Aliases for CPE Gene
External Ids for CPE Gene
Previous GeneCards Identifiers for CPE Gene
This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]
GeneCards Summary for CPE Gene
CPE (Carboxypeptidase E) is a Protein Coding gene. Diseases associated with CPE include Gas Gangrene and Hyperproinsulinemia. Among its related pathways are Arf6 trafficking events and Peptide hormone metabolism. Gene Ontology (GO) annotations related to this gene include cell adhesion molecule binding and carboxypeptidase activity. An important paralog of this gene is CPZ.
UniProtKB/Swiss-Prot Summary for CPE Gene
Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.