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Aliases for COX5B Gene

Aliases for COX5B Gene

  • Cytochrome C Oxidase Subunit 5B 2 3 5
  • Cytochrome C Oxidase Subunit Vb 2 3
  • Cytochrome C Oxidase Polypeptide VB, Mitochondrial 3
  • Cytochrome C Oxidase Subunit 5B, Mitochondrial 3
  • Cytochrome C Oxidase Polypeptide Vb 4
  • COXVB 3

External Ids for COX5B Gene

Previous GeneCards Identifiers for COX5B Gene

  • GC02P096143
  • GC02P096715
  • GC02P097867
  • GC02P097883
  • GC02P097721
  • GC02P098262
  • GC02P092031

Summaries for COX5B Gene

Entrez Gene Summary for COX5B Gene

  • Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme. [provided by RefSeq, Jul 2008]

GeneCards Summary for COX5B Gene

COX5B (Cytochrome C Oxidase Subunit 5B) is a Protein Coding gene. Among its related pathways are Gene Expression and Metabolism. Gene Ontology (GO) annotations related to this gene include cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot for COX5B Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Gene Wiki entry for COX5B Gene

Additional gene information for COX5B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX5B Gene

Genomics for COX5B Gene

GeneHancer (GH) Regulatory Elements for COX5B Gene

Promoters and enhancers for COX5B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J097644 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.1 119 2.8 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 PIR38581 COX5B ACTR1B UNC50 TMEM131 ANKRD36 ANKRD36B LOC100506123 C2orf92
GH02J097588 Promoter/Enhancer 1.5 Ensembl ENCODE 12.2 -56.0 -55956 3 HDGF PKNOX1 ATF1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF48 ANKRD36B COX5B RNU4-8P C2orf92 ACTR1B ZAP70 PIR49158
GH02J097673 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 12.5 +27.7 27710 1.3 PKNOX1 ATF1 BMI1 TCF12 ZNF766 ATF7 IKZF2 RUNX3 CREM ZBTB11 PIR32897 ANKRD36B COX5B ZAP70 FAHD2B TMEM131 RNU4-8P C2orf92
GH02J097725 Enhancer 1 Ensembl ENCODE dbSUPER 11 +81.1 81072 3.6 BCOR MEIS2 ZMYM3 GABPA ZNF217 CTBP1 ATF4 JUND POLR2A ADNP ACTR1B C2orf92 COX5B RNU4-8P ANKRD36B LOC100506123 ZAP70 HMGN1P36
GH02J097712 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.9 +70.2 70185 7.6 PKNOX1 ATF1 TCF12 ZNF766 CAVIN1 ZNF592 KAT8 MEF2D MIER3 SMARCA4 ZAP70 ANKRD36B LMAN2L UNC50 ACTR1B ANKRD36 CNNM3 SEMA4C TMEM131 FAHD2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around COX5B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the COX5B gene promoter:
  • C/EBPalpha
  • p53
  • GR-alpha
  • GR
  • AML1a
  • RFX1
  • SREBP-1c
  • SREBP-1b
  • SREBP-1a

Genomic Locations for COX5B Gene

Genomic Locations for COX5B Gene
2,344 bases
Plus strand
2,344 bases
Plus strand

Genomic View for COX5B Gene

Genes around COX5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX5B Gene

Proteins for COX5B Gene

  • Protein details for COX5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase subunit 5B, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q53YB7
    • Q96J18
    • Q99610

    Protein attributes for COX5B Gene

    129 amino acids
    Molecular mass:
    13696 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX5B Gene

Post-translational modifications for COX5B Gene

  • Ubiquitination at posLast=8686, posLast=6868, and posLast=5757
  • Modification sites at PhosphoSitePlus

Other Protein References for COX5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COX5B Gene

Domains & Families for COX5B Gene

Gene Families for COX5B Gene

Suggested Antigen Peptide Sequences for COX5B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome c oxidase subunit 5B family.
  • Belongs to the cytochrome c oxidase subunit 5B family.
genes like me logo Genes that share domains with COX5B: view

Function for COX5B Gene

Molecular function for COX5B Gene

UniProtKB/Swiss-Prot Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
GENATLAS Biochemistry:
cytochrome c oxidase,subunit Vb,component of the complex IV,terminal enzyme complex for electron transfert,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane

Phenotypes From GWAS Catalog for COX5B Gene

Gene Ontology (GO) - Molecular Function for COX5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 contributes_to cytochrome-c oxidase activity IBA --
GO:0005515 protein binding IPI 21516116
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with COX5B: view
genes like me logo Genes that share phenotypes with COX5B: view

Animal Model Products

miRNA for COX5B Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COX5B Gene

Localization for COX5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX5B Gene

Mitochondrion inner membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COX5B gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for COX5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
GO:0005740 mitochondrial envelope IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005751 mitochondrial respiratory chain complex IV IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with COX5B: view

Pathways & Interactions for COX5B Gene

genes like me logo Genes that share pathways with COX5B: view

Gene Ontology (GO) - Biological Process for COX5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen IBA,TAS --
GO:0007585 respiratory gaseous exchange TAS 1646156
GO:0042776 mitochondrial ATP synthesis coupled proton transport IBA --
genes like me logo Genes that share ontologies with COX5B: view

No data available for SIGNOR curated interactions for COX5B Gene

Drugs & Compounds for COX5B Gene

(4) Drugs for COX5B Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cholic acid Approved Pharma Full agonist, Agonist, Target 0
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
N-Formylmethionine Experimental Pharma Target 0
genes like me logo Genes that share compounds with COX5B: view

Transcripts for COX5B Gene

mRNA/cDNA for COX5B Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(309) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for COX5B Gene

Cytochrome c oxidase subunit Vb:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX5B Gene

No ASD Table

Relevant External Links for COX5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX5B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COX5B Gene

mRNA differential expression in normal tissues according to GTEx for COX5B Gene

This gene is overexpressed in Heart - Left Ventricle (x4.0).

Protein differential expression in normal tissues from HIPED for COX5B Gene

This gene is overexpressed in Nasal epithelium (44.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for COX5B Gene

Protein tissue co-expression partners for COX5B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COX5B Gene:


SOURCE GeneReport for Unigene cluster for COX5B Gene:


Evidence on tissue expression from TISSUES for COX5B Gene

  • Liver(4.8)
  • Skin(4.3)
  • Nervous system(3.3)
  • Intestine(3)
  • Muscle(2.7)
  • Heart(2.6)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with COX5B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for COX5B Gene

Orthologs for COX5B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for COX5B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC741789 33
  • 98.97 (n)
COX5B 34
  • 97 (a)
(Bos Taurus)
Mammalia COX5B 34 33
  • 85.53 (n)
-- 34
  • 55 (a)
(Mus musculus)
Mammalia Gm11273 34
  • 84 (a)
Cox5b 34
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia COX5B 34
  • 83 (a)
(Rattus norvegicus)
Mammalia Cox5b 33
  • 82.69 (n)
(Monodelphis domestica)
Mammalia COX5B 34
  • 79 (a)
(Canis familiaris)
Mammalia COX5B 34 33
  • 76.96 (n)
(Anolis carolinensis)
Reptilia COX5B 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cox5b.2 33
  • 58.47 (n)
Str.6748 33
(Danio rerio)
Actinopterygii COX5B (2 of 3) 34
  • 63 (a)
LOC100002384 33
  • 62.73 (n)
COX5B (1 of 3) 34
  • 62 (a)
cox5b2 34
  • 43 (a)
hmzeh0438 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.306 33
fruit fly
(Drosophila melanogaster)
Insecta CoVb 34
  • 34 (a)
(Caenorhabditis elegans)
Secernentea cco-1 34
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX4 36
Species where no ortholog for COX5B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COX5B Gene

Gene Tree for COX5B (if available)
Gene Tree for COX5B (if available)
Evolutionary constrained regions (ECRs) for COX5B: view image

Paralogs for COX5B Gene

No data available for Paralogs for COX5B Gene

Variants for COX5B Gene

Sequence variations from dbSNP and Humsavar for COX5B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000155022 -- 97,646,859(+) A/G intron_variant
rs1001217359 -- 97,645,856(+) C/T upstream_transcript_variant
rs1001316585 -- 97,644,802(+) T/A upstream_transcript_variant
rs1001681184 -- 97,645,209(+) C/A upstream_transcript_variant
rs1002008531 -- 97,646,244(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for COX5B Gene

Variant ID Type Subtype PubMed ID
dgv4025n100 CNV gain 25217958
dgv4026n100 CNV gain 25217958
esv2759077 CNV gain+loss 17122850
esv2763630 CNV gain+loss 21179565
esv3575281 CNV gain 25503493
esv3575285 CNV gain 25503493
esv3591717 CNV gain 21293372
nsv522486 CNV gain 19592680

Variation tolerance for COX5B Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COX5B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX5B Gene

Disorders for COX5B Gene

Additional Disease Information for COX5B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for COX5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX5B Gene

Publications for COX5B Gene

  1. Phylogenetic footprinting of the human cytochrome c oxidase subunit VB promoter. (PMID: 8806766) Bachman NJ … Lomax MI (Archives of biochemistry and biophysics 1996) 3 4 22 58
  2. Structure of the human cytochrome c oxidase subunit Vb gene and chromosomal mapping of the coding gene and of seven pseudogenes. (PMID: 1646156) Lomax MI … Francke U (Genomics 1991) 3 4 22 58
  3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 44 58
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 44 58
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58

Products for COX5B Gene

Sources for COX5B Gene

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