

Proteins for CPN2 Gene

  • Protein details for CPN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22792-CPN2_HUMAN
    Recommended name:
    Carboxypeptidase N subunit 2
    Protein Accession:
    P22792
    Secondary Accessions:
    • B2RPE7
    • Q86SU4
    • Q8N5V4

    Protein attributes for CPN2 Gene

    Size:
    545 amino acids
    Molecular mass:
    60557 Da
    Quaternary structure:
    • Tetramer of two catalytic chains and two glycosylated inactive chains.

neXtProt entry for CPN2 Gene

Post-translational modifications for CPN2 Gene

  • Whether or not any Cys residues participate in intrachain bonds is unknown, but they do not form interchain disulfide bonds with the 50 kDa catalytic subunit.
  • Glycosylation at Asn518, Asn359, posLast=348348, Asn266, Asn228, posLast=119119, Asn111, and Asn74
  • Modification sites at PhosphoSitePlus

Other Protein References for CPN2 Gene

No data available for DME Specific Peptides for CPN2 Gene

Domains & Families for CPN2 Gene

Gene Families for CPN2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CPN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CPN2: view

No data available for UniProtKB/Swiss-Prot for CPN2 Gene

Function for CPN2 Gene

Molecular function for CPN2 Gene

UniProtKB/Swiss-Prot Function:
The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit.
GENATLAS Biochemistry:
carboxypeptidase N2 regulatory subunit,83kDa

Gene Ontology (GO) - Molecular Function for CPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 metallocarboxypeptidase activity TAS --
GO:0005515 protein binding IEA --
GO:0030234 enzyme regulator activity NAS 2378615
genes like me logo Genes that share ontologies with CPN2: view
genes like me logo Genes that share phenotypes with CPN2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CPN2

miRNA for CPN2 Gene

miRTarBase miRNAs that target CPN2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPN2 Gene

Localization for CPN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPN2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPN2 gene
Compartment Confidence
extracellular 5
plasma membrane 1
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0070062 extracellular exosome HDA 23533145
GO:0072562 blood microparticle HDA 22516433
genes like me logo Genes that share ontologies with CPN2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CPN2 Gene

Pathways & Interactions for CPN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0030449 regulation of complement activation TAS --
GO:0050790 regulation of catalytic activity IEA --
GO:0050821 protein stabilization NAS 2378615
genes like me logo Genes that share ontologies with CPN2: view

No data available for Pathways by source and SIGNOR curated interactions for CPN2 Gene

Drugs & Compounds for CPN2 Gene

(1) Drugs for CPN2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma Target 2430
genes like me logo Genes that share compounds with CPN2: view

Transcripts for CPN2 Gene

mRNA/cDNA for CPN2 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CPN2 Gene

Carboxypeptidase N, polypeptide 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPN2 Gene

No ASD Table

Relevant External Links for CPN2 Gene

GeneLoc Exon Structure for
CPN2
ECgene alternative splicing isoforms for
CPN2

Expression for CPN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPN2 Gene

This gene is overexpressed in Liver (x45.2) and Kidney - Cortex (x6.1).

Protein differential expression in normal tissues from HIPED for CPN2 Gene

This gene is overexpressed in Serum (33.6), Plasma (11.5), Synovial fluid (8.8), and Urine (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CPN2 Gene



Protein tissue co-expression partners for CPN2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CPN2 Gene:

CPN2

SOURCE GeneReport for Unigene cluster for CPN2 Gene:

Hs.528368

Evidence on tissue expression from TISSUES for CPN2 Gene

  • Bone marrow(4.2)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with CPN2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPN2 Gene

Orthologs for CPN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPN2 34 33
  • 98.47 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CPN2 34 33
  • 81.47 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CPN2 34 33
  • 81.19 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpn2 33
  • 77.35 (n)
mouse
(Mus musculus)
Mammalia Cpn2 16 34 33
  • 75.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CPN2 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPN2 34 33
  • 57.82 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPN2 34
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734844 33
  • 45.59 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:153913 33
  • 48.72 (n)
CPN2 34
  • 30 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG16974 34
  • 12 (a)
OneToMany
Species where no ortholog for CPN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPN2 Gene

ENSEMBL:
Gene Tree for CPN2 (if available)
TreeFam:
Gene Tree for CPN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CPN2: view image

Paralogs for CPN2 Gene

(5) SIMAP similar genes for CPN2 Gene using alignment to 1 proteins:

  • CPN2_HUMAN
genes like me logo Genes that share paralogs with CPN2: view

Variants for CPN2 Gene

Sequence variations from dbSNP and Humsavar for CPN2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000115445 -- 194,344,686(-) C/T intron_variant
rs1000199710 -- 194,346,119(-) A/T intron_variant
rs1000402367 -- 194,344,415(-) G/A intron_variant
rs1000475195 -- 194,351,847(-) A/G upstream_transcript_variant
rs1000653432 -- 194,348,385(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CPN2 Gene

Variant ID Type Subtype PubMed ID
dgv2671n106 CNV deletion 24896259
esv24336 CNV gain 19812545
esv2563733 CNV insertion 19546169
esv2726431 CNV deletion 23290073
nsv1073274 CNV deletion 25765185
nsv592957 CNV loss 21841781
nsv950294 CNV deletion 24416366

Variation tolerance for CPN2 Gene

Residual Variation Intolerance Score: 64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.43; 81.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPN2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPN2 Gene

Disorders for CPN2 Gene

Additional Disease Information for CPN2

No disorders were found for CPN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPN2 Gene

Publications for CPN2 Gene

  1. The deduced protein sequence of the human carboxypeptidase N high molecular weight subunit reveals the presence of leucine-rich tandem repeats. (PMID: 2378615) Tan F … Erdös EG (The Journal of biological chemistry 1990) 2 3 4 58
  2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 58
  3. Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PMID: 14760718) Bunkenborg J … Wiśniewski JR (Proteomics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1). (PMID: 9628828) Riley DA … Skidgel RA (Genomics 1998) 2 3 58

Products for CPN2 Gene

Sources for CPN2 Gene

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