Aliases for CORO7 Gene
External Ids for CORO7 Gene
Previous GeneCards Identifiers for CORO7 Gene
This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology. Alternative splicing results in multiple transcripts variants; some of which form read-through transcripts with a neighboring gene. [provided by RefSeq, Dec 2016]
GeneCards Summary for CORO7 Gene
CORO7 (Coronin 7) is a Protein Coding gene. Diseases associated with CORO7 include Chromosomal Disease. Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is CORO7-PAM16.
UniProtKB/Swiss-Prot for CORO7 Gene
F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via Lys-33-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.