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Aliases for CPA1 Gene

Aliases for CPA1 Gene

  • Carboxypeptidase A1 2 3 5
  • Carboxypeptidase A1 (Pancreatic) 2 3
  • Pancreatic Carboxypeptidase A 2 3
  • EC 3.4.17.1 4 56
  • CPA 3 4
  • EC 3.4.17 56

External Ids for CPA1 Gene

Previous HGNC Symbols for CPA1 Gene

  • CPA

Previous GeneCards Identifiers for CPA1 Gene

  • GC07P128496
  • GC07P129559
  • GC07P129573
  • GC07P129614
  • GC07P129807
  • GC07P130020
  • GC07P124382

Summaries for CPA1 Gene

Entrez Gene Summary for CPA1 Gene

  • This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. This enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chromosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic cancer. [provided by RefSeq, Jan 2015]

GeneCards Summary for CPA1 Gene

CPA1 (Carboxypeptidase A1) is a Protein Coding gene. Diseases associated with CPA1 include Pancreatitis and Borna Disease. Among its related pathways are Collagen chain trimerization and Pancreatic secretion. Gene Ontology (GO) annotations related to this gene include metallocarboxypeptidase activity and exopeptidase activity. An important paralog of this gene is CPA2.

UniProtKB/Swiss-Prot for CPA1 Gene

  • Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.

Gene Wiki entry for CPA1 Gene

Additional gene information for CPA1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPA1 Gene

Genomics for CPA1 Gene

GeneHancer (GH) Regulatory Elements for CPA1 Gene

Promoters and enhancers for CPA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I130378 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.2 -169 2.7 CTCF RCOR1 NR2F2 CHD2 CPA1 CPA5 MEST LOC105375504
GH07I130362 Enhancer 2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 52.3 -11.3 -11259 12.7 PKNOX1 FOXA2 MLX ARID4B FEZF1 DMAP1 ZNF2 IRF4 SLC30A9 FOS LOC105375504 CPA5 CPA1 CPA2 MKLN1 MEST CDC26P1 KLHDC10 NRF1 CEP41
GH07I130354 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.9 -22.8 -22779 5.7 PKNOX1 ZNF133 SIN3A FEZF1 GLI4 ZNF2 FOS KLF13 YY2 TSHZ1 CPA5 MEST NRF1 CPA1 KLHDC10 CPA4 CPA2 COPG2 LOC105375504
GH07I130344 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 11.8 -34.9 -34892 2.5 BCOR ZNF263 ATF1 NRF1 ZMYM3 ZIC2 ATF2 POLR2A ZNF341 CREB1 CPA5 LOC105375503 CPA1 CPA4 LOC105375504
GH07I130349 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.9 -28.4 -28358 4.5 HDGF PKNOX1 ZFP64 BATF IRF4 RAD21 ETV6 FOS IKZF2 RUNX3 CPA5 MEST CDC26P1 CPA1 MKLN1 CPA4 CPA2 NRF1 COPG2 LOC105375504
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CPA1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CPA1 gene promoter:

Genomic Locations for CPA1 Gene

Genomic Locations for CPA1 Gene
chr7:130,380,339-130,388,114
(GRCh38/hg38)
Size:
7,776 bases
Orientation:
Plus strand
chr7:130,020,180-130,027,955
(GRCh37/hg19)

Genomic View for CPA1 Gene

Genes around CPA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPA1 Gene

Proteins for CPA1 Gene

  • Protein details for CPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15085-CBPA1_HUMAN
    Recommended name:
    Carboxypeptidase A1
    Protein Accession:
    P15085
    Secondary Accessions:
    • A4D1M1
    • Q53XU0
    • Q9BS67
    • Q9UCF2

    Protein attributes for CPA1 Gene

    Size:
    419 amino acids
    Molecular mass:
    47140 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer. May form a complex with proelastase 2.

    Three dimensional structures from OCA and Proteopedia for CPA1 Gene

neXtProt entry for CPA1 Gene

Selected DME Specific Peptides for CPA1 Gene

P15085:
  • YHTLEEI
  • GASSNPCS
  • HSYSQLL
  • VLKFSTG
  • FELRDTG
  • DEAQVQKV
  • NSEVEVKS
  • PIDVRVPFP
  • GIHSREW
  • EHLQLDFW
  • GIKYSFT

Post-translational modifications for CPA1 Gene

No Post-translational modifications

Other Protein References for CPA1 Gene

Domains & Families for CPA1 Gene

Gene Families for CPA1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CPA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15085

UniProtKB/Swiss-Prot:

CBPA1_HUMAN :
  • Belongs to the peptidase M14 family.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPA1: view

Function for CPA1 Gene

Molecular function for CPA1 Gene

GENATLAS Biochemistry:
carboxypeptidase A1,pancreatic
UniProtKB/Swiss-Prot CatalyticActivity:
Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
UniProtKB/Swiss-Prot Function:
Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.

Enzyme Numbers (IUBMB) for CPA1 Gene

Phenotypes From GWAS Catalog for CPA1 Gene

Gene Ontology (GO) - Molecular Function for CPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 metallocarboxypeptidase activity IEA,IBA --
GO:0005515 protein binding IPI 19179285
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008238 exopeptidase activity IEA --
genes like me logo Genes that share ontologies with CPA1: view
genes like me logo Genes that share phenotypes with CPA1: view

Human Phenotype Ontology for CPA1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for CPA1 Gene

miRTarBase miRNAs that target CPA1

Inhibitory RNA Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CPA1 Gene

Localization for CPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPA1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPA1 gene
Compartment Confidence
extracellular 5
lysosome 1

Gene Ontology (GO) - Cellular Components for CPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 2920728
genes like me logo Genes that share ontologies with CPA1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CPA1 Gene

Pathways & Interactions for CPA1 Gene

genes like me logo Genes that share pathways with CPA1: view

Pathways by source for CPA1 Gene

Gene Ontology (GO) - Biological Process for CPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CPA1: view

No data available for SIGNOR curated interactions for CPA1 Gene

Drugs & Compounds for CPA1 Gene

(22) Drugs for CPA1 Gene - From: DrugBank, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Desirudin Approved Pharma Enzyme, substrate 9
(2R)-2-benzyl-3-nitropropanoic acid Experimental Pharma Target 0
(2R)-4,4-dihydroxy-5-nitro-2-(phenylmethyl)pentanoic acid Experimental Pharma Target 0
2-Benzyl-3-Iodopropanoic Acid Experimental Pharma Target 0
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0

(1) Additional Compounds for CPA1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CPA1 Gene

Compound Action Cas Number
CPA inhibitor Potent carboxypeptidase A (CPA) inhibitor 223532-02-3
genes like me logo Genes that share compounds with CPA1: view

Drug Products

Transcripts for CPA1 Gene

Unigene Clusters for CPA1 Gene

Carboxypeptidase A1 (pancreatic):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPA1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^
SP1: - - -
SP2: -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - -
SP10: - - - - - - - - - -
SP11:
SP12:
SP13:

ExUns: 12a · 12b ^ 13a · 13b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:

Relevant External Links for CPA1 Gene

GeneLoc Exon Structure for
CPA1
ECgene alternative splicing isoforms for
CPA1

Expression for CPA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPA1 Gene

This gene is overexpressed in Pancreas (x52.9).

Protein differential expression in normal tissues from HIPED for CPA1 Gene

This gene is overexpressed in Pancreatic juice (60.9) and Pancreas (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CPA1 Gene



Protein tissue co-expression partners for CPA1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CPA1 Gene:

CPA1

SOURCE GeneReport for Unigene cluster for CPA1 Gene:

Hs.2879

Evidence on tissue expression from TISSUES for CPA1 Gene

  • Pancreas(5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CPA1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • nervous
  • respiratory
  • urinary
Regions:
Head and neck:
  • brain
  • ear
  • eye
  • head
Thorax:
  • diaphragm
  • esophagus
  • heart
  • lung
Abdomen:
  • intestine
  • kidney
  • large intestine
  • pancreas
  • small intestine
  • stomach
General:
  • blood
  • blood vessel
  • coagulation system
  • peripheral nerve
  • peripheral nervous system
  • white blood cell
genes like me logo Genes that share expression patterns with CPA1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CPA1 Gene

Orthologs for CPA1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPA1 33 34
  • 98.81 (n)
dog
(Canis familiaris)
Mammalia CPA1 33 34
  • 89.27 (n)
cow
(Bos Taurus)
Mammalia CPA1 33 34
  • 86.48 (n)
rat
(Rattus norvegicus)
Mammalia Cpa1 33
  • 83.62 (n)
mouse
(Mus musculus)
Mammalia Cpa1 33 16 34
  • 83.54 (n)
oppossum
(Monodelphis domestica)
Mammalia CPA1 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPA1 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPA1 33 34
  • 75 (n)
lizard
(Anolis carolinensis)
Reptilia CPA1 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpa1 33
  • 65.67 (n)
Str.8435 33
African clawed frog
(Xenopus laevis)
Amphibia MGC64526 33
zebrafish
(Danio rerio)
Actinopterygii cpa5 33 34
  • 67.9 (n)
cpa1 34
  • 62 (a)
OneToMany
cpa 33
fruit fly
(Drosophila melanogaster)
Insecta CG17633 35 33 34
  • 53.03 (n)
CG18585 35 34
  • 35 (a)
CG7025 35 34
  • 35 (a)
CG14820 35 34
  • 34 (a)
CG8563 35 34
  • 34 (a)
CG3097 35 34
  • 33 (a)
CG4017 35 34
  • 33 (a)
CG3108 35 34
  • 32 (a)
CG18415 35
  • 30 (a)
CG8560 35 34
  • 30 (a)
CG12374 35 34
  • 29 (a)
CG8539 35 34
  • 29 (a)
CG15769 35
  • 28 (a)
CG2915 35 34
  • 28 (a)
CG4408 35 34
  • 28 (a)
CG8562 35 34
  • 28 (a)
CG32379 34
  • 28 (a)
ManyToMany
CG8945 35 34
  • 26 (a)
CG18417 34
  • 26 (a)
ManyToMany
CG42264 34
  • 18 (a)
ManyToMany
CG8564 34
  • 16 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta CBPA1_ANOGA 33
  • 51.9 (n)
worm
(Caenorhabditis elegans)
Secernentea Y18H1A.9 35 34
  • 36 (a)
Y47G6A.19 35 34
  • 31 (a)
Y59C2A.1 35 34
  • 31 (a)
ZC434.9 35 34
  • 31 (a)
W01A8.6 35 34
  • 30 (a)
R11A5.7 35
  • 29 (a)
T06A4.3 35 34
  • 28 (a)
F02D8.4 34
  • 27 (a)
ManyToMany
T06A4.1 34
  • 24 (a)
ManyToMany
suro-1 34
  • 19 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM14 34
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
ManyToMany
-- 34
  • 39 (a)
ManyToMany
CSA.11311 34
  • 37 (a)
ManyToMany
-- 34
  • 34 (a)
ManyToMany
CSA.4005 34
  • 21 (a)
ManyToMany
Species where no ortholog for CPA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPA1 Gene

ENSEMBL:
Gene Tree for CPA1 (if available)
TreeFam:
Gene Tree for CPA1 (if available)

Paralogs for CPA1 Gene

Paralogs for CPA1 Gene

(9) SIMAP similar genes for CPA1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CPA1: view

Variants for CPA1 Gene

Sequence variations from dbSNP and Humsavar for CPA1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs144546424 uncertain-significance, not provided 130,383,404(+) G/A coding_sequence_variant, missense_variant
rs1057524778 uncertain-significance, not specified 130,383,755(+) C/G/T coding_sequence_variant, missense_variant, synonymous_variant
rs782561684 uncertain-significance, not specified 130,385,205(+) G/A coding_sequence_variant, missense_variant
rs1126899 benign, not specified 130,381,647(+) G/A/C/T coding_sequence_variant, synonymous_variant
rs12706927 benign, not specified 130,383,698(+) C/G/T coding_sequence_variant, stop_gained, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for CPA1 Gene

Variant ID Type Subtype PubMed ID
esv23964 CNV gain 19812545
nsv515945 CNV gain+loss 19592680

Variation tolerance for CPA1 Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 28.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CPA1 Gene

Human Gene Mutation Database (HGMD)
CPA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPA1 Gene

Disorders for CPA1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CPA1 Gene - From: HGMD, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pancreatitis
borna disease
  • enzootic encephalomyelitis
pancreatitis, hereditary
  • cp
splenic infarction
  • splenic infarct
silver-russell syndrome
  • srs
- elite association - COSMIC cancer census association via MalaCards
Search CPA1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CPA1

genes like me logo Genes that share disorders with CPA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPA1 Gene

Publications for CPA1 Gene

  1. Mammalian metallopeptidase inhibition at the defense barrier of Ascaris parasite. (PMID: 19179285) Sanglas L … Arolas JL (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 22 58
  2. Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid). (PMID: 18566513) Pallarès I … Vendrell J (Acta crystallographica. Section D, Biological crystallography 2008) 3 4 22 58
  3. Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2. (PMID: 8806703) Laethem RM … Smith GK (Archives of biochemistry and biophysics 1996) 3 4 22 58
  4. Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31-qter. (PMID: 1969228) Stewart EA … Bowcock AM (American journal of human genetics 1990) 3 4 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CPA1 Gene

Sources for CPA1 Gene

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