Aliases for COX8A Gene
Aliases for COX8A Gene
External Ids for COX8A Gene
- HGNC: 2294
- Entrez Gene: 1351
- Ensembl: ENSG00000176340
- OMIM: 123870
- UniProtKB: P10176
Previous HGNC Symbols for COX8A Gene
- COX8
Previous GeneCards Identifiers for COX8A Gene
- GC11P063518
- GC11P063498
- GC11P063742
- GC11P060070
Summaries for COX8A Gene
-
The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008]
GeneCards Summary for COX8A Gene
COX8A (Cytochrome C Oxidase Subunit 8A) is a Protein Coding gene. Diseases associated with COX8A include Mitochondrial Complex Iv Deficiency and Cardiomyopathy, Familial Hypertrophic, 4. Among its related pathways are Gene Expression and Metabolism. Gene Ontology (GO) annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is ENSG00000256100.
UniProtKB/Swiss-Prot for COX8A Gene
-
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Additional gene information for COX8A Gene
- Monarch Initiative
- Search for COX8A at DataMed
- Search for COX8A at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX8A Gene
Genomics for COX8A Gene
GeneHancer (GH) Regulatory Elements for COX8A Gene
Promoters and enhancers for COX8A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around COX8A on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the COX8A gene promoter:
-
- Zic3
- AREB6
- Olf-1
- Oct-B1
- oct-B2
- POU2F1
- POU2F1a
- POU2F2
- POU2F2 (Oct-2.1)
- POU2F2B
Regulatory Element Products
Genomic Locations for COX8A Gene
Genomic Locations for COX8A Gene
- chr11:63,974,607-63,976,543
- (GRCh38/hg38)
- Size:
- 1,937 bases
- Orientation:
- Plus strand
- chr11:63,742,079-63,744,015
- (GRCh37/hg19)
- Size:
- 1,937 bases
- Orientation:
- Plus strand
Genomic View for COX8A Gene
Genes around COX8A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
- 11q13.1 by Ensembl
COX8A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for COX8A Gene
Proteins for COX8A Gene
-
Protein details for COX8A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P10176-COX8A_HUMAN
- Recommended name:
- Cytochrome c oxidase subunit 8A, mitochondrial
- Protein Accession:
- P10176
- P15955
Protein attributes for COX8A Gene
- Size:
- 69 amino acids
- Molecular mass:
- 7579 Da
- Quaternary structure:
- No Data Available
Protein Expression for COX8A Gene
Post-translational modifications for COX8A Gene
Other Protein References for COX8A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for COX8A
-
Abcam antibodies for COX8A
- Invitrogen Antibodies for COX8A (AFLGC-COX8A)
- GeneTex COX8A Antibody for COX8A
-
Biorbyt antibodies for COX8A
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for COX8A
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- antibodies-online: Search results for 3 available COX8A Proteins ranked by validation data
- Compare Top COX8A Proteins
-
Quality Products:
- Search GeneTex for Proteins for COX8A
-
Abcam proteins for COX8A
Assay Products
No data available for DME Specific Peptides for COX8A Gene
Domains & Families for COX8A Gene
Gene Families for COX8A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for COX8A Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for COX8A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P10176- Family:
-
- Belongs to the cytochrome c oxidase VIII family.
Function for COX8A Gene
Molecular function for COX8A Gene
- UniProtKB/Swiss-Prot Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004129 | cytochrome-c oxidase activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for COX8A Gene
- GenomeRNAi human phenotypes for COX8A:
-
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- no effect
- Decreased viability after sindbis virus (SIN) dsTE12Q infection
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
- Decreased mitophagy mCherry-Parkin protein expression after carbonyl cyanide m-chlorphenylhydrazone (CCCP) stimulation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for COX8A
-
CRISPR Products
-
OriGene CRISPR knockouts for COX8A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for COX8A
- genomics-online: gRNA clones - Search results for 131 available COX8A gene related products
- Overview of 131 available COX8A gene related products
- Applied Biological Materials CRISPR for COX8A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for COX8A
- GenScript: Design CRISPR guide RNA sequences for COX8A
miRNA for COX8A Gene
- miRTarBase miRNAs that target COX8A
-
- hsa-mir-26b-5p (MIRT030182)
- hsa-mir-484 (MIRT042264)
- hsa-mir-105-5p (MIRT761091)
- hsa-mir-1273h-3p (MIRT762015)
- hsa-mir-134-5p (MIRT762586)
- hsa-mir-139-3p (MIRT762605)
- hsa-mir-298 (MIRT764356)
- hsa-mir-3118 (MIRT764770)
- hsa-mir-335-5p (MIRT765649)
- hsa-mir-3678-3p (MIRT766725)
- hsa-mir-3913-3p (MIRT767601)
- hsa-mir-433-3p (MIRT768718)
- hsa-mir-4685-5p (MIRT771049)
- hsa-mir-4719 (MIRT771433)
- hsa-mir-5197-3p (MIRT773647)
- hsa-mir-6089 (MIRT775734)
- hsa-mir-6128 (MIRT775814)
- hsa-mir-640 (MIRT776153)
- hsa-mir-6825-5p (MIRT779890)
- hsa-mir-6837-5p (MIRT780075)
- hsa-mir-7113-5p (MIRT781468)
- hsa-mir-7153-3p (MIRT781536)
- hsa-mir-7853-5p (MIRT782247)
- hsa-mir-7854-3p (MIRT782254)
- hsa-mir-802 (MIRT782289)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for COX8A
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COX8A
- genomics-online: shRNA clones - Search results for 131 available COX8A gene related products
- Overview of 131 available COX8A gene related products
Clone Products
- Sino Biological Human cDNA Clone for COX8A
- Addgene plasmids for COX8A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for COX8A
- Applied Biological Materials Clones for COX8A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for COX8A
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COX8A Gene
Localization for COX8A Gene
Subcellular locations from UniProtKB/Swiss-Prot for COX8A Gene
- Mitochondrion inner membrane.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| nucleus | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005743 | mitochondrial inner membrane | TAS | -- |
| GO:0005751 | mitochondrial respiratory chain complex IV | IBA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for COX8A Gene
Pathways & Interactions for COX8A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
.40
|
|
| 2 | Metabolism |
.37
|
|
| 3 | Gene Expression |
.48
|
|
| 4 | Cardiac muscle contraction | ||
| 5 | AMPK Enzyme Complex Pathway | ||
Pathways by source for COX8A Gene
2 BioSystems pathways for COX8A Gene
8 KEGG pathways for COX8A Gene
1 Qiagen pathway for COX8A Gene
Interacting Proteins for COX8A Gene
Selected Interacting proteins:
ENSP00000321260
P10176-COX8A_HUMAN
for COX8A Gene via
STRING
IID
UniProtKB
GPS-Prot Interaction Network for COX8A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006091 | generation of precursor metabolites and energy | TAS | 2543673 |
| GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen | IBA,TAS | -- |
| GO:0022900 | electron transport chain | IEA | -- |
| GO:1902600 | proton transmembrane transport | IBA | -- |
No data available for SIGNOR curated interactions for COX8A Gene
Transcripts for COX8A Gene
mRNA/cDNA for COX8A Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (1333) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000314133 507 bps (uc001nye.3)
Unigene Clusters for COX8A Gene
CRISPR Products
-
OriGene CRISPR knockouts for COX8A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for COX8A
- genomics-online: gRNA clones - Search results for 131 available COX8A gene related products
- Overview of 131 available COX8A gene related products
- Applied Biological Materials CRISPR for COX8A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for COX8A
- GenScript: Design CRISPR guide RNA sequences for COX8A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for COX8A
- Browse OriGene Inhibitory RNA Products For COX8A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COX8A
- genomics-online: shRNA clones - Search results for 131 available COX8A gene related products
- Overview of 131 available COX8A gene related products
Clone Products
- Sino Biological Human cDNA Clone for COX8A
- Addgene plasmids for COX8A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for COX8A
- Applied Biological Materials Clones for COX8A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for COX8A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Nasal epithelium (39.8) and Hair follicle (20.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for COX8A Gene
NURSA nuclear receptor signaling pathways regulating expression of COX8A Gene:
COX8ASOURCE GeneReport for Unigene cluster for COX8A Gene:
Hs.743989Evidence on tissue expression from TISSUES for COX8A Gene
- Heart(4.7)
- Liver(4.5)
- Pancreas(4.5)
- Nervous system(4.1)
- Muscle(3.3)
- Lung(3.2)
- Eye(3.1)
- Blood(2.4)
- Kidney(2.3)
- Stomach(2.2)
- Thyroid gland(2.1)
- Adrenal gland(2)
- Bone marrow(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for COX8A
- genomics-online: primer clones - Search results for 131 available COX8A gene related products
- Overview of 131 available COX8A gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for COX8A Gene
Orthologs for COX8A Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | COX8A 34 33 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | LOC783202 33 |
|
||
| COX8A 34 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | COX8A 34 33 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| mouse (Mus musculus) |
Mammalia | Cox8a 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cox8a 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany |
- Species where no ortholog for COX8A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for COX8A Gene
- ENSEMBL:
- Gene Tree for COX8A (if available)
- TreeFam:
- Gene Tree for COX8A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for COX8A: view image
Paralogs for COX8A Gene
Paralogs for COX8A Gene
Variants for COX8A Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs869025575 | pathogenic, Hepatic failure, early-onset, and neurologic disorder due to cytochrome C oxidase deficiency | 63,976,224(+) | G/C | splice_acceptor_variant | |
| rs1001707448 | -- | 63,976,386(+) | C/A | 3_prime_UTR_variant | |
| rs1002159789 | -- | 63,976,995(+) | /C | downstream_transcript_variant | |
| rs1003160916 | -- | 63,975,289(+) | C/T | intron_variant | |
| rs1005259418 | -- | 63,972,788(+) | G/A | upstream_transcript_variant |
Residual Variation Intolerance Score:
60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.65;
13.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for COX8A Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX8A Gene
Disorders for COX8A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mitochondrial complex iv deficiency |
|
|
| cardiomyopathy, familial hypertrophic, 4 |
|
|
Search COX8A in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for COX8A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for COX8A Gene
Publications for COX8A Gene
- A gene specifying subunit VIII of human cytochrome c oxidase is localized to chromosome 11 and is expressed in both muscle and non-muscle tissues. (PMID: 2543673) Rizzuto R … Schon EA (The Journal of biological chemistry 1989) 2 3 4 58
- Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence. (PMID: 2847943) Van Kuilenburg AB … Van Beeumen JJ (FEBS letters 1988) 2 3 4 58
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- A third isoform of cytochrome c oxidase subunit VIII is present in mammals. (PMID: 12909344) Hüttemann M … Grossman LI (Gene 2003) 3 22 58
Products for COX8A Gene
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- antibodies-online: Search results for 13 available COX8A Antibodies ranked by validation data
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- Quality Products:
- GeneTex COX8A Antibody for COX8A
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- Overview of 131 available COX8A gene related products
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- Overview of 131 available COX8A gene related products
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- Overview of 131 available COX8A gene related products
- genomics-online: primer clones - Search results for 131 available COX8A gene related products
- Overview of 131 available COX8A gene related products
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- Overview of 131 available COX8A gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for COX8A
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- Biorbyt antibodies for COX8A
Sources for COX8A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
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