The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this p... See more...

Aliases for CPM Gene

Aliases for CPM Gene

  • Carboxypeptidase M 2 3 4 5
  • Urinary Carboxypeptidase B 2 3
  • Renal Carboxypeptidase 2 3
  • EC 3.4.17.12 4
  • EC 3.4.17 51
  • CPM 5

External Ids for CPM Gene

Previous GeneCards Identifiers for CPM Gene

  • GC12P068885
  • GC12M069120
  • GC12M068952
  • GC12M067534
  • GC12M067531
  • GC12M069244
  • GC12M066295

Summaries for CPM Gene

Entrez Gene Summary for CPM Gene

  • The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPM Gene

CPM (Carboxypeptidase M) is a Protein Coding gene. Diseases associated with CPM include Lateral Medullary Syndrome and Esophagus Sarcoma. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on ester bonds and carboxypeptidase activity. An important paralog of this gene is CPD.

UniProtKB/Swiss-Prot Summary for CPM Gene

  • Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.

Gene Wiki entry for CPM Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CPM Gene

Genomics for CPM Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CPM Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J068932 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.3 +39.2 39170 3.6 RNF2 POLR2A ZNF692 PRDM1 IKZF2 EZH2 ZNF341 PKNOX1 ZNF561 SCRT2 lnc-MDM2-2 CPM ENSG00000257289 lnc-MDM2-1 MDM2
GH12J068961 Promoter/Enhancer 1 EPDnew FANTOM5 ENCODE 652 +8.3 8302 3 NFE2 CEBPB YY1 CEBPG HLF CPM piR-57801-009 RAP1B LYZ MN297169 lnc-CPM-4 MDM2
GH12J068970 Enhancer 0.5 ENCODE 600.7 +0.1 121 0.8 JUND JUN FOS EP300 FOSL2 CPM MN297170 lnc-CPM-4 MN297169 MDM2
GH12J069052 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas 57.4 -83.4 -83431 6 GATAD2A TEAD4 RCOR2 ZNF7 RELA RXRB IRF2 SP1 CEBPA SOX13 CPM CPSF6 NUP107 RAP1B LYZ lnc-CPSF6-3 lnc-CPM-7
GH12J069006 Enhancer 1.2 FANTOM5 ENCODE CraniofacialAtlas 37.6 -36.3 -36337 3.3 CEBPG CREB1 ZNF629 ZNF692 FOXA1 PRDM1 PKNOX1 POLR2A PATZ1 CEBPA LOC107984471 lnc-MDM2-3 lnc-CPM-7 CPM RAP1B LYZ CPSF6 MDM2 FRS2 YEATS4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CPM on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CPM

Top Transcription factor binding sites by QIAGEN in the CPM gene promoter:
  • AML1a
  • c-Myb
  • FOXD3
  • FOXL1
  • FOXO1
  • FOXO1a
  • Nkx2-2
  • Pax-2
  • Pax-2a
  • TBP

Genomic Locations for CPM Gene

Genomic Locations for CPM Gene
chr12:68,842,193-68,971,570
(GRCh38/hg38)
Size:
129,378 bases
Orientation:
Minus strand
chr12:69,235,977-69,365,350
(GRCh37/hg19)
Size:
129,374 bases
Orientation:
Minus strand

Genomic View for CPM Gene

Genes around CPM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPM Gene

Proteins for CPM Gene

  • Protein details for CPM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14384-CBPM_HUMAN
    Recommended name:
    Carboxypeptidase M
    Protein Accession:
    P14384
    Secondary Accessions:
    • B2R800
    • Q9H2K9

    Protein attributes for CPM Gene

    Size:
    443 amino acids
    Molecular mass:
    50514 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CPM Gene

neXtProt entry for CPM Gene

Selected DME Specific Peptides for CPM Gene

P14384:
  • PEFKYVANMHG
  • FVLSANLHGG
  • DLNRNFPD
  • MPSMNPDG
  • CFEITLELSC
  • ELSCCKYP
  • TRIHIMPS

Post-translational modifications for CPM Gene

  • Glycosylation at Asn38, Asn115, Asn164, Asn363, and Asn384
  • Modification sites at PhosphoSitePlus

Domains & Families for CPM Gene

Gene Families for CPM Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CPM Gene

Suggested Antigen Peptide Sequences for CPM Gene

GenScript: Design optimal peptide antigens:
  • Carboxypeptidase M (CBPM_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P14384

UniProtKB/Swiss-Prot:

CBPM_HUMAN :
  • Belongs to the peptidase M14 family.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPM: view

Function for CPM Gene

Molecular function for CPM Gene

UniProtKB/Swiss-Prot Function:
Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Cleavage of C-terminal arginine or lysine residues from polypeptides.; EC=3.4.17.12; Evidence={ECO:0000269|PubMed:12457462};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=59 uM for synthetic dansyl-Ala-Arg {ECO:0000269|PubMed:12457462}; KM=57 uM for placental peptide hormones {ECO:0000269|PubMed:12457462}; pH dependence: Optimum pH is 7.0. {ECO:0000269|PubMed:12457462};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by O-phenanthroline and MGTA and activated by cobalt.
GENATLAS Biochemistry:
carboxypeptidase M,involved in monocyte to macrophage differentiation

Enzyme Numbers (IUBMB) for CPM Gene

Phenotypes From GWAS Catalog for CPM Gene

Gene Ontology (GO) - Molecular Function for CPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity TAS 7797563
GO:0004181 metallocarboxypeptidase activity TAS,IBA 21873635
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CPM: view
genes like me logo Genes that share phenotypes with CPM: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CPM

CRISPR Products

miRNA for CPM Gene

miRTarBase miRNAs that target CPM

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPM

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPM Gene

Localization for CPM Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPM Gene

Cell membrane. Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPM gene
Compartment Confidence
extracellular 5
plasma membrane 4
endoplasmic reticulum 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface HDA 19581412
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CPM: view

Pathways & Interactions for CPM Gene

genes like me logo Genes that share pathways with CPM: view

SIGNOR curated interactions for CPM Gene

Inactivates:

Gene Ontology (GO) - Biological Process for CPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006518 peptide metabolic process IBA 21873635
GO:0009653 anatomical structure morphogenesis TAS 7797563
GO:0016485 protein processing IBA 21873635
genes like me logo Genes that share ontologies with CPM: view

Drugs & Compounds for CPM Gene

(22) Drugs for CPM Gene - From: ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dopamine Approved Pharma Agonist, Full agonist 3978
Norepinephrine Approved Pharma 952
Pregabalin Approved, Investigational Pharma 441
Cobalt Approved, Experimental Pharma 200
Serotonin Investigational Nutra 4255

(1) Additional Compounds for CPM Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CPM: view

Transcripts for CPM Gene

mRNA/cDNA for CPM Gene

3 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPM

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPM Gene

No ASD Table

Relevant External Links for CPM Gene

GeneLoc Exon Structure for
CPM

Expression for CPM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CPM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPM Gene

This gene is overexpressed in Adipose - Subcutaneous (x7.5) and Adipose - Visceral (Omentum) (x4.5).

Protein differential expression in normal tissues from HIPED for CPM Gene

This gene is overexpressed in Cervix (47.4) and Adipocyte (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CPM Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CPM

SOURCE GeneReport for Unigene cluster for CPM Gene:

Hs.654387

Evidence on tissue expression from TISSUES for CPM Gene

  • Lung(4.6)
  • Liver(4.4)
  • Nervous system(3.1)
  • Kidney(2.7)
  • Skin(2.7)
  • Lymph node(2.6)
  • Heart(2.5)
  • Muscle(2.3)
  • Thyroid gland(2.3)
  • Gall bladder(2.3)
  • Blood(2.2)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with CPM: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPM Gene

Orthologs for CPM Gene

This gene was present in the common ancestor of animals.

Orthologs for CPM Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CPM 30 31
  • 99.47 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CPM 30 31
  • 86.35 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cpm 30
  • 83.14 (n)
Mouse
(Mus musculus)
Mammalia Cpm 30 17 31
  • 81.97 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CPM 31
  • 76 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CPM 31
  • 66 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CPM 31
  • 53 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CPM 30 31
  • 68.21 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CPM 31
  • 62 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cpm 30
  • 63.23 (n)
Str.11982 30
Zebrafish
(Danio rerio)
Actinopterygii cpm 30 31
  • 58.03 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG4678 30 31 32
  • 54.79 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000756 30
  • 51.69 (n)
Worm
(Caenorhabditis elegans)
Secernentea F59A3.1 32
  • 43 (a)
cpd-2 31
  • 31 (a)
ManyToMany
cpd-1 31
  • 16 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 33 (a)
ManyToMany
Species where no ortholog for CPM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CPM Gene

ENSEMBL:
Gene Tree for CPM (if available)
TreeFam:
Gene Tree for CPM (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CPM: view image

Paralogs for CPM Gene

Paralogs for CPM Gene

(7) SIMAP similar genes for CPM Gene using alignment to 7 proteins:

  • CBPM_HUMAN
  • F8VR29_HUMAN
  • F8VU13_HUMAN
  • F8VVI6_HUMAN
  • F8W111_HUMAN
  • H0YHG6_HUMAN
  • H0YHN7_HUMAN
genes like me logo Genes that share paralogs with CPM: view

Variants for CPM Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CPM Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs7309831 - p.Val133Ile
rs7978197 - p.Arg24His

Additional dbSNP identifiers (rs#s) for CPM Gene

Structural Variations from Database of Genomic Variants (DGV) for CPM Gene

Variant ID Type Subtype PubMed ID
esv21511 CNV gain+loss 19812545
esv2662286 CNV deletion 23128226
esv2666786 CNV deletion 23128226
esv2746013 CNV deletion 23290073
esv3549349 CNV deletion 23714750
esv3629859 CNV loss 21293372
esv3629860 CNV loss 21293372
esv3629861 CNV gain 21293372
nsv1042799 CNV gain 25217958
nsv1071040 CNV deletion 25765185
nsv512281 CNV loss 21212237
nsv523088 CNV loss 19592680
nsv523272 CNV loss 19592680
nsv52755 CNV deletion 16902084
nsv559220 CNV loss 21841781
nsv559221 CNV loss 21841781
nsv559222 CNV loss 21841781
nsv820353 CNV deletion 20802225
nsv826408 CNV gain 20364138
nsv826410 CNV loss 20364138

Variation tolerance for CPM Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.96; 84.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPM

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPM Gene

Disorders for CPM Gene

MalaCards: The human disease database

(6) MalaCards diseases for CPM Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lateral medullary syndrome
  • vertebral artery syndrome
esophagus sarcoma
  • esophageal sarcoma
well-differentiated liposarcoma
  • pleomorphic lipoma
dentine erosion
brain stem infarction
  • brainstem infarction
- elite association - COSMIC cancer census association via MalaCards
Search CPM in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CPM

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CPM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPM Gene

Publications for CPM Gene

  1. Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity. (PMID: 15066430) Reverter D … Bode W (Journal of molecular biology 2004) 3 4 23
  2. Effect of mutation of two critical glutamic acid residues on the activity and stability of human carboxypeptidase M and characterization of its signal for glycosylphosphatidylinositol anchoring. (PMID: 12457462) Tan F … Skidgel RA (The Biochemical journal 2003) 3 4 23
  3. Molecular structure and alternative splicing of the human carboxypeptidase M gene. (PMID: 11934264) Pessoa LG … Pesquero JB (Biological chemistry 2002) 3 4 23
  4. Type 2 diabetes locus on 12q15. Further mapping and mutation screening of two candidate genes. (PMID: 11147789) Bektas A … Doria A (Diabetes 2001) 3 4 23
  5. Carboxypeptidase M: a biomarker for the discrimination of well-differentiated liposarcoma from lipoma. (PMID: 19820690) Erickson-Johnson MR … Oliveira AM (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2009) 3 23

Products for CPM Gene

Sources for CPM Gene