Aliases for COX5B Gene
Aliases for COX5B Gene
External Ids for COX5B Gene
- HGNC: 2269
- Entrez Gene: 1329
- Ensembl: ENSG00000135940
- OMIM: 123866
- UniProtKB: P10606
Previous GeneCards Identifiers for COX5B Gene
- GC02P096143
- GC02P096715
- GC02P097867
- GC02P097883
- GC02P097721
- GC02P098262
- GC02P092031
Summaries for COX5B Gene
-
Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme. [provided by RefSeq, Jul 2008]
GeneCards Summary for COX5B Gene
COX5B (Cytochrome C Oxidase Subunit 5B) is a Protein Coding gene. Among its related pathways are Gene Expression and Metabolism. Gene Ontology (GO) annotations related to this gene include cytochrome-c oxidase activity.
UniProtKB/Swiss-Prot for COX5B Gene
-
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX5B Gene
Genomics for COX5B Gene
GeneHancer (GH) Regulatory Elements for COX5B Gene
Promoters and enhancers for COX5B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around COX5B on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the COX5B gene promoter:
-
- C/EBPalpha
- p53
- GR-alpha
- GR
- AML1a
- RFX1
- SREBP-1c
- SREBP-1b
- SREBP-1a
Regulatory Element Products
Genomic Locations for COX5B Gene
Genomic Locations for COX5B Gene
- chr2:97,646,040-97,648,383
- (GRCh38/hg38)
- Size:
- 2,344 bases
- Orientation:
- Plus strand
- chr2:98,262,503-98,264,846
- (GRCh37/hg19)
- Size:
- 2,344 bases
- Orientation:
- Plus strand
Genomic View for COX5B Gene
Genes around COX5B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q11.2 by Entrez Gene
- 2q11.2 by HGNC
- 2q11.2 by Ensembl
COX5B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for COX5B Gene
Proteins for COX5B Gene
-
Protein details for COX5B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P10606-COX5B_HUMAN
- Recommended name:
- Cytochrome c oxidase subunit 5B, mitochondrial
- Protein Accession:
- P10606
- Q53YB7
- Q96J18
- Q99610
Protein attributes for COX5B Gene
- Size:
- 129 amino acids
- Molecular mass:
- 13696 Da
- Quaternary structure:
- No Data Available
Protein Expression for COX5B Gene
Post-translational modifications for COX5B Gene
Other Protein References for COX5B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for COX5B
-
Abcam antibodies for COX5B
- Invitrogen Antibodies for COX5B (AFLGC-COX5B)
- GeneTex COX5B Antibody for COX5B
-
Santa Cruz Biotechnology (SCBT) Antibodies for COX5B
- Sino Biological Antibodies for COX5B
Protein Products
-
OriGene Purified Proteins for COX5B
- Search Origene for MassSpec and Protein Over-expression Lysates for COX5B
- Origene Custom Protein Services for COX5B
- Sino Biological Recombinant Proteins for COX5B
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for COX5B
- Search GeneTex for Proteins for COX5B
-
Abcam proteins for COX5B
Assay Products
No data available for DME Specific Peptides for COX5B Gene
Domains & Families for COX5B Gene
Gene Families for COX5B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transporters
Protein Domains for COX5B Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for COX5B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P10606- Family:
-
- Belongs to the cytochrome c oxidase subunit 5B family.
Function for COX5B Gene
Molecular function for COX5B Gene
- UniProtKB/Swiss-Prot Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- GENATLAS Biochemistry:
- cytochrome c oxidase,subunit Vb,component of the complex IV,terminal enzyme complex for electron transfert,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
Phenotypes From GWAS Catalog for COX5B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004129 | contributes_to cytochrome-c oxidase activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 21516116 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for COX5B Gene
Animal Model Products
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-
CRISPR Products
-
OriGene CRISPR knockouts for COX5B
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- Overview of 118 available COX5B gene related products
- Applied Biological Materials CRISPR for COX5B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for COX5B
- GenScript: Design CRISPR guide RNA sequences for COX5B
miRNA for COX5B Gene
- miRTarBase miRNAs that target COX5B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for COX5B
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- genomics-online: shRNA clones - Search results for 118 available COX5B gene related products
- Overview of 118 available COX5B gene related products
Clone Products
- Sino Biological Human cDNA Clone for COX5B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for COX5B
- Applied Biological Materials Clones for COX5B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COX5B Gene
Localization for COX5B Gene
Subcellular locations from UniProtKB/Swiss-Prot for COX5B Gene
- Mitochondrion inner membrane.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 5 |
| nucleus | 2 |
| cytosol | 2 |
- Mitochondria (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA,IDA | -- |
| GO:0005740 | mitochondrial envelope | IEA | -- |
| GO:0005743 | mitochondrial inner membrane | TAS | -- |
| GO:0005751 | mitochondrial respiratory chain complex IV | IBA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for COX5B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
.40
|
|
| 2 | Metabolism |
.37
|
|
| 3 | Gene Expression |
.48
|
|
| 4 | Cardiac muscle contraction | ||
| 5 | AMPK Enzyme Complex Pathway | ||
Pathways by source for COX5B Gene
1 BioSystems pathway for COX5B Gene
8 KEGG pathways for COX5B Gene
1 Qiagen pathway for COX5B Gene
Interacting Proteins for COX5B Gene
Selected Interacting proteins:
P10606-COX5B_HUMAN
ENSP00000258424
for COX5B Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for COX5B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen | IBA,TAS | -- |
| GO:0007585 | respiratory gaseous exchange | TAS | 1646156 |
| GO:0042776 | mitochondrial ATP synthesis coupled proton transport | IBA | -- |
No data available for SIGNOR curated interactions for COX5B Gene
Transcripts for COX5B Gene
mRNA/cDNA for COX5B Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (309) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000258424 712 bps (uc002sya.4)
- ENST00000464949 613 bps (uc061lzv.1)
- ENST00000491989 611 bps (uc061lzw.1)
- ENST00000494306 738 bps (uc061lzx.1)
Unigene Clusters for COX5B Gene
CRISPR Products
-
OriGene CRISPR knockouts for COX5B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for COX5B
- genomics-online: gRNA clones - Search results for 118 available COX5B gene related products
- Overview of 118 available COX5B gene related products
- Applied Biological Materials CRISPR for COX5B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for COX5B
- GenScript: Design CRISPR guide RNA sequences for COX5B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for COX5B
- Browse OriGene Inhibitory RNA Products For COX5B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COX5B
- genomics-online: shRNA clones - Search results for 118 available COX5B gene related products
- Overview of 118 available COX5B gene related products
Clone Products
- Sino Biological Human cDNA Clone for COX5B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for COX5B
- Applied Biological Materials Clones for COX5B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for COX5B Gene
mRNA differential expression in normal tissues according to GTEx for COX5B Gene
This gene is overexpressed in Heart - Left Ventricle (x4.0).
This gene is overexpressed in Nasal epithelium (44.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for COX5B Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of COX5B Gene:
COX5BSOURCE GeneReport for Unigene cluster for COX5B Gene:
Hs.1342Evidence on tissue expression from TISSUES for COX5B Gene
- Liver(4.8)
- Skin(4.3)
- Nervous system(3.3)
- Intestine(3)
- Muscle(2.7)
- Heart(2.6)
- Kidney(2.5)
Primer Products
-
OriGene qPCR primer pairs for COX5B
-
OriGene qPCR primer pairs and template standards for COX5B
- genomics-online: primer clones - Search results for 118 available COX5B gene related products
- Overview of 118 available COX5B gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for COX5B Gene
Orthologs for COX5B Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC741789 33 |
|
||
| COX5B 34 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | COX5B 34 33 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Gm11273 34 |
|
OneToMany | |
| Cox5b 34 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | COX5B 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Cox5b 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | COX5B 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | COX5B 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | COX5B 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cox5b.2 33 |
|
||
| Str.6748 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | COX5B (2 of 3) 34 |
|
OneToMany | |
| LOC100002384 33 |
|
||||
| COX5B (1 of 3) 34 |
|
OneToMany | |||
| cox5b2 34 |
|
OneToMany | |||
| hmzeh0438 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.306 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CoVb 34 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | cco-1 34 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | COX4 36 |
|
|
- Species where no ortholog for COX5B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for COX5B Gene
- ENSEMBL:
- Gene Tree for COX5B (if available)
- TreeFam:
- Gene Tree for COX5B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for COX5B: view image
Paralogs for COX5B Gene
Pseudogenes.org Pseudogenes for COX5B Gene
No data available for Paralogs for COX5B Gene
Variants for COX5B Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000155022 | -- | 97,646,859(+) | A/G | intron_variant | |
| rs1001217359 | -- | 97,645,856(+) | C/T | upstream_transcript_variant | |
| rs1001316585 | -- | 97,644,802(+) | T/A | upstream_transcript_variant | |
| rs1001681184 | -- | 97,645,209(+) | C/A | upstream_transcript_variant | |
| rs1002008531 | -- | 97,646,244(+) | C/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4025n100 | CNV | gain | 25217958 |
| dgv4026n100 | CNV | gain | 25217958 |
| esv2759077 | CNV | gain+loss | 17122850 |
| esv2763630 | CNV | gain+loss | 21179565 |
| esv3575281 | CNV | gain | 25503493 |
| esv3575285 | CNV | gain | 25503493 |
| esv3591717 | CNV | gain | 21293372 |
| nsv522486 | CNV | gain | 19592680 |
Residual Variation Intolerance Score:
69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.26;
25.23% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for COX5B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- COX5B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX5B Gene
Disorders for COX5B Gene
Additional Disease Information for COX5B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for COX5B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX5B Gene
Publications for COX5B Gene
- Phylogenetic footprinting of the human cytochrome c oxidase subunit VB promoter. (PMID: 8806766) Bachman NJ … Lomax MI (Archives of biochemistry and biophysics 1996) 3 4 22 58
- Structure of the human cytochrome c oxidase subunit Vb gene and chromosomal mapping of the coding gene and of seven pseudogenes. (PMID: 1646156) Lomax MI … Francke U (Genomics 1991) 3 4 22 58
- Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 44 58
- Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 44 58
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
Products for COX5B Gene
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- antibodies-online: Search results for 90 available COX5B Antibodies ranked by validation data
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- antibodies-online: Search results for 12 available COX5B Proteins ranked by validation data
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- Quality Products:
- GeneTex COX5B Antibody for COX5B
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- genomics-online: cdna clones - Search results for 118 available COX5B gene related products
- Overview of 118 available COX5B gene related products
- orf clones - Search results for 118 available COX5B gene related products
- Overview of 118 available COX5B gene related products
- genomics-online: gRNA clones - Search results for 118 available COX5B gene related products
- Overview of 118 available COX5B gene related products
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- Overview of 118 available COX5B gene related products
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Sources for COX5B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
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