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Aliases for CPLX4 Gene

Aliases for CPLX4 Gene

  • Complexin 4 2 3 5
  • Complexin IV 3 4
  • CPX IV 3 4
  • Complexin-4 3
  • CPX-IV 3
  • CPXIV 3

External Ids for CPLX4 Gene

Previous GeneCards Identifiers for CPLX4 Gene

  • GC18M056748
  • GC18M055112
  • GC18M055111
  • GC18M055113
  • GC18M056962
  • GC18M053671

Summaries for CPLX4 Gene

Entrez Gene Summary for CPLX4 Gene

  • This gene likely encodes a member of the complexin family. The encoded protein may be involved in synaptic vesicle exocytosis. [provided by RefSeq, Jan 2009]

GeneCards Summary for CPLX4 Gene

CPLX4 (Complexin 4) is a Protein Coding gene. Among its related pathways are Synaptic vesicle cycle. Gene Ontology (GO) annotations related to this gene include syntaxin binding and SNARE binding. An important paralog of this gene is CPLX3.

UniProtKB/Swiss-Prot for CPLX4 Gene

  • Positively regulates a late step in synaptic vesicle exocytosis.

Additional gene information for CPLX4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPLX4 Gene

Genomics for CPLX4 Gene

GeneHancer (GH) Regulatory Elements for CPLX4 Gene

Promoters and enhancers for CPLX4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J059318 Promoter 0.5 EPDnew 650.7 0.0 -20 0.1 CPLX4 LMAN1
GH18J059897 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10 -581.8 -581823 6.5 HDGF FOXA2 SMAD1 SIN3A FEZF1 IRF4 POLR2B E2F8 FOS KLF13 PMAIP1 ENSG00000267462 SDCCAG3P1 ENSG00000267269 ENSG00000267686 LOC342784 ENSG00000267061 LOC105372155 ENSG00000267215 CPLX4
GH18J059880 Enhancer 1.4 Ensembl ENCODE dbSUPER 10 -563.6 -563578 2.5 FOXA2 ZNF493 ZFP64 YY1 TCF12 ZNF121 ZNF213 RUNX3 ZNF202 ZC3H11A SDCCAG3P1 ENSG00000267462 ENSG00000267269 ENSG00000267686 ENSG00000267061 LOC342784 LOC105372155 ENSG00000267215 CPLX4 GC18M059879
GH18J059455 Promoter 1.2 EPDnew 10.1 -136.6 -136593 0.1 PKNOX1 ARNT FEZF1 ZNF121 GLIS2 ZNF213 KLF7 TSHZ1 ZNF488 ZNF623 CCBE1 ENSG00000267061 ENSG00000267269 ENSG00000267215 ENSG00000267462 SDCCAG3P1 ENSG00000267686 LOC105372145 LOC105372155 LOC342784
GH18J059484 Enhancer 0.9 ENCODE 10 -166.5 -166454 0.4 PKNOX1 ARNT FEZF1 ZNF2 ZNF213 KLF7 SP3 YY2 TSHZ1 ZNF488 ENSG00000267061 ENSG00000267269 ENSG00000267215 ENSG00000267686 SDCCAG3P1 ENSG00000267462 LOC342784 LOC105372155 LOC105372145 ZNF532
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CPLX4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CPLX4 gene promoter:

Genomic Locations for CPLX4 Gene

Genomic Locations for CPLX4 Gene
43,494 bases
Minus strand

Genomic View for CPLX4 Gene

Genes around CPLX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPLX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPLX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPLX4 Gene

Proteins for CPLX4 Gene

  • Protein details for CPLX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • F1T0L6

    Protein attributes for CPLX4 Gene

    160 amino acids
    Molecular mass:
    18336 Da
    Quaternary structure:
    • Weakly binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.

neXtProt entry for CPLX4 Gene

Post-translational modifications for CPLX4 Gene

  • Farnesylation mediates presynaptic targeting and is important for function in neurotransmitter release.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPLX4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CPLX4 Gene

Domains & Families for CPLX4 Gene

Gene Families for CPLX4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CPLX4 Gene


Suggested Antigen Peptide Sequences for CPLX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the complexin/synaphin family.
  • Belongs to the complexin/synaphin family.
genes like me logo Genes that share domains with CPLX4: view

Function for CPLX4 Gene

Molecular function for CPLX4 Gene

UniProtKB/Swiss-Prot Function:
Positively regulates a late step in synaptic vesicle exocytosis.

Gene Ontology (GO) - Molecular Function for CPLX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0019905 syntaxin binding IEA --
genes like me logo Genes that share ontologies with CPLX4: view
genes like me logo Genes that share phenotypes with CPLX4: view

Animal Models for CPLX4 Gene

MGI Knock Outs for CPLX4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPLX4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CPLX4 Gene

Localization for CPLX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPLX4 Gene

Membrane; Lipid-anchor. Cell junction, synapse. Note=Enriched at the synaptic terminal. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPLX4 gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for CPLX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
GO:0031201 SNARE complex IBA --
GO:0043195 terminal bouton IBA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with CPLX4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CPLX4 Gene

Pathways & Interactions for CPLX4 Gene

SuperPathways for CPLX4 Gene

SuperPathway Contained pathways
1 Synaptic vesicle cycle
genes like me logo Genes that share pathways with CPLX4: view

Pathways by source for CPLX4 Gene

1 KEGG pathway for CPLX4 Gene

Interacting Proteins for CPLX4 Gene

Gene Ontology (GO) - Biological Process for CPLX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006836 neurotransmitter transport IEA --
GO:0006887 exocytosis IEA --
GO:0016079 synaptic vesicle exocytosis IBA --
GO:0046928 regulation of neurotransmitter secretion IEA --
genes like me logo Genes that share ontologies with CPLX4: view

No data available for SIGNOR curated interactions for CPLX4 Gene

Drugs & Compounds for CPLX4 Gene

No Compound Related Data Available

Transcripts for CPLX4 Gene

mRNA/cDNA for CPLX4 Gene

(13) Selected AceView cDNA sequences:
(9) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CPLX4 Gene

Complexin 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPLX4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPLX4 Gene

No ASD Table

Relevant External Links for CPLX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPLX4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPLX4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPLX4 Gene

This gene is overexpressed in Brain - Cerebellum (x21.4) and Brain - Cerebellar Hemisphere (x20.7).

Protein differential expression in normal tissues from HIPED for CPLX4 Gene

This gene is overexpressed in Retina (54.9) and Heart (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CPLX4 Gene

Protein tissue co-expression partners for CPLX4 Gene

NURSA nuclear receptor signaling pathways regulating expression of CPLX4 Gene:


SOURCE GeneReport for Unigene cluster for CPLX4 Gene:


Evidence on tissue expression from TISSUES for CPLX4 Gene

  • Nervous system(4.4)
  • Eye(4.3)
genes like me logo Genes that share expression patterns with CPLX4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPLX4 Gene

Orthologs for CPLX4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CPLX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CPLX4 34 33
  • 99.79 (n)
(Canis familiaris)
Mammalia CPLX4 34 33
  • 92.71 (n)
(Monodelphis domestica)
Mammalia CPLX4 34
  • 91 (a)
(Bos Taurus)
Mammalia CPLX4 34 33
  • 89.79 (n)
(Ornithorhynchus anatinus)
Mammalia CPLX4 34
  • 89 (a)
(Mus musculus)
Mammalia Cplx4 16 34 33
  • 87.29 (n)
(Rattus norvegicus)
Mammalia Cplx4 33
  • 86.25 (n)
(Gallus gallus)
Aves CPLX4 34 33
  • 80 (n)
(Anolis carolinensis)
Reptilia CPLX4 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cplx4 33
  • 72.5 (n)
Str.12479 33
(Danio rerio)
Actinopterygii cplx4a 34 33
  • 68.76 (n)
cplx4b 34
  • 68 (a)
Species where no ortholog for CPLX4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPLX4 Gene

Gene Tree for CPLX4 (if available)
Gene Tree for CPLX4 (if available)
Evolutionary constrained regions (ECRs) for CPLX4: view image

Paralogs for CPLX4 Gene

Paralogs for CPLX4 Gene

(1) SIMAP similar genes for CPLX4 Gene using alignment to 2 proteins:

  • K7EM04_HUMAN
genes like me logo Genes that share paralogs with CPLX4: view

Variants for CPLX4 Gene

Sequence variations from dbSNP and Humsavar for CPLX4 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000051832 -- 59,310,766(-) T/A intron_variant
rs1000120215 -- 59,303,822(-) G/A intron_variant
rs1000165791 -- 59,310,062(-) C/T intron_variant
rs1000242913 -- 59,316,948(-) G/A intron_variant
rs1000474080 -- 59,314,647(-) T/TT intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CPLX4 Gene

Variant ID Type Subtype PubMed ID
nsv577051 CNV loss 21841781

Variation tolerance for CPLX4 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPLX4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPLX4 Gene

Disorders for CPLX4 Gene

Additional Disease Information for CPLX4

No disorders were found for CPLX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPLX4 Gene

Publications for CPLX4 Gene

  1. Structurally and functionally unique complexins at retinal ribbon synapses. (PMID: 15911881) Reim K … Brose N (The Journal of cell biology 2005) 2 3 4 58
  2. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M … Kato S (Investigative ophthalmology & visual science 2011) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for CPLX4 Gene

Sources for CPLX4 Gene

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