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CPD Gene(Protein Coding)

Carboxypeptidase D

GCID:
GC17P030378
GIFtS:
47
Genes Participants
UDN Logo

Aliases for CPD Gene

Aliases for CPD Gene

  • Carboxypeptidase D 2 3 3 5
  • Metallocarboxypeptidase D 2 3 4
  • EC 3.4.17.22 4
  • GP180 3
  • Gp180 4

External Ids for CPD Gene

Previous GeneCards Identifiers for CPD Gene

  • GC17P028459
  • GC17P030612
  • GC17P028851
  • GC17P025730
  • GC17P028705
  • GC17P024916

Summaries for CPD Gene

Entrez Gene Summary for CPD Gene

  • The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPD Gene

CPD (Carboxypeptidase D) is a Protein Coding gene. Diseases associated with CPD include Hepatitis B. Among its related pathways are Vesicle-mediated transport and Clathrin derived vesicle budding. Gene Ontology (GO) annotations related to this gene include metallocarboxypeptidase activity and serine-type carboxypeptidase activity. An important paralog of this gene is AEBP1.

Gene Wiki entry for CPD Gene

Additional gene information for CPD Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPD Gene

Genomics for CPD Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CPD Gene

Promoters and enhancers for CPD Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17J030376 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 650.7 -0.3 -289 5.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CPD GOSR1 ATAD5 SMURF2P1 SH3GL1P2 ENSG00000265791 LRRC37BP1 CORO6 SUZ12P1 TMIGD1
GH17J030476 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.9 +98.7 98664 2 ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC PPARGC1A GOSR1 ATAD5 SH3GL1P2 ENSG00000264456 RNF135 TEFM LRRC37BP1 SUZ12P1 DPRXP4 NF1
GH17J030350 Enhancer 1 Ensembl ENCODE 11.7 -27.3 -27325 2.9 BATF IRF4 RAD21 ZBTB40 RARA FOS IKZF2 RUNX3 CREM ZNF362 CPD BLMH RNU6-1267P SLC6A4 GC17P030362 GC17M030345 ENSG00000207132
GH17J030363 Enhancer 1.3 FANTOM5 Ensembl ENCODE 8.3 -15.0 -14968 1.1 HDAC1 PKNOX1 SMAD1 BMI1 EGR1 ZNF143 ATF7 FOS BCLAF1 IKZF2 GC17P030363 GOSR1 TEFM ATAD5 CPD BLMH LOC101927093 NSRP1 SSH2
GH17J030343 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.8 -33.7 -33713 4 PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 IRF4 YY1 GC17P030343 GC17M030345 ENSG00000207132 BLMH RNU6-1267P TBC1D29 CPD EFCAB5 NSRP1 GC17P030362
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CPD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CPD gene promoter:
  • AP-1
  • deltaCREB
  • CREB
  • c-Jun
  • ATF-2
  • GATA-3

Genomic Locations for CPD Gene

Genomic Locations for CPD Gene
chr17:30,378,905-30,469,989
(GRCh38/hg38)
Size:
91,085 bases
Orientation:
Plus strand
chr17:28,705,923-28,797,007
(GRCh37/hg19)
Size:
91,085 bases
Orientation:
Plus strand

Genomic View for CPD Gene

Genes around CPD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPD Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CPD Gene

Proteins for CPD Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CPD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75976-CBPD_HUMAN
    Recommended name:
    Carboxypeptidase D
    Protein Accession:
    O75976
    Secondary Accessions:
    • B7Z7T9
    • B7ZAU4
    • F5GZH6
    • O15377
    • Q86SH9
    • Q86XE6

    Protein attributes for CPD Gene

    Size:
    1380 amino acids
    Molecular mass:
    152931 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CPD Gene

    Alternative splice isoforms for CPD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPD Gene

Protein Expression for CPD Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CPD Gene

  • Glycosylation at posLast=11421142, Asn1070, Asn978, posLast=955955, Asn879, posLast=867867, Asn855, posLast=811811, posLast=626626, Asn522, Thr489, posLast=429429, posLast=410410, posLast=399399, posLast=217217, posLast=172172, Ser45, Thr44, Thr43, posLast=4242, Thr41, and posLast=4040
  • Modification sites at PhosphoSitePlus

Other Protein References for CPD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CPD Gene

Domains & Families for CPD Gene

Gene Families for CPD Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CPD Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CPD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75976

UniProtKB/Swiss-Prot:

CBPD_HUMAN :
  • There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity.
  • Belongs to the peptidase M14 family.
Domain:
  • There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPD: view

Function for CPD Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CPD Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Releases C-terminal Arg and Lys from polypeptides.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6.0-6.5.;
GENATLAS Biochemistry:
carboxypeptidase D,175-180kDa ,regulatory family,highly expressed in placenta,pancreas,hepatoma cells,most cell glycoprotein binding duck hepatitis B virus particles,involved in secretory pathway

Enzyme Numbers (IUBMB) for CPD Gene

Gene Ontology (GO) - Molecular Function for CPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 metallocarboxypeptidase activity IEA,IBA --
GO:0004185 serine-type carboxypeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CPD: view
genes like me logo Genes that share phenotypes with CPD: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CPD

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPD Gene

Localization for CPD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPD Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPD gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 2
golgi apparatus 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nuclear speckles (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005794 Golgi apparatus IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane HDA,TAS 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CPD: view

Pathways & Interactions for CPD Gene

genes like me logo Genes that share pathways with CPD: view

Gene Ontology (GO) - Biological Process for CPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006518 peptide metabolic process IBA --
GO:0016485 protein processing IBA --
GO:0030070 insulin processing IBA --
genes like me logo Genes that share ontologies with CPD: view

No data available for SIGNOR curated interactions for CPD Gene

Drugs & Compounds for CPD Gene

Products:

  1. Drug

(29) Drugs for CPD Gene - From: DrugBank, ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational, Vet_approved Pharma Agonist Anti-inflammatory glucocorticoid 2314
Pomalidomide Approved Pharma 139
Thalidomide Approved, Investigational, Withdrawn Pharma Immunomodulatory agent,sedative drug,angiogenesis inhibitor, Immunomodulatory agents, TNF-alpha synthesis inhibitor 1195
Zinc Approved, Investigational Pharma 2430
Guanidinoethylmercaptosuccinic acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with CPD: view

Transcripts for CPD Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CPD Gene

(2) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(373) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CPD Gene

Carboxypeptidase D:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPD Gene

No ASD Table

Relevant External Links for CPD Gene

GeneLoc Exon Structure for
CPD
ECgene alternative splicing isoforms for
CPD

Expression for CPD Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPD Gene

mRNA expression in normal human tissues for CPD Gene
mRNA expression by BioGPS for CPD GenemRNA expression by GTEx for CPD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPD Gene

This gene is overexpressed in Whole Blood (x5.9).

Protein differential expression in normal tissues from HIPED for CPD Gene

This gene is overexpressed in Salivary gland (21.6) and Oral epithelium (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CPD Gene



Protein tissue co-expression partners for CPD Gene

NURSA nuclear receptor signaling pathways regulating expression of CPD Gene:

CPD

SOURCE GeneReport for Unigene cluster for CPD Gene:

Hs.446079

mRNA Expression by UniProt/SwissProt for CPD Gene:

O75976-CBPD_HUMAN
Tissue specificity: Highly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal muscle, heart and colon carcinoma and melanoma cell lines.

Evidence on tissue expression from TISSUES for CPD Gene

  • Nervous system(4.8)
  • Liver(4.6)
genes like me logo Genes that share expression patterns with CPD: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CPD Gene

Orthologs for CPD Gene

This gene was present in the common ancestor of animals.

Orthologs for CPD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CPD 34 33
  • 99.71 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia CPD 34 33
  • 92.52 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia CPD 34
  • 92 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Cpd 16 34 33
  • 88.26 (n)
rat
(Rattus norvegicus)
 Mammalia Cpd 33
  • 87.83 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia CPD 34
  • 87 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia CPD 34
  • 81 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CPD 34 33
  • 75.04 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 34 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC101730225 33
  • 69.58 (n)
zebrafish
(Danio rerio)
 Actinopterygii cpda 34 33
  • 62.68 (n)
 OneToMany
cpdb 34
  • 46 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta svr 34 35 33
  • 48.74 (n)
 OneToOne
CG4678 35
  • 44 (a)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP002414 33
  • 47.32 (n)
worm
(Caenorhabditis elegans)
 Secernentea cpd-2 34 33
  • 53.75 (n)
 ManyToMany
F59A3.1 35
  • 49 (a)
T27A8.1 35
  • 45 (a)
F01D4.4 35
  • 42 (a)
cpd-1 34
  • 28 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 56 (a)
 OneToOne
Species where no ortholog for CPD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPD Gene

ENSEMBL:
Gene Tree for CPD (if available)
TreeFam:
Gene Tree for CPD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CPD: view image

Paralogs for CPD Gene

Paralogs for CPD Gene

(3) SIMAP similar genes for CPD Gene using alignment to 4 proteins:

  • CBPD_HUMAN
  • J3QQJ4_HUMAN
  • J3QRJ9_HUMAN
  • K7ELF0_HUMAN

Pseudogenes.org Pseudogenes for CPD Gene

genes like me logo Genes that share paralogs with CPD: view

Variants for CPD Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CPD Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000039223 -- 30,455,075(+) T/C intron_variant
rs1000081517 -- 30,434,420(+) G/A intron_variant
rs1000139534 -- 30,447,741(+) G/A intron_variant
rs1000149770 -- 30,397,430(+) A/G intron_variant
rs1000241630 -- 30,383,104(+) G/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CPD Gene

Variant ID Type Subtype PubMed ID
esv2673490 CNV deletion 23128226
esv3554304 CNV deletion 23714750
nsv1064611 CNV gain 25217958
nsv515870 CNV gain 19592680

Variation tolerance for CPD Gene

Residual Variation Intolerance Score: 13.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.27; 62.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPD Gene

Human Gene Mutation Database (HGMD)
CPD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPD

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPD Gene

Disorders for CPD Gene

MalaCards: The human disease database

(1) MalaCards diseases for CPD Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatitis b
  • chronic hepatitis b
- elite association - COSMIC cancer census association via MalaCards
Search CPD in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CPD

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CPD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPD Gene

Publications for CPD Gene

  1. Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains. (PMID: 9355738) Tan F … Skidgel RA (The Biochemical journal 1997) 2 3 4 22 58
  2. Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking. (PMID: 12643288) Kalinina EV … Fricker LD (The Journal of biological chemistry 2003) 3 4 22 58
  3. Cloning, functional expression, and chromosomal localization of the human and mouse gp180-carboxypeptidase D-like enzyme. (PMID: 9714835) Ishikawa T … Kuroki K (Gene 1998) 3 4 22 58
  4. Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1). (PMID: 9628828) Riley DA … Skidgel RA (Genomics 1998) 2 3 22 58
  5. Identification of a membrane-bound carboxypeptidase as the mammalian homolog of duck gp180, a hepatitis B virus-binding protein. (PMID: 9064476) McGwire GB … Skidgel RA (Life sciences 1997) 3 4 22 58

Products for CPD Gene

Sources for CPD Gene

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