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Aliases for CPA2 Gene

Aliases for CPA2 Gene

  • Carboxypeptidase A2 2 3 3 5
  • Carboxypeptidase A2 (Pancreatic) 2 3
  • EC 3.4.17.15 4

External Ids for CPA2 Gene

Previous GeneCards Identifiers for CPA2 Gene

  • GC07P128383
  • GC07P129445
  • GC07P129459
  • GC07P129500
  • GC07P129693
  • GC07P129906
  • GC07P124269

Summaries for CPA2 Gene

Entrez Gene Summary for CPA2 Gene

  • Three different forms of human pancreatic procarboxypeptidase A have been isolated. The encoded protein represents the A2 form, which is a monomeric protein with different biochemical properties from the A1 and A3 forms. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues and is a secreted protein. [provided by RefSeq, Dec 2008]

GeneCards Summary for CPA2 Gene

CPA2 (Carboxypeptidase A2) is a Protein Coding gene. Among its related pathways are Collagen chain trimerization and Pancreatic secretion. Gene Ontology (GO) annotations related to this gene include metallocarboxypeptidase activity and carboxypeptidase activity. An important paralog of this gene is CPA4.

Gene Wiki entry for CPA2 Gene

Additional gene information for CPA2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPA2 Gene

Genomics for CPA2 Gene

GeneHancer (GH) Regulatory Elements for CPA2 Gene

Promoters and enhancers for CPA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J130266 Promoter/Enhancer 0.9 EPDnew ENCODE 650.7 +0.1 54 1.3 STAT1 ZNF512 CPA2 KLHDC10 GC07M130268
GH07J130362 Enhancer 2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 51.7 +102.3 102253 12.7 PKNOX1 FOXA2 MLX ARID4B FEZF1 DMAP1 ZNF2 IRF4 YY1 SLC30A9 LOC105375504 CPA5 CPA1 CPA2 MKLN1 MEST CDC26P1 KLHDC10 NRF1 CEP41
GH07J130290 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 11.1 +26.1 26068 5 PKNOX1 RAD21 BRCA1 RFX5 ZNF366 RCOR1 FOS DEK EGR2 CEBPB CPA4 CPA5 CPA2 GC07M130268
GH07J130354 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.2 +90.7 90733 5.7 PKNOX1 ZNF133 SIN3A FEZF1 GLI4 ZNF2 FOS KLF13 RXRA YY2 CPA5 MEST NRF1 CPA1 KLHDC10 CPA4 CPA2 COPG2 LOC105375504
GH07J130349 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.7 +85.2 85154 4.5 HDGF PKNOX1 ZFP64 STAT5A BATF IRF4 RAD21 FOS ETV6 IKZF2 CPA5 MEST CDC26P1 CPA1 MKLN1 CPA4 CPA2 NRF1 COPG2 LOC105375504
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CPA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CPA2 gene promoter:
  • E2F
  • NF-Y
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • CBF(2)

Genomic Locations for CPA2 Gene

Genomic Locations for CPA2 Gene
chr7:130,266,827-130,289,798
(GRCh38/hg38)
Size:
22,972 bases
Orientation:
Plus strand
chr7:129,906,667-129,929,638
(GRCh37/hg19)
Size:
22,972 bases
Orientation:
Plus strand

Genomic View for CPA2 Gene

Genes around CPA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPA2 Gene

Proteins for CPA2 Gene

  • Protein details for CPA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48052-CBPA2_HUMAN
    Recommended name:
    Carboxypeptidase A2
    Protein Accession:
    P48052
    Secondary Accessions:
    • A4D1M4
    • C9JIK1
    • Q53XS1
    • Q96A12
    • Q96QN3
    • Q9UCF1

    Protein attributes for CPA2 Gene

    Size:
    419 amino acids
    Molecular mass:
    47030 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA74425.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH07009.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH14571.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH15140.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAL24092.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CPA2 Gene

neXtProt entry for CPA2 Gene

Post-translational modifications for CPA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CPA2 Gene

Domains & Families for CPA2 Gene

Gene Families for CPA2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CPA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P48052

UniProtKB/Swiss-Prot:

CBPA2_HUMAN :
  • Belongs to the peptidase M14 family.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPA2: view

Function for CPA2 Gene

Molecular function for CPA2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Similar to that of carboxypeptidase A (EC 3.4.17.1), but with a preference for bulkier C-terminal residues.

Enzyme Numbers (IUBMB) for CPA2 Gene

Phenotypes From GWAS Catalog for CPA2 Gene

Gene Ontology (GO) - Molecular Function for CPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity IDA 2920728
GO:0004181 metallocarboxypeptidase activity IDA,IEA 2920728
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IDA,IEA 2920728
genes like me logo Genes that share ontologies with CPA2: view
genes like me logo Genes that share phenotypes with CPA2: view

Animal Models for CPA2 Gene

MGI Knock Outs for CPA2:
  • Cpa2 Cpa2<tm1b(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for CPA2

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CPA2 Gene

Localization for CPA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPA2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPA2 gene
Compartment Confidence
extracellular 5
golgi apparatus 2
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,IDA 2920728
GO:0005615 extracellular space IBA --
GO:0005773 vacuole IEA --
genes like me logo Genes that share ontologies with CPA2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CPA2 Gene

Pathways & Interactions for CPA2 Gene

genes like me logo Genes that share pathways with CPA2: view

Pathways by source for CPA2 Gene

Gene Ontology (GO) - Biological Process for CPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007039 protein catabolic process in the vacuole TAS 2920728
genes like me logo Genes that share ontologies with CPA2: view

No data available for SIGNOR curated interactions for CPA2 Gene

Drugs & Compounds for CPA2 Gene

(2) Drugs for CPA2 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
asparaginase Pharma 238
CPA inhibitor Pharma Potent carboxypeptidase A (CPA) inhibitor 0
genes like me logo Genes that share compounds with CPA2: view

Transcripts for CPA2 Gene

mRNA/cDNA for CPA2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(99) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CPA2 Gene

Carboxypeptidase A2 (pancreatic):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPA2 Gene

No ASD Table

Relevant External Links for CPA2 Gene

GeneLoc Exon Structure for
CPA2
ECgene alternative splicing isoforms for
CPA2

Expression for CPA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPA2 Gene

This gene is overexpressed in Pancreas (x52.5).

Protein differential expression in normal tissues from HIPED for CPA2 Gene

This gene is overexpressed in Pancreatic juice (44.6) and Pancreas (22.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CPA2 Gene



Protein tissue co-expression partners for CPA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CPA2 Gene:

CPA2

SOURCE GeneReport for Unigene cluster for CPA2 Gene:

Hs.490038

Evidence on tissue expression from TISSUES for CPA2 Gene

  • Pancreas(4.8)
  • Nervous system(4.2)
  • Stomach(2.4)
genes like me logo Genes that share expression patterns with CPA2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPA2 Gene

Orthologs for CPA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPA2 34 33
  • 99.68 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 90 (a)
OneToMany
-- 34
  • 81 (a)
OneToMany
-- 34
  • 75 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CPA2 33
  • 89.29 (n)
rat
(Rattus norvegicus)
Mammalia Cpa2 33
  • 85.61 (n)
mouse
(Mus musculus)
Mammalia Cpa2 16 34 33
  • 85.53 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 56 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CPA2 34 33
  • 72.26 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 68 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii cpa4 34 33
  • 64.5 (n)
ManyToMany
cpa2 34
  • 54 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7025 34 35 33
  • 48.6 (n)
ManyToMany
CG3108 35
  • 35 (a)
CG8560 34 35
  • 34 (a)
ManyToMany
CG4017 34 35
  • 34 (a)
ManyToMany
CG3097 35
  • 34 (a)
CG17633 34 35
  • 31 (a)
ManyToMany
CG8562 34 35
  • 31 (a)
ManyToMany
CG18417 34 35
  • 30 (a)
ManyToMany
CG18585 34 35
  • 30 (a)
ManyToMany
CG32379 34
  • 29 (a)
ManyToMany
CG14820 34 35
  • 29 (a)
ManyToMany
CG18415 35
  • 29 (a)
CG8563 34 35
  • 28 (a)
ManyToMany
CG15769 35
  • 28 (a)
CG2915 34 35
  • 27 (a)
ManyToMany
CG4408 34 35
  • 27 (a)
ManyToMany
CG8945 35
  • 26 (a)
CG8539 34 35
  • 25 (a)
ManyToMany
CG12374 34 35
  • 25 (a)
ManyToMany
CG8564 34
  • 18 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011434 33
  • 48.55 (n)
worm
(Caenorhabditis elegans)
Secernentea Y18H1A.9 34 35 33
  • 50.26 (n)
ManyToMany
Y59C2A.1 35
  • 32 (a)
R11A5.7 35
  • 32 (a)
Y47G6A.19 34 35
  • 30 (a)
ManyToMany
F02D8.4 34
  • 30 (a)
ManyToMany
W01A8.6 34 35
  • 29 (a)
ManyToMany
T06A4.3 34 35
  • 29 (a)
ManyToMany
T06A4.1 34
  • 26 (a)
ManyToMany
suro-1 34
  • 21 (a)
ManyToMany
ZC434.9 34 35
  • 21 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM14 34
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
ManyToMany
CSA.11311 34
  • 41 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
CSA.4005 34
  • 22 (a)
ManyToMany
Species where no ortholog for CPA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CPA2 Gene

ENSEMBL:
Gene Tree for CPA2 (if available)
TreeFam:
Gene Tree for CPA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CPA2: view image

Paralogs for CPA2 Gene

Paralogs for CPA2 Gene

(9) SIMAP similar genes for CPA2 Gene using alignment to 2 proteins:

  • CBPA2_HUMAN
  • J3QT58_HUMAN
genes like me logo Genes that share paralogs with CPA2: view

Variants for CPA2 Gene

Sequence variations from dbSNP and Humsavar for CPA2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000100332 -- 130,279,871(+) A/G intron_variant
rs1000162820 -- 130,272,961(+) C/T intron_variant
rs1000186947 -- 130,286,473(+) C/G intron_variant
rs1000368920 -- 130,281,004(+) G/A intron_variant
rs1000407638 -- 130,266,427(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CPA2 Gene

Variant ID Type Subtype PubMed ID
esv2673566 CNV deletion 23128226
esv3615020 CNV loss 21293372
esv3615021 CNV loss 21293372
nsv1024261 CNV gain 25217958
nsv508481 CNV deletion 20534489

Variation tolerance for CPA2 Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPA2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPA2 Gene

Disorders for CPA2 Gene

Additional Disease Information for CPA2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CPA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPA2 Gene

Publications for CPA2 Gene

  1. The sequence and conformation of human pancreatic procarboxypeptidase A2. cDNA cloning, sequence analysis, and three-dimensional model. (PMID: 7896805) Catasús L … Billeter M (The Journal of biological chemistry 1995) 2 3 4 22 58
  2. Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2. (PMID: 10742178) Reverter D … Avilés FX (Nature structural biology 2000) 3 4 22 58
  3. Characterisation and preliminary X-ray diffraction analysis of human pancreatic procarboxypeptidase A2. (PMID: 9450539) Reverter D … Avilés FX (FEBS letters 1997) 3 4 22 58
  4. Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2. (PMID: 8806703) Laethem RM … Smith GK (Archives of biochemistry and biophysics 1996) 3 4 22 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for CPA2 Gene

Sources for CPA2 Gene

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