Aliases for CORO7 Gene
External Ids for CORO7 Gene
Previous GeneCards Identifiers for CORO7 Gene
This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology. Alternative splicing results in multiple transcripts variants; some of which form read-through transcripts with a neighboring gene. [provided by RefSeq, Dec 2016]
GeneCards Summary for CORO7 Gene
CORO7 (Coronin 7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is CORO7-PAM16.
UniProtKB/Swiss-Prot Summary for CORO7 Gene
F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.