Free for academic non-profit institutions. Other users need a Commercial license
Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme. [provided by RefSeq, Jul 2008]
COX5B (Cytochrome C Oxidase Subunit 5B) is a Protein Coding gene. Diseases associated with COX5B include Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Cardiac muscle contraction. Gene Ontology (GO) annotations related to this gene include cytochrome-c oxidase activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004129 | cytochrome-c oxidase activity | TAS,IEA | -- |
GO:0005515 | protein binding | IPI | 21516116 |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IEA,IDA | -- |
GO:0005740 | mitochondrial envelope | IEA | -- |
GO:0005743 | mitochondrial inner membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
.40
|
|
2 | Parkinson disease | ||
3 | Metabolism |
.40
|
|
4 | Gene Expression |
.48
|
|
5 | Cardiac muscle contraction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006119 | oxidative phosphorylation | IEA | -- |
GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen | IBA,TAS | -- |
GO:0007585 | respiratory gaseous exchange | TAS | 1646156 |
GO:0022900 | electron transport chain | IEA | -- |
GO:0042776 | mitochondrial ATP synthesis coupled proton transport | IBA | 21873635 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC741789 30 |
|
||
COX5B 31 |
|
OneToOne | |||
Cow (Bos Taurus) |
Mammalia | COX5B 30 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Gm11273 31 |
|
OneToMany | |
Cox5b 31 |
|
OneToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | COX5B 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cox5b 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | COX5B 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | COX5B 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | COX5B 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cox5b.2 30 |
|
||
Str.6748 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | COX5B (2 of 3) 31 |
|
OneToMany | |
LOC100002384 30 |
|
||||
COX5B (1 of 3) 31 |
|
OneToMany | |||
cox5b2 31 |
|
OneToMany | |||
hmzeh0438 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.306 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CoVb 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | cco-1 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | COX4 33 |
|
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4025n100 | CNV | gain | 25217958 |
dgv4026n100 | CNV | gain | 25217958 |
esv2759077 | CNV | gain+loss | 17122850 |
esv2763630 | CNV | gain+loss | 21179565 |
esv3575281 | CNV | gain | 25503493 |
esv3575285 | CNV | gain | 25503493 |
esv3591717 | CNV | gain | 21293372 |
nsv522486 | CNV | gain | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes |
|
|