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Aliases for CPEB4 Gene

Aliases for CPEB4 Gene

  • Cytoplasmic Polyadenylation Element Binding Protein 4 2 3 5
  • CPE-Binding Protein 4 3 4
  • CPE-BP4 3 4
  • HCPEB-4 3 4
  • Cytoplasmic Polyadenylation Element-Binding Protein 4 3
  • KIAA1673 4

External Ids for CPEB4 Gene

Previous GeneCards Identifiers for CPEB4 Gene

  • GC05P173250
  • GC05P173297
  • GC05P173248
  • GC05P168411
  • GC05P173315

Summaries for CPEB4 Gene

GeneCards Summary for CPEB4 Gene

CPEB4 (Cytoplasmic Polyadenylation Element Binding Protein 4) is a Protein Coding gene. Among its related pathways are Oocyte meiosis. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CPEB2.

UniProtKB/Swiss-Prot for CPEB4 Gene

  • Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5-UUUUUAU-3) within the mRNA 3-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity).

Additional gene information for CPEB4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPEB4 Gene

Genomics for CPEB4 Gene

GeneHancer (GH) Regulatory Elements for CPEB4 Gene

Promoters and enhancers for CPEB4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J173883 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 653.7 +0.1 54 10.5 CLOCK DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC MEF2D GLIS1 NBN CPEB4 CREBRF NSG2 GC05M173953
GH05J173905 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.4 +16.9 16949 0.1 CPEB4 BOD1 GC05M173953
GH05J173777 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 20.3 -107.5 -107524 7.4 HDGF PKNOX1 FOXA2 ARNT YY1 POLR2B ZNF766 E2F8 FOS ZNF592 BOD1 CPEB4 LINC01485 LINC01484
GH05J173865 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 19 -20.4 -20410 4.3 PKNOX1 ATF1 ZNF280A POLR2B CBX5 FOS ATF7 REST MEF2D ATF4 PIR46909 CPEB4 BOD1 NSG2
GH05J173819 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.4 -64.6 -64562 7.9 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B NEUROD1 SIN3A DMAP1 YY1 CPEB4 BOD1 LINC01485 PIR46909
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CPEB4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CPEB4 gene promoter:
  • N-Myc
  • HOXA5
  • IRF-7A
  • POU2F1
  • POU2F1a
  • SRF
  • SRF (504 AA)
  • AREB6
  • POU3F1

Genomic Locations for CPEB4 Gene

Genomic Locations for CPEB4 Gene
chr5:173,888,280-173,961,976
(GRCh38/hg38)
Size:
73,697 bases
Orientation:
Plus strand
chr5:173,315,283-173,388,979
(GRCh37/hg19)
Size:
73,697 bases
Orientation:
Plus strand

Genomic View for CPEB4 Gene

Genes around CPEB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPEB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPEB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPEB4 Gene

Proteins for CPEB4 Gene

  • Protein details for CPEB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17RY0-CPEB4_HUMAN
    Recommended name:
    Cytoplasmic polyadenylation element-binding protein 4
    Protein Accession:
    Q17RY0
    Secondary Accessions:
    • B7ZLQ7
    • Q7Z310
    • Q8N405
    • Q9C0J0

    Protein attributes for CPEB4 Gene

    Size:
    729 amino acids
    Molecular mass:
    80152 Da
    Quaternary structure:
    • Interacts with TOB1.

    Three dimensional structures from OCA and Proteopedia for CPEB4 Gene

    Alternative splice isoforms for CPEB4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPEB4 Gene

Post-translational modifications for CPEB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CPEB4 Gene

Domains & Families for CPEB4 Gene

Gene Families for CPEB4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CPEB4 Gene

Graphical View of Domain Structure for InterPro Entry

Q17RY0

UniProtKB/Swiss-Prot:

CPEB4_HUMAN :
  • The 2 RRM domains and the C-terminal region mediate interaction with CPE-containing RNA (PubMed:24990967). The interdomain linker (564-579) acts as a hinge to fix the relative orientation of the 2 RRMs (PubMed:24990967). The ZZ domain (509-566) coordinates 2 Zn ions and is probably implicated in mediating interactions with other proteins in addition to increasing the affinity of the RRMs for the CPEs (By similarity). Unlike in CPEB1, a continuous polar interface is formed between the 2 RRMs (PubMed:24990967).
  • Belongs to the RRM CPEB family.
Domain:
  • The 2 RRM domains and the C-terminal region mediate interaction with CPE-containing RNA (PubMed:24990967). The interdomain linker (564-579) acts as a hinge to fix the relative orientation of the 2 RRMs (PubMed:24990967). The ZZ domain (509-566) coordinates 2 Zn ions and is probably implicated in mediating interactions with other proteins in addition to increasing the affinity of the RRMs for the CPEs (By similarity). Unlike in CPEB1, a continuous polar interface is formed between the 2 RRMs (PubMed:24990967).
Family:
  • Belongs to the RRM CPEB family.
genes like me logo Genes that share domains with CPEB4: view

Function for CPEB4 Gene

Molecular function for CPEB4 Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5-UUUUUAU-3) within the mRNA 3-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity).

Phenotypes From GWAS Catalog for CPEB4 Gene

Gene Ontology (GO) - Molecular Function for CPEB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000900 translation repressor activity, mRNA regulatory element binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003730 mRNA 3-UTR binding IBA --
GO:0005515 protein binding IPI 21336257
genes like me logo Genes that share ontologies with CPEB4: view
genes like me logo Genes that share phenotypes with CPEB4: view

Animal Models for CPEB4 Gene

MGI Knock Outs for CPEB4:
  • Cpeb4 Cpeb4<tm1a(EUCOMM)Wtsi>
  • Cpeb4 Cpeb4<tm1.1Yshu>
  • Cpeb4 Cpeb4<tm1d(EUCOMM)Wtsi>

Animal Model Products

miRNA for CPEB4 Gene

miRTarBase miRNAs that target CPEB4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CPEB4 Gene

Localization for CPEB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPEB4 Gene

Cytoplasm. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, axon. Cell projection, growth cone. Endoplasmic reticulum. Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPEB4 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4
plasma membrane 3
golgi apparatus 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CPEB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005783 endoplasmic reticulum ISS --
GO:0005886 plasma membrane IEA --
GO:0014069 postsynaptic density ISS --
genes like me logo Genes that share ontologies with CPEB4: view

Pathways & Interactions for CPEB4 Gene

SuperPathways for CPEB4 Gene

SuperPathway Contained pathways
1 Oocyte meiosis
genes like me logo Genes that share pathways with CPEB4: view

Pathways by source for CPEB4 Gene

Gene Ontology (GO) - Biological Process for CPEB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002931 response to ischemia ISS --
GO:0006412 translation IEA --
GO:0006417 regulation of translation IEA --
GO:0035235 ionotropic glutamate receptor signaling pathway ISS --
GO:0036294 cellular response to decreased oxygen levels ISS --
genes like me logo Genes that share ontologies with CPEB4: view

No data available for SIGNOR curated interactions for CPEB4 Gene

Drugs & Compounds for CPEB4 Gene

No Compound Related Data Available

Transcripts for CPEB4 Gene

Unigene Clusters for CPEB4 Gene

Cytoplasmic polyadenylation element binding protein 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPEB4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - -
SP3: - -
SP4: -
SP5: - - -

Relevant External Links for CPEB4 Gene

GeneLoc Exon Structure for
CPEB4
ECgene alternative splicing isoforms for
CPEB4

Expression for CPEB4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPEB4 Gene

mRNA differential expression in normal tissues according to GTEx for CPEB4 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for CPEB4 Gene

This gene is overexpressed in Placenta (24.0), Adrenal (17.5), Peripheral blood mononuclear cells (10.5), and Retina (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CPEB4 Gene



Protein tissue co-expression partners for CPEB4 Gene

NURSA nuclear receptor signaling pathways regulating expression of CPEB4 Gene:

CPEB4

SOURCE GeneReport for Unigene cluster for CPEB4 Gene:

Hs.127126

mRNA Expression by UniProt/SwissProt for CPEB4 Gene:

Q17RY0-CPEB4_HUMAN
Tissue specificity: Expressed in pancreas in islets and ductal cells (at protein level) (PubMed:22138752). Expressed in melanocytes (PubMed:27857118).

Evidence on tissue expression from TISSUES for CPEB4 Gene

  • Nervous system(4.5)
  • Liver(4.4)
genes like me logo Genes that share expression patterns with CPEB4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPEB4 Gene

Orthologs for CPEB4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPEB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPEB4 34 33
  • 99.73 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CPEB4 34
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPEB4 34
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPEB4 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPEB4 34 33
  • 95.52 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cpeb4 16 34 33
  • 93 (n)
rat
(Rattus norvegicus)
Mammalia Cpeb4 33
  • 92.46 (n)
chicken
(Gallus gallus)
Aves CPEB4 34 33
  • 86.4 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPEB4 34
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpeb4 33
  • 83.73 (n)
Str.4214 33
zebrafish
(Danio rerio)
Actinopterygii CPEB4 (2 of 3) 34
  • 99 (a)
OneToMany
CPEB4 (3 of 3) 34
  • 77 (a)
OneToMany
cpeb4 34 33
  • 72.06 (n)
OneToMany
zgc66166 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11294 33
fruit fly
(Drosophila melanogaster)
Insecta orb2 34
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cpb-1 34
  • 32 (a)
ManyToMany
cpb-2 34
  • 29 (a)
ManyToMany
fog-1 34
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 90 (a)
ManyToMany
-- 34
  • 80 (a)
ManyToMany
Cin.14697 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14697 33
Species where no ortholog for CPEB4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPEB4 Gene

ENSEMBL:
Gene Tree for CPEB4 (if available)
TreeFam:
Gene Tree for CPEB4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CPEB4: view image

Paralogs for CPEB4 Gene

Paralogs for CPEB4 Gene

(5) SIMAP similar genes for CPEB4 Gene using alignment to 6 proteins:

  • CPEB4_HUMAN
  • B7ZLQ8_HUMAN
  • D3DQM9_HUMAN
  • E5RFP2_HUMAN
  • E5RJM0_HUMAN
  • H0YBG1_HUMAN
genes like me logo Genes that share paralogs with CPEB4: view

Variants for CPEB4 Gene

Sequence variations from dbSNP and Humsavar for CPEB4 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000031740 -- 173,961,479(+) T/C downstream_transcript_variant
rs1000081230 -- 173,915,925(+) T/C intron_variant
rs1000095673 -- 173,911,942(+) A/G intron_variant
rs1000176169 -- 173,901,598(+) C/T intron_variant
rs1000209149 -- 173,905,142(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CPEB4 Gene

Variant ID Type Subtype PubMed ID
nsv600298 CNV gain 21841781
nsv600323 CNV gain 21841781
nsv950446 CNV duplication 24416366

Variation tolerance for CPEB4 Gene

Residual Variation Intolerance Score: 8.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPEB4 Gene

Human Gene Mutation Database (HGMD)
CPEB4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPEB4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPEB4 Gene

Disorders for CPEB4 Gene

Additional Disease Information for CPEB4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CPEB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPEB4 Gene

Publications for CPEB4 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Global Analysis of CPEBs Reveals Sequential and Non-Redundant Functions in Mitotic Cell Cycle. (PMID: 26398195) Giangarrà V … Mendez R (PloS one 2015) 3 4 58
  3. Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. (PMID: 22210626) Mead S … Collinge J (Human molecular genetics 2012) 3 44 58
  4. Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase. (PMID: 21336257) Hosoda N … Hoshino S (The EMBO journal 2011) 3 4 58
  5. Key contribution of CPEB4-mediated translational control to cancer progression. (PMID: 22138752) Ortiz-Zapater E … Navarro P (Nature medicine 2011) 3 4 58

Products for CPEB4 Gene

Sources for CPEB4 Gene

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