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This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromos... See more...
Aliases for COTL1 Gene
Aliases for COTL1 Gene
External Ids for COTL1 Gene
- HGNC: 18304
- Entrez Gene: 23406
- Ensembl: ENSG00000103187
- OMIM: 606748
- UniProtKB: Q14019
Previous GeneCards Identifiers for COTL1 Gene
- GC16M075449
- GC16M085565
- GC16M084338
- GC16M084378
- GC16M083156
- GC16M084599
- GC16M070353
Summaries for COTL1 Gene
-
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]
GeneCards Summary for COTL1 Gene
COTL1 (Coactosin Like F-Actin Binding Protein 1) is a Protein Coding gene. Diseases associated with COTL1 include Lung Cancer and Clivus Chordoma. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include enzyme binding and actin binding. An important paralog of this gene is DBNL.
UniProtKB/Swiss-Prot Summary for COTL1 Gene
-
Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.
Additional gene information for COTL1 Gene
- HGNC(18304)
- Entrez Gene(23406)
- Ensembl(ENSG00000103187)
- OMIM(606748)
- UniProtKB(Q14019)
- Open Targets Platform(ENSG00000103187)
- Monarch Initiative
- Search for COTL1 at DataMed
- Search for COTL1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for COTL1 Gene
Genomics for COTL1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for COTL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around COTL1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for COTL1
- Top Transcription factor binding sites by QIAGEN in the COTL1 gene promoter:
-
- AML1a
- E47
- MyoD
- Olf-1
- Pax-2
- Pax-2a
- POU2F1
- POU2F1a
- Tal-1beta
- ZIC2
Genomic Locations for COTL1 Gene
Genomic Locations for COTL1 Gene
- chr16:84,565,596-84,618,078
- (GRCh38/hg38)
- Size:
- 52,483 bases
- Orientation:
- Minus strand
- chr16:84,599,200-84,651,683
- (GRCh37/hg19)
- Size:
- 52,484 bases
- Orientation:
- Minus strand
Genomic View for COTL1 Gene
Genes around COTL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q24.1 by HGNC
- 16q24.1 by Entrez Gene
- 16q24.1 by Ensembl
COTL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for COTL1 Gene
Proteins for COTL1 Gene
-
Protein details for COTL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14019-COTL1_HUMAN
- Recommended name:
- Coactosin-like protein
- Protein Accession:
- Q14019
- B2RDU3
- D3DUL9
- Q86XM5
Protein attributes for COTL1 Gene
- Size:
- 142 amino acids
- Molecular mass:
- 15945 Da
- Quaternary structure:
-
- Interacts with 5-lipoxygenase (ALOX5/5LO) in a calcium-independent manner. Binds to F-actin with a stoichiometry of 1:2.
Protein Expression for COTL1 Gene
Post-translational modifications for COTL1 Gene
Other Protein References for COTL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for COTL1
- Novus Biologicals Antibodies for COTL1
-
Abcam antibodies for COTL1
- Invitrogen Antibodies for COTL1 (AFLGC-Cotl1)
-
Boster Bio Antibodies for COTL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for COTL1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for COTL1
- Origene Custom Protein Services for COTL1
- ProSpec Recombinant Proteins for COTL1
-
Abcam proteins for COTL1
Assay Products
No data available for DME Specific Peptides for COTL1 Gene
Domains & Families for COTL1 Gene
Gene Families for COTL1 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for COTL1 Gene
- InterPro:
- Blocks:
-
- Actin-binding, cofilin/tropomyosin type
- ProtoNet:
Suggested Antigen Peptide Sequences for COTL1 Gene
- GenScript: Design optimal peptide antigens:
-
- Coactosin-like protein (COTL1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q14019UniProtKB/Swiss-Prot:
COTL1_HUMAN :- Belongs to the actin-binding proteins ADF family. Coactosin subfamily.
- Family:
-
- Belongs to the actin-binding proteins ADF family. Coactosin subfamily.
Function for COTL1 Gene
Molecular function for COTL1 Gene
- UniProtKB/Swiss-Prot Function:
- Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.
- GENATLAS Biochemistry:
- rat peroxisomal carnitine octanoyl transferase-like 1
Phenotypes From GWAS Catalog for COTL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | IEA,IDA | 11583571 |
| GO:0005515 | protein binding | IPI | 11297527 |
| GO:0019899 | enzyme binding | IPI | 11297527 |
| GO:0051015 | actin filament binding | IBA | 21873635 |
Phenotypes for COTL1 Gene
- MGI mutant phenotypes for COTL1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for COTL1:
-
- Decreased hepcidin::fluc mRNA expression
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Decreased shRNA abundance (Z-score < -2)
- Increased gamma-H2AX phosphorylation
- Increased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased NF-kappaB reporter expression
- FOXO1 nuclear localization
- Increased G2M DNA content
- Increased shRNA abundance (Z-score > 2)
- Increased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Increased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- G2 arrest
- Two nuclei (binuclear), dynamic nuclei (hole, folded or small irregular), decreased viability (cell death)
Animal Models for COTL1 Gene
- MGI Knock Outs for COTL1:
-
- Cotl1 Cotl1<tm1b(EUCOMM)Hmgu>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for COTL1 - Select products 50% OFF >
- * COTL1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for COTL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for COTL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for COTL1
miRNA for COTL1 Gene
- miRTarBase miRNAs that target COTL1
-
- mmu-miR-30e-5p (MIRT013383)
- hsa-miR-193b-3p (MIRT016551)
- hsa-miR-1-3p (MIRT024011)
- hsa-miR-744-5p (MIRT037467)
- hsa-miR-331-3p (MIRT043571)
- hsa-miR-320a (MIRT044527)
- hsa-miR-506-3p (MIRT734364)
- hsa-miR-1205 (MIRT761243)
- hsa-miR-1273h-3p (MIRT762014)
- hsa-miR-127-3p (MIRT762106)
- hsa-miR-1286 (MIRT762238)
- hsa-miR-147a (MIRT762743)
- hsa-miR-3166 (MIRT765200)
- hsa-miR-3169 (MIRT765213)
- hsa-miR-3612 (MIRT765896)
- hsa-miR-3911 (MIRT767595)
- hsa-miR-3936 (MIRT767844)
- hsa-miR-4418 (MIRT768732)
- hsa-miR-4459 (MIRT769253)
- hsa-miR-449b-3p (MIRT769782)
- hsa-miR-4695-5p (MIRT771178)
- hsa-miR-4722-5p (MIRT771541)
- hsa-miR-4740-5p (MIRT771877)
- hsa-miR-4755-3p (MIRT771944)
- hsa-miR-4771 (MIRT772194)
- hsa-miR-4786-3p (MIRT772274)
- hsa-miR-5006-5p (MIRT772942)
- hsa-miR-501-5p (MIRT773016)
- hsa-miR-509-3-5p (MIRT773260)
- hsa-miR-509-5p (MIRT773298)
- hsa-miR-548ad-3p (MIRT774059)
- hsa-miR-6124 (MIRT775785)
- hsa-miR-644a (MIRT776173)
- hsa-miR-650 (MIRT776654)
- hsa-miR-6890-3p (MIRT781135)
- hsa-miR-7843-3p (MIRT782097)
- hsa-miR-873-5p (MIRT782485)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for COTL1
- Browse OriGene Inhibitory RNA Products For COTL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COTL1
Clone Products
- Applied Biological Materials (abm): Clones for COTL1 - Select products 50% OFF >
- * COTL1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for COTL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for COTL1
Cell Line Products
-
Horizon Cell Lines for COTL1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for COTL1 Gene
Localization for COTL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for COTL1 Gene
- Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 4 |
| extracellular | 4 |
| cytoskeleton | 4 |
| nucleus | 4 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
Pathways & Interactions for COTL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
Pathways by source for COTL1 Gene
3 Reactome pathways for COTL1 Gene
Interacting Proteins for COTL1 Gene
Selected Interacting proteins:
Q14019-COTL1_HUMAN
ENSP00000262428
for COTL1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for COTL1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008150 | biological_process | ND | -- |
| GO:0030833 | regulation of actin filament polymerization | IBA | 21873635 |
| GO:0043312 | neutrophil degranulation | TAS | -- |
| GO:0050832 | defense response to fungus | IEA | -- |
No data available for SIGNOR curated interactions for COTL1 Gene
Drugs & Compounds for COTL1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Calcium | Nutra | 6556 |
Transcripts for COTL1 Gene
mRNA/cDNA for COTL1 Gene
- 1 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000262428 1842 nts (view in UCSC)
- ENST00000567278 5330 nts (view in UCSC)
- ENST00000564057 1677 nts (view in UCSC)
- ENST00000561707 781 nts (view in UCSC)
- ENST00000564662 713 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for COTL1 - Select products 50% OFF >
- * COTL1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for COTL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for COTL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for COTL1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for COTL1
- Browse OriGene Inhibitory RNA Products For COTL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COTL1
Clone Products
- Applied Biological Materials (abm): Clones for COTL1 - Select products 50% OFF >
- * COTL1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for COTL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for COTL1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4 | ^ | 5a | · | 5b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||
| SP3: | - | - | |||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||
| SP5: |
Relevant External Links for COTL1 Gene
- GeneLoc Exon Structure for
- COTL1
Expression for COTL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Medulla Oblongata
- Cerebral Cortex
-
Blood (Cardiovascular System)
- T Helper Cells Thymus
- T-Cytotoxic Cells Thymus
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
- T-Cytotoxic Cells Thymus
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Gut Tube (Gastrointestinal Tract)
- Eye (Sensory Organs)
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Tonsil (Hematopoietic System)
-
Kidney (Urinary System)
-
Stomach (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for COTL1 Gene
This gene is overexpressed in Whole Blood (x21.6).
This gene is overexpressed in Amniocyte (8.1) and Peripheral blood mononuclear cells (7.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for COTL1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for COTL1
SOURCE GeneReport for Unigene cluster for COTL1 Gene:
Hs.289092mRNA Expression by UniProt/SwissProt for COTL1 Gene:
Q14019-COTL1_HUMAN
Tissue specificity:
Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas.
Evidence on tissue expression from TISSUES for COTL1 Gene
- Nervous system(4.9)
- Lung(4.6)
- Blood(4.6)
- Kidney(4.5)
- Skin(3.4)
- Eye(3.4)
- Pancreas(3.2)
- Lymph node(2.8)
- Spleen(2.7)
- Liver(2.7)
- Intestine(2.5)
- Bone marrow(2.5)
Primer Products
-
OriGene qPCR primer pairs for COTL1
-
OriGene qPCR primer pairs and template standards for COTL1
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for COTL1 Gene
Orthologs for COTL1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | COTL1 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | COTL1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | COTL1 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | COTL1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | COTL1 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cotl1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Cotl1 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | COTL1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | COTL1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cotl1 30 |
|
||
| Str.2192 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | cotl1-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | cotl1 30 31 |
|
OneToOne | |
| wufb08h08 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG6891 30 31 |
|
OneToMany | |
| CG6900 31 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000889 30 |
|
- Species where no ortholog for COTL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for COTL1 Gene
- ENSEMBL:
- Gene Tree for COTL1 (if available)
- TreeFam:
- Gene Tree for COTL1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for COTL1: view image
Paralogs for COTL1 Gene
Variants for COTL1 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3058n100 | CNV | loss | 25217958 |
| dgv5262n54 | CNV | loss | 21841781 |
| dgv550e214 | CNV | loss | 21293372 |
| nsv1055503 | CNV | gain | 25217958 |
| nsv1064308 | CNV | loss | 25217958 |
| nsv1071341 | CNV | deletion | 25765185 |
| nsv1136221 | CNV | deletion | 24896259 |
| nsv1138474 | CNV | deletion | 24896259 |
| nsv1144775 | CNV | deletion | 24896259 |
| nsv151 | CNV | deletion | 15895083 |
| nsv1911 | CNV | deletion | 18451855 |
| nsv457605 | CNV | loss | 19166990 |
| nsv471109 | CNV | loss | 18288195 |
| nsv483044 | CNV | gain | 15286789 |
| nsv573425 | CNV | loss | 21841781 |
| nsv573464 | CNV | loss | 21841781 |
| nsv833311 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
27.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.54;
11.76% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for COTL1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- COTL1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for COTL1 Gene
Disorders for COTL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lung cancer |
|
|
| clivus chordoma |
|
|
| bleeding disorder, platelet-type, 8 |
|
|
| churg-strauss syndrome |
|
|
Search COTL1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for COTL1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for COTL1 Gene
Publications for COTL1 Gene
- Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102. (PMID: 19807693) Esser J … Rådmark O (The Biochemical journal 2009) 3 4 23
- Binding model of human coactosin-like protein with filament actin revealed by mutagenesis. (PMID: 17070122) Dai H … Shi Y (Biochimica et biophysica acta 2006) 3 4 23
- Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production. (PMID: 16924104) Rakonjac M … Rådmark O (Proceedings of the National Academy of Sciences of the United States of America 2006) 2 3 23
- Crystal structure of human coactosin-like protein at 1.9 A resolution. (PMID: 15459340) Li X … Rao Z (Protein science : a publication of the Protein Society 2004) 3 4 23
- 5-Lipoxygenase interacts with coactosin-like protein. (PMID: 11297527) Provost P … Radmark O (The Journal of biological chemistry 2001) 3 4 23
ExternalLinks
Products for COTL1 Gene
- Custom Antibody ServicesOriGene Antibodies for COTL1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for COTL1
- Origene Custom Protein Services for COTL1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for COTL1
- Browse OriGene Inhibitory RNA Products For COTL1
- OriGene qPCR primer pairs for COTL1
- OriGene qPCR primer pairs and template standards for COTL1
- OriGene CRISPR knockouts for COTL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For COTL1
- Sino Biological Human cDNA Clone for COTL1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for COTL1
- Novus Biologicals proteins and lysates for COTL1
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- Abcam antibodies for COTL1
- Abcam proteins for COTL1
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- VectorBuilder Custom and pre-made DNA vectors for COTL1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for COTL1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for COTL1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for COTL1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for COTL1
- antibodies-online: Show 24 available Coactosin-Like Protein Antibodies ranked by validation data
- antibodies-online: Search results for available Coactosin-Like Protein related products ranked by validation data
- antibodies-online: Search results for available Coactosin-Like Protein related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for COTL1
- Search Santa Cruz Biotechnology (SCBT) for COTL1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for COTL1
- Horizon Cell Lines for COTL1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for COTL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for COTL1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for COTL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COTL1
- Boster Bio Antibodies for COTL1
- Browse Boster Bio ELISA Kits
Sources for COTL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB