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Aliases for CORO7-PAM16 Gene

Aliases for CORO7-PAM16 Gene

  • CORO7-PAM16 Readthrough 2 3 5
  • 70 KDa WD Repeat Tumor Rejection Antigen Homolog 3
  • CORO7-PAM16 Protein 3
  • Coronin-7 3
  • Coronin 13
  • CORO7 3
  • PAM16 13
  • Crn7 3

External Ids for CORO7-PAM16 Gene

Previous GeneCards Identifiers for CORO7-PAM16 Gene

  • GC16U901294
  • GC16M004392

Summaries for CORO7-PAM16 Gene

Entrez Gene Summary for CORO7-PAM16 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring CORO7 (coronin 7) and PAM16 (presequence translocase-associated motor 16) genes on chromosome 16. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jan 2011]

GeneCards Summary for CORO7-PAM16 Gene

CORO7-PAM16 (CORO7-PAM16 Readthrough) is a Protein Coding gene. Diseases associated with CORO7-PAM16 include Spondylometaphyseal Dysplasia, Megarbane-Dagher-Melki Type. An important paralog of this gene is CORO7.

Additional gene information for CORO7-PAM16 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO7-PAM16 Gene

Genomics for CORO7-PAM16 Gene

GeneHancer (GH) Regulatory Elements for CORO7-PAM16 Gene

Promoters and enhancers for CORO7-PAM16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J004420 Promoter 0.6 Ensembl 600.7 -0.3 -307 0.4 PRDM10 CORO7-PAM16 NMRAL1 CORO7
GH16J004407 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.4 +8.0 7957 10.2 HDGF SP1 ELF3 ZFX MNT CBFA2T2 NKRF MLLT1 ZNF121 CEBPG CORO7 NMRAL1 HMOX2 MGRN1 NUDT16L1 CORO7-PAM16 VASN
GH16J004368 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.3 +46.2 46186 11 ZNF652 ZFX ELF3 MNT CBFA2T2 ZNF148 POLR2A CEBPG RERE NCOA3 VASN NMRAL1 CREBBP HMOX2 MGRN1 UBN1 PAM16 GLIS2 CORO7 GC16P004366
GH16J004349 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 0.2 +69.4 69439 2.9 SP1 ZFX ELF3 NKRF POLR2A GTF2F1 ZNF687 TFE3 SP5 KLF14 PAM16 NMRAL1 ZNF500 ZNF174 CREBBP ENSG00000261938 HMOX2 MGRN1 ENSG00000280063 CORO7-PAM16
GH16J004402 Enhancer 1 ENCODE 0.4 +17.6 17612 1.1 CC2D1A CTCF ELF3 AHR ZBTB7A SP7 PPARG KLF14 RAD21 SMARCA4 NMRAL1 CORO7-PAM16 CORO7 VASN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CORO7-PAM16 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CORO7-PAM16 Gene

Genomic Locations for CORO7-PAM16 Gene
80,244 bases
Minus strand
80,244 bases
Minus strand

Genomic View for CORO7-PAM16 Gene

Genes around CORO7-PAM16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO7-PAM16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO7-PAM16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO7-PAM16 Gene

Proteins for CORO7-PAM16 Gene

  • Protein details for CORO7-PAM16 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for CORO7-PAM16 Gene

    535 amino acids
    Molecular mass:
    57677 Da
    Quaternary structure:
    No Data Available
  • Protein details for CORO7-PAM16 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for CORO7-PAM16 Gene

    1048 amino acids
    Molecular mass:
    114166 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CORO7-PAM16 Gene

Post-translational modifications for CORO7-PAM16 Gene

No Post-translational modifications

Other Protein References for CORO7-PAM16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CORO7-PAM16 Gene

Domains & Families for CORO7-PAM16 Gene

Gene Families for CORO7-PAM16 Gene

  • Belongs to the WD repeat coronin family.
  • Belongs to the WD repeat coronin family.
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CORO7-PAM16: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CORO7-PAM16 Gene

Function for CORO7-PAM16 Gene

Phenotypes From GWAS Catalog for CORO7-PAM16 Gene

Phenotypes for CORO7-PAM16 Gene

genes like me logo Genes that share phenotypes with CORO7-PAM16: view

Animal Models for CORO7-PAM16 Gene

MGI Knock Outs for CORO7-PAM16:
  • Coro7 Coro7<tm1a(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for CORO7-PAM16 Gene

miRTarBase miRNAs that target CORO7-PAM16

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CORO7-PAM16 Gene

Localization for CORO7-PAM16 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Microtubules (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CORO7-PAM16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with CORO7-PAM16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for CORO7-PAM16 Gene

Pathways & Interactions for CORO7-PAM16 Gene

PathCards logo

SuperPathways for CORO7-PAM16 Gene

No Data Available

Interacting Proteins for CORO7-PAM16 Gene

Gene Ontology (GO) - Biological Process for CORO7-PAM16 Gene


No data available for Pathways by source and SIGNOR curated interactions for CORO7-PAM16 Gene

Drugs & Compounds for CORO7-PAM16 Gene

No Compound Related Data Available

Transcripts for CORO7-PAM16 Gene

mRNA/cDNA for CORO7-PAM16 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORO7-PAM16 Gene

No ASD Table

Relevant External Links for CORO7-PAM16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CORO7-PAM16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CORO7-PAM16 Gene

This gene is overexpressed in NK cells (14.8) and Lymph node (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for CORO7-PAM16 Gene

Protein tissue co-expression partners for CORO7-PAM16 Gene

genes like me logo Genes that share expression patterns with CORO7-PAM16: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CORO7-PAM16 Gene

Orthologs for CORO7-PAM16 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CORO7-PAM16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 99 (a)
CORO7 34
  • 97.06 (n)
(Canis familiaris)
Mammalia -- 35
  • 87 (a)
CORO7 34
  • 86.04 (n)
(Bos Taurus)
Mammalia CORO7 35 34
  • 86.43 (n)
(Mus musculus)
Mammalia Coro7 17 35 34
  • 81.47 (n)
(Rattus norvegicus)
Mammalia Coro7 34
  • 80.67 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 72 (a)
(Gallus gallus)
Aves CORO7 35 34
  • 68.89 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia coro7 34
  • 60.85 (n)
(Danio rerio)
Actinopterygii CABZ01076758.1 35
  • 67 (a)
coro7 35 34
  • 61.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta pod1 35 34
  • 51.29 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000930 34
  • 43.86 (n)
(Caenorhabditis elegans)
Secernentea pod-1 35 34
  • 45.94 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRN1 35
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
Species where no ortholog for CORO7-PAM16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CORO7-PAM16 Gene

Gene Tree for CORO7-PAM16 (if available)
Gene Tree for CORO7-PAM16 (if available)

Paralogs for CORO7-PAM16 Gene

Paralogs for CORO7-PAM16 Gene

(5) SIMAP similar genes for CORO7-PAM16 Gene using alignment to 1 proteins:

  • I3L167_HUMAN
genes like me logo Genes that share paralogs with CORO7-PAM16: view

Variants for CORO7-PAM16 Gene

Sequence variations from dbSNP and Humsavar for CORO7-PAM16 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1555468179 uncertain-significance, Acute megakaryoblastic leukemia, Mediastinal germ cell tumor 4,355,236(-) G/A intron_variant
rs786203989 pathogenic, Spondylometaphyseal dysplasia, megarbane-dagher-melki type 4,340,985(-) T/C coding_sequence_variant, missense_variant
rs1000072235 -- 4,344,003(-) C/T intron_variant
rs1000088603 -- 4,348,904(-) A/G intron_variant
rs1000093995 -- 4,411,979(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CORO7-PAM16 Gene

Variant ID Type Subtype PubMed ID
esv1211300 CNV insertion 17803354
esv1548790 CNV insertion 17803354
esv23732 CNV gain 19812545
esv2659570 CNV deletion 23128226
esv2667108 CNV deletion 23128226
esv3335033 CNV duplication 20981092
esv3584924 CNV gain 24956385
esv3637695 CNV loss 21293372
esv3637696 CNV loss 21293372
nsv103783 CNV deletion 16902084
nsv1046986 CNV gain 25217958
nsv1160332 CNV duplication 26073780
nsv471075 CNV loss 18288195
nsv475644 CNV novel sequence insertion 20440878
nsv520212 CNV loss 19592680
nsv527866 CNV loss 19592680
nsv571274 CNV gain 21841781
nsv571301 CNV gain+loss 21841781
nsv833132 CNV loss 17160897

Variation tolerance for CORO7-PAM16 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.98; 60.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CORO7-PAM16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORO7-PAM16 Gene

Disorders for CORO7-PAM16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CORO7-PAM16 Gene - From: GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CORO7-PAM16

genes like me logo Genes that share disorders with CORO7-PAM16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CORO7-PAM16 Gene

Publications for CORO7-PAM16 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 13 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for CORO7-PAM16 Gene

Sources for CORO7-PAM16 Gene

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