COX5B Gene (Protein Coding)

Cytochrome C Oxidase Subunit 5B

GC02P097628
GIFtS:
41
Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitoch... See more...

Aliases for COX5B Gene

Aliases for COX5B Gene

  • Cytochrome C Oxidase Subunit 5B 2 3 5
  • Cytochrome C Oxidase Subunit 5B, Mitochondrial 3 4
  • Cytochrome C Oxidase Subunit Vb 2 3
  • Cytochrome C Oxidase Polypeptide VB, Mitochondrial 3
  • Epididymis Secretory Sperm Binding Protein 3
  • Cytochrome C Oxidase Polypeptide Vb 4
  • COXVB 3

External Ids for COX5B Gene

Previous GeneCards Identifiers for COX5B Gene

  • GC02P096143
  • GC02P096715
  • GC02P097867
  • GC02P097883
  • GC02P097721
  • GC02P098262
  • GC02P092031

Summaries for COX5B Gene

Entrez Gene Summary for COX5B Gene

  • Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme. [provided by RefSeq, Jul 2008]

GeneCards Summary for COX5B Gene

COX5B (Cytochrome C Oxidase Subunit 5B) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot Summary for COX5B Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Gene Wiki entry for COX5B Gene

Additional gene information for COX5B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for COX5B Gene

Genomics for COX5B Gene

GeneHancer (GH) Regulatory Elements for COX5B Gene

Promoters and enhancers for COX5B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around COX5B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the COX5B gene promoter:
  • AML1a
  • C/EBPalpha
  • GR
  • GR-alpha
  • p53
  • RFX1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for COX5B Gene

Genomic Locations for COX5B Gene
chr2:97,646,040-97,648,383
(GRCh38/hg38)
Size:
2,344 bases
Orientation:
Plus strand
chr2:98,262,503-98,264,846
(GRCh37/hg19)
Size:
2,344 bases
Orientation:
Plus strand

Genomic View for COX5B Gene

Genes around COX5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX5B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for COX5B Gene

Proteins for COX5B Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for COX5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10606-COX5B_HUMAN
    Recommended name:
    Cytochrome c oxidase subunit 5B, mitochondrial
    Protein Accession:
    P10606
    Secondary Accessions:
    • Q53YB7
    • Q96J18
    • Q99610

    Protein attributes for COX5B Gene

    Size:
    129 amino acids
    Molecular mass:
    13696 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for COX5B Gene

neXtProt entry for COX5B Gene

Protein Expression for COX5B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for COX5B Gene

  • Ubiquitination at Lys57, Lys68, and Lys86
  • Modification sites at PhosphoSitePlus

Other Protein References for COX5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COX5B Gene

Domains & Families for COX5B Gene

Gene Families for COX5B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for COX5B Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for COX5B Gene

GenScript: Design optimal peptide antigens:
  • Cytochrome c oxidase polypeptide Vb (COX5B_HUMAN)
  • COX5B protein (Q6FHJ9_HUMAN)
  • COX5B protein (Q6FHM4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P10606

UniProtKB/Swiss-Prot:

COX5B_HUMAN :
  • Belongs to the cytochrome c oxidase subunit 5B family.
Family:
  • Belongs to the cytochrome c oxidase subunit 5B family.
genes like me logo Genes that share domains with COX5B: view

Function for COX5B Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for COX5B Gene

UniProtKB/Swiss-Prot Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
GENATLAS Biochemistry:
cytochrome c oxidase,subunit Vb,component of the complex IV,terminal enzyme complex for electron transfert,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane

Phenotypes From GWAS Catalog for COX5B Gene

Gene Ontology (GO) - Molecular Function for COX5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 contributes_to cytochrome-c oxidase activity IBA 21873635
GO:0005515 protein binding IPI 21516116
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with COX5B: view
genes like me logo Genes that share phenotypes with COX5B: view

Animal Model Products

CRISPR Products

miRNA for COX5B Gene

miRTarBase miRNAs that target COX5B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COX5B Gene

Localization for COX5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX5B Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COX5B gene
Compartment Confidence
mitochondrion 5
nucleus 1
cytosol 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COX5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
GO:0005740 mitochondrial envelope IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with COX5B: view

Pathways & Interactions for COX5B Gene

genes like me logo Genes that share pathways with COX5B: view

SIGNOR curated interactions for COX5B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for COX5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen TAS,IBA --
GO:0007585 respiratory gaseous exchange TAS 1646156
GO:0022900 electron transport chain IEA --
GO:0042776 mitochondrial ATP synthesis coupled proton transport IBA 21873635
GO:1902600 proton transmembrane transport IEA --
genes like me logo Genes that share ontologies with COX5B: view

Drugs & Compounds for COX5B Gene

Products:

  1. Drug

(4) Drugs for COX5B Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cholic acid Approved Pharma Full agonist, Agonist, Target 0
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
N-Formylmethionine Experimental Pharma Target 0
genes like me logo Genes that share compounds with COX5B: view

Transcripts for COX5B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for COX5B Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(309) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX5B Gene

No ASD Table

Relevant External Links for COX5B Gene

GeneLoc Exon Structure for
COX5B
ECgene alternative splicing isoforms for
COX5B

Expression for COX5B Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COX5B Gene

mRNA expression in normal human tissues for COX5B Gene
mRNA expression by BioGPS for COX5B GenemRNA expression by GTEx for COX5B Gene

mRNA differential expression in normal tissues according to GTEx for COX5B Gene

This gene is overexpressed in Heart - Left Ventricle (x4.0).

Protein differential expression in normal tissues from HIPED for COX5B Gene

This gene is overexpressed in Nasal epithelium (44.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for COX5B Gene



Protein tissue co-expression partners for COX5B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COX5B Gene:

COX5B

SOURCE GeneReport for Unigene cluster for COX5B Gene:

Hs.1342

Evidence on tissue expression from TISSUES for COX5B Gene

  • Liver(4.8)
  • Skin(4.3)
  • Nervous system(3.3)
  • Intestine(3)
  • Muscle(2.7)
  • Heart(2.6)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with COX5B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for COX5B Gene

Orthologs for COX5B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for COX5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia LOC741789 32
  • 98.97 (n)
COX5B 33
  • 97 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia COX5B 33 32
  • 85.53 (n)
 OneToMany
-- 33
  • 55 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Gm11273 33
  • 84 (a)
 OneToMany
Cox5b 33
  • 84 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia COX5B 33
  • 83 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Cox5b 32
  • 82.69 (n)
oppossum
(Monodelphis domestica)
 Mammalia COX5B 33
  • 79 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia COX5B 33 32
  • 76.96 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia COX5B 33
  • 58 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia cox5b.2 32
  • 58.47 (n)
Str.6748 32
zebrafish
(Danio rerio)
 Actinopterygii COX5B (2 of 3) 33
  • 63 (a)
 OneToMany
LOC100002384 32
  • 62.73 (n)
COX5B (1 of 3) 33
  • 62 (a)
 OneToMany
cox5b2 33
  • 43 (a)
 OneToMany
hmzeh0438 32
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.306 32
fruit fly
(Drosophila melanogaster)
 Insecta CoVb 33
  • 34 (a)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea cco-1 33
  • 28 (a)
 OneToOne
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes COX4 35
Species where no ortholog for COX5B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COX5B Gene

ENSEMBL:
Gene Tree for COX5B (if available)
TreeFam:
Gene Tree for COX5B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for COX5B: view image

Paralogs for COX5B Gene

No data available for Paralogs for COX5B Gene

Variants for COX5B Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for COX5B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000155022 -- 97,646,859(+) A/G intron_variant
rs1001217359 -- 97,645,856(+) C/T upstream_transcript_variant
rs1001316585 -- 97,644,802(+) T/A upstream_transcript_variant
rs1001681184 -- 97,645,209(+) C/A upstream_transcript_variant
rs1002008531 -- 97,646,244(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for COX5B Gene

Variant ID Type Subtype PubMed ID
dgv4025n100 CNV gain 25217958
dgv4026n100 CNV gain 25217958
esv2759077 CNV gain+loss 17122850
esv2763630 CNV gain+loss 21179565
esv3575281 CNV gain 25503493
esv3575285 CNV gain 25503493
esv3591717 CNV gain 21293372
nsv522486 CNV gain 19592680

Variation tolerance for COX5B Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COX5B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COX5B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX5B Gene

Disorders for COX5B Gene

Additional Disease Information for COX5B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for COX5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX5B Gene

Publications for COX5B Gene

  1. Phylogenetic footprinting of the human cytochrome c oxidase subunit VB promoter. (PMID: 8806766) Bachman NJ … Lomax MI (Archives of biochemistry and biophysics 1996) 3 4 23 56
  2. Structure of the human cytochrome c oxidase subunit Vb gene and chromosomal mapping of the coding gene and of seven pseudogenes. (PMID: 1646156) Lomax MI … Francke U (Genomics 1991) 3 4 23 56
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 43 56
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 43 56
  5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 43 56

ExternalLinks

View latest publications for COX5B gene in Mastermind

Products for COX5B Gene

Sources for COX5B Gene