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Aliases for CPE Gene

Aliases for CPE Gene

  • Carboxypeptidase E 2 3 3 5
  • Enkephalin Convertase 2 3 4
  • Carboxypeptidase H 2 3 4
  • Cobalt-Stimulated Chromaffin Granule Carboxypeptidase 2 3
  • Insulin Granule-Associated Carboxypeptidase 2 3
  • Prohormone-Processing Carboxypeptidase 3 4
  • CPH 3 4
  • EC 4

External Ids for CPE Gene

Previous GeneCards Identifiers for CPE Gene

  • GC04P167151
  • GC04P166728
  • GC04P166877
  • GC04P166657
  • GC04P166519
  • GC04P166300
  • GC04P162051

Summaries for CPE Gene

Entrez Gene Summary for CPE Gene

  • This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]

GeneCards Summary for CPE Gene

CPE (Carboxypeptidase E) is a Protein Coding gene. Diseases associated with CPE include Hyperproinsulinemia and Phlebotomus Fever. Among its related pathways are Metabolism of proteins and Peptide hormone metabolism. Gene Ontology (GO) annotations related to this gene include cell adhesion molecule binding and carboxypeptidase activity. An important paralog of this gene is CPD.

UniProtKB/Swiss-Prot for CPE Gene

  • Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.

Gene Wiki entry for CPE Gene

Additional gene information for CPE Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPE Gene

Genomics for CPE Gene

GeneHancer (GH) Regulatory Elements for CPE Gene

Promoters and enhancers for CPE Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J165378 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.4 +18.1 18104 2.1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GLIS2 ZNF213 NFKBIZ YY2 CPE NACA3P KLHL2 RPL21P51 GC04P165387
GH04J165359 Enhancer 0.6 Ensembl 655.4 -0.8 -811 0.9 TEAD4 TAL1 CEBPB CEBPG EP300 TCF12 FOSL1 ZFHX2 ATF4 ZNF766 CPE LOC105377519
GH04J165323 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.2 -34.1 -34091 8.1 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 MSMO1 KLHL2 TMEM192 NACA3P CPE GC04M165293
GH04J165439 Enhancer 1.3 FANTOM5 Ensembl ENCODE 5.9 +79.2 79188 1.6 PKNOX1 FEZF1 ZNF2 ZNF213 FOS SP3 TSHZ1 ZNF518A GLIS1 STAT3 MIR578 HADHAP1 CPE FAM218A GC04M165414 GC04P165491
GH04J165369 Enhancer 0.9 ENCODE 7.2 +8.9 8916 1.9 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 ATF7 NFKBIZ RXRA CPE KLHL2 GC04P165387
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CPE on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CPE gene promoter:
  • ATF
  • AP-4
  • Pax-5
  • HOXA5
  • GATA-2
  • E47
  • IRF-1
  • XBP-1
  • Cdc5

Genomic Locations for CPE Gene

Genomic Locations for CPE Gene
137,137 bases
Plus strand
137,137 bases
Plus strand

Genomic View for CPE Gene

Genes around CPE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPE Gene

Proteins for CPE Gene

  • Protein details for CPE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carboxypeptidase E
    Protein Accession:
    Secondary Accessions:
    • A8K4N1
    • B3KR42
    • B4DFN4
    • D3DP33
    • Q9UIU9

    Protein attributes for CPE Gene

    476 amino acids
    Molecular mass:
    53151 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Isoform 2 interacts with HDAC1 and HDAC2.
    • Sequence=BAG52254.1; Type=Frameshift; Positions=415; Evidence={ECO:0000305};

    Alternative splice isoforms for CPE Gene


neXtProt entry for CPE Gene

Post-translational modifications for CPE Gene

  • Glycosylation at posLast=390390 and Asn139
  • Modification sites at PhosphoSitePlus

Other Protein References for CPE Gene

No data available for DME Specific Peptides for CPE Gene

Domains & Families for CPE Gene

Gene Families for CPE Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CPE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M14 family.
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPE: view

Function for CPE Gene

Molecular function for CPE Gene

UniProtKB/Swiss-Prot Function:
Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.
UniProtKB/Swiss-Prot CatalyticActivity:
Release of C-terminal arginine or lysine residues from polypeptides.
GENATLAS Biochemistry:
carboxypeptidase E,metallo carboxypeptidase family,regulated secretory pathway sorting receptor,involved in the trimming of paired basic residues at the C terminus of prohormone-derived peptides,mutated in the obese fat mouse

Enzyme Numbers (IUBMB) for CPE Gene

Phenotypes From GWAS Catalog for CPE Gene

Gene Ontology (GO) - Molecular Function for CPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity TAS 9019408
GO:0004181 metallocarboxypeptidase activity TAS,IEA --
GO:0004185 serine-type carboxypeptidase activity IBA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
genes like me logo Genes that share ontologies with CPE: view
genes like me logo Genes that share phenotypes with CPE: view

Animal Models for CPE Gene

MGI Knock Outs for CPE:
  • Cpe Cpe<tm1b(EUCOMM)Hmgu>
  • Cpe Cpe<tm1Yplo>

Animal Model Products

CRISPR Products

miRNA for CPE Gene

miRTarBase miRNAs that target CPE

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPE

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CPE Gene

Localization for CPE Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPE Gene

Isoform 1: Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions. {ECO:0000250 UniProtKB:P15087}.
Isoform 2: Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPE gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 5
nucleus 4
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA,IBA --
GO:0005634 nucleus IEA --
GO:0005794 Golgi apparatus IDA 19166515
GO:0005886 plasma membrane TAS 9019408
genes like me logo Genes that share ontologies with CPE: view

Pathways & Interactions for CPE Gene

genes like me logo Genes that share pathways with CPE: view

Pathways by source for CPE Gene

1 BioSystems pathway for CPE Gene
1 KEGG pathway for CPE Gene

Gene Ontology (GO) - Biological Process for CPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003214 cardiac left ventricle morphogenesis IMP 19593212
GO:0006464 cellular protein modification process NAS 2334405
GO:0006508 proteolysis IEA --
GO:0006518 peptide metabolic process IBA --
GO:0007218 neuropeptide signaling pathway NAS 2334405
genes like me logo Genes that share ontologies with CPE: view

No data available for SIGNOR curated interactions for CPE Gene

Drugs & Compounds for CPE Gene

(17) Drugs for CPE Gene - From: DrugBank, ClinicalTrials, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Insulin Human Approved, Investigational Pharma Target 0
Insulin Pork Approved Pharma Target 0
Zinc Approved, Investigational Pharma Enzyme 2430
Colistin Approved Pharma 69
Meropenem Approved, Investigational Pharma 110

(8) Additional Compounds for CPE Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CPE: view

Transcripts for CPE Gene

mRNA/cDNA for CPE Gene

Unigene Clusters for CPE Gene

Carboxypeptidase E:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CPE

Alternative Splicing Database (ASD) splice patterns (SP) for CPE Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14
SP1: - - - -
SP2: - - - - -
SP3: -
SP4: - -
SP5: - - - -
SP6: - -
SP7: -

Relevant External Links for CPE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPE Gene

mRNA differential expression in normal tissues according to GTEx for CPE Gene

This gene is overexpressed in Brain - Amygdala (x4.5), Brain - Caudate (basal ganglia) (x4.4), and Brain - Nucleus accumbens (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for CPE Gene

This gene is overexpressed in Islet of Langerhans (17.8), Vitreous humor (14.6), Pancreas (6.7), Cerebrospinal fluid (6.6), and Amniocyte (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CPE Gene

Protein tissue co-expression partners for CPE Gene

NURSA nuclear receptor signaling pathways regulating expression of CPE Gene:


SOURCE GeneReport for Unigene cluster for CPE Gene:


mRNA Expression by UniProt/SwissProt for CPE Gene:

Tissue specificity: Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas.

Evidence on tissue expression from TISSUES for CPE Gene

  • Nervous system(5)
  • Pancreas(4.8)
  • Eye(4.5)
  • Intestine(4.4)
  • Adrenal gland(3.1)
  • Lung(3.1)
  • Heart(2.5)
  • Kidney(2.5)
  • Muscle(2.5)
  • Thyroid gland(2.5)
  • Liver(2.4)
  • Stomach(2.4)
genes like me logo Genes that share expression patterns with CPE: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPE Gene

Orthologs for CPE Gene

This gene was present in the common ancestor of animals.

Orthologs for CPE Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CPE 34 33
  • 99.3 (n)
(Ornithorhynchus anatinus)
Mammalia CPE 34
  • 92 (a)
(Monodelphis domestica)
Mammalia CPE 34
  • 92 (a)
(Canis familiaris)
Mammalia CPE 34 33
  • 90.2 (n)
(Bos Taurus)
Mammalia CPE 34 33
  • 90.18 (n)
(Rattus norvegicus)
Mammalia Cpe 33
  • 88.87 (n)
(Mus musculus)
Mammalia Cpe 16 34 33
  • 88.66 (n)
(Gallus gallus)
Aves CPE 34 33
  • 83.74 (n)
(Anolis carolinensis)
Reptilia CPE 34
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpe 33
  • 76.45 (n)
Str.15474 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8836 33
(Danio rerio)
Actinopterygii cpe 34 33
  • 74.08 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4678 35
  • 41 (a)
(Caenorhabditis elegans)
Secernentea egl-21 33
  • 53.81 (n)
F01D4.4 35
  • 44 (a)
F59A3.1 35
  • 40 (a)
T27A8.1 35
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.504 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.504 33
Species where no ortholog for CPE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPE Gene

Gene Tree for CPE (if available)
Gene Tree for CPE (if available)
Evolutionary constrained regions (ECRs) for CPE: view image

Paralogs for CPE Gene

Paralogs for CPE Gene

(8) SIMAP similar genes for CPE Gene using alignment to 5 proteins:

  • C9JE88_HUMAN
  • D6R930_HUMAN
  • D6RF88_HUMAN
genes like me logo Genes that share paralogs with CPE: view

Variants for CPE Gene

Sequence variations from dbSNP and Humsavar for CPE Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs541147146 A colorectal cancer sample 165,484,521(+) G/A coding_sequence_variant, missense_variant
rs1000017131 -- 165,446,739(+) G/T intron_variant
rs10000308 -- 165,398,072(+) C/A intron_variant
rs10000363 -- 165,419,071(+) T/A intron_variant
rs1000042088 -- 165,382,085(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CPE Gene

Variant ID Type Subtype PubMed ID
esv3569803 CNV loss 25503493
esv3569804 CNV loss 25503493
nsv1128107 CNV deletion 24896259
nsv472010 CNV novel sequence insertion 20440878
nsv819783 CNV loss 19587683
nsv822819 CNV loss 20364138
nsv822820 CNV loss 20364138
nsv964109 CNV duplication 23825009

Variation tolerance for CPE Gene

Residual Variation Intolerance Score: 79.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPE Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPE Gene

Disorders for CPE Gene

MalaCards: The human disease database

(6) MalaCards diseases for CPE Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • hpri
phlebotomus fever
  • pappataci fever
gas gangrene
  • gas bacillus infection
diabetes mellitus, insulin-dependent
  • iddm
diabetes mellitus
  • diabetes
- elite association - COSMIC cancer census association via MalaCards
Search CPE in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CPE

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CPE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPE Gene

Publications for CPE Gene

  1. Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro. (PMID: 2334405) Manser E … Lim L (The Biochemical journal 1990) 2 3 4 22 58
  2. Association of the mutation for the human carboxypeptidase E gene exon 4 with the severity of coronary artery atherosclerosis. (PMID: 18080843) Jia EZ … Ma WZ (Molecular biology reports 2009) 3 22 44 58
  3. Molecular scanning of the human carboxypeptidase E gene for mutations in Chinese subjects with coronary atherosclerosis. (PMID: 17957445) Jia EZ … Ma WZ (Molecular and cellular biochemistry 2008) 3 22 44 58
  4. Association of human carboxypeptidase E exon5 gene polymorphisms with angiographical characteristics of coronary atherosclerosis in a Chinese population. (PMID: 18501121) Wang J … Jia EZ (Acta pharmacologica Sinica 2008) 3 22 44 58
  5. Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity. (PMID: 9662053) Utsunomiya N … Nanjo K (Diabetologia 1998) 3 4 22 58

Products for CPE Gene

Sources for CPE Gene

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