Free for academic non-profit institutions. Other users need a Commercial license

Aliases for COX19 Gene

Aliases for COX19 Gene

  • COX19, Cytochrome C Oxidase Assembly Factor 2 3 5
  • HCOX19 3 4
  • COX19 Cytochrome C Oxidase Assembly Homolog (S. Cerevisiae) 2
  • Cytochrome C Oxidase Assembly Homolog 19 (S. Cerevisiae) 2
  • COX19 Cytochrome C Oxidase Assembly Homolog 3
  • Cytochrome C Oxidase Assembly Protein COX19 3
  • Cytochrome C Oxidase Assembly Homolog 19 3

External Ids for COX19 Gene

Previous GeneCards Identifiers for COX19 Gene

  • GC07M000972
  • GC07M000939

Summaries for COX19 Gene

Entrez Gene Summary for COX19 Gene

  • COX19 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox19 protein may play a role in metal transport to the mitochondrial intermembrane space and assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005 [PubMed 16212937]).[supplied by OMIM, Mar 2008]

GeneCards Summary for COX19 Gene

COX19 (COX19, Cytochrome C Oxidase Assembly Factor) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Mitochondrial protein import.

UniProtKB/Swiss-Prot for COX19 Gene

  • May be required for the assembly of mitochondrial cytochrome c oxidase.

Additional gene information for COX19 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX19 Gene

Genomics for COX19 Gene

GeneHancer (GH) Regulatory Elements for COX19 Gene

Promoters and enhancers for COX19 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I000971 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 559.8 -0.6 -645 8.8 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 COX19 CYP2W1 LOC105375120 GPR146 DNAAF5 MIR339 ADAP1 ENSG00000225146 C7orf50 SUN1
GH07I001022 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -50.9 -50873 7.4 HDGF CLOCK FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YBX1 PIR42102 LOC105375120 LOC101927021 CYP2W1 ZFAND2A COX19 DNAAF5 SUN1 GPER1 FAM20C
GH07I001051 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 12.5 -78.8 -78798 4.8 HDAC1 ZNF335 ZNF121 GLIS2 GATA2 ATF7 CREM EGR2 ZBTB2 CEBPB GPR146 LOC105375120 LOC101927021 ZFAND2A COX19 GPER1 FAM20C ENSG00000257607 GC07P001058 PIR31890
GH07I000981 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 12 -9.7 -9700 7.1 HDGF MLX ARID4B DMAP1 ZBTB7B ZNF48 TCF12 ZNF121 GLIS2 FOS CYP2W1 LOC105375120 GPR146 MIR339 ADAP1 COX19 ENSG00000225146 C7orf50 LOC101927021 GC07M001007
GH07I001043 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 11.3 -69.1 -69137 3 FOXA2 ARNT ARID4B SIN3A YY1 ZNF766 E2F8 ZNF143 SP3 ZHX2 GPR146 LOC105375120 ZFAND2A MIR339 CYP2W1 COX19 LOC101927021 C7orf50 GPER1 PIR31890
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around COX19 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the COX19 gene promoter:

Genomic Locations for COX19 Gene

Genomic Locations for COX19 Gene
76,822 bases
Minus strand

Genomic View for COX19 Gene

Genes around COX19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX19 Gene

Proteins for COX19 Gene

  • Protein details for COX19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase assembly protein COX19
    Protein Accession:
    Secondary Accessions:
    • A4FTX0

    Protein attributes for COX19 Gene

    90 amino acids
    Molecular mass:
    10394 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX19 Gene

Post-translational modifications for COX19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COX19 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COX19 Gene

Domains & Families for COX19 Gene

Gene Families for COX19 Gene

Protein Domains for COX19 Gene


Suggested Antigen Peptide Sequences for COX19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the COX19 family.
  • Belongs to the COX19 family.
genes like me logo Genes that share domains with COX19: view

Function for COX19 Gene

Molecular function for COX19 Gene

UniProtKB/Swiss-Prot Function:
May be required for the assembly of mitochondrial cytochrome c oxidase.

Phenotypes From GWAS Catalog for COX19 Gene

Phenotypes for COX19 Gene

MGI mutant phenotypes for COX19:
inferred from 1 alleles
GenomeRNAi human phenotypes for COX19:
genes like me logo Genes that share phenotypes with COX19: view

Animal Models for COX19 Gene

MGI Knock Outs for COX19:

Animal Model Products

miRNA for COX19 Gene

miRTarBase miRNAs that target COX19

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for COX19 Gene

Localization for COX19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX19 Gene

Cytoplasm, cytosol.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COX19 gene
Compartment Confidence
mitochondrion 4
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for COX19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005758 mitochondrial intermembrane space IBA --
GO:0005829 cytosol IEA,IDA --
genes like me logo Genes that share ontologies with COX19: view

Pathways & Interactions for COX19 Gene

genes like me logo Genes that share pathways with COX19: view

Pathways by source for COX19 Gene

2 Reactome pathways for COX19 Gene

Interacting Proteins for COX19 Gene

Gene Ontology (GO) - Biological Process for COX19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009060 aerobic respiration IBA --
GO:0033617 mitochondrial respiratory chain complex IV assembly IBA --
genes like me logo Genes that share ontologies with COX19: view

No data available for SIGNOR curated interactions for COX19 Gene

Drugs & Compounds for COX19 Gene

No Compound Related Data Available

Transcripts for COX19 Gene

mRNA/cDNA for COX19 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for COX19 Gene

Cytochrome c oxidase assembly homolog 19 (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX19 Gene

No ASD Table

Relevant External Links for COX19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COX19 Gene

Protein differential expression in normal tissues from HIPED for COX19 Gene

This gene is overexpressed in Heart (43.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COX19 Gene

NURSA nuclear receptor signaling pathways regulating expression of COX19 Gene:


SOURCE GeneReport for Unigene cluster for COX19 Gene:


mRNA Expression by UniProt/SwissProt for COX19 Gene:

Tissue specificity: Ubiquitously expressed. Highly expressed in skeletal muscle.

Evidence on tissue expression from TISSUES for COX19 Gene

  • Lung(4.1)
  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with COX19: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for COX19 Gene

Orthologs for COX19 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for COX19 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COX19 33 34
  • 99.26 (n)
(Bos Taurus)
Mammalia COX19 33 34
  • 86.59 (n)
(Canis familiaris)
Mammalia COX19 34
  • 84 (a)
(Mus musculus)
Mammalia Cox19 33 16 34
  • 81.27 (n)
(Rattus norvegicus)
Mammalia Cox19 33
  • 80.9 (n)
(Ornithorhynchus anatinus)
Mammalia COX19 34
  • 77 (a)
(Gallus gallus)
Aves COX19 33 34
  • 66.67 (n)
(Anolis carolinensis)
Reptilia COX19 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cox19 33
  • 71.49 (n)
Str.15707 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.34176 33
(Danio rerio)
Actinopterygii COX19 34
  • 70 (a)
zgc:162175 33
  • 68.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG42496 34
  • 36 (a)
(Caenorhabditis elegans)
Secernentea F45H11.5 34
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX19 34 36
  • 34 (a)
Species where no ortholog for COX19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COX19 Gene

Gene Tree for COX19 (if available)
Gene Tree for COX19 (if available)

Paralogs for COX19 Gene Pseudogenes for COX19 Gene

genes like me logo Genes that share paralogs with COX19: view

No data available for Paralogs for COX19 Gene

Variants for COX19 Gene

Sequence variations from dbSNP and Humsavar for COX19 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000154253 -- 975,123(-) C/T intron_variant
rs1000377491 -- 970,147(-) T/C intron_variant
rs1000553979 -- 965,040(-) G/C 3_prime_UTR_variant
rs1000766496 -- 967,043(-) T/G 3_prime_UTR_variant
rs1000979995 -- 974,184(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for COX19 Gene

Variant ID Type Subtype PubMed ID
dgv11111n54 CNV loss 21841781
esv3571557 CNV loss 25503493
esv3571558 CNV loss 25503493
nsv1024118 CNV gain 25217958
nsv1028282 CNV gain 25217958
nsv1161477 CNV deletion 26073780
nsv464244 CNV loss 19166990
nsv464245 CNV gain 19166990
nsv509182 CNV insertion 20534489
nsv605699 CNV loss 21841781
nsv605700 CNV gain 21841781
nsv605705 CNV loss 21841781
nsv823958 CNV loss 20364138
nsv950784 CNV deletion 24416366

Variation tolerance for COX19 Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COX19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX19 Gene

Disorders for COX19 Gene

Additional Disease Information for COX19

No disorders were found for COX19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX19 Gene

Publications for COX19 Gene

  1. hCOX18 and hCOX19: two human genes involved in cytochrome c oxidase assembly. (PMID: 16212937) Sacconi S … Salviati L (Biochemical and biophysical research communications 2005) 2 3 4 58
  2. COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A-mediated cellular copper efflux. (PMID: 23345593) Leary SC … Shoubridge EA (Molecular biology of the cell 2013) 2 3 58
  3. Studies of COX16, COX19, and PET191 in human cytochrome-c oxidase deficiency. (PMID: 15596615) Tay SK … Dimauro S (Archives of neurology 2004) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 58

Products for COX19 Gene

Sources for COX19 Gene

Loading form....