Aliases for CPM Gene
External Ids for CPM Gene
Previous GeneCards Identifiers for CPM Gene
The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for CPM Gene
CPM (Carboxypeptidase M) is a Protein Coding gene. Diseases associated with CPM include Well-Differentiated Liposarcoma and Lateral Medullary Syndrome. Among its related pathways are Post-translational modification- synthesis of GPI-anchored proteins and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on ester bonds and carboxypeptidase activity. An important paralog of this gene is CPD.
UniProtKB/Swiss-Prot Summary for CPM Gene
Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.