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Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]
COX7A2L (Cytochrome C Oxidase Subunit 7A2 Like) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Cardiac muscle contraction. Gene Ontology (GO) annotations related to this gene include electron transfer activity and cytochrome-c oxidase activity. An important paralog of this gene is COX7A2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004129 | cytochrome-c oxidase activity | TAS,IEA | -- |
GO:0009055 | electron transfer activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005730 | nucleolus | IDA | -- |
GO:0005739 | mitochondrion | IEA,IDA | -- |
GO:0005743 | mitochondrial inner membrane | TAS | -- |
GO:0005746 | mitochondrial respiratory chain | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
.40
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2 | Parkinson disease | ||
3 | Metabolism |
.40
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4 | Gene Expression |
.48
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5 | Cardiac muscle contraction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002082 | regulation of oxidative phosphorylation | IBA | 21873635 |
GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen | TAS | -- |
GO:0022900 | electron transport chain | IEA | -- |
GO:0097250 | mitochondrial respiratory chain supercomplex assembly | IBA | 21873635 |
GO:1902600 | proton transmembrane transport | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | ||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||
SP6: | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | COX7A2L 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | COX7A2L 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | COX7A2L 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cox7a2l 30 17 |
|
||
Gm10242 31 |
|
OneToOne | |||
Rat (Rattus norvegicus) |
Mammalia | Cox7a2l 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | COX7A2L 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | COX7A2L 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | COX7A2L 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | COX7A2L 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cox7a2l 30 |
|
||
Str.8113 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | cox7a3 30 31 |
|
OneToOne | |
wufp89f04 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3583758 | CNV | loss | 25503493 |
nsv524679 | CNV | loss | 19592680 |
No disorders were found for COX7A2L Gene.