Aliases for COX16 Gene
External Ids for COX16 Gene
Previous HGNC Symbols for COX16 Gene
Previous GeneCards Identifiers for COX16 Gene
GeneCards Summary for COX16 Gene
COX16 (COX16, Cytochrome C Oxidase Assembly Homolog) is a Protein Coding gene. Diseases associated with COX16 include Atrial Heart Septal Defect. Among its related pathways are Gene Expression and Metabolism.
UniProtKB/Swiss-Prot for COX16 Gene
Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:29355485, PubMed:29381136). Promotes the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2) (PubMed:29355485, PubMed:29381136). Interacts specifically with newly synthesized MT-CO2/COX and its copper center-forming metallochaperones SCO1, SCO2 and COA6 (PubMed:29381136). Probably facilitates MT-CO2/COX2 association with the MITRAC assembly intermediate containing MT-CO1/COX1, thereby participating in merging the MT-CO1/COX1 and MT-CO2/COX2 assembly lines (PubMed:29381136).