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Aliases for CPM Gene

Aliases for CPM Gene

  • Carboxypeptidase M 2 3 5
  • Urinary Carboxypeptidase B 2
  • Renal Carboxypeptidase 2
  • EC 3.4.17.12 4
  • EC 3.4.17 56

External Ids for CPM Gene

Previous GeneCards Identifiers for CPM Gene

  • GC12P068885
  • GC12M069120
  • GC12M068952
  • GC12M067534
  • GC12M067531
  • GC12M069244
  • GC12M066295

Summaries for CPM Gene

Entrez Gene Summary for CPM Gene

  • The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPM Gene

CPM (Carboxypeptidase M) is a Protein Coding gene. Diseases associated with CPM include Well-Differentiated Liposarcoma. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on ester bonds and carboxypeptidase activity. An important paralog of this gene is CPD.

UniProtKB/Swiss-Prot for CPM Gene

  • Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.

Gene Wiki entry for CPM Gene

Additional gene information for CPM Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPM Gene

Genomics for CPM Gene

GeneHancer (GH) Regulatory Elements for CPM Gene

Promoters and enhancers for CPM Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I068932 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 550.3 +38.7 38674 1.8 PKNOX1 SIN3A RAD21 ZNF335 SCRT2 IKZF2 EGR2 CEBPB SMARCB1 ZFP69B CPM CPSF6 NUP107 KRT8P39 MDM2 RPL10P12 ENSG00000257289 PRELID2P1
GH12I068961 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE 602 +8.3 8302 3 HLF CEBPB CEBPG NFE2 CPM RAP1B LYZ PRELID2P1
GH12I068943 Promoter/Enhancer 1 EPDnew ENCODE 561.1 +27.2 27206 1.3 SOX5 SOX13 HNF1A ZNF26 CPM CPSF6 RNU7-4P NUP107 KRT8P39 PRELID2P1 ENSG00000257289
GH12I068970 Enhancer 0.7 Ensembl ENCODE 550.8 +0.3 270 1.4 JUND ZNF316 JUN FOSL2 FOS EP300 CPM PRELID2P1
GH12I069006 Enhancer 1.3 FANTOM5 Ensembl ENCODE 37.6 -36.3 -36337 3.3 PKNOX1 SIN3A FEZF1 BRCA1 RFX5 SCRT2 SMARCC2 FOS DEK ZNF362 GC12M069009 CPM RAP1B LYZ CPSF6 MDM2 FRS2 YEATS4 SLC35E3 NUP107
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CPM on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CPM gene promoter:

Genomic Locations for CPM Gene

Genomic Locations for CPM Gene
chr12:68,842,197-68,971,570
(GRCh38/hg38)
Size:
129,374 bases
Orientation:
Minus strand
chr12:69,235,977-69,365,350
(GRCh37/hg19)

Genomic View for CPM Gene

Genes around CPM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPM Gene

Proteins for CPM Gene

  • Protein details for CPM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14384-CBPM_HUMAN
    Recommended name:
    Carboxypeptidase M
    Protein Accession:
    P14384
    Secondary Accessions:
    • B2R800
    • Q9H2K9

    Protein attributes for CPM Gene

    Size:
    443 amino acids
    Molecular mass:
    50514 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CPM Gene

neXtProt entry for CPM Gene

Selected DME Specific Peptides for CPM Gene

P14384:
  • PEFKYVANMHG
  • FVLSANLHGG
  • DLNRNFPD
  • MPSMNPDG
  • CFEITLELSC
  • ELSCCKYP
  • TRIHIMPS

Post-translational modifications for CPM Gene

  • Glycosylation at Asn38, Asn115, Asn164, posLast=363363, and posLast=384384

Domains & Families for CPM Gene

Gene Families for CPM Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CPM Gene

Suggested Antigen Peptide Sequences for CPM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P14384

UniProtKB/Swiss-Prot:

CBPM_HUMAN :
  • Belongs to the peptidase M14 family.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPM: view

Function for CPM Gene

Molecular function for CPM Gene

GENATLAS Biochemistry:
carboxypeptidase M,involved in monocyte to macrophage differentiation
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=59 uM for synthetic dansyl-Ala-Arg {ECO:0000269 PubMed:12457462}; KM=57 uM for placental peptide hormones {ECO:0000269 PubMed:12457462}; pH dependence: Optimum pH is 7.0. {ECO:0000269 PubMed:12457462};
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of C-terminal arginine or lysine residues from polypeptides.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by O-phenanthroline and MGTA and activated by cobalt.
UniProtKB/Swiss-Prot Function:
Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.

Enzyme Numbers (IUBMB) for CPM Gene

Phenotypes From GWAS Catalog for CPM Gene

Gene Ontology (GO) - Molecular Function for CPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity TAS 7797563
GO:0004181 metallocarboxypeptidase activity TAS,IBA --
GO:0004185 serine-type carboxypeptidase activity IBA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
genes like me logo Genes that share ontologies with CPM: view
genes like me logo Genes that share phenotypes with CPM: view

Animal Model Products

CRISPR Products

miRNA for CPM Gene

miRTarBase miRNAs that target CPM

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPM Gene

Localization for CPM Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPM Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPM gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IDA,HDA 19581412
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CPM: view

Pathways & Interactions for CPM Gene

genes like me logo Genes that share pathways with CPM: view

Gene Ontology (GO) - Biological Process for CPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0006508 proteolysis IEA --
GO:0006518 peptide metabolic process IBA --
GO:0009653 anatomical structure morphogenesis TAS 7797563
GO:0016485 protein processing IBA --
genes like me logo Genes that share ontologies with CPM: view

No data available for SIGNOR curated interactions for CPM Gene

Drugs & Compounds for CPM Gene

(24) Drugs for CPM Gene - From: ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dopamine Approved Pharma Full agonist, Agonist 4008
Norepinephrine Approved Pharma 737
Pregabalin Approved, Illicit, Investigational Pharma GABA analog/VDCC ligand;anticonvulsant/anxiolytic analgesic 383
Analgesics Pharma 12601
Anti-Anxiety Agents Pharma 2024

(1) Additional Compounds for CPM Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CPM: view

Transcripts for CPM Gene

Unigene Clusters for CPM Gene

Carboxypeptidase M:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPM Gene

No ASD Table

Relevant External Links for CPM Gene

GeneLoc Exon Structure for
CPM
ECgene alternative splicing isoforms for
CPM

Expression for CPM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPM Gene

This gene is overexpressed in Adipose - Subcutaneous (x7.5) and Adipose - Visceral (Omentum) (x4.5).

Protein differential expression in normal tissues from HIPED for CPM Gene

This gene is overexpressed in Cervix (47.4) and Adipocyte (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CPM Gene



NURSA nuclear receptor signaling pathways regulating expression of CPM Gene:

CPM

SOURCE GeneReport for Unigene cluster for CPM Gene:

Hs.654387

Evidence on tissue expression from TISSUES for CPM Gene

  • Lung(4.6)
  • Liver(4.2)
  • Kidney(2.5)
  • Gall bladder(2.3)
  • Lymph node(2.3)
  • Nervous system(2.3)
  • Heart(2)
genes like me logo Genes that share expression patterns with CPM: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPM Gene

Orthologs for CPM Gene

This gene was present in the common ancestor of animals.

Orthologs for CPM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPM 33 34
  • 99.47 (n)
cow
(Bos Taurus)
Mammalia CPM 33 34
  • 86.35 (n)
rat
(Rattus norvegicus)
Mammalia Cpm 33
  • 83.14 (n)
mouse
(Mus musculus)
Mammalia Cpm 33 16 34
  • 81.97 (n)
dog
(Canis familiaris)
Mammalia CPM 34
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPM 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPM 34
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPM 33 34
  • 68.21 (n)
lizard
(Anolis carolinensis)
Reptilia CPM 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpm 33
  • 63.23 (n)
Str.11982 33
zebrafish
(Danio rerio)
Actinopterygii cpm 33 34
  • 58.03 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4678 35 33 34
  • 54.79 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000756 33
  • 51.69 (n)
worm
(Caenorhabditis elegans)
Secernentea F59A3.1 35
  • 43 (a)
cpd-2 34
  • 31 (a)
ManyToMany
cpd-1 34
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
ManyToMany
Species where no ortholog for CPM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPM Gene

ENSEMBL:
Gene Tree for CPM (if available)
TreeFam:
Gene Tree for CPM (if available)

Paralogs for CPM Gene

Paralogs for CPM Gene

(7) SIMAP similar genes for CPM Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CPM: view

Variants for CPM Gene

Sequence variations from dbSNP and Humsavar for CPM Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000002086 -- 68,873,156(-) C/A intron_variant
rs1000053632 -- 68,917,795(-) A/G/T intron_variant
rs1000055740 -- 68,855,769(-) T/G 3_prime_UTR_variant, intron_variant
rs1000065196 -- 68,844,417(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000091227 -- 68,845,383(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CPM Gene

Variant ID Type Subtype PubMed ID
nsv826410 CNV loss 20364138
nsv826408 CNV gain 20364138
nsv820353 CNV deletion 20802225
nsv559222 CNV loss 21841781
nsv559221 CNV loss 21841781
nsv559220 CNV loss 21841781
nsv52755 CNV deletion 16902084
nsv523272 CNV loss 19592680
nsv523088 CNV loss 19592680
nsv512281 CNV loss 21212237
nsv1071040 CNV deletion 25765185
nsv1042799 CNV gain 25217958
esv3629861 CNV gain 21293372
esv3629860 CNV loss 21293372
esv3629859 CNV loss 21293372
esv3549349 CNV deletion 23714750
esv2746013 CNV deletion 23290073
esv2666786 CNV deletion 23128226
esv2662286 CNV deletion 23128226
esv21511 CNV gain+loss 19812545

Variation tolerance for CPM Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.96; 84.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPM Gene

Disorders for CPM Gene

MalaCards: The human disease database

(1) MalaCards diseases for CPM Gene - From: GeneCards

Disorder Aliases PubMed IDs
well-differentiated liposarcoma
  • pleomorphic lipoma
- elite association - COSMIC cancer census association via MalaCards
Search CPM in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CPM

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CPM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPM Gene

Publications for CPM Gene

  1. Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity. (PMID: 15066430) Reverter D … Bode W (Journal of molecular biology 2004) 3 4 22 58
  2. Effect of mutation of two critical glutamic acid residues on the activity and stability of human carboxypeptidase M and characterization of its signal for glycosylphosphatidylinositol anchoring. (PMID: 12457462) Tan F … Skidgel RA (The Biochemical journal 2003) 3 4 22 58
  3. Molecular structure and alternative splicing of the human carboxypeptidase M gene. (PMID: 11934264) Pessoa LG … Pesquero JB (Biological chemistry 2002) 3 4 22 58
  4. Type 2 diabetes locus on 12q15. Further mapping and mutation screening of two candidate genes. (PMID: 11147789) Bektas A … Doria A (Diabetes 2001) 3 4 22 58
  5. Carboxypeptidase M: a biomarker for the discrimination of well-differentiated liposarcoma from lipoma. (PMID: 19820690) Erickson-Johnson MR … Oliveira AM (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2009) 3 22 58

Products for CPM Gene

Sources for CPM Gene

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