Aliases for CORT Gene
External Ids for CORT Gene
Previous GeneCards Identifiers for CORT Gene
This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010]
GeneCards Summary for CORT Gene
CORT (Cortistatin) is a Protein Coding gene. Diseases associated with CORT include Pituitary Adenoma, Prolactin-Secreting and Neuroblastoma. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include hormone activity and neuropeptide hormone activity. An important paralog of this gene is CENPS-CORT.
UniProtKB/Swiss-Prot Summary for CORT Gene
Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.