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Aliases for COX6B2 Gene

Aliases for COX6B2 Gene

  • Cytochrome C Oxidase Subunit 6B2 2 3 5
  • Cancer/Testis Antigen 59 2 3 4
  • Cytochrome C Oxidase Subunit VIb Polypeptide 2 (Testis) 2 3
  • COX VIb-2 3 4
  • CT59 3 4
  • Cytochrome C Oxidase Subunit VIb, Testis-Specific Isoform 4
  • Cytochrome C Oxidase Subunit VIb, Testes Specific 2
  • Cytochrome C Oxidase Subunit VIb, Testes-Specific 3
  • Cytochrome C Oxidase Subunit VIb Isoform 2 4
  • COXVIB2 3

External Ids for COX6B2 Gene

Previous GeneCards Identifiers for COX6B2 Gene

  • GC19M060553
  • GC19M055861
  • GC19M052183

Summaries for COX6B2 Gene

GeneCards Summary for COX6B2 Gene

COX6B2 (Cytochrome C Oxidase Subunit 6B2) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and AMPK Enzyme Complex Pathway. Gene Ontology (GO) annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is COX6B1.

UniProtKB/Swiss-Prot for COX6B2 Gene

  • Connects the two COX monomers into the physiological dimeric form.

Additional gene information for COX6B2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX6B2 Gene

Genomics for COX6B2 Gene

GeneHancer (GH) Regulatory Elements for COX6B2 Gene

Promoters and enhancers for COX6B2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I055353 Promoter/Enhancer 1.3 Ensembl ENCODE 563.1 +0.8 799 1.2 RB1 SIN3A ZNF335 GLIS2 SP3 NCOA1 SP1 NFIC ZNF341 ZBTB26 COX6B2 PIR31434 PIR52348 ENSG00000267706
GH19I055354 Promoter 0.9 EPDnew 550.8 +0.1 77 0.1 ZBTB10 NCOA6 ZNF777 HIC1 GLIS2 NFIC PATZ1 VEZF1 PRDM10 EZH2 COX6B2 PIR31434 ENSG00000267706
GH19I055382 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.6 -32.1 -32050 8.2 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF213 RPL28 MIR6805 PIR44435 TMEM238 ZNF628 LENG8-AS1 ZNF581 U2AF2 COX6B2 BRSK1
GH19I055368 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 4.3 -15.2 -15176 2.9 PKNOX1 SIN3A GLI4 ZNF48 ZNF121 GLIS2 SP3 NFYC REST SMARCB1 IL11 TMEM190 RPL28 COX6B2 NAT14 ZNF579 FAM71E2
GH19I055405 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 1.4 -52.6 -52612 3.7 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 UBE2S U2AF2 ZNF628 LENG8 ENSG00000267523 ZNF581 LENG8-AS1 RPL28 ENSG00000235681 ENSG00000267096
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around COX6B2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the COX6B2 gene promoter:

Genomic Locations for COX6B2 Gene

Genomic Locations for COX6B2 Gene
5,509 bases
Minus strand

Genomic View for COX6B2 Gene

Genes around COX6B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX6B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX6B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX6B2 Gene

Proteins for COX6B2 Gene

  • Protein details for COX6B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase subunit 6B2
    Protein Accession:
    Secondary Accessions:
    • Q7L1R4
    • Q96DL5

    Protein attributes for COX6B2 Gene

    88 amino acids
    Molecular mass:
    10529 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX6B2 Gene

Post-translational modifications for COX6B2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COX6B2 Gene

No data available for DME Specific Peptides for COX6B2 Gene

Domains & Families for COX6B2 Gene

Gene Families for COX6B2 Gene

Protein Domains for COX6B2 Gene

Suggested Antigen Peptide Sequences for COX6B2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome c oxidase subunit 6B family.
  • Belongs to the cytochrome c oxidase subunit 6B family.
genes like me logo Genes that share domains with COX6B2: view

Function for COX6B2 Gene

Molecular function for COX6B2 Gene

UniProtKB/Swiss-Prot Function:
Connects the two COX monomers into the physiological dimeric form.

Gene Ontology (GO) - Molecular Function for COX6B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with COX6B2: view
genes like me logo Genes that share phenotypes with COX6B2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COX6B2 Gene

Localization for COX6B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX6B2 Gene

Mitochondrion intermembrane space.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COX6B2 gene
Compartment Confidence
mitochondrion 5
plasma membrane 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COX6B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005758 mitochondrial intermembrane space IEA --
GO:0030061 mitochondrial crista IDA 12874793
genes like me logo Genes that share ontologies with COX6B2: view

Pathways & Interactions for COX6B2 Gene

genes like me logo Genes that share pathways with COX6B2: view

Pathways by source for COX6B2 Gene

Gene Ontology (GO) - Biological Process for COX6B2 Gene


No data available for SIGNOR curated interactions for COX6B2 Gene

Drugs & Compounds for COX6B2 Gene

(2) Drugs for COX6B2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with COX6B2: view

Transcripts for COX6B2 Gene

Unigene Clusters for COX6B2 Gene

Cytochrome c oxidase subunit VIb polypeptide 2 (testis):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX6B2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - - - - -
SP3: -
SP4: -

Relevant External Links for COX6B2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX6B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COX6B2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COX6B2 Gene

This gene is overexpressed in Testis (x37.7) and Colon - Transverse (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of COX6B2 Gene:


SOURCE GeneReport for Unigene cluster for COX6B2 Gene:


mRNA Expression by UniProt/SwissProt for COX6B2 Gene:

Tissue specificity: Testis specific. Weak expression in thymus and heart. Expressed in cancer cell lines.
genes like me logo Genes that share expression patterns with COX6B2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for COX6B2 Gene

Orthologs for COX6B2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for COX6B2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COX6B2 33 34
  • 99.62 (n)
(Bos Taurus)
Mammalia COX6B2 33 34
  • 87.88 (n)
(Mus musculus)
Mammalia Cox6b2 33 16 34
  • 82.95 (n)
(Rattus norvegicus)
Mammalia Cox6b2 33
  • 80.68 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
-- 34
  • 60 (a)
-- 34
  • 60 (a)
-- 34
  • 56 (a)
-- 34
  • 56 (a)
-- 34
  • 55 (a)
-- 34
  • 49 (a)
(Danio rerio)
Actinopterygii cox6b2 34
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CoVIb 34
  • 39 (a)
(Caenorhabditis elegans)
Secernentea Y71H2AM.5 34
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX12 34
  • 40 (a)
Species where no ortholog for COX6B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for COX6B2 Gene

Gene Tree for COX6B2 (if available)
Gene Tree for COX6B2 (if available)

Paralogs for COX6B2 Gene

Paralogs for COX6B2 Gene

(1) SIMAP similar genes for COX6B2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with COX6B2: view

Variants for COX6B2 Gene

Sequence variations from dbSNP and Humsavar for COX6B2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000147287 -- 55,353,753(-) T/G coding_sequence_variant, missense_variant
rs1000483841 -- 55,352,568(-) C/A intron_variant
rs1001809020 -- 55,353,347(-) G/A intron_variant
rs1001923007 -- 55,353,521(-) C/T intron_variant
rs1002312740 -- 55,352,655(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for COX6B2 Gene

Variant ID Type Subtype PubMed ID
nsv1071551 CNV deletion 25765185
nsv470162 CNV loss 18288195
nsv516199 CNV loss 19592680
nsv953624 CNV deletion 24416366

Variation tolerance for COX6B2 Gene

Residual Variation Intolerance Score: 67.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COX6B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX6B2 Gene

Disorders for COX6B2 Gene

Additional Disease Information for COX6B2

No disorders were found for COX6B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX6B2 Gene

Publications for COX6B2 Gene

  1. Cytochrome c oxidase of mammals contains a testes-specific isoform of subunit VIb--the counterpart to testes-specific cytochrome c? (PMID: 12874793) Hüttemann M … Grossman LI (Molecular reproduction and development 2003) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for COX6B2 Gene

Sources for COX6B2 Gene

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