The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternative... See more...

Aliases for CPEB2 Gene

Aliases for CPEB2 Gene

  • Cytoplasmic Polyadenylation Element Binding Protein 2 2 3 5
  • Cytoplasmic Polyadenylation Element-Binding Protein 2 3 4
  • CPE-Binding Protein 2 3 4
  • CPE-BP2 3 4
  • HCPEB-2 3 4
  • CPEB-2 3
  • CPEB2 5

External Ids for CPEB2 Gene

Previous GeneCards Identifiers for CPEB2 Gene

  • GC04P014707
  • GC04P014756
  • GC04P014681
  • GC04P014355

Summaries for CPEB2 Gene

Entrez Gene Summary for CPEB2 Gene

  • The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPEB2 Gene

CPEB2 (Cytoplasmic Polyadenylation Element Binding Protein 2) is a Protein Coding gene. Among its related pathways are Oocyte meiosis. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is CPEB4.

UniProtKB/Swiss-Prot Summary for CPEB2 Gene

  • May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity). Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195).

Additional gene information for CPEB2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CPEB2 Gene

Genomics for CPEB2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CPEB2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J015000 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 610.2 +1.7 1675 7.4 GATAD2A CTCF HNRNPL REST ZNF629 TFE3 ZNF512 RFX1 IKZF1 POLR2A CPEB2 CPEB2-DT C1QTNF7 LINC00504 C1QTNF7-AS1
GH04J014855 Enhancer 1.3 FANTOM5 Ensembl ENCODE 5.1 -145.6 -145625 4.4 SP1 CREB1 LEF1 BACH1 JUND STAT3 RELA PKNOX1 IKZF2 ZNF24 LINC01085 CPEB2 CC2D2A lnc-FBXL5-13 LINC00504 piR-47211-510
GH04J014997 Enhancer 0.5 Ensembl 11.1 -4.3 -4326 1 NR2F1 NR2F6 ATF3 ZEB2 FOS NR2C1 RF00994-720 CPEB2 CPEB2-DT lnc-FBXL5-12
GH04J015078 Enhancer 0.9 Ensembl ENCODE 5.9 +79.3 79274 9.4 CEBPG ATF7 SP1 CEBPA CEBPB FOXA2 ZNF585B CHD2 JUN NR2C2 CC2D2A LINC00504 CPEB2-DT CPEB2 LINC01085 RN7SKP170 lnc-FBXL5-11 C1QTNF7 C1QTNF7-AS1
GH04J015118 Enhancer 0.6 Ensembl 8.1 +116.1 116075 0.6 SOX13 FOXA2 BCL6 HNF4A REST RXRA RARA NFIA TEAD3 NR2F6 CPEB2 piR-38423-041 piR-48209-543 C1QTNF7 C1QTNF7-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CPEB2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CPEB2

Top Transcription factor binding sites by QIAGEN in the CPEB2 gene promoter:
  • AhR
  • Evi-1
  • HOXA3
  • HSF2
  • NF-kappaB1
  • POU2F1
  • POU2F1a
  • S8
  • SRY

Genomic Locations for CPEB2 Gene

Genomic Locations for CPEB2 Gene
chr4:15,002,426-15,070,153
(GRCh38/hg38)
Size:
67,728 bases
Orientation:
Plus strand
chr4:15,004,298-15,071,777
(GRCh37/hg19)
Size:
67,480 bases
Orientation:
Plus strand

Genomic View for CPEB2 Gene

Genes around CPEB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPEB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPEB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPEB2 Gene

Proteins for CPEB2 Gene

  • Protein details for CPEB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5Q1-CPEB2_HUMAN
    Recommended name:
    Cytoplasmic polyadenylation element-binding protein 2
    Protein Accession:
    Q7Z5Q1
    Secondary Accessions:
    • E7EPM3
    • F5H160
    • Q3B8N6
    • Q3MI89
    • Q3MI90
    • Q3MI92
    • Q7Z5Q0

    Protein attributes for CPEB2 Gene

    Size:
    589 amino acids
    Molecular mass:
    64944 Da
    Quaternary structure:
    • Interacts with TENT2/GLD2.

    Alternative splice isoforms for CPEB2 Gene

neXtProt entry for CPEB2 Gene

Post-translational modifications for CPEB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CPEB2 Gene

Domains & Families for CPEB2 Gene

Gene Families for CPEB2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CPEB2 Gene

InterPro:
Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
ProtoNet:

Suggested Antigen Peptide Sequences for CPEB2 Gene

GenScript: Design optimal peptide antigens:
  • Cytoplasmic polyadenylation element-binding protein 2 (CPEB2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z5Q1

UniProtKB/Swiss-Prot:

CPEB2_HUMAN :
  • Belongs to the RRM CPEB family.
Family:
  • Belongs to the RRM CPEB family.
genes like me logo Genes that share domains with CPEB2: view

Function for CPEB2 Gene

Molecular function for CPEB2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity). Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195).

Phenotypes From GWAS Catalog for CPEB2 Gene

Gene Ontology (GO) - Molecular Function for CPEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000900 translation repressor activity, mRNA regulatory element binding ISS --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003730 mRNA 3'-UTR binding IBA 21873635
GO:0005095 GTPase inhibitor activity ISS --
genes like me logo Genes that share ontologies with CPEB2: view
genes like me logo Genes that share phenotypes with CPEB2: view

Animal Models for CPEB2 Gene

MGI Knock Outs for CPEB2:

Animal Model Products

CRISPR Products

miRNA for CPEB2 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPEB2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CPEB2 Gene

Localization for CPEB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPEB2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPEB2 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CPEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 20639532
GO:0005737 cytoplasm IBA,IDA 20639532
GO:0043005 neuron projection IBA 21873635
GO:0045202 synapse IBA 21873635
GO:1990124 messenger ribonucleoprotein complex ISS --
genes like me logo Genes that share ontologies with CPEB2: view

Pathways & Interactions for CPEB2 Gene

PathCards logo

SuperPathways for CPEB2 Gene

SuperPathway Contained pathways
1 Oocyte meiosis
genes like me logo Genes that share pathways with CPEB2: view

Pathways by source for CPEB2 Gene

Gene Ontology (GO) - Biological Process for CPEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006417 regulation of translation IEA --
GO:0032869 cellular response to insulin stimulus IDA 18752464
GO:0034260 negative regulation of GTPase activity ISS --
GO:0034599 cellular response to oxidative stress ISS --
genes like me logo Genes that share ontologies with CPEB2: view

No data available for SIGNOR curated interactions for CPEB2 Gene

Drugs & Compounds for CPEB2 Gene

No Compound Related Data Available

Transcripts for CPEB2 Gene

mRNA/cDNA for CPEB2 Gene

6 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPEB2

Alternative Splicing Database (ASD) splice patterns (SP) for CPEB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - - - -
SP6: - - -
SP7:

Relevant External Links for CPEB2 Gene

GeneLoc Exon Structure for
CPEB2

Expression for CPEB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CPEB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CPEB2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (66.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CPEB2 Gene



Protein tissue co-expression partners for CPEB2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CPEB2

SOURCE GeneReport for Unigene cluster for CPEB2 Gene:

Hs.656937

Evidence on tissue expression from TISSUES for CPEB2 Gene

  • Nervous system(2.5)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with CPEB2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPEB2 Gene

Orthologs for CPEB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPEB2 Gene

Organism Taxonomy Gene Similarity Type Details
Platypus
(Ornithorhynchus anatinus)
Mammalia CPEB2 31
  • 99 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia CPEB2 30 31
  • 97.68 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CPEB2 30 31
  • 95.78 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CPEB2 31
  • 94 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia CPEB2 30 31
  • 93.2 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cpeb2 30
  • 91.37 (n)
Mouse
(Mus musculus)
Mammalia Cpeb2 30 17 31
  • 88.09 (n)
OneToOne
Chicken
(Gallus gallus)
Aves CPEB2 30 31
  • 90.04 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 97 (a)
OneToMany
-- 31
  • 84 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.7084 30
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.7189 30
Zebrafish
(Danio rerio)
Actinopterygii CPEB2 31
  • 89 (a)
OneToOne
cpeb2 30
  • 70.51 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta orb2 31
  • 44 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea cpb-1 31
  • 31 (a)
ManyToMany
cpb-2 31
  • 28 (a)
ManyToMany
fog-1 31
  • 20 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 90 (a)
ManyToMany
-- 31
  • 80 (a)
ManyToMany
Species where no ortholog for CPEB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CPEB2 Gene

ENSEMBL:
Gene Tree for CPEB2 (if available)
TreeFam:
Gene Tree for CPEB2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CPEB2: view image

Paralogs for CPEB2 Gene

Paralogs for CPEB2 Gene

(5) SIMAP similar genes for CPEB2 Gene using alignment to 6 proteins:

  • CPEB2_HUMAN
  • E7EPM3_HUMAN
  • F5H160_HUMAN
  • F5H659_HUMAN
  • H0Y9D9_HUMAN
  • J3KN18_HUMAN
genes like me logo Genes that share paralogs with CPEB2: view

Variants for CPEB2 Gene

Additional dbSNP identifiers (rs#s) for CPEB2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CPEB2 Gene

Variant ID Type Subtype PubMed ID
dgv8976n54 CNV gain+loss 21841781
dgv8977n54 CNV loss 21841781
dgv8978n54 CNV loss 21841781
esv2437263 CNV deletion 19546169
esv29275 CNV loss 19812545
esv3563459 CNV deletion 23714750
nsv1073312 CNV deletion 25765185
nsv1145026 CNV deletion 24896259
nsv461280 CNV loss 19166990
nsv518661 CNV loss 19592680
nsv593757 CNV loss 21841781
nsv593758 CNV gain 21841781
nsv593759 CNV loss 21841781
nsv593760 CNV gain 21841781
nsv829868 CNV gain 17160897

Variation tolerance for CPEB2 Gene

Residual Variation Intolerance Score: 12.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.16; 98.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPEB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPEB2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CPEB2 Gene

Disorders for CPEB2 Gene

Additional Disease Information for CPEB2

No disorders were found for CPEB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPEB2 Gene

Publications for CPEB2 Gene

  1. Global Analysis of CPEBs Reveals Sequential and Non-Redundant Functions in Mitotic Cell Cycle. (PMID: 26398195) Giangarrà V … Mendez R (PloS one 2015) 3 4
  2. Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2 bind to the HIF-1alpha mRNA 3'-UTR and modulate HIF-1alpha protein expression. (PMID: 18752464) Hägele S … Katschinski DM (The Biochemical journal 2009) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. CPEB2, a novel putative translational regulator in mouse haploid germ cells. (PMID: 12672660) Kurihara Y … Uesugi S (Biology of reproduction 2003) 2 3
  5. Serine/Arginine-Rich Splicing Factor 3 Modulates the Alternative Splicing of Cytoplasmic Polyadenylation Element Binding Protein 2. (PMID: 31138601) DeLigio JT … Park MA (Molecular cancer research : MCR 2019) 3

Products for CPEB2 Gene

Sources for CPEB2 Gene