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The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008]
CPD (Carboxypeptidase D) is a Protein Coding gene. Diseases associated with CPD include Hepatitis B and Hepatitis. Among its related pathways are Clathrin derived vesicle budding and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include metallocarboxypeptidase activity and serine-type carboxypeptidase activity. An important paralog of this gene is CPZ.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004180 | carboxypeptidase activity | IEA | -- |
GO:0004181 | metallocarboxypeptidase activity | IEA,IBA | 21873635 |
GO:0004185 | serine-type carboxypeptidase activity | IEA | -- |
GO:0008233 | peptidase activity | IEA | -- |
GO:0008237 | metallopeptidase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | TAS,HDA | 19946888 |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0070062 | extracellular exosome | HDA | 19199708 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Clathrin derived vesicle budding | ||
2 | Vesicle-mediated transport |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | IEA | -- |
GO:0006518 | peptide metabolic process | IBA | 21873635 |
GO:0016485 | protein processing | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Dexamethasone | Approved, Investigational, Vet_approved | Pharma | Agonist | Anti-inflammatory glucocorticoid | 2886 | |
Dexamethasone acetate | Approved, Investigational, Vet_approved | Pharma | 2886 | |||
Pomalidomide | Approved | Pharma | 180 | |||
Zinc | Approved, Investigational | Pharma | 1594 | |||
Guanidinoethylmercaptosuccinic acid | Experimental | Pharma | Target | 0 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CPD 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CPD 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CPD 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cpd 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cpd 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | CPD 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CPD 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CPD 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101730225 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cpda 30 31 |
|
OneToMany | |
cpdb 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | svr 30 31 32 |
|
OneToOne | |
CG4678 32 |
|
|
|||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002414 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | cpd-2 30 31 |
|
ManyToMany | |
F59A3.1 32 |
|
|
|||
T27A8.1 32 |
|
|
|||
F01D4.4 32 |
|
|
|||
cpd-1 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
739309 | Benign: not provided | 30,445,843(+) | C/T | MISSENSE_VARIANT | |
770445 | Benign: not provided | 30,422,862(+) | A/G | MISSENSE_VARIANT | |
778687 | Benign: not provided | 30,378,993(+) | C/A | SYNONYMOUS_VARIANT | |
791199 | Benign: not provided | 30,431,785(+) | T/G | SYNONYMOUS_VARIANT | |
rs17854355 | - | p.His505Asn |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2673490 | CNV | deletion | 23128226 |
esv3554304 | CNV | deletion | 23714750 |
nsv1064611 | CNV | gain | 25217958 |
nsv515870 | CNV | gain | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
hepatitis b |
|
|
hepatitis |
|
|