Aliases for COTL1 Gene
External Ids for COTL1 Gene
Previous GeneCards Identifiers for COTL1 Gene
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]
GeneCards Summary for COTL1 Gene
COTL1 (Coactosin Like F-Actin Binding Protein 1) is a Protein Coding gene. Diseases associated with COTL1 include Lung Cancer and Clivus Chordoma. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include enzyme binding and actin binding. An important paralog of this gene is DBNL.
UniProtKB/Swiss-Prot Summary for COTL1 Gene
Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.