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CPB1 Gene(Protein Coding)

Carboxypeptidase B1

GCID:
GC03P148791
GIFtS:
51
Genes Participants
UDN Logo

Aliases for CPB1 Gene

Aliases for CPB1 Gene

  • Carboxypeptidase B1 2 3 5
  • Pancreatic Carboxypeptidase B 2 3
  • Carboxypeptidase B1 (Tissue) 2 3
  • Tissue Carboxypeptidase B 2 3
  • Pancreas-Specific Protein 3 4
  • Protaminase 2 3
  • EC 3.4.17.2 4 56
  • PASP 3 4
  • PCPB 3 4
  • CPB 3 4
  • Procarboxypeptidase B 3
  • Carboxypeptidase B 3
  • EC 3.4.17 56

External Ids for CPB1 Gene

Previous GeneCards Identifiers for CPB1 Gene

  • GC03P145494
  • GC03P149430
  • GC03P149827
  • GC03P149866
  • GC03P150028
  • GC03P148508
  • GC03P145918

Summaries for CPB1 Gene

Entrez Gene Summary for CPB1 Gene

  • Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPB1 Gene

CPB1 (Carboxypeptidase B1) is a Protein Coding gene. Diseases associated with CPB1 include Acute Pancreatitis and Pancreatitis. Among its related pathways are Peptide hormone metabolism and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include metallocarboxypeptidase activity and carboxypeptidase activity. An important paralog of this gene is CPA3.

Additional gene information for CPB1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPB1 Gene

Genomics for CPB1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CPB1 Gene

Promoters and enhancers for CPB1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH03I148790 Enhancer 0.8 FANTOM5 Ensembl ENCODE 550.8 +0.4 421 2.9 POLR2A RCOR1 CPB1 CPA3 HMGB1P30
GH03I148826 Promoter/Enhancer 0.7 EPDnew ENCODE 550.3 +36.7 36706 1.9 CPB1 HMGB1P30 CPA3
GH03I148697 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 0.2 -93.2 -93164 1.3 DRAP1 PKNOX1 USF1 TAF1 MAX ARID4B SIN3A ZNF48 RAD21 YY1 AGTR1 GC03M148696 RPL38P1 CPB1
GH03I148723 Enhancer 0.7 Ensembl ENCODE 0.2 -67.3 -67273 1 SP1 JUND SMAD4 FOSL2 FOS HOMEZ RARA RPL38P1 AGTR1 CPB1
GH03I148736 Enhancer 0.7 ENCODE 0.2 -54.1 -54148 0.5 FOXA2 MAX CEBPG RAD21 YY1 HNF4G SMARCC1 NFIA RXRA CEBPB AGTR1 CPB1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CPB1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CPB1 gene promoter:

Genomic Locations for CPB1 Gene

Genomic Locations for CPB1 Gene
chr3:148,791,102-148,860,192
(GRCh38/hg38)
Size:
69,091 bases
Orientation:
Plus strand
chr3:148,508,889-148,577,974
(GRCh37/hg19)

Genomic View for CPB1 Gene

Genes around CPB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPB1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CPB1 Gene

Proteins for CPB1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CPB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15086-CBPB1_HUMAN
    Recommended name:
    Carboxypeptidase B
    Protein Accession:
    P15086
    Secondary Accessions:
    • O60834
    • Q53XJ0
    • Q96BQ8

    Protein attributes for CPB1 Gene

    Size:
    417 amino acids
    Molecular mass:
    47368 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CPB1 Gene

neXtProt entry for CPB1 Gene

Protein Expression for CPB1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CPB1 Gene

P15086:
  • AFCQWFV
  • ESEKETKA
  • HAREWIS
  • FELRDTG
  • RNFDAGWC
  • YTYGPGA
  • WETIEAW

Post-translational modifications for CPB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CPB1 (Carboxypeptidase B1/CPB1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CPB1

Domains & Families for CPB1 Gene

Gene Families for CPB1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CPB1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CPB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15086

UniProtKB/Swiss-Prot:

CBPB1_HUMAN :
  • Belongs to the peptidase M14 family.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPB1: view

Function for CPB1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CPB1 Gene

GENATLAS Biochemistry:
carboxypeptidase B1 (tissue)
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential release of a C-terminal lysine or arginine amino acid.

Enzyme Numbers (IUBMB) for CPB1 Gene

Gene Ontology (GO) - Molecular Function for CPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity TAS 1370825
GO:0004181 metallocarboxypeptidase activity IBA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CPB1: view
genes like me logo Genes that share phenotypes with CPB1: view

Animal Models for CPB1 Gene

MGI Knock Outs for CPB1:
  • Cpb1 tm1.1(KOMP)Vlcg

Animal Model Products

  • Taconic Biosciences Mouse Models for CPB1

CRISPR Products

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CPB1 Gene

Localization for CPB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPB1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPB1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
lysosome 2
endosome 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CPB1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CPB1 Gene

Pathways & Interactions for CPB1 Gene

genes like me logo Genes that share pathways with CPB1: view

Pathways by source for CPB1 Gene

Gene Ontology (GO) - Biological Process for CPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CPB1: view

No data available for SIGNOR curated interactions for CPB1 Gene

Drugs & Compounds for CPB1 Gene

Products:

  1. Drug

(11) Drugs for CPB1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citric Acid Approved, Vet_approved Nutra Agonist, Activator, Target 1243
Zinc Approved, Investigational Pharma 2430
(2S)-2-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-3-[(S)-HYDROXY(3-PHENYLPROPYL)PHOSPHORYL]PROPANOIC ACID Experimental Pharma Target 0
(2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(R)-[(1R)-1-{[(BENZYLOXY)CARBONYL]AMINO}-2-METHYLPROPYL](HYDROXY)PHOSPHORYL]PROPANOIC ACID Experimental Pharma Target 0
(2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(R)-HYDROXY{(1R)-2-METHYL-1-[(PHENYLSULFONYL)AMINO]PROPYL}PHOSPHORYL]PROPANOIC ACID Experimental Pharma Target 0

(1) Additional Compounds for CPB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CPB1: view

Transcripts for CPB1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CPB1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(474) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CPB1 Gene

Carboxypeptidase B1 (tissue):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPB1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b
SP1: - - - -
SP2: - - - - - - - - - -
SP3:
SP4: -
SP5: -
SP6:

Relevant External Links for CPB1 Gene

GeneLoc Exon Structure for
CPB1
ECgene alternative splicing isoforms for
CPB1

Expression for CPB1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPB1 Gene

mRNA expression in normal human tissues for CPB1 Gene
mRNA expression by GTEx for CPB1 GenemRNA expression by BioGPS for CPB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPB1 Gene

This gene is overexpressed in Pancreas (x52.6).

Protein differential expression in normal tissues from HIPED for CPB1 Gene

This gene is overexpressed in Pancreatic juice (61.5) and Pancreas (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CPB1 Gene



Protein tissue co-expression partners for CPB1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CPB1 Gene:

CPB1

SOURCE GeneReport for Unigene cluster for CPB1 Gene:

Hs.477891

mRNA Expression by UniProt/SwissProt for CPB1 Gene:

P15086-CBPB1_HUMAN
Tissue specificity: Pancreas.

Evidence on tissue expression from TISSUES for CPB1 Gene

  • Pancreas(5)
  • Adrenal gland(4.6)
  • Liver(2.7)
  • Heart(2.5)
  • Nervous system(2.3)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with CPB1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CPB1 Gene

Orthologs for CPB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CPB1 33 34
  • 98.96 (n)
dog
(Canis familiaris)
 Mammalia CPB1 33 34
  • 87.66 (n)
cow
(Bos Taurus)
 Mammalia CPB1 33 34
  • 86.25 (n)
rat
(Rattus norvegicus)
 Mammalia Cpb1 33
  • 79.2 (n)
mouse
(Mus musculus)
 Mammalia Cpb1 33 16 34
  • 78.07 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 78 (a)
 OneToMany
-- 34
  • 73 (a)
 OneToMany
-- 34
  • 73 (a)
 OneToMany
-- 34
  • 59 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia CPB1 34
  • 76 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CPB1 33 34
  • 69.06 (n)
lizard
(Anolis carolinensis)
 Reptilia CPB1 34
  • 70 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100494117 33
  • 58.82 (n)
Str.5708 33
African clawed frog
(Xenopus laevis)
 Amphibia Xl.26001 33
zebrafish
(Danio rerio)
 Actinopterygii cpb1 33 34
  • 69.44 (n)
wufb60d07 33
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.2214 33
fruit fly
(Drosophila melanogaster)
 Insecta CG4017 35 33 34
  • 45.93 (n)
CG18417 35 34
  • 35 (a)
CG3108 35
  • 35 (a)
CG17633 35 34
  • 33 (a)
CG18585 35 34
  • 32 (a)
CG7025 35 34
  • 32 (a)
CG8560 35 34
  • 32 (a)
CG8562 35 34
  • 32 (a)
CG2915 35 34
  • 31 (a)
CG14820 35 34
  • 30 (a)
CG15769 35
  • 30 (a)
CG12374 35 34
  • 30 (a)
CG32379 34
  • 30 (a)
 ManyToMany
CG18415 35
  • 29 (a)
CG3097 35
  • 28 (a)
CG4408 35 34
  • 28 (a)
CG8539 35 34
  • 28 (a)
CG8563 34
  • 27 (a)
 ManyToMany
CG8564 34
  • 18 (a)
 ManyToMany
worm
(Caenorhabditis elegans)
 Secernentea Y18H1A.9 35 34
  • 33 (a)
R11A5.7 35
  • 32 (a)
W01A8.6 35 34
  • 31 (a)
Y47G6A.19 35 34
  • 31 (a)
ZC434.9 35 34
  • 31 (a)
Y59C2A.1 35
  • 29 (a)
F02D8.4 34
  • 28 (a)
 ManyToMany
T06A4.3 34
  • 25 (a)
 ManyToMany
T06A4.1 34
  • 24 (a)
 ManyToMany
suro-1 34
  • 20 (a)
 ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes ECM14 34
  • 27 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 36 (a)
 ManyToMany
-- 34
  • 35 (a)
 ManyToMany
CSA.11311 34
  • 35 (a)
 ManyToMany
CSA.4005 34
  • 18 (a)
 ManyToMany
Species where no ortholog for CPB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPB1 Gene

ENSEMBL:
Gene Tree for CPB1 (if available)
TreeFam:
Gene Tree for CPB1 (if available)

Paralogs for CPB1 Gene

Paralogs for CPB1 Gene

(9) SIMAP similar genes for CPB1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CPB1: view

Variants for CPB1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CPB1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000010665 -- 148,836,728(+) A/T intron_variant
rs1000049329 -- 148,826,122(+) T/C upstream_transcript_variant
rs1000051883 -- 148,829,654(+) C/G intron_variant
rs1000078965 -- 148,833,380(+) A/G intron_variant
rs1000195533 -- 148,855,232(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CPB1 Gene

Variant ID Type Subtype PubMed ID
dgv127n6 CNV deletion 16902084
dgv2618n106 CNV deletion 24896259
esv1368988 CNV deletion 17803354
esv1937920 CNV deletion 18987734
esv2507087 CNV deletion 19546169
esv2726034 CNV deletion 23290073
esv2833236 CNV deletion 24192839
esv3562699 CNV deletion 23714750
esv3598134 CNV loss 21293372
esv5048 CNV loss 18987735
esv6949 CNV loss 19470904
esv998869 CNV deletion 20482838
nsv1074632 CNV deletion 25765185
nsv1147810 CNV deletion 26484159
nsv829751 CNV loss 17160897
nsv955536 CNV deletion 24416366

Variation tolerance for CPB1 Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.48; 55.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPB1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPB1 Gene

Disorders for CPB1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CPB1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute pancreatitis
  • acute necrotizing pancreatitis
pancreatitis
trachea leiomyoma
  • leiomyoma of the trachea
char syndrome
  • char
- elite association - COSMIC cancer census association via MalaCards
Search CPB1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CPB1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CPB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPB1 Gene

Publications for CPB1 Gene

  1. Comparative analysis of the sequences and three-dimensional models of human procarboxypeptidases A1, A2 and B. (PMID: 9524066) Aloy P … Avilés FX (Biological chemistry 1998) 3 4 22 58
  2. Isolation of a cDNA encoding a human serum marker for acute pancreatitis. Identification of pancreas-specific protein as pancreatic procarboxypeptidase B. (PMID: 1370825) Yamamoto KK … French CK (The Journal of biological chemistry 1992) 3 4 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Human procarboxypeptidase B: three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (TAFI). (PMID: 12162965) Barbosa Pereira PJ … Vendrell J (Journal of molecular biology 2002) 3 4 58

Products for CPB1 Gene

Sources for CPB1 Gene

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