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Aliases for CORO7 Gene

Aliases for CORO7 Gene

  • Coronin 7 2 3 5
  • 70 KDa WD Repeat Tumor Rejection Antigen Homolog 3 4
  • CRN7 3 4
  • 0610011B16Rik 3
  • Coronin-7 3
  • POD1 3

External Ids for CORO7 Gene

Previous GeneCards Identifiers for CORO7 Gene

  • GC16M004344
  • GC16M004405

Summaries for CORO7 Gene

Entrez Gene Summary for CORO7 Gene

  • This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology. Alternative splicing results in multiple transcripts variants; some of which form read-through transcripts with a neighboring gene. [provided by RefSeq, Dec 2016]

GeneCards Summary for CORO7 Gene

CORO7 (Coronin 7) is a Protein Coding gene. Diseases associated with CORO7 include Chromosomal Disease. Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is CORO7-PAM16.

UniProtKB/Swiss-Prot for CORO7 Gene

  • F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via Lys-33-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.

Additional gene information for CORO7 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO7 Gene

Genomics for CORO7 Gene

GeneHancer (GH) Regulatory Elements for CORO7 Gene

Promoters and enhancers for CORO7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I004407 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 561.9 +13.2 13168 10.2 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A FEZF1 IRF4 SLC30A9 POLR2B CORO7 CORO7-PAM16 NMRAL1 HMOX2 MGRN1 NUDT16L1 VASN
GH16I004424 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.4 -389 3.3 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B CORO7 DNAJA3 ENSG00000277170 NMRAL1 CREBBP ZNF500 ZNF597 ANKS3 UBN1 HMOX2
GH16I004313 Promoter/Enhancer 1.9 Ensembl ENCODE dbSUPER 4.5 +106.1 106139 12.3 HDGF CLOCK FOXA2 ARNT ZFP64 ARID4B SIN3A ZNF2 E2F8 ZNF207 ZNF500 ANKS3 ENSG00000261938 PAM16 ZSCAN32 VASN CREBBP ZNF174 CLUAP1 NMRAL1
GH16I004485 Enhancer 1.1 Ensembl ENCODE dbSUPER 6.6 -62.7 -62687 6.2 MAX RAD21 YY1 ZNF121 POLR2A ZNF362 RFX1 RXRA REST GABPA NMRAL1 CDIP1 HMOX2 NUDT16L1 CORO7 MGRN1
GH16I004327 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 4.5 +97.2 97237 2.7 ELF3 PKNOX1 ZFP64 ARID4B ZNF48 ZSCAN9 RAD21 RARA YY1 GLIS2 GLIS2-AS1 PAM16 CORO7 ENSG00000262712 GLIS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CORO7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CORO7 gene promoter:

Genomic Locations for CORO7 Gene

Genomic Locations for CORO7 Gene
chr16:4,354,542-4,425,705
(GRCh38/hg38)
Size:
71,164 bases
Orientation:
Minus strand
chr16:4,404,543-4,475,706
(GRCh37/hg19)

Genomic View for CORO7 Gene

Genes around CORO7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO7 Gene

Proteins for CORO7 Gene

  • Protein details for CORO7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57737-CORO7_HUMAN
    Recommended name:
    Coronin-7
    Protein Accession:
    P57737
    Secondary Accessions:
    • B4DFD6
    • B4DL18
    • I3L416
    • Q17RK4

    Protein attributes for CORO7 Gene

    Size:
    925 amino acids
    Molecular mass:
    100605 Da
    Quaternary structure:
    • Interacts with clathrin adapter AP1 complex. This interaction takes place at Golgi membranes and not AP1-positive endosomal membranes. Interacts (when ubiquitinated at Lys-472) with EPS15.

    Alternative splice isoforms for CORO7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CORO7 Gene

Post-translational modifications for CORO7 Gene

  • The membrane-associated form is phosphorylated on tyrosine residues.
  • Ubiquitinated via Lys-33-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex: Lys-33-linked ubiquitination promotes interaction with EPS15 and facilitates actin polymerization at the trans-Golgi network, thereby facilitating post-Golgi trafficking. Deubiquitinated by ZRANB1/TRABID.
  • Ubiquitination at posLast=157157, Lys348, posLast=472472, posLast=491491, posLast=508508, Lys596, posLast=680680, and Lys903

No data available for DME Specific Peptides for CORO7 Gene

Domains & Families for CORO7 Gene

Gene Families for CORO7 Gene

Suggested Antigen Peptide Sequences for CORO7 Gene

Graphical View of Domain Structure for InterPro Entry

P57737

UniProtKB/Swiss-Prot:

CORO7_HUMAN :
  • Belongs to the WD repeat coronin family.
Family:
  • Belongs to the WD repeat coronin family.
genes like me logo Genes that share domains with CORO7: view

Function for CORO7 Gene

Molecular function for CORO7 Gene

UniProtKB/Swiss-Prot Function:
F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via Lys-33-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.

Phenotypes From GWAS Catalog for CORO7 Gene

Gene Ontology (GO) - Molecular Function for CORO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA,IEA 24768539
GO:0005515 protein binding IPI 21130766
genes like me logo Genes that share ontologies with CORO7: view

Phenotypes for CORO7 Gene

genes like me logo Genes that share phenotypes with CORO7: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CORO7 Gene

Localization for CORO7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORO7 Gene

Golgi apparatus membrane. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle. Cytoplasm, cytosol. Note=Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi. Not associated with actin filaments.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CORO7 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CORO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA,ISS --
GO:0005802 trans-Golgi network IDA 24768539
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with CORO7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CORO7 Gene

Pathways & Interactions for CORO7 Gene

SuperPathways for CORO7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CORO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006895 Golgi to endosome transport IMP 24768539
GO:0015031 protein transport IEA --
GO:0030041 actin filament polymerization IMP 24768539
genes like me logo Genes that share ontologies with CORO7: view

No data available for Pathways by source and SIGNOR curated interactions for CORO7 Gene

Drugs & Compounds for CORO7 Gene

No Compound Related Data Available

Transcripts for CORO7 Gene

Unigene Clusters for CORO7 Gene

Coronin 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORO7 Gene

No ASD Table

Relevant External Links for CORO7 Gene

GeneLoc Exon Structure for
CORO7
ECgene alternative splicing isoforms for
CORO7

Expression for CORO7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CORO7 Gene

mRNA differential expression in normal tissues according to GTEx for CORO7 Gene

This gene is overexpressed in Testis (x11.7) and Whole Blood (x7.4).

Protein differential expression in normal tissues from HIPED for CORO7 Gene

This gene is overexpressed in Lymph node (11.2), Tlymphocyte (8.6), NK cells (7.9), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CORO7 Gene



Protein tissue co-expression partners for CORO7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CORO7 Gene:

CORO7

SOURCE GeneReport for Unigene cluster for CORO7 Gene:

Hs.437957

mRNA Expression by UniProt/SwissProt for CORO7 Gene:

P57737-CORO7_HUMAN
Tissue specificity: Widely expressed. Expressed in the spleen, peripheral leukocytes, testes, brain, thymus and small intestine.

Evidence on tissue expression from TISSUES for CORO7 Gene

  • Nervous system(5)
  • Intestine(4.2)
  • Lung(2.9)
genes like me logo Genes that share expression patterns with CORO7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CORO7 Gene

Orthologs for CORO7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CORO7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 99 (a)
OneToMany
CORO7 33
  • 97.06 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 87 (a)
OneToMany
CORO7 33
  • 86.04 (n)
cow
(Bos Taurus)
Mammalia CORO7 33 34
  • 86.45 (n)
mouse
(Mus musculus)
Mammalia Coro7 33 34
  • 81.49 (n)
rat
(Rattus norvegicus)
Mammalia Coro7 33
  • 80.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 75 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 71 (a)
OneToMany
chicken
(Gallus gallus)
Aves CORO7 33 34
  • 68.92 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 38 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia coro7 33
  • 60.85 (n)
Str.18329 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6618 33
zebrafish
(Danio rerio)
Actinopterygii coro7 33 34
  • 61.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta pod1 33 34
  • 51.29 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000930 33
  • 43.84 (n)
worm
(Caenorhabditis elegans)
Secernentea pod-1 33 34
  • 45.96 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRN1 34
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToMany
Species where no ortholog for CORO7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CORO7 Gene

ENSEMBL:
Gene Tree for CORO7 (if available)
TreeFam:
Gene Tree for CORO7 (if available)

Paralogs for CORO7 Gene

Variants for CORO7 Gene

Sequence variations from dbSNP and Humsavar for CORO7 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs864309494 uncertain-significance, Acute megakaryoblastic leukemia, Mediastinal germ cell tumor 4,355,236(-) G/A intron_variant
rs1000093995 -- 4,411,979(-) C/T intron_variant
rs1000120584 -- 4,380,768(-) T/C intron_variant
rs1000142618 -- 4,402,768(-) G/A intron_variant
rs1000178796 -- 4,402,652(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CORO7 Gene

Variant ID Type Subtype PubMed ID
nsv833132 CNV loss 17160897
nsv571274 CNV gain 21841781
nsv527866 CNV loss 19592680
nsv520212 CNV loss 19592680
nsv475644 CNV novel sequence insertion 20440878
nsv471075 CNV loss 18288195
nsv1160332 CNV duplication 26073780
nsv1046986 CNV gain 25217958
esv3637696 CNV loss 21293372
esv3584924 CNV gain 24956385
esv2659570 CNV deletion 23128226
esv23732 CNV gain 19812545

Variation tolerance for CORO7 Gene

Residual Variation Intolerance Score: 96.6% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CORO7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CORO7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORO7 Gene

Disorders for CORO7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CORO7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosomal disease
  • chromosomal disorders
- elite association - COSMIC cancer census association via MalaCards
Search CORO7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CORO7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CORO7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CORO7 Gene

Publications for CORO7 Gene

  1. Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi apparatus. (PMID: 15327992) Rybakin V … Hasse A (FEBS letters 2004) 2 3 4 58
  2. K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking. (PMID: 24768539) Yuan WC … Chen RH (Molecular cell 2014) 3 4 58
  3. Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob. (PMID: 21130766) Watanabe M … Yamamoto T (FEBS letters 2011) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Molecular mechanism underlying the association of Coronin-7 with Golgi membranes. (PMID: 18581049) Rybakin V … Clemen CS (Cellular and molecular life sciences : CMLS 2008) 3 22 58

Products for CORO7 Gene

Sources for CORO7 Gene

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