Aliases for COX6B2 Gene

Aliases for COX6B2 Gene

  • Cytochrome C Oxidase Subunit 6B2 2 3 4 5
  • Cancer/Testis Antigen 59 2 3 4
  • CT59 2 3 4
  • Cytochrome C Oxidase Subunit VIb Polypeptide 2 (Testis) 2 3
  • COX VIb-2 3 4
  • COXVIB2 2 3
  • Cytochrome C Oxidase Subunit VIb, Testis-Specific Isoform 4
  • Cytochrome C Oxidase Subunit VIb, Testes Specific 2
  • Cytochrome C Oxidase Subunit VIb, Testes-Specific 3
  • Cytochrome C Oxidase Subunit VIb Isoform 2 4
  • FLJ32865 2
  • COX6B2 5

External Ids for COX6B2 Gene

Previous GeneCards Identifiers for COX6B2 Gene

  • GC19M060553
  • GC19M055861
  • GC19M052183

Summaries for COX6B2 Gene

GeneCards Summary for COX6B2 Gene

COX6B2 (Cytochrome C Oxidase Subunit 6B2) is a Protein Coding gene. Among its related pathways are Pathways of neurodegeneration - multiple diseases and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is COX6B1.

UniProtKB/Swiss-Prot Summary for COX6B2 Gene

  • Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for COX6B2 Gene

Genomics for COX6B2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for COX6B2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around COX6B2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for COX6B2

Top Transcription factor binding sites by QIAGEN in the COX6B2 gene promoter:
  • AML1a
  • ER-alpha
  • NF-1
  • NRSF form 1
  • NRSF form 2
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT3

Genomic Locations for COX6B2 Gene

Latest Assembly
chr19:55,349,306-55,354,719
(GRCh38/hg38)
Size:
5,414 bases
Orientation:
Minus strand

Previous Assembly
chr19:55,861,072-55,866,087
(GRCh37/hg19 by Entrez Gene)
Size:
5,016 bases
Orientation:
Minus strand

chr19:55,860,674-55,866,182
(GRCh37/hg19 by Ensembl)
Size:
5,509 bases
Orientation:
Minus strand

Genomic View for COX6B2 Gene

Genes around COX6B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX6B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX6B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX6B2 Gene

Proteins for COX6B2 Gene

  • Protein details for COX6B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6YFQ2-CX6B2_HUMAN
    Recommended name:
    Cytochrome c oxidase subunit 6B2
    Protein Accession:
    Q6YFQ2
    Secondary Accessions:
    • Q7L1R4
    • Q96DL5

    Protein attributes for COX6B2 Gene

    Size:
    88 amino acids
    Molecular mass:
    10529 Da
    Quaternary structure:
    • Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or COX4I2), COX5A, COX5B, COX6A1 (or COX6A2), COX6B1 (or COX6B2), COX6C, COX7A2 (or COX7A1), COX7B, COX7C, COX8A and NDUFA4, which are encoded in the nuclear genome (By similarity). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity).

neXtProt entry for COX6B2 Gene

Post-translational modifications for COX6B2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for COX6B2 Gene

Domains & Families for COX6B2 Gene

Gene Families for COX6B2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for COX6B2 Gene

InterPro:
Blocks:
  • Cytochrome oxidase c, subunit VIb

Suggested Antigen Peptide Sequences for COX6B2 Gene

GenScript: Design optimal peptide antigens:
  • Cytochrome c oxidase subunit VIb, testis-specific isoform (CX6B2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6YFQ2

UniProtKB/Swiss-Prot:

CX6B2_HUMAN :
  • Belongs to the cytochrome c oxidase subunit 6B family.
Family:
  • Belongs to the cytochrome c oxidase subunit 6B family.
genes like me logo Genes that share domains with COX6B2: view

Function for COX6B2 Gene

Molecular function for COX6B2 Gene

UniProtKB/Swiss-Prot Function:
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Phenotypes From GWAS Catalog for COX6B2 Gene

Gene Ontology (GO) - Molecular Function for COX6B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with COX6B2: view
genes like me logo Genes that share phenotypes with COX6B2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COX6B2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COX6B2 Gene

Localization for COX6B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX6B2 Gene

Mitochondrion inner membrane. Peripheral membrane protein. Intermembrane side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COX6B2 gene
Compartment Confidence
mitochondrion 5
plasma membrane 2
nucleus 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COX6B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA 21873635
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0030061 mitochondrial crista IBA,IDA 12874793
GO:0045277 respiratory chain complex IV IEA --
genes like me logo Genes that share ontologies with COX6B2: view

Pathways & Interactions for COX6B2 Gene

genes like me logo Genes that share pathways with COX6B2: view

Pathways by source for COX6B2 Gene

1 Qiagen pathway for COX6B2 Gene
  • AMPK Enzyme Complex Pathway

UniProtKB/Swiss-Prot Q6YFQ2-CX6B2_HUMAN

  • Pathway: Energy metabolism; oxidative phosphorylation.

Gene Ontology (GO) - Biological Process for COX6B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006119 oxidative phosphorylation IEA --
genes like me logo Genes that share ontologies with COX6B2: view

No data available for SIGNOR curated interactions for COX6B2 Gene

Drugs & Compounds for COX6B2 Gene

(2) Drugs for COX6B2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with COX6B2: view

Transcripts for COX6B2 Gene

mRNA/cDNA for COX6B2 Gene

4 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COX6B2

Alternative Splicing Database (ASD) splice patterns (SP) for COX6B2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - - - - -
SP3: -
SP4: -
SP5:

Relevant External Links for COX6B2 Gene

GeneLoc Exon Structure for
COX6B2

Expression for COX6B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for COX6B2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COX6B2 Gene

This gene is overexpressed in Testis (x37.7) and Colon - Transverse (x4.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for COX6B2

SOURCE GeneReport for Unigene cluster for COX6B2 Gene:

Hs.550544

mRNA Expression by UniProt/SwissProt for COX6B2 Gene:

Q6YFQ2-CX6B2_HUMAN
Tissue specificity: Testis specific. Weak expression in thymus and heart. Expressed in cancer cell lines.
genes like me logo Genes that share expression patterns with COX6B2: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for COX6B2 Gene

Orthologs for COX6B2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for COX6B2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia COX6B2 29 30
  • 99.62 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia COX6B2 29 30
  • 87.88 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cox6b2 29 16 30
  • 82.95 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cox6b2 29
  • 80.68 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 67 (a)
OneToMany
-- 30
  • 60 (a)
OneToMany
-- 30
  • 60 (a)
OneToMany
-- 30
  • 56 (a)
OneToMany
-- 30
  • 56 (a)
OneToMany
-- 30
  • 55 (a)
OneToMany
-- 30
  • 49 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii cox6b2 30
  • 55 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CoVIb 30
  • 39 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.5 30
  • 23 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX12 30
  • 40 (a)
OneToMany
Species where no ortholog for COX6B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for COX6B2 Gene

ENSEMBL:
Gene Tree for COX6B2 (if available)
TreeFam:
Gene Tree for COX6B2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for COX6B2: view image
Alliance of Genome Resources:
Additional Orthologs for COX6B2

Paralogs for COX6B2 Gene

Paralogs for COX6B2 Gene

(1) SIMAP similar genes for COX6B2 Gene using alignment to 1 proteins:

  • CX6B2_HUMAN
genes like me logo Genes that share paralogs with COX6B2: view

Variants for COX6B2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for COX6B2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for COX6B2 Gene

Variant ID Type Subtype PubMed ID
nsv1071551 CNV deletion 25765185
nsv470162 CNV loss 18288195
nsv516199 CNV loss 19592680
nsv953624 CNV deletion 24416366

Variation tolerance for COX6B2 Gene

Residual Variation Intolerance Score: 67.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COX6B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COX6B2
Leiden Open Variation Database (LOVD)
COX6B2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for COX6B2 Gene

Disorders for COX6B2 Gene

Additional Disease Information for COX6B2

No disorders were found for COX6B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX6B2 Gene

Publications for COX6B2 Gene

  1. Cytochrome c oxidase of mammals contains a testes-specific isoform of subunit VIb--the counterpart to testes-specific cytochrome c? (PMID: 12874793) Hüttemann M … Grossman LI (Molecular reproduction and development 2003) 2 3 4 22
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma. (PMID: 32990599) Cheng CC … Whitehurst AW (eLife 2020) 3

Products for COX6B2 Gene

Sources for COX6B2 Gene