Aliases for COX7B2 Gene

Aliases for COX7B2 Gene

  • Cytochrome C Oxidase Subunit 7B2 2 3 5
  • Cytochrome C Oxidase Subunit 7B2, Mitochondrial 3 4
  • Cytochrome C Oxidase Polypeptide VIIb2 3 4
  • Cytochrome C Oxidase Subunit VIIb2 2 3

External Ids for COX7B2 Gene

Previous GeneCards Identifiers for COX7B2 Gene

  • GC04M046807
  • GC04M047046
  • GC04M046586
  • GC04M046652
  • GC04M046577
  • GC04M046431
  • GC04M046055

Summaries for COX7B2 Gene

GeneCards Summary for COX7B2 Gene

COX7B2 (Cytochrome C Oxidase Subunit 7B2) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. Gene Ontology (GO) annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is COX7B.

UniProtKB/Swiss-Prot Summary for COX7B2 Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Additional gene information for COX7B2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for COX7B2 Gene

Genomics for COX7B2 Gene

GeneHancer (GH) Regulatory Elements for COX7B2 Gene

Promoters and enhancers for COX7B2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J046909 Promoter 0.5 EPDnew 796.9 +0.0 2 0.1 GABPA GATA3 COX7B2 piR-41838-025
GH04J046804 Promoter 0.3 EPDnew 750.1 +104.7 104655 0.1 piR-39098-172 piR-33422-312 piR-30449-116 piR-58297-339 COX7B2
GH04J046947 Enhancer 0.4 Ensembl 32.4 -37.9 -37934 1.6 CEBPB POLR2A NFE2 JUN COX7B2 piR-48325-116 GABRA4 GABRB1
GH04J046993 Promoter 1 EPDnew Ensembl 13 -84.4 -84434 1.4 MLLT1 PRDM1 ZBTB33 POLR2A EZH2 DPF2 GABRA4 GABRB1 COX7B2 piR-48325-116
GH04J047011 Enhancer 0.7 ENCODE 7.8 -101.8 -101812 0.2 ZNF24 SP1 MLLT1 ZNF687 IKZF1 BACH1 TRIM22 IKZF2 IRF2 DPF2 COX7B2 HSALNG0034230 GABRA4 GABRB1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around COX7B2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the COX7B2 gene promoter:
  • AP-4
  • Oct-B1
  • oct-B2
  • oct-B3
  • Pbx1a
  • POU2F1
  • POU2F1a
  • POU2F2
  • SRF
  • SRF (504 AA)

Genomic Locations for COX7B2 Gene

Genomic Locations for COX7B2 Gene
174,441 bases
Minus strand
174,409 bases
Minus strand

Genomic View for COX7B2 Gene

Genes around COX7B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX7B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX7B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX7B2 Gene

Proteins for COX7B2 Gene

  • Protein details for COX7B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase subunit 7B2, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q32Q40

    Protein attributes for COX7B2 Gene

    81 amino acids
    Molecular mass:
    9077 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH35923.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI07856.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL75946.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for COX7B2 Gene

Post-translational modifications for COX7B2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for COX7B2 Gene

Domains & Families for COX7B2 Gene

Gene Families for COX7B2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for COX7B2 Gene

Suggested Antigen Peptide Sequences for COX7B2 Gene

GenScript: Design optimal peptide antigens:
  • Cytochrome c oxidase polypeptide VIIb2 (CX7B2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome c oxidase VIIb family.
  • Belongs to the cytochrome c oxidase VIIb family.
genes like me logo Genes that share domains with COX7B2: view

Function for COX7B2 Gene

Molecular function for COX7B2 Gene

UniProtKB/Swiss-Prot Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Phenotypes From GWAS Catalog for COX7B2 Gene

Gene Ontology (GO) - Molecular Function for COX7B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity IEA --
genes like me logo Genes that share ontologies with COX7B2: view
genes like me logo Genes that share phenotypes with COX7B2: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COX7B2 Gene

Localization for COX7B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX7B2 Gene

Mitochondrion inner membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COX7B2 gene
Compartment Confidence
mitochondrion 4

Gene Ontology (GO) - Cellular Components for COX7B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005746 mitochondrial respiratory chain IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with COX7B2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for COX7B2 Gene

Pathways & Interactions for COX7B2 Gene

genes like me logo Genes that share pathways with COX7B2: view

Pathways by source for COX7B2 Gene

1 Qiagen pathway for COX7B2 Gene
  • AMPK Enzyme Complex Pathway

Interacting Proteins for COX7B2 Gene

Gene Ontology (GO) - Biological Process for COX7B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022900 electron transport chain IEA --
GO:1902600 proton transmembrane transport IEA --
genes like me logo Genes that share ontologies with COX7B2: view

No data available for SIGNOR curated interactions for COX7B2 Gene

Drugs & Compounds for COX7B2 Gene

(2) Drugs for COX7B2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with COX7B2: view

Transcripts for COX7B2 Gene

mRNA/cDNA for COX7B2 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX7B2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for COX7B2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX7B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COX7B2 Gene

mRNA differential expression in normal tissues according to GTEx for COX7B2 Gene

This gene is overexpressed in Testis (x52.4).

NURSA nuclear receptor signaling pathways regulating expression of COX7B2 Gene:


SOURCE GeneReport for Unigene cluster for COX7B2 Gene:


Evidence on tissue expression from TISSUES for COX7B2 Gene

  • Skin(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with COX7B2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for COX7B2 Gene

Orthologs for COX7B2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COX7B2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COX7B2 33
  • 99 (a)
LOC100615314 32
  • 98.77 (n)
(Canis familiaris)
Mammalia COX7B2 33 32
  • 82.92 (n)
(Bos Taurus)
Mammalia COX7B 33
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 63 (a)
(Mus musculus)
Mammalia Cox7b2 33
  • 57 (a)
(Monodelphis domestica)
Mammalia -- 33
  • 35 (a)
(Gallus gallus)
Aves -- 33
  • 48 (a)
Species where no ortholog for COX7B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for COX7B2 Gene

Gene Tree for COX7B2 (if available)
Gene Tree for COX7B2 (if available)
Evolutionary constrained regions (ECRs) for COX7B2: view image

Paralogs for COX7B2 Gene

Paralogs for COX7B2 Gene

(1) SIMAP similar genes for COX7B2 Gene using alignment to 2 proteins:

  • D6R9N1_HUMAN
genes like me logo Genes that share paralogs with COX7B2: view

Variants for COX7B2 Gene

Sequence variations from dbSNP and Humsavar for COX7B2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000005790 -- 46,822,381(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000009873 -- 46,784,429(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000031904 -- 46,868,343(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000046409 -- 46,903,261(-) G/A/C genic_upstream_transcript_variant, intron_variant
rs1000056926 -- 46,829,754(-) G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for COX7B2 Gene

Variant ID Type Subtype PubMed ID
esv2410412 CNV deletion 18987734
esv2450256 CNV deletion 19546169
esv2657595 CNV deletion 23128226
esv2666146 CNV deletion 23128226
esv2672767 CNV deletion 23128226
esv2727525 CNV deletion 23290073
esv2727526 CNV deletion 23290073
esv3308957 CNV mobile element insertion 20981092
esv3393492 CNV insertion 20981092
esv3563820 CNV deletion 23714750
esv3600436 CNV loss 21293372
esv3600438 CNV loss 21293372
esv3600439 CNV loss 21293372
esv3600440 CNV loss 21293372
nsv1123781 CNV deletion 24896259
nsv1136844 CNV deletion 24896259
nsv1161081 CNV duplication 26073780
nsv291043 CNV insertion 16902084
nsv292736 CNV insertion 16902084
nsv594117 CNV loss 21841781
nsv958247 CNV deletion 24416366

Variation tolerance for COX7B2 Gene

Residual Variation Intolerance Score: 51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COX7B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX7B2 Gene

Disorders for COX7B2 Gene

Additional Disease Information for COX7B2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for COX7B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX7B2 Gene

Publications for COX7B2 Gene

  1. A rare polymorphism of the COX7B2 gene in a Cantonese family with nasopharyngeal carcinoma. (PMID: 15623157) Liang H … Zeng Y (Science in China. Series C, Life sciences 2004) 2 3 4 23 56
  2. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L … Thibodeau SN (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 43 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Genome-wide meta-analysis identifies new susceptibility loci for migraine. (PMID: 23793025) Anttila V … Palotie A (Nature genetics 2013) 3 56
  5. A genome-wide search for type 2 diabetes susceptibility genes in an extended Arab family. (PMID: 23937595) Al Safar HS … Blackwell JM (Annals of human genetics 2013) 3 56

Products for COX7B2 Gene

Sources for COX7B2 Gene