Aliases for CORO2B Gene

Aliases for CORO2B Gene

  • Coronin 2B 2 3 5
  • Coronin-Like Protein C 3 4
  • Coronin-2B 3 4
  • Clipin C 2 3
  • Coronin, Actin Binding Protein, 2B 3
  • Coronin, Actin-Binding Protein, 2B 2
  • Coronin, Actin-Binding, 2B 2
  • Protein FC96 4
  • Clipin-C 4
  • KIAA0925 4

External Ids for CORO2B Gene

Previous GeneCards Identifiers for CORO2B Gene

  • GC15P064711
  • GC15P061970
  • GC15P066450
  • GC15P066587
  • GC15P066658
  • GC15P068871
  • GC15P045742

Summaries for CORO2B Gene

GeneCards Summary for CORO2B Gene

CORO2B (Coronin 2B) is a Protein Coding gene. Diseases associated with CORO2B include Complex Partial Epilepsy and Bardet-Biedl Syndrome 9. Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is CORO2A.

UniProtKB/Swiss-Prot Summary for CORO2B Gene

Additional gene information for CORO2B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CORO2B Gene

Genomics for CORO2B Gene

GeneHancer (GH) Regulatory Elements for CORO2B Gene

Promoters and enhancers for CORO2B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J068577 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.4 +20.9 20892 5.7 ZNF217 CTCF ZNF354C ZIC2 ZBTB10 ZNF423 ZBTB26 KLF7 CHD1 EZH2 CORO2B HSALNG0106807 CARS1P1 ENSG00000271232
GH15J068557 Promoter/Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas 503.5 -0.2 -224 3.2 ZNF217 CTCF NRF1 TCF12 MYC USF1 ZNF639 ZIC2 ZBTB10 ZNF423 CORO2B NOX5 HSALNG0106803
GH15J068510 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE dbSUPER 500.3 -47.5 -47474 2.4 NR2F2 SPI1 EZH2 EGR2 CORO2B HSALNG0106803
GH15J068275 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 13.3 -280.0 -279964 8.6 RXRA EP300 FOXK2 ZBTB40 ZNF217 CTCF ZSCAN5C SIN3A NRF1 TCF12 ENSG00000260657 FEM1B SKOR1 IQCH-AS1 PIAS1 CORO2B MAP2K5 SPESP1 NOX5 lnc-CLN6-27
GH15J069451 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 13.3 +893.9 893907 4.1 ZBTB40 ZNF217 SIN3A NRF1 TCF12 USF1 POLR2G SP1 RBAK GTF2E2 NONHSAG017284.2 RPLP1 lnc-TLE3-6 CORO2B NOX5 ENSG00000207119
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CORO2B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CORO2B

Top Transcription factor binding sites by QIAGEN in the CORO2B gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • CREB
  • deltaCREB
  • ER-alpha
  • TGIF
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for CORO2B Gene

Genomic Locations for CORO2B Gene
168,532 bases
Plus strand
148,838 bases
Plus strand

Genomic View for CORO2B Gene

Genes around CORO2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO2B Gene

Proteins for CORO2B Gene

  • Protein details for CORO2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K0W3
    • O94767
    • Q8TAN1

    Protein attributes for CORO2B Gene

    480 amino acids
    Molecular mass:
    54953 Da
    Quaternary structure:
    • Binds to F-actin and to vinculin.
    • Sequence=AAH26335.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA36341.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CORO2B Gene


neXtProt entry for CORO2B Gene

Post-translational modifications for CORO2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CORO2B Gene

No data available for DME Specific Peptides for CORO2B Gene

Domains & Families for CORO2B Gene

Gene Families for CORO2B Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CORO2B Gene

GenScript: Design optimal peptide antigens:
  • Protein FC96 (COR2B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat coronin family.
  • Belongs to the WD repeat coronin family.
genes like me logo Genes that share domains with CORO2B: view

Function for CORO2B Gene

Molecular function for CORO2B Gene

UniProtKB/Swiss-Prot Function:
May play a role in the reorganization of neuronal actin structure.
GENATLAS Biochemistry:
coronin 2B,homolog to Dictyostelium discoideum coronin,a soluble actin-binding protein,predominantly expressed in brain,accumulating at focal adhesions as well as at neurite tips and stress fibers where it associates with vinculin,suggesting that coronin 2B plays a specific role in cross-binding the actin cytoskeleton and plasma membrane

Phenotypes From GWAS Catalog for CORO2B Gene

Gene Ontology (GO) - Molecular Function for CORO2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding NAS 10224093
GO:0005515 protein binding IEA,IPI 25416956
GO:0017166 vinculin binding IPI 29162887
GO:0051015 actin filament binding IBA 21873635
GO:1990147 talin binding IDA 29162887
genes like me logo Genes that share ontologies with CORO2B: view
genes like me logo Genes that share phenotypes with CORO2B: view

Animal Models for CORO2B Gene

MGI Knock Outs for CORO2B:

Animal Model Products

miRNA for CORO2B Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CORO2B Gene

Localization for CORO2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORO2B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CORO2B gene
Compartment Confidence
cytoskeleton 5
plasma membrane 2
nucleus 2
cytosol 2
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CORO2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005925 focal adhesion IDA 29162887
GO:0015629 actin cytoskeleton NAS 10224093
GO:0016020 membrane IEA,NAS 10224093
genes like me logo Genes that share ontologies with CORO2B: view

Pathways & Interactions for CORO2B Gene

PathCards logo

SuperPathways for CORO2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for CORO2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003093 regulation of glomerular filtration IEA --
GO:0010812 negative regulation of cell-substrate adhesion IDA 29162887
GO:0030036 actin cytoskeleton organization NAS 10224093
GO:0032956 regulation of actin cytoskeleton organization IDA 29162887
GO:0048041 focal adhesion assembly IEA --
genes like me logo Genes that share ontologies with CORO2B: view

No data available for Pathways by source and SIGNOR curated interactions for CORO2B Gene

Drugs & Compounds for CORO2B Gene

No Compound Related Data Available

Transcripts for CORO2B Gene

mRNA/cDNA for CORO2B Gene

13 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORO2B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^
SP1: - - - - - - - -
SP2: -
SP3: - - - -
SP4: - -
SP5: - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP9: - -

ExUns: 18a · 18b · 18c · 18d

Relevant External Links for CORO2B Gene

GeneLoc Exon Structure for

Expression for CORO2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CORO2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CORO2B Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.0).

Protein differential expression in normal tissues from HIPED for CORO2B Gene

This gene is overexpressed in Frontal cortex (21.5), Retina (13.7), Spinal cord (9.7), and Fetal Brain (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CORO2B Gene

Protein tissue co-expression partners for CORO2B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CORO2B

SOURCE GeneReport for Unigene cluster for CORO2B Gene:


mRNA Expression by UniProt/SwissProt for CORO2B Gene:

Tissue specificity: Expressed predominantly in brain.

Evidence on tissue expression from TISSUES for CORO2B Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with CORO2B: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CORO2B Gene

Orthologs for CORO2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CORO2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CORO2B 31 30
  • 99.44 (n)
(Canis familiaris)
Mammalia CORO2B 31 30
  • 93.75 (n)
(Bos Taurus)
Mammalia CORO2B 31 30
  • 92.97 (n)
(Mus musculus)
Mammalia Coro2b 17 31 30
  • 91.46 (n)
(Rattus norvegicus)
Mammalia Coro2b 30
  • 91.18 (n)
(Ornithorhynchus anatinus)
Mammalia CORO2B 31
  • 90 (a)
(Monodelphis domestica)
Mammalia CORO2B 31
  • 89 (a)
(Gallus gallus)
Aves CORO2B 31 30
  • 83.86 (n)
(Anolis carolinensis)
Reptilia CORO2B 31
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia coro2b 30
  • 75.6 (n)
(Danio rerio)
Actinopterygii coro2ba 31 30
  • 77.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta coro 31
  • 40 (a)
(Caenorhabditis elegans)
Secernentea cor-1 31 32
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRN1 31
  • 27 (a)
Species where no ortholog for CORO2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CORO2B Gene

Gene Tree for CORO2B (if available)
Gene Tree for CORO2B (if available)
Evolutionary constrained regions (ECRs) for CORO2B: view image

Paralogs for CORO2B Gene

Paralogs for CORO2B Gene

(7) SIMAP similar genes for CORO2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CORO2B: view

Variants for CORO2B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CORO2B Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs1314209013 A colorectal cancer sample p.Pro318Leu
rs17852400 - p.Leu238Val

Additional dbSNP identifiers (rs#s) for CORO2B Gene

Structural Variations from Database of Genomic Variants (DGV) for CORO2B Gene

Variant ID Type Subtype PubMed ID
esv2487574 CNV deletion 19546169
esv2672538 CNV deletion 23128226
esv2749817 CNV deletion 23290073
esv2749818 CNV deletion 23290073
esv3306659 CNV mobile element insertion 20981092
esv3327513 CNV insertion 20981092
esv3351322 CNV insertion 20981092
esv33989 CNV gain 17666407
esv3552616 CNV deletion 23714750
esv3636807 CNV loss 21293372
esv3636808 CNV loss 21293372
nsv1070711 CNV deletion 25765185
nsv1108965 CNV deletion 24896259
nsv457189 CNV loss 19166990
nsv515835 CNV loss 19592680
nsv569807 CNV loss 21841781
nsv833046 CNV loss 17160897

Variation tolerance for CORO2B Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CORO2B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORO2B Gene

Disorders for CORO2B Gene

MalaCards: The human disease database

(2) MalaCards diseases for CORO2B Gene - From: DISEASES

Disorder Aliases PubMed IDs
complex partial epilepsy
  • complex partial epileptic seizure
bardet-biedl syndrome 9
  • bbs9
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CORO2B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CORO2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CORO2B Gene

Publications for CORO2B Gene

  1. A neurally enriched coronin-like protein, ClipinC, is a novel candidate for an actin cytoskeleton-cortical membrane-linking protein. (PMID: 10224093) Nakamura T … Mori N (The Journal of biological chemistry 1999) 2 3 4 23 54
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need AC … Goldstein DB (Human molecular genetics 2009) 3 41 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for CORO2B Gene

Sources for CORO2B Gene