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Aliases for CPA5 Gene

Aliases for CPA5 Gene

  • Carboxypeptidase A5 2 3 3 5
  • Testicular Tissue Protein Li 32 3
  • EC 3.4.17.- 4

External Ids for CPA5 Gene

Previous GeneCards Identifiers for CPA5 Gene

  • GC07P128462
  • GC07P129523
  • GC07P129537
  • GC07P129578
  • GC07P129772
  • GC07P129986
  • GC07P124346

Summaries for CPA5 Gene

Entrez Gene Summary for CPA5 Gene

  • Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002 [PubMed 11836249]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CPA5 Gene

CPA5 (Carboxypeptidase A5) is a Protein Coding gene. Diseases associated with CPA5 include Silver-Russell Syndrome. Gene Ontology (GO) annotations related to this gene include peptidase activity and carboxypeptidase activity. An important paralog of this gene is CPA1.

Gene Wiki entry for CPA5 Gene

Additional gene information for CPA5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPA5 Gene

Genomics for CPA5 Gene

GeneHancer (GH) Regulatory Elements for CPA5 Gene

Promoters and enhancers for CPA5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J130344 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 664.3 +0.7 657 2.5 BCOR ZNF263 ATF1 NRF1 ZMYM3 ZIC2 ATF2 POLR2A ZNF341 CREB1 CPA5 LOC105375503 NRF1 CPA1 CPA4 LOC105375504
GH07J130362 Enhancer 2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 59.7 +24.3 24290 12.7 PKNOX1 FOXA2 MLX ARID4B FEZF1 DMAP1 ZNF2 IRF4 YY1 SLC30A9 LOC105375504 CPA5 CPA1 CPA2 MKLN1 MEST CDC26P1 KLHDC10 NRF1 CEP41
GH07J130354 Enhancer 1.4 Ensembl ENCODE dbSUPER 34.4 +12.8 12770 5.7 PKNOX1 ZNF133 SIN3A FEZF1 GLI4 ZNF2 FOS KLF13 RXRA YY2 CPA5 MEST NRF1 CPA1 KLHDC10 CPA4 CPA2 COPG2 LOC105375504
GH07J130349 Enhancer 1.2 Ensembl ENCODE dbSUPER 31.3 +7.2 7191 4.5 HDGF PKNOX1 ZFP64 STAT5A BATF IRF4 RAD21 FOS ETV6 IKZF2 CPA5 MEST CDC26P1 CPA1 MKLN1 CPA4 CPA2 NRF1 COPG2 LOC105375504
GH07J130488 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 12.1 +146.9 146930 7.5 ATF1 ARNT SIN3A TCF12 GATA2 E2F8 ATF7 NCOA1 REST MBD2 ENSG00000274500 MESTIT1 MEST COPG2 CPA5 ENSG00000278055 GC07P130490 GC07P130498
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CPA5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CPA5 gene promoter:
  • FOXL1
  • Egr-4
  • FOXD3
  • Ik-1
  • GATA-1
  • GATA-2
  • GATA-3
  • AML1a
  • IRF-7A

Genomic Locations for CPA5 Gene

Genomic Locations for CPA5 Gene
29,920 bases
Plus strand
23,942 bases
Plus strand

Genomic View for CPA5 Gene

Genes around CPA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPA5 Gene

Proteins for CPA5 Gene

  • Protein details for CPA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carboxypeptidase A5
    Protein Accession:
    Secondary Accessions:
    • G3V0G8
    • Q6ZNI6
    • Q86SE2
    • Q86XM3
    • Q8NA08

    Protein attributes for CPA5 Gene

    436 amino acids
    Molecular mass:
    49036 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CPA5 Gene


neXtProt entry for CPA5 Gene

Post-translational modifications for CPA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CPA5 Gene

Domains & Families for CPA5 Gene

Gene Families for CPA5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CPA5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M14 family.
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPA5: view

Function for CPA5 Gene

Enzyme Numbers (IUBMB) for CPA5 Gene

Phenotypes From GWAS Catalog for CPA5 Gene

Gene Ontology (GO) - Molecular Function for CPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 metallocarboxypeptidase activity IBA,IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CPA5: view
genes like me logo Genes that share phenotypes with CPA5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CPA5

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CPA5 Gene

Localization for CPA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPA5 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPA5 gene
Compartment Confidence
extracellular 4
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CPA5: view

Pathways & Interactions for CPA5 Gene

No Data Available

Interacting Proteins for CPA5 Gene

Gene Ontology (GO) - Biological Process for CPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CPA5: view

No data available for Pathways by source and SIGNOR curated interactions for CPA5 Gene

Drugs & Compounds for CPA5 Gene

(1) Drugs for CPA5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma 2430
genes like me logo Genes that share compounds with CPA5: view

Transcripts for CPA5 Gene

Unigene Clusters for CPA5 Gene

Carboxypeptidase A5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPA5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a ·
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - - -
SP8: - -

ExUns: 15b

Relevant External Links for CPA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPA5 Gene

mRNA differential expression in normal tissues according to GTEx for CPA5 Gene

This gene is overexpressed in Testis (x46.7).

Protein differential expression in normal tissues from HIPED for CPA5 Gene

This gene is overexpressed in Pancreatic juice (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CPA5 Gene

Protein tissue co-expression partners for CPA5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CPA5 Gene:


SOURCE GeneReport for Unigene cluster for CPA5 Gene:


mRNA Expression by UniProt/SwissProt for CPA5 Gene:

Tissue specificity: Expression is very low or not detectable.

Evidence on tissue expression from TISSUES for CPA5 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CPA5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPA5 Gene

Orthologs for CPA5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CPA5 34 33
  • 99.08 (n)
(Canis familiaris)
Mammalia CPA5 34 33
  • 89.76 (n)
(Bos Taurus)
Mammalia CPA5 34 33
  • 87.57 (n)
(Mus musculus)
Mammalia Cpa5 16 34 33
  • 84.24 (n)
(Rattus norvegicus)
Mammalia Cpa5 33
  • 82.98 (n)
(Monodelphis domestica)
Mammalia CPA5 34
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia CPA5 34
  • 64 (a)
(Gallus gallus)
Aves CPA5 34 33
  • 66.11 (n)
(Anolis carolinensis)
Reptilia CPA5 34
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3108 35
  • 35 (a)
CG3097 35
  • 33 (a)
CG14820 34 35
  • 32 (a)
CG4017 34 35
  • 31 (a)
CG18585 34 35
  • 31 (a)
CG7025 34 35
  • 30 (a)
CG18415 35
  • 29 (a)
CG17633 34 35
  • 28 (a)
CG12374 34 35
  • 27 (a)
CG2915 34 35
  • 27 (a)
CG32379 34
  • 27 (a)
CG15769 35
  • 27 (a)
CG8563 34
  • 26 (a)
CG8560 34
  • 26 (a)
CG8562 34
  • 26 (a)
CG4408 34 35
  • 26 (a)
CG8945 35
  • 25 (a)
CG18417 34
  • 24 (a)
CG8539 34 35
  • 23 (a)
CG8564 34
  • 17 (a)
(Caenorhabditis elegans)
Secernentea Y59C2A.1 35
  • 31 (a)
R11A5.7 35
  • 30 (a)
Y18H1A.9 34 35
  • 28 (a)
T06A4.3 34 35
  • 26 (a)
Y47G6A.19 34 35
  • 26 (a)
W01A8.6 34 35
  • 25 (a)
F02D8.4 34
  • 25 (a)
T06A4.1 34
  • 23 (a)
suro-1 34
  • 19 (a)
ZC434.9 34 35
  • 18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM14 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
-- 34
  • 38 (a)
CSA.11311 34
  • 36 (a)
CSA.4005 34
  • 20 (a)
Species where no ortholog for CPA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CPA5 Gene

Gene Tree for CPA5 (if available)
Gene Tree for CPA5 (if available)
Evolutionary constrained regions (ECRs) for CPA5: view image

Paralogs for CPA5 Gene

Paralogs for CPA5 Gene

(9) SIMAP similar genes for CPA5 Gene using alignment to 5 proteins:

  • A4D1M2_HUMAN
  • H7C4Q6_HUMAN
genes like me logo Genes that share paralogs with CPA5: view

Variants for CPA5 Gene

Sequence variations from dbSNP and Humsavar for CPA5 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000617180 -- 130,364,056(+) C/T intron_variant
rs1000841071 -- 130,358,969(+) T/C intron_variant
rs1001440689 -- 130,360,611(+) A/G intron_variant
rs1001891949 -- 130,361,015(+) C/T intron_variant
rs1001900491 -- 130,343,498(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CPA5 Gene

Variant ID Type Subtype PubMed ID
esv23964 CNV gain 19812545
esv2735153 CNV deletion 23290073
nsv515945 CNV gain+loss 19592680

Variation tolerance for CPA5 Gene

Residual Variation Intolerance Score: 93.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.65; 89.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPA5 Gene

Disorders for CPA5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CPA5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
silver-russell syndrome
  • srs
- elite association - COSMIC cancer census association via MalaCards
Search CPA5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CPA5

genes like me logo Genes that share disorders with CPA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPA5 Gene

Publications for CPA5 Gene

  1. Identification and characterization of three members of the human metallocarboxypeptidase gene family. (PMID: 11836249) Wei S … Fricker LD (The Journal of biological chemistry 2002) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome. (PMID: 12676894) Bentley L … Moore GE (Journal of medical genetics 2003) 3 4 58
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58

Products for CPA5 Gene

Sources for CPA5 Gene

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