Aliases for CORO6 Gene

Aliases for CORO6 Gene

  • Coronin 6 2 3 5
  • Coronin-Like Protein E 3 4
  • Coronin-6 3 4
  • Clipin-E 3 4
  • Coronin, Actin Binding Protein 6 3

External Ids for CORO6 Gene

Previous GeneCards Identifiers for CORO6 Gene

  • GC17M024965
  • GC17M027941
  • GC17M024151

Summaries for CORO6 Gene

GeneCards Summary for CORO6 Gene

CORO6 (Coronin 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin filament binding. An important paralog of this gene is CORO1C.

Additional gene information for CORO6 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CORO6 Gene

Genomics for CORO6 Gene

GeneHancer (GH) Regulatory Elements for CORO6 Gene

Promoters and enhancers for CORO6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J029618 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 791.1 +0.5 475 7.2 CTCF ZBTB6 SMARCE1 L3MBTL2 POLR2A NFIB SP1 ZNF148 SP7 SMARCA4 CORO6 ENSG00000264007 lnc-SSH2-2 GOSR1 SUPT6H NUFIP2 ENSG00000264577 ENSG00000265205 ENSG00000265908 PHF12
GH17J029756 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 49.5 -137.2 -137151 6.3 ZNF24 SP1 POLR2A NR2F1 MYC ETV6 MAX SREBF1 ZBTB33 NKRF ENSG00000263657 SSH2 CORO6 RNU6-920P ENSG00000264007 ENSG00000231421 piR-61101-273 lnc-CORO6-4
GH17J029586 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 35.3 +32.3 32306 8.4 SIN3A ZBTB40 CTCF SIX5 ZBTB6 SMARCE1 POLR2A USF2 CREB1 HCFC1 ANKRD13B GIT1 ENSG00000264647 SUPT6H NUFIP2 ENSG00000264577 GOSR1 PHF12 TP53I13 ENSG00000265908
GH17J029638 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 51.8 -19.6 -19565 8.2 SIN3A CTCF SMARCE1 POLR2A CTBP1 ZNF362 CC2D1A L3MBTL2 RAD21 DACH1 RF00026-429 RNU6-920P CORO6 NUFIP2 ENSG00000264577 SUPT6H ENSG00000265205 ENSG00000265908 LOC101927018 PHF12
GH17J029718 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 48.6 -99.1 -99107 6.5 ZNF24 SMARCE1 ETV6 L3MBTL2 CEBPB TEAD4 ZKSCAN8 ZNF148 SP1 BACH1 CORO6 RNU6-920P ENSG00000265908 NSRP1 PHF12 ENSG00000264577 NUFIP2 SSH2 TAOK1 RF00017-2335
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CORO6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CORO6 gene promoter:
  • C/EBPbeta
  • CREB
  • deltaCREB
  • E47
  • NF-kappaB
  • POU2F1
  • POU2F1a
  • SEF-1 (1)
  • USF-1
  • USF1

Genomic Locations for CORO6 Gene

Genomic Locations for CORO6 Gene
chr17:29,614,756-29,622,908
(GRCh38/hg38)
Size:
8,153 bases
Orientation:
Minus strand
chr17:27,941,774-27,949,925
(GRCh37/hg19)
Size:
8,152 bases
Orientation:
Minus strand

Genomic View for CORO6 Gene

Genes around CORO6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO6 Gene

Proteins for CORO6 Gene

  • Protein details for CORO6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6QEF8-CORO6_HUMAN
    Recommended name:
    Coronin-6
    Protein Accession:
    Q6QEF8
    Secondary Accessions:
    • B3KU26
    • Q71MF3
    • Q8WYH7
    • Q96K02

    Protein attributes for CORO6 Gene

    Size:
    472 amino acids
    Molecular mass:
    52762 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG22467.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAG53288.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CORO6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CORO6 Gene

Post-translational modifications for CORO6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CORO6 Gene

Domains & Families for CORO6 Gene

Gene Families for CORO6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CORO6 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ35111 fis, clone PLACE6007180, highly similar to Coronin-6 (B3KRY9_HUMAN)
  • Coronin-like protein E (CORO6_HUMAN)
genes like me logo Genes that share domains with CORO6: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CORO6 Gene

Function for CORO6 Gene

Phenotypes From GWAS Catalog for CORO6 Gene

Gene Ontology (GO) - Molecular Function for CORO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0051015 actin filament binding IBA 21873635
genes like me logo Genes that share ontologies with CORO6: view
genes like me logo Genes that share phenotypes with CORO6: view

Animal Models for CORO6 Gene

MGI Knock Outs for CORO6:
  • Coro6 Coro6<tm1e(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for CORO6 Gene

miRTarBase miRNAs that target CORO6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CORO6

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CORO6 Gene

Localization for CORO6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CORO6 gene
Compartment Confidence
cytosol 2
golgi apparatus 2
mitochondrion 1
nucleus 1
plasma membrane 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CORO6 Gene

Pathways & Interactions for CORO6 Gene

PathCards logo

SuperPathways for CORO6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CORO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IBA 21873635
GO:0016477 cell migration IBA 21873635
genes like me logo Genes that share ontologies with CORO6: view

No data available for Pathways by source and SIGNOR curated interactions for CORO6 Gene

Drugs & Compounds for CORO6 Gene

No Compound Related Data Available

Transcripts for CORO6 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CORO6

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORO6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^
SP1: -
SP2: - - - - - -
SP3: - - -
SP4: - - - -
SP5: -
SP6:
SP7:
SP8: - - - - - - - - - - - - - - - -
SP9: - - -
SP10: - - - - - - -
SP11: -
SP12:

ExUns: 13a · 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CORO6 Gene

GeneLoc Exon Structure for
CORO6
ECgene alternative splicing isoforms for
CORO6

Expression for CORO6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CORO6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CORO6 Gene

This gene is overexpressed in Muscle - Skeletal (x16.4).

Protein differential expression in normal tissues from HIPED for CORO6 Gene

This gene is overexpressed in Fetal heart (31.7) and Heart (20.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CORO6 Gene



Protein tissue co-expression partners for CORO6 Gene

NURSA nuclear receptor signaling pathways regulating expression of CORO6 Gene:

CORO6

SOURCE GeneReport for Unigene cluster for CORO6 Gene:

Hs.143046

Evidence on tissue expression from TISSUES for CORO6 Gene

  • Muscle(2.9)
genes like me logo Genes that share expression patterns with CORO6: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CORO6 Gene

Orthologs for CORO6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CORO6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CORO6 33 32
  • 99.51 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CORO6 33
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CORO6 33
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CORO6 33 32
  • 92.71 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Coro6 32
  • 89.48 (n)
mouse
(Mus musculus)
Mammalia Coro6 17 33 32
  • 86.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CORO6 33
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves CORO6 33 32
  • 78.63 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CORO6 33
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia coro6 32
  • 71.7 (n)
zebrafish
(Danio rerio)
Actinopterygii coro6 33 32
  • 73.49 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.313 33
  • 43 (a)
OneToMany
Species where no ortholog for CORO6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CORO6 Gene

ENSEMBL:
Gene Tree for CORO6 (if available)
TreeFam:
Gene Tree for CORO6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CORO6: view image

Paralogs for CORO6 Gene

Paralogs for CORO6 Gene

(10) SIMAP similar genes for CORO6 Gene using alignment to 6 proteins:

  • CORO6_HUMAN
  • J3KSS5_HUMAN
  • J3QLV6_HUMAN
  • J3QRV4_HUMAN
  • J3QSC1_HUMAN
  • K7ERF4_HUMAN
genes like me logo Genes that share paralogs with CORO6: view

Variants for CORO6 Gene

Sequence variations from dbSNP and Humsavar for CORO6 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs772136445 uncertain-significance, Ductal breast carcinoma 29,615,803(-) C/A/T coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000003705 -- 29,624,223(-) C/A/T upstream_transcript_variant
rs1000039998 -- 29,623,807(-) A/G upstream_transcript_variant
rs1000050372 -- 29,621,785(-) G/A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000108303 -- 29,614,083(-) GGG/GG downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CORO6 Gene

Variant ID Type Subtype PubMed ID
nsv833409 CNV gain 17160897
nsv833410 CNV loss 17160897
nsv953874 CNV deletion 24416366

Variation tolerance for CORO6 Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CORO6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CORO6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORO6 Gene

Disorders for CORO6 Gene

Additional Disease Information for CORO6

No disorders were found for CORO6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CORO6 Gene

Publications for CORO6 Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

Products for CORO6 Gene

Sources for CORO6 Gene