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Aliases for COX6A2 Gene

Aliases for COX6A2 Gene

  • Cytochrome C Oxidase Subunit 6A2 2 3 5
  • Cytochrome C Oxidase Subunit VIa Polypeptide 2 2 3
  • Cytochrome C Oxidase Polypeptide VIa-Heart 3 4
  • Cytochrome C Oxidase Subunit VIA-Muscle 3 4
  • COX VIa-M 3 4
  • COXVIAH 3 4
  • COX6AH 3 4
  • Cytochrome C Oxidase Subunit 6A2, Mitochondrial 3
  • COX6A 4

External Ids for COX6A2 Gene

Previous GeneCards Identifiers for COX6A2 Gene

  • GC16U990015
  • GC16M031935
  • GC16M031435
  • GC16M031475
  • GC16M031346
  • GC16M028999

Summaries for COX6A2 Gene

Entrez Gene Summary for COX6A2 Gene

  • Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (heart/muscle isoform) of subunit VIa, and polypeptide 2 is present only in striated muscles. Polypeptide 1 (liver isoform) of subunit VIa is encoded by a different gene, and is found in all non-muscle tissues. These two polypeptides share 66% amino acid sequence identity. [provided by RefSeq, Jul 2008]

GeneCards Summary for COX6A2 Gene

COX6A2 (Cytochrome C Oxidase Subunit 6A2) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Cardiac muscle contraction. Gene Ontology (GO) annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is COX6A1.

UniProtKB/Swiss-Prot for COX6A2 Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Additional gene information for COX6A2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX6A2 Gene

Genomics for COX6A2 Gene

GeneHancer (GH) Regulatory Elements for COX6A2 Gene

Promoters and enhancers for COX6A2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J031427 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 650.7 -1.0 -981 4.5 ZNF639 MEIS2 USF1 L3MBTL2 ZNF740 RNF2 NRF1 MAX MNT ZNF592 COX6A2 ENSG00000277543 ENSG00000260740 ARMC5 PYDC1 PRSS8 PYCARD PRSS36 FUS ZNF646
GH16J031404 Enhancer 1.1 Ensembl ENCODE 12.9 +23.7 23700 1.2 HDAC1 PKNOX1 NFIB KLF17 SIN3A ZBTB40 ZNF335 ZNF366 ZNF143 ZFP91 COX6A2 ARMC5 PRSS8 PRSS36 PYCARD STX4 STX1B ENSG00000260740 ENSG00000260757 ITGAD
GH16J031386 Enhancer 0.9 Ensembl ENCODE 11.5 +41.8 41794 0.9 HDAC1 MAX SIN3A CEBPG BMI1 FOSL1 ZFHX2 GATA3 ZNF766 HSF1 GC16M031380 SETD1A YBX3P1 ENSG00000260304 ITGAX PYCARD COX6A2 HSD3B7 PRSS36 STX4
GH16J031382 Enhancer 0.8 ENCODE 11.6 +45.7 45683 0.1 HDGF RB1 ZNF48 RAD21 ZNF614 ZNF143 BCLAF1 ZNF654 ZBTB25 CEBPB GC16M031380 ITGAX COX6A2 PYCARD ARMC5 GC16M031365
GH16J031399 Enhancer 0.5 Ensembl 12.9 +28.2 28227 0.8 POLR2A MAX MYC GABPA COX6A2 PRSS8 ARMC5 PRSS36 PYCARD STX4 STX1B ENSG00000260740 ENSG00000260757 ITGAD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around COX6A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the COX6A2 gene promoter:
  • Elk-1
  • GCNF-2
  • GCNF-1
  • GCNF
  • AML1a
  • Egr-2
  • RSRFC4
  • AREB6
  • GATA-1
  • RORalpha1

Genomic Locations for COX6A2 Gene

Genomic Locations for COX6A2 Gene
698 bases
Minus strand
916 bases
Minus strand

Genomic View for COX6A2 Gene

Genes around COX6A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX6A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX6A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX6A2 Gene

Proteins for COX6A2 Gene

  • Protein details for COX6A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase subunit 6A2, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • O00761
    • Q6GTW6

    Protein attributes for COX6A2 Gene

    97 amino acids
    Molecular mass:
    10815 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX6A2 Gene

Post-translational modifications for COX6A2 Gene

  • Ubiquitination at Lys70
  • Modification sites at PhosphoSitePlus

Other Protein References for COX6A2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COX6A2 Gene

Domains & Families for COX6A2 Gene

Gene Families for COX6A2 Gene

Protein Domains for COX6A2 Gene

Suggested Antigen Peptide Sequences for COX6A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome c oxidase subunit 6A family.
  • Belongs to the cytochrome c oxidase subunit 6A family.
genes like me logo Genes that share domains with COX6A2: view

Function for COX6A2 Gene

Molecular function for COX6A2 Gene

UniProtKB/Swiss-Prot Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
GENATLAS Biochemistry:
cytochrome c oxidase,subunit VIa2,component of the complex IV,terminal enzyme complex for electron transfert,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane

Gene Ontology (GO) - Molecular Function for COX6A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 contributes_to cytochrome-c oxidase activity IBA --
GO:0030234 enzyme regulator activity IBA --
genes like me logo Genes that share ontologies with COX6A2: view
genes like me logo Genes that share phenotypes with COX6A2: view

Animal Models for COX6A2 Gene

MGI Knock Outs for COX6A2:

Animal Model Products

miRNA for COX6A2 Gene

miRTarBase miRNAs that target COX6A2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for COX6A2 Gene

Localization for COX6A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX6A2 Gene

Mitochondrion inner membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COX6A2 gene
Compartment Confidence
mitochondrion 5
plasma membrane 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for COX6A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005751 mitochondrial respiratory chain complex IV IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with COX6A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for COX6A2 Gene

Pathways & Interactions for COX6A2 Gene

genes like me logo Genes that share pathways with COX6A2: view

Pathways by source for COX6A2 Gene

Gene Ontology (GO) - Biological Process for COX6A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 9284905
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen IBA --
GO:0009060 aerobic respiration IBA --
GO:0050790 regulation of catalytic activity IEA --
GO:1902600 proton transmembrane transport IEA --
genes like me logo Genes that share ontologies with COX6A2: view

No data available for SIGNOR curated interactions for COX6A2 Gene

Drugs & Compounds for COX6A2 Gene

(4) Drugs for COX6A2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cholic acid Approved Pharma Full agonist, Agonist, Target 0
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
N-Formylmethionine Experimental Pharma Target 0
genes like me logo Genes that share compounds with COX6A2: view

Transcripts for COX6A2 Gene

mRNA/cDNA for COX6A2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(246) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for COX6A2 Gene

Cytochrome c oxidase subunit VIa polypeptide 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX6A2 Gene

No ASD Table

Relevant External Links for COX6A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX6A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COX6A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COX6A2 Gene

This gene is overexpressed in Muscle - Skeletal (x22.1), Heart - Left Ventricle (x19.5), and Heart - Atrial Appendage (x9.9).

Protein differential expression in normal tissues from HIPED for COX6A2 Gene

This gene is overexpressed in Fetal heart (45.5) and Heart (23.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for COX6A2 Gene

Protein tissue co-expression partners for COX6A2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COX6A2 Gene:


SOURCE GeneReport for Unigene cluster for COX6A2 Gene:


mRNA Expression by UniProt/SwissProt for COX6A2 Gene:

Tissue specificity: Expressed specifically in heart and muscle.

Evidence on tissue expression from TISSUES for COX6A2 Gene

  • Muscle(4.8)
  • Nervous system(4.1)
  • Heart(3.3)
genes like me logo Genes that share expression patterns with COX6A2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for COX6A2 Gene

Orthologs for COX6A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for COX6A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COX6A2 34 33
  • 99.66 (n)
(Bos Taurus)
Mammalia COX6A2 34 33
  • 82.82 (n)
(Canis familiaris)
Mammalia COX6A2 34 33
  • 82.13 (n)
(Mus musculus)
Mammalia Cox6a2 16 34 33
  • 80.07 (n)
(Rattus norvegicus)
Mammalia Cox6a2 33
  • 78.01 (n)
(Monodelphis domestica)
Mammalia COX6A2 34
  • 78 (a)
(Danio rerio)
Actinopterygii cox6a2 34
  • 56 (a)
fruit fly
(Drosophila melanogaster)
Insecta levy 34
  • 39 (a)
CG30093 34
  • 39 (a)
CG14077 34
  • 11 (a)
(Caenorhabditis elegans)
Secernentea tag-174 34
  • 24 (a)
Species where no ortholog for COX6A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for COX6A2 Gene

Gene Tree for COX6A2 (if available)
Gene Tree for COX6A2 (if available)
Evolutionary constrained regions (ECRs) for COX6A2: view image

Paralogs for COX6A2 Gene

Paralogs for COX6A2 Gene

(2) SIMAP similar genes for COX6A2 Gene using alignment to 2 proteins:

  • H6SG13_HUMAN
genes like me logo Genes that share paralogs with COX6A2: view

Variants for COX6A2 Gene

Sequence variations from dbSNP and Humsavar for COX6A2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000630589 -- 31,429,958(-) A/G upstream_transcript_variant
rs1001390326 -- 31,429,241(-) C/T upstream_transcript_variant
rs1002278435 -- 31,428,922(-) G/A upstream_transcript_variant
rs1002300977 -- 31,428,388(-) C/T 5_prime_UTR_variant
rs1004741423 -- 31,430,309(-) G/A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for COX6A2 Gene

Variant ID Type Subtype PubMed ID
nsv1066280 CNV gain 25217958
nsv833194 CNV loss 17160897

Variation tolerance for COX6A2 Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COX6A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX6A2 Gene

Disorders for COX6A2 Gene

Additional Disease Information for COX6A2

No disorders were found for COX6A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX6A2 Gene

Publications for COX6A2 Gene

  1. Structure of the human gene (COX6A2) for the heart/muscle isoform of cytochrome c oxidase subunit VIa and its chromosomal location in humans, mice, and cattle. (PMID: 9177785) Bachman NJ … Lomax MI (Genomics 1997) 2 3 4 22 58
  2. Differential expression of genes specifying two isoforms of subunit VIa of human cytochrome c oxidase. (PMID: 1327966) Fabrizi GM … Schon EA (Gene 1992) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase. (PMID: 22419111) Lecoeur H … Jacotot E (Cell death & disease 2012) 3 58
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58

Products for COX6A2 Gene

Sources for COX6A2 Gene

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