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Aliases for CORT Gene

Aliases for CORT Gene

  • Cortistatin 2 3 3 5
  • Prepro-Cortistatin 2 3
  • Preprocortistatin 3
  • Cortistatin-14 3
  • Cortistatin-17 3
  • Cortistatin-29 3
  • CST-14 3
  • CST-17 3
  • CST-29 3

External Ids for CORT Gene

Previous GeneCards Identifiers for CORT Gene

  • GC01P010471
  • GC01P010333
  • GC01P010099
  • GC01P010199
  • GC01P010424
  • GC01P010509
  • GC01P009663

Summaries for CORT Gene

Entrez Gene Summary for CORT Gene

  • This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010]

GeneCards Summary for CORT Gene

CORT (Cortistatin) is a Protein Coding gene. Diseases associated with CORT include Pituitary Adenoma, Prolactin-Secreting and Intestinal Disease. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include hormone activity and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for CORT Gene

  • Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.

Gene Wiki entry for CORT Gene

Additional gene information for CORT Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORT Gene

Genomics for CORT Gene

GeneHancer (GH) Regulatory Elements for CORT Gene

Promoters and enhancers for CORT Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I010449 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 550.8 +1.4 1359 2.2 ZNF362 ZNF600 CORT PGD ENSG00000271989 CENPS CENPS-CORT DFFA PEX14 C1orf127 ENSG00000203469
GH01I010450 Promoter 0.5 EPDnew 550.8 -0.1 -76 0.1 CORT ENSG00000271989 CENPS-CORT
GH01I010494 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +47.2 47228 4.7 HDGF ELF3 PKNOX1 RB1 ARID4B BMI1 ZNF2 RAD21 RFX5 ZNF335 PEX14 DFFA CENPS CENPS-CORT CORT ENSG00000203469 ENSG00000271989 PGD GC01P010513
GH01I010413 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.1 -34.3 -34284 3.1 HDGF PKNOX1 ATF1 ARNT POLR2B ZNF766 ATF7 KDM4B PAF1 ZNF592 PGD CORT PEX14 DFFA CENPS-CORT CENPS
GH01I010351 Enhancer 0.6 dbSUPER 10.9 -96.7 -96683 2.6 ZNF639 ZNF316 TSC22D4 MAFG MAFK EMSY PRDM1 ZNF18 PGD KIF1B CENPS CORT RNU6-37P RNU6-828P LOC105376725 RN7SL731P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CORT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CORT gene promoter:

Genomic Locations for CORT Gene

Genomic Locations for CORT Gene
2,285 bases
Plus strand

Genomic View for CORT Gene

Genes around CORT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORT Gene

Proteins for CORT Gene

  • Protein details for CORT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q5T6G0
    • Q6UX11

    Protein attributes for CORT Gene

    105 amino acids
    Molecular mass:
    11532 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI19725.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI19726.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ89950.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19195.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW71650.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CORT Gene

Post-translational modifications for CORT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CORT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CORT Gene

Domains & Families for CORT Gene

Gene Families for CORT Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CORT Gene

Suggested Antigen Peptide Sequences for CORT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the somatostatin family.
  • Belongs to the somatostatin family.
genes like me logo Genes that share domains with CORT: view

Function for CORT Gene

Molecular function for CORT Gene

GENATLAS Biochemistry:
preprocortistatin,expressed in GABAergic interneurons in the cerebral cortex and hippocampus,highly homologous to somatostatin,not tumor suppressor for neuroblastoma
UniProtKB/Swiss-Prot Function:
Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.

Phenotypes From GWAS Catalog for CORT Gene

Gene Ontology (GO) - Molecular Function for CORT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IPI 12915402
GO:0003682 NOT chromatin binding IBA --
GO:0003690 NOT double-stranded DNA binding IBA --
GO:0005179 hormone activity IEA --
GO:0005184 neuropeptide hormone activity IDA 9125122
genes like me logo Genes that share ontologies with CORT: view
genes like me logo Genes that share phenotypes with CORT: view

Animal Models for CORT Gene

MGI Knock Outs for CORT:

Animal Model Products

  • Taconic Biosciences Mouse Models for CORT

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CORT Gene

Localization for CORT Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORT Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CORT gene
Compartment Confidence
extracellular 5
nucleus 2
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CORT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space NAS 9125122
GO:0043240 NOT Fanconi anaemia nuclear complex IBA --
GO:0071821 NOT FANCM-MHF complex IBA --
genes like me logo Genes that share ontologies with CORT: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CORT Gene

Pathways & Interactions for CORT Gene

genes like me logo Genes that share pathways with CORT: view

SIGNOR curated interactions for CORT Gene


Gene Ontology (GO) - Biological Process for CORT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000712 NOT resolution of meiotic recombination intermediates IBA --
GO:0006312 NOT mitotic recombination IBA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA 9125122
GO:0007268 chemical synaptic transmission NAS 9125122
genes like me logo Genes that share ontologies with CORT: view

Drugs & Compounds for CORT Gene

(9) Drugs for CORT Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0

(2) Additional Compounds for CORT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CORT: view

Transcripts for CORT Gene

mRNA/cDNA for CORT Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(150) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CORT Gene

Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORT Gene

No ASD Table

Relevant External Links for CORT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CORT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CORT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CORT Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x10.8), Brain - Caudate (basal ganglia) (x9.3), and Brain - Nucleus accumbens (basal ganglia) (x5.4).

NURSA nuclear receptor signaling pathways regulating expression of CORT Gene:


SOURCE GeneReport for Unigene cluster for CORT Gene:


mRNA Expression by UniProt/SwissProt for CORT Gene:

Tissue specificity: Expressed in a subset of GABAergic cells in the cortex and hippocampus.

Evidence on tissue expression from TISSUES for CORT Gene

  • Nervous system(4.7)
  • Adrenal gland(3)
  • Blood(2.5)
genes like me logo Genes that share expression patterns with CORT: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CORT Gene

Orthologs for CORT Gene

This gene was present in the common ancestor of mammals.

Orthologs for CORT Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CORT 33 34
  • 98.73 (n)
(Bos Taurus)
Mammalia CORT 33 34
  • 81.65 (n)
(Rattus norvegicus)
Mammalia Cort 33
  • 73.03 (n)
(Mus musculus)
Mammalia Cort 33 16 34
  • 72.35 (n)
(Monodelphis domestica)
Mammalia CORT 34
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia CORT 34
  • 43 (a)
Species where no ortholog for CORT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CORT Gene

Gene Tree for CORT (if available)
Gene Tree for CORT (if available)

Paralogs for CORT Gene

No data available for Paralogs for CORT Gene

Variants for CORT Gene

Sequence variations from dbSNP and Humsavar for CORT Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1001417607 -- 10,448,348(+) A/G upstream_transcript_variant
rs1001762701 -- 10,448,556(+) A/G upstream_transcript_variant
rs1002363836 -- 10,449,578(+) A/G upstream_transcript_variant
rs1003749246 -- 10,448,451(+) G/C upstream_transcript_variant
rs1004227637 -- 10,449,523(+) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CORT Gene

Variant ID Type Subtype PubMed ID
esv2758920 CNV gain+loss 17122850
esv2764192 CNV gain 21179565

Variation tolerance for CORT Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CORT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORT Gene

Disorders for CORT Gene

MalaCards: The human disease database

(7) MalaCards diseases for CORT Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pituitary adenoma, prolactin-secreting
  • prolactinoma, familial
intestinal disease
  • intestinal diseases
  • neuroblastoma, susceptibility to
corticosteroid-binding globulin deficiency
  • cbg deficiency
mental depression
  • depression
- elite association - COSMIC cancer census association via MalaCards
Search CORT in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CORT

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CORT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CORT Gene

Publications for CORT Gene

  1. Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin. (PMID: 9205124) de Lecea L … Sutcliffe JG (Genomics 1997) 2 3 4 22 58
  2. Identification and characterization of a novel human cortistatin-like peptide. (PMID: 9125122) Fukusumi S … Fujino M (Biochemical and biophysical research communications 1997) 3 4 22 58
  3. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PMID: 20398908) Saus E … Estivill X (Journal of psychiatric research 2010) 3 44 58
  4. Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients. (PMID: 20164562) Gahete MD … Castaño JP (Journal of Alzheimer's disease : JAD 2010) 3 22 58
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) Gratacòs M … Psychiatric Genetics Network Group (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 44 58

Products for CORT Gene

Sources for CORT Gene

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