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Aliases for CPLX3 Gene

Aliases for CPLX3 Gene

  • Complexin 3 2 3 5
  • Complexin III 3 4
  • CPX III 3 4
  • Complexin-3 3
  • Nbla11589 3
  • CPX-III 3
  • CPXIII 3

External Ids for CPLX3 Gene

Previous GeneCards Identifiers for CPLX3 Gene

  • GC15U900493
  • GC15P072906
  • GC15P075118
  • GC15P051915

Summaries for CPLX3 Gene

GeneCards Summary for CPLX3 Gene

CPLX3 (Complexin 3) is a Protein Coding gene. Diseases associated with CPLX3 include Acute Dacryocystitis and Chromosome 15Q24 Deletion Syndrome. Among its related pathways are Synaptic vesicle cycle. Gene Ontology (GO) annotations related to this gene include syntaxin binding and neurotransmitter transporter activity. An important paralog of this gene is CPLX4.

UniProtKB/Swiss-Prot for CPLX3 Gene

  • Positively regulates a late step in synaptic vesicle exocytosis.

Additional gene information for CPLX3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPLX3 Gene

Genomics for CPLX3 Gene

GeneHancer (GH) Regulatory Elements for CPLX3 Gene

Promoters and enhancers for CPLX3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I074826 Promoter/Enhancer 1.1 EPDnew dbSUPER 550.8 +0.1 61 0.1 SMARCE1 MAX SIN3A USF2 MIER2 MNT REST ZNF766 EGR1 VEZF1 CPLX3 LOC105370897 ENSG00000261606
GH15I074775 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.7 -38.4 -38374 26 DMAP1 IRF4 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D GLIS1 RCOR2 CSK MIR4513 EDC3 SIN3A LOC441728 ULK3 ENSG00000260274 C15orf39 DNM1P35 ENSG00000203392
GH15I074953 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 10.5 +130.1 130109 5.4 PKNOX1 CLOCK SMAD1 ARNT SIN3A DMAP1 YY1 ZNF766 E2F8 ZNF207 RPP25 SCAMP5 MAN2C1 ENSG00000260274 FBXO22 ENSG00000203392 SIN3A FAM219B MPI ULK3
GH15I074613 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.1 -210.2 -210233 4.9 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 CLK3 LOC102723750 ENSG00000260919 SIN3A EDC3 MAN2C1 ENSG00000260274 PML UBL7-AS1 FAM219B
GH15I074412 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.7 -402.4 -402364 22.6 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A ZNF2 POLR2B ZNF207 ZNF143 SEMA7A ENSG00000260274 MAN2C1 EDC3 CLK3 LOC101929333 PML COMMD4 ENSG00000212279 UBL7-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CPLX3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CPLX3 gene promoter:

Genomic Locations for CPLX3 Gene

Genomic Locations for CPLX3 Gene
5,256 bases
Plus strand

Genomic View for CPLX3 Gene

Genes around CPLX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPLX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPLX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPLX3 Gene

Proteins for CPLX3 Gene

  • Protein details for CPLX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D3DW66
    • Q8TEM6
    • Q9H818

    Protein attributes for CPLX3 Gene

    158 amino acids
    Molecular mass:
    17557 Da
    Quaternary structure:
    • Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.
    • Sequence=BAB84922.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CPLX3 Gene

Post-translational modifications for CPLX3 Gene

Other Protein References for CPLX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CPLX3 Gene

Domains & Families for CPLX3 Gene

Gene Families for CPLX3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CPLX3 Gene


Suggested Antigen Peptide Sequences for CPLX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the complexin/synaphin family.
  • Belongs to the complexin/synaphin family.
genes like me logo Genes that share domains with CPLX3: view

Function for CPLX3 Gene

Molecular function for CPLX3 Gene

UniProtKB/Swiss-Prot Function:
Positively regulates a late step in synaptic vesicle exocytosis.

Phenotypes From GWAS Catalog for CPLX3 Gene

Gene Ontology (GO) - Molecular Function for CPLX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005326 neurotransmitter transporter activity IEA --
GO:0019905 syntaxin binding IEA --
genes like me logo Genes that share ontologies with CPLX3: view

Phenotypes for CPLX3 Gene

genes like me logo Genes that share phenotypes with CPLX3: view

Animal Models for CPLX3 Gene

MGI Knock Outs for CPLX3:

miRNA for CPLX3 Gene

miRTarBase miRNAs that target CPLX3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CPLX3 Gene

Localization for CPLX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPLX3 Gene

Membrane; Lipid-anchor. Cell junction, synapse. Note=Enriched at the synaptic terminal. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPLX3 gene
Compartment Confidence
cytosol 3
plasma membrane 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CPLX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with CPLX3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CPLX3 Gene

Pathways & Interactions for CPLX3 Gene

genes like me logo Genes that share pathways with CPLX3: view

Pathways by source for CPLX3 Gene

1 BioSystems pathway for CPLX3 Gene
1 KEGG pathway for CPLX3 Gene

Interacting Proteins for CPLX3 Gene

Gene Ontology (GO) - Biological Process for CPLX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006836 neurotransmitter transport IEA --
GO:0006887 exocytosis IEA --
GO:0016079 synaptic vesicle exocytosis IEA --
GO:0030073 insulin secretion IEA --
genes like me logo Genes that share ontologies with CPLX3: view

No data available for SIGNOR curated interactions for CPLX3 Gene

Drugs & Compounds for CPLX3 Gene

No Compound Related Data Available

Transcripts for CPLX3 Gene

mRNA/cDNA for CPLX3 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CPLX3 Gene

Complexin 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPLX3 Gene

No ASD Table

Relevant External Links for CPLX3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPLX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPLX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPLX3 Gene

This gene is overexpressed in Spleen (x13.5), Prostate (x11.4), Brain - Cerebellum (x7.1), Heart - Atrial Appendage (x6.8), and Brain - Cerebellar Hemisphere (x5.1).

Protein differential expression in normal tissues from HIPED for CPLX3 Gene

This gene is overexpressed in Brain (53.2) and Retina (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CPLX3 Gene

Protein tissue co-expression partners for CPLX3 Gene

NURSA nuclear receptor signaling pathways regulating expression of CPLX3 Gene:


SOURCE GeneReport for Unigene cluster for CPLX3 Gene:


Evidence on tissue expression from TISSUES for CPLX3 Gene

  • Nervous system(4.7)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with CPLX3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPLX3 Gene

Orthologs for CPLX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CPLX3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CPLX3 33 34
  • 99.16 (n)
(Bos Taurus)
Mammalia CPLX3 33 34
  • 93.67 (n)
(Canis familiaris)
Mammalia CPLX3 33 34
  • 91.77 (n)
(Mus musculus)
Mammalia Cplx3 33 16 34
  • 89.66 (n)
(Monodelphis domestica)
Mammalia CPLX3 34
  • 89 (a)
(Rattus norvegicus)
Mammalia Cplx3 33
  • 88.82 (n)
(Gallus gallus)
Aves CPLX3 33 34
  • 76.43 (n)
(Anolis carolinensis)
Reptilia CPLX3 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lman1l 33
  • 73.63 (n)
(Danio rerio)
Actinopterygii cplx3b 33 34
  • 68.59 (n)
cplx3a 34 34
  • 63 (a)
Species where no ortholog for CPLX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPLX3 Gene

Gene Tree for CPLX3 (if available)
Gene Tree for CPLX3 (if available)

Paralogs for CPLX3 Gene

Paralogs for CPLX3 Gene

(1) SIMAP similar genes for CPLX3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CPLX3: view

Variants for CPLX3 Gene

Sequence variations from dbSNP and Humsavar for CPLX3 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000166146 -- 74,828,130(+) G/A intron_variant
rs1000562940 -- 74,826,455(+) G/C upstream_transcript_variant
rs1000642636 -- 74,827,888(+) G/T intron_variant
rs1000933654 -- 74,826,820(+) G/A coding_sequence_variant, missense_variant
rs1000950751 -- 74,828,399(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CPLX3 Gene

Variant ID Type Subtype PubMed ID
nsv1121512 CNV deletion 24896259
nsv520527 CNV loss 19592680
nsv833055 CNV loss 17160897

Variation tolerance for CPLX3 Gene

Residual Variation Intolerance Score: 63.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPLX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPLX3 Gene

Disorders for CPLX3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CPLX3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
acute dacryocystitis
  • dacryocystitis - acute
chromosome 15q24 deletion syndrome
  • 15q24 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CPLX3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CPLX3

genes like me logo Genes that share disorders with CPLX3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPLX3 Gene

Publications for CPLX3 Gene

  1. Structurally and functionally unique complexins at retinal ribbon synapses. (PMID: 15911881) Reim K … Brose N (The Journal of cell biology 2005) 2 3 4 58
  2. Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. (PMID: 21876539) Amin N … van Duijn CM (Molecular psychiatry 2012) 3 44 58
  3. Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. (PMID: 21490707) Cornelis MC … Caporaso NE (PLoS genetics 2011) 3 44 58
  4. Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C … Munroe PB (Nature genetics 2009) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for CPLX3 Gene

Sources for CPLX3 Gene

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