Aliases for COX7A2 Gene
- Cytochrome C Oxidase Subunit 7A2 2 3 5
- Cytochrome C Oxidase Subunit VIIa Polypeptide 2 (Liver) 2 3
- Cytochrome C Oxidase Subunit VIIa-Liver/Heart 3 4
- Cytochrome C Oxidase Subunit VIIa-L 3 4
- Cytochrome C Oxidase Subunit VIIaL 3 4
- COX7AL 3 4
- Cytochrome C Oxidase Polypeptide 7A2, Mitochondrial 3
- Cytochrome C Oxidase Polypeptide VIIa-Liver/Heart 3
External Ids for COX7A2 Gene
Previous GeneCards Identifiers for COX7A2 Gene
Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14. [provided by RefSeq, Oct 2009]
GeneCards Summary for COX7A2 Gene
COX7A2 (Cytochrome C Oxidase Subunit 7A2) is a Protein Coding gene. Diseases associated with COX7A2 include Barrett's Adenocarcinoma and Esophagus Adenocarcinoma. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and AMPK Enzyme Complex Pathway. Gene Ontology (GO) annotations related to this gene include electron transfer activity and cytochrome-c oxidase activity. An important paralog of this gene is COX7A1.
UniProtKB/Swiss-Prot for COX7A2 Gene
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.