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Aliases for COX7A2L Gene

Aliases for COX7A2L Gene

  • Cytochrome C Oxidase Subunit 7A2 Like 2 3 5
  • Cytochrome C Oxidase Subunit VIIa Polypeptide 2 Like 2 3
  • Cytochrome C Oxidase Subunit VIIa-Related Protein 3 4
  • COX7a-Related Protein 3 4
  • COX7AR 3 4
  • COX7RP 3 4
  • EB1 3 4
  • Cytochrome C Oxidase Subunit 7A-Related Protein, Mitochondrial 3
  • Cytochrome C Oxidase Subunit VII-Related Protein 3
  • Estrogen Receptor Binding CpG Island 3
  • SIG81 3

External Ids for COX7A2L Gene

Previous GeneCards Identifiers for COX7A2L Gene

  • GC02M042566
  • GC02M042746
  • GC02M042552
  • GC02M042489

Summaries for COX7A2L Gene

Entrez Gene Summary for COX7A2L Gene

  • Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for COX7A2L Gene

COX7A2L (Cytochrome C Oxidase Subunit 7A2 Like) is a Protein Coding gene. Among its related pathways are Gene Expression and Metabolism. Gene Ontology (GO) annotations related to this gene include electron transfer activity and cytochrome-c oxidase activity. An important paralog of this gene is COX7A2.

UniProtKB/Swiss-Prot for COX7A2L Gene

  • Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity).

Gene Wiki entry for COX7A2L Gene

Additional gene information for COX7A2L Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX7A2L Gene

Genomics for COX7A2L Gene

GeneHancer (GH) Regulatory Elements for COX7A2L Gene

Promoters and enhancers for COX7A2L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J042358 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 669 +64.3 64310 4 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 COX7A2L GC02M042355 GC02P042392
GH02J042340 Enhancer 1.1 Ensembl ENCODE 67.1 +82.1 82082 4.1 CLOCK NEUROD1 SIN3A FOS PAF1 RXRA ZNF592 SSRP1 HNF4A KDM1A COX7A2L LOC102723824 EML4 GC02M042355 GC02P042307
GH02J042168 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 27.9 +253.9 253924 5.1 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF207 PAF1 EML4 LOC102723824 COX7A2L GC02M042233
GH02J042189 Enhancer 1.2 Ensembl ENCODE 36.2 +231.3 231343 9 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 EML4 COX7A2L LOC102723824 HAAO GC02M042233
GH02J042419 Enhancer 1 Ensembl ENCODE 41.7 +4.1 4140 2.5 FEZF1 ZNF366 SCRT2 FOS ZNF362 CEBPB ZEB2 SP1 ZFP69B PRDM6 COX7A2L EML4 LOC105374537 GC02M042414
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around COX7A2L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the COX7A2L gene promoter:
  • Bach2
  • Pax-4a
  • Ik-2
  • GATA-1
  • GATA-2
  • GATA-3
  • AML1a
  • MEF-2A
  • aMEF-2

Genomic Locations for COX7A2L Gene

Genomic Locations for COX7A2L Gene
91,543 bases
Minus strand
91,543 bases
Minus strand

Genomic View for COX7A2L Gene

Genes around COX7A2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX7A2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX7A2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX7A2L Gene

Proteins for COX7A2L Gene

  • Protein details for COX7A2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase subunit 7A-related protein, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q9P118

    Protein attributes for COX7A2L Gene

    114 amino acids
    Molecular mass:
    12615 Da
    Quaternary structure:
    • Interacts with the mitochondrial respiratory supercomplex.

neXtProt entry for COX7A2L Gene

Post-translational modifications for COX7A2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for COX7A2L Gene

Domains & Families for COX7A2L Gene

Gene Families for COX7A2L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome c oxidase VIIa family.
  • Belongs to the cytochrome c oxidase VIIa family.
genes like me logo Genes that share domains with COX7A2L: view

Function for COX7A2L Gene

Molecular function for COX7A2L Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity).
UniProtKB/Swiss-Prot Induction:
By estrogen.

Phenotypes From GWAS Catalog for COX7A2L Gene

Gene Ontology (GO) - Molecular Function for COX7A2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity IEA --
GO:0009055 electron transfer activity IEA --
genes like me logo Genes that share ontologies with COX7A2L: view
genes like me logo Genes that share phenotypes with COX7A2L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for COX7A2L

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COX7A2L Gene

Localization for COX7A2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX7A2L Gene

Mitochondrion inner membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COX7A2L gene
Compartment Confidence
mitochondrion 5
nucleus 5
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (4)
  • Nucleoli (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COX7A2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005746 mitochondrial respiratory chain IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with COX7A2L: view

Pathways & Interactions for COX7A2L Gene

genes like me logo Genes that share pathways with COX7A2L: view

Gene Ontology (GO) - Biological Process for COX7A2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen TAS --
GO:0022900 electron transport chain IEA --
GO:1902600 proton transmembrane transport IEA --
genes like me logo Genes that share ontologies with COX7A2L: view

No data available for SIGNOR curated interactions for COX7A2L Gene

Drugs & Compounds for COX7A2L Gene

(3) Drugs for COX7A2L Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with COX7A2L: view

Transcripts for COX7A2L Gene

Unigene Clusters for COX7A2L Gene

Cytochrome c oxidase subunit VIIa polypeptide 2 like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX7A2L Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - -
SP3: -
SP4: - - - - - - -
SP5: -
SP6: - -

Relevant External Links for COX7A2L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX7A2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COX7A2L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for COX7A2L Gene

This gene is overexpressed in Frontal cortex (10.7) and Peripheral blood mononuclear cells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for COX7A2L Gene

Protein tissue co-expression partners for COX7A2L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COX7A2L Gene:


SOURCE GeneReport for Unigene cluster for COX7A2L Gene:


Evidence on tissue expression from TISSUES for COX7A2L Gene

  • Lung(4.5)
  • Nervous system(4.1)
  • Kidney(2.9)
  • Liver(2.2)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with COX7A2L: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for COX7A2L Gene

Orthologs for COX7A2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for COX7A2L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COX7A2L 34 33
  • 100 (n)
(Bos Taurus)
Mammalia COX7A2L 34 33
  • 91.23 (n)
(Canis familiaris)
Mammalia COX7A2L 34 33
  • 90.06 (n)
(Mus musculus)
Mammalia Cox7a2l 16 33
  • 89.79 (n)
Gm10242 34
  • 73 (a)
(Rattus norvegicus)
Mammalia Cox7a2l 33
  • 87.41 (n)
(Monodelphis domestica)
Mammalia COX7A2L 34
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia COX7A2L 34
  • 52 (a)
(Gallus gallus)
Aves COX7A2L 34 33
  • 71.35 (n)
(Anolis carolinensis)
Reptilia COX7A2L 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cox7a2l 33
  • 71.98 (n)
Str.8113 33
(Danio rerio)
Actinopterygii cox7a3 34 33
  • 64.33 (n)
wufp89f04 33
Species where no ortholog for COX7A2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COX7A2L Gene

Gene Tree for COX7A2L (if available)
Gene Tree for COX7A2L (if available)
Evolutionary constrained regions (ECRs) for COX7A2L: view image

Paralogs for COX7A2L Gene

Paralogs for COX7A2L Gene

(3) SIMAP similar genes for COX7A2L Gene using alignment to 5 proteins:

  • Q6FGA0_HUMAN Pseudogenes for COX7A2L Gene

genes like me logo Genes that share paralogs with COX7A2L: view

Variants for COX7A2L Gene

Sequence variations from dbSNP and Humsavar for COX7A2L Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000016509 -- 42,348,261(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000147526 -- 42,343,292(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000197278 -- 42,348,352(-) G/C genic_downstream_transcript_variant, intron_variant
rs1000246684 -- 42,338,381(-) TAG/ genic_downstream_transcript_variant, intron_variant
rs1000292515 -- 42,359,796(-) A/C intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for COX7A2L Gene

Variant ID Type Subtype PubMed ID
esv3583758 CNV loss 25503493
nsv524679 CNV loss 19592680

Variation tolerance for COX7A2L Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COX7A2L Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX7A2L Gene

Disorders for COX7A2L Gene

Additional Disease Information for COX7A2L

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for COX7A2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX7A2L Gene

Publications for COX7A2L Gene

  1. Isolation of estrogen-responsive genes with a CpG island library. (PMID: 9418891) Watanabe T … Muramatsu M (Molecular and cellular biology 1998) 2 3 4 22 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 44 58
  4. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L … Thibodeau SN (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for COX7A2L Gene

Sources for COX7A2L Gene

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