This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination v... See more...

Aliases for CORO7 Gene

Aliases for CORO7 Gene

  • Coronin 7 2 3 5
  • 70 KDa WD Repeat Tumor Rejection Antigen Homolog 3 4
  • Coronin-7 3 4
  • 0610011B16Rik 3
  • FLJ22021 2
  • CORO7 5
  • CRN7 3
  • POD1 3
  • Crn7 4

External Ids for CORO7 Gene

Previous GeneCards Identifiers for CORO7 Gene

  • GC16M004344
  • GC16M004405

Summaries for CORO7 Gene

Entrez Gene Summary for CORO7 Gene

  • This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology. Alternative splicing results in multiple transcripts variants; some of which form read-through transcripts with a neighboring gene. [provided by RefSeq, Dec 2016]

GeneCards Summary for CORO7 Gene

CORO7 (Coronin 7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is CORO7-PAM16.

UniProtKB/Swiss-Prot Summary for CORO7 Gene

  • F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.

Additional gene information for CORO7 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CORO7 Gene

Genomics for CORO7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CORO7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CORO7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CORO7

Top Transcription factor binding sites by QIAGEN in the CORO7 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • STAT3

Genomic Locations for CORO7 Gene

Genomic Locations for CORO7 Gene
chr16:4,354,542-4,425,705
(GRCh38/hg38)
Size:
71,164 bases
Orientation:
Minus strand
chr16:4,404,543-4,475,706
(GRCh37/hg19)
Size:
71,164 bases
Orientation:
Minus strand

Genomic View for CORO7 Gene

Genes around CORO7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO7 Gene

Proteins for CORO7 Gene

  • Protein details for CORO7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57737-CORO7_HUMAN
    Recommended name:
    Coronin-7
    Protein Accession:
    P57737
    Secondary Accessions:
    • B4DFD6
    • B4DL18
    • I3L416
    • Q17RK4

    Protein attributes for CORO7 Gene

    Size:
    925 amino acids
    Molecular mass:
    100605 Da
    Quaternary structure:
    • Interacts with clathrin adapter AP1 complex. This interaction takes place at Golgi membranes and not AP1-positive endosomal membranes. Interacts (when ubiquitinated at Lys-472) with EPS15.

    Alternative splice isoforms for CORO7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CORO7 Gene

Post-translational modifications for CORO7 Gene

  • The membrane-associated form is phosphorylated on tyrosine residues.
  • Ubiquitinated via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex: 'Lys-33'-linked ubiquitination promotes interaction with EPS15 and facilitates actin polymerization at the trans-Golgi network, thereby facilitating post-Golgi trafficking. Deubiquitinated by ZRANB1/TRABID.
  • Ubiquitination at Lys157, Lys348, Lys472, Lys491, Lys508, Lys596, Lys680, and Lys903
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CORO7 Gene

Domains & Families for CORO7 Gene

Gene Families for CORO7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CORO7 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ37277 fis, clone BRAMY2012581, highly similar to Coronin-7 (B3KSY4_HUMAN)
  • 70 kDa WD repeat tumor rejection antigen homolog (CORO7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P57737

UniProtKB/Swiss-Prot:

CORO7_HUMAN :
  • Belongs to the WD repeat coronin family.
Family:
  • Belongs to the WD repeat coronin family.
genes like me logo Genes that share domains with CORO7: view

Function for CORO7 Gene

Molecular function for CORO7 Gene

UniProtKB/Swiss-Prot Function:
F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.

Phenotypes From GWAS Catalog for CORO7 Gene

Gene Ontology (GO) - Molecular Function for CORO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA,IDA 24768539
GO:0005515 protein binding IEA,IPI 21130766
GO:0051015 actin filament binding IBA 21873635
genes like me logo Genes that share ontologies with CORO7: view
genes like me logo Genes that share phenotypes with CORO7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CORO7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CORO7 Gene

Localization for CORO7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORO7 Gene

Golgi apparatus membrane. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle. Cytoplasm, cytosol. Note=Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi. Not associated with actin filaments.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CORO7 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CORO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA,ISS --
GO:0005802 trans-Golgi network IDA 24768539
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with CORO7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CORO7 Gene

Pathways & Interactions for CORO7 Gene

PathCards logo

SuperPathways for CORO7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CORO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006895 Golgi to endosome transport IMP 24768539
GO:0007015 actin filament organization IBA 21873635
GO:0015031 protein transport IEA --
GO:0030041 actin filament polymerization IMP 24768539
genes like me logo Genes that share ontologies with CORO7: view

No data available for Pathways by source and SIGNOR curated interactions for CORO7 Gene

Drugs & Compounds for CORO7 Gene

(1) Drugs for CORO7 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methylphenidate Approved, Investigational Pharma 431
genes like me logo Genes that share compounds with CORO7: view

Transcripts for CORO7 Gene

mRNA/cDNA for CORO7 Gene

4 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
33 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CORO7

Alternative Splicing Database (ASD) splice patterns (SP) for CORO7 Gene

No ASD Table

Relevant External Links for CORO7 Gene

GeneLoc Exon Structure for
CORO7

Expression for CORO7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CORO7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Thymus (Hematopoietic System)

mRNA differential expression in normal tissues according to GTEx for CORO7 Gene

This gene is overexpressed in Testis (x11.7) and Whole Blood (x7.4).

Protein differential expression in normal tissues from HIPED for CORO7 Gene

This gene is overexpressed in Lymph node (11.2), Tlymphocyte (8.6), NK cells (7.9), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CORO7 Gene



Protein tissue co-expression partners for CORO7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CORO7

SOURCE GeneReport for Unigene cluster for CORO7 Gene:

Hs.437957

mRNA Expression by UniProt/SwissProt for CORO7 Gene:

P57737-CORO7_HUMAN
Tissue specificity: Widely expressed. Expressed in the spleen, peripheral leukocytes, testes, brain, thymus and small intestine.

Evidence on tissue expression from TISSUES for CORO7 Gene

  • Nervous system(4.2)
  • Intestine(4)
genes like me logo Genes that share expression patterns with CORO7: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CORO7 Gene

Orthologs for CORO7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CORO7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 99 (a)
OneToMany
CORO7 30
  • 97.06 (n)
Dog
(Canis familiaris)
Mammalia -- 31
  • 87 (a)
OneToMany
CORO7 30
  • 86.04 (n)
Cow
(Bos Taurus)
Mammalia CORO7 30 31
  • 86.45 (n)
OneToMany
Mouse
(Mus musculus)
Mammalia Coro7 30 31
  • 81.49 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Coro7 30
  • 80.69 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 75 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 71 (a)
OneToMany
Chicken
(Gallus gallus)
Aves CORO7 30 31
  • 68.92 (n)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 38 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia coro7 30
  • 60.85 (n)
Str.18329 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.6618 30
Zebrafish
(Danio rerio)
Actinopterygii coro7 30 31
  • 61.85 (n)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta pod1 30 31
  • 51.29 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000930 30
  • 43.84 (n)
Worm
(Caenorhabditis elegans)
Secernentea pod-1 30 31
  • 45.96 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRN1 31
  • 21 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 41 (a)
OneToMany
Species where no ortholog for CORO7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CORO7 Gene

ENSEMBL:
Gene Tree for CORO7 (if available)
TreeFam:
Gene Tree for CORO7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CORO7: view image

Paralogs for CORO7 Gene

Paralogs for CORO7 Gene

(11) SIMAP similar genes for CORO7 Gene using alignment to 20 proteins:

  • CORO7_HUMAN
  • B3KSY4_HUMAN
  • E7EP81_HUMAN
  • I3L0X8_HUMAN
  • I3L0Z7_HUMAN
  • I3L1G9_HUMAN
  • I3L1M1_HUMAN
  • I3L1T5_HUMAN
  • I3L1Z1_HUMAN
  • I3L212_HUMAN
  • I3L258_HUMAN
  • I3L2S7_HUMAN
  • I3L2Y6_HUMAN
  • I3L351_HUMAN
  • I3L359_HUMAN
  • I3L423_HUMAN
  • I3L426_HUMAN
  • I3L442_HUMAN
  • I3L482_HUMAN
  • I3NI06_HUMAN
genes like me logo Genes that share paralogs with CORO7: view

Variants for CORO7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CORO7 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
711641 Benign: not provided 4,381,582(-) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
775367 Benign: not provided 4,407,594(-) G/A SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
785522 Benign: not provided 4,359,512(-) G/A MISSENSE_VARIANT
rs1555468179 Uncertain Significance: Acute megakaryoblastic leukemia; Mediastinal germ cell tumor 4,355,236(-) G/A INTRON_VARIANT
rs17137007 - p.Ala174Val

Additional dbSNP identifiers (rs#s) for CORO7 Gene

Structural Variations from Database of Genomic Variants (DGV) for CORO7 Gene

Variant ID Type Subtype PubMed ID
esv23732 CNV gain 19812545
esv2659570 CNV deletion 23128226
esv3584924 CNV gain 24956385
esv3637696 CNV loss 21293372
nsv1046986 CNV gain 25217958
nsv1160332 CNV duplication 26073780
nsv471075 CNV loss 18288195
nsv475644 CNV novel sequence insertion 20440878
nsv520212 CNV loss 19592680
nsv527866 CNV loss 19592680
nsv571274 CNV gain 21841781
nsv833132 CNV loss 17160897

Variation tolerance for CORO7 Gene

Residual Variation Intolerance Score: 96.6% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CORO7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CORO7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORO7 Gene

Disorders for CORO7 Gene

Additional Disease Information for CORO7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for CORO7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CORO7 Gene

Publications for CORO7 Gene

  1. Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi apparatus. (PMID: 15327992) Rybakin V … Hasse A (FEBS letters 2004) 2 3 4
  2. K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking. (PMID: 24768539) Yuan WC … Chen RH (Molecular cell 2014) 3 4
  3. Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob. (PMID: 21130766) Watanabe M … Yamamoto T (FEBS letters 2011) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. Molecular mechanism underlying the association of Coronin-7 with Golgi membranes. (PMID: 18581049) Rybakin V … Clemen CS (Cellular and molecular life sciences : CMLS 2008) 3 23

Products for CORO7 Gene

  • Signalway Proteins for CORO7

Sources for CORO7 Gene