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Aliases for CORO1C Gene

Aliases for CORO1C Gene

  • Coronin 1C 2 3 5
  • Coronin-3 3 4
  • HCRNN4 3 4
  • Coronin, Actin Binding Protein, 1C 3
  • Coronin, Actin-Binding Protein, 1C 2
  • Coronin-1C 3
  • CRNN4 4
  • CRN2 4

External Ids for CORO1C Gene

Previous GeneCards Identifiers for CORO1C Gene

  • GC12M108144
  • GC12M108919
  • GC12M108971
  • GC12M107541
  • GC12M109038
  • GC12M106103

Summaries for CORO1C Gene

Entrez Gene Summary for CORO1C Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

GeneCards Summary for CORO1C Gene

CORO1C (Coronin 1C) is a Protein Coding gene. Diseases associated with CORO1C include Coronin-1A Deficiency and Lung Squamous Cell Carcinoma. Gene Ontology (GO) annotations related to this gene include actin filament binding. An important paralog of this gene is CORO1B.

UniProtKB/Swiss-Prot for CORO1C Gene

  • May be involved in cytokinesis, motility, and signal transduction.

  • Isoform 3: Involved in myogenic differentiation.

Gene Wiki entry for CORO1C Gene

Additional gene information for CORO1C Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO1C Gene

Genomics for CORO1C Gene

GeneHancer (GH) Regulatory Elements for CORO1C Gene

Promoters and enhancers for CORO1C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J108849 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 657.5 -122.8 -122783 9.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A ZBTB7B IRF4 ZNF766 ZNF213 CORO1C SSH1 SART3 ALKBH2 UBE3B ENSG00000257221 SELPLG DAO MIR619
GH12J108726 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 660.1 +0.5 491 9.3 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC CORO1C LOC101929162 RNU4-32P RNU7-169P SSH1 SART3 SELPLG UBE3B PRDM4 ENSG00000257221
GH12J108626 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.5 +92.7 92732 24.2 HDGF PKNOX1 SMAD1 ARNT FEZF1 IRF4 YY1 POLR2B ZNF766 CBX5 SELPLG PWP1 SART3 PRDM4 UBE3B RNU4-32P CORO1C FICD LOC101929162 TMEM119
GH12J108684 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 20.6 +40.0 39960 13.6 FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC MEF2D SSRP1 LOC101929162 CORO1C SART3 PRDM4 RNU7-169P SELPLG RNU4-32P ALKBH2 UBE3B ENSG00000257221
GH12J108663 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.2 +65.6 65579 5.8 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 CORO1C SELPLG SSH1 SART3 ISCU ENSG00000257221 MVK ACACB GC12P108669 RNU7-169P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CORO1C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CORO1C gene promoter:
  • AML1a
  • Pax-2a
  • Pax-2
  • RSRFC4
  • MRF-2
  • GATA-1
  • POU2F1
  • POU2F1a
  • POU2F1b

Genomic Locations for CORO1C Gene

Genomic Locations for CORO1C Gene
86,488 bases
Minus strand
86,488 bases
Minus strand

Genomic View for CORO1C Gene

Genes around CORO1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO1C Gene

Proteins for CORO1C Gene

  • Protein details for CORO1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A7MAP0
    • A7MAP1
    • B3KU12
    • Q9NSK5

    Protein attributes for CORO1C Gene

    474 amino acids
    Molecular mass:
    53249 Da
    Quaternary structure:
    • Binds F-actin. Isoform 1 and isoform 2 appear as homotrimers, while isoform 3 seems to exist as monomers.
    • Sequence=CAB82406.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CORO1C Gene


neXtProt entry for CORO1C Gene

Post-translational modifications for CORO1C Gene

  • Ubiquitination at Lys391 and Lys311
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CORO1C Gene

Domains & Families for CORO1C Gene

Gene Families for CORO1C Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CORO1C Gene

Graphical View of Domain Structure for InterPro Entry



  • The C-terminal coiled-coil domain is essential for cortical membrane localization and oligomerization.
  • Belongs to the WD repeat coronin family.
  • The C-terminal coiled-coil domain is essential for cortical membrane localization and oligomerization.
  • Belongs to the WD repeat coronin family.
genes like me logo Genes that share domains with CORO1C: view

Function for CORO1C Gene

Molecular function for CORO1C Gene

UniProtKB/Swiss-Prot Function:
May be involved in cytokinesis, motility, and signal transduction.
UniProtKB/Swiss-Prot Function:
Isoform 3: Involved in myogenic differentiation.

Phenotypes From GWAS Catalog for CORO1C Gene

Gene Ontology (GO) - Molecular Function for CORO1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 25074804
GO:0048365 Rac GTPase binding IEA --
GO:0051015 actin filament binding IMP 22364218
genes like me logo Genes that share ontologies with CORO1C: view
genes like me logo Genes that share phenotypes with CORO1C: view

Animal Models for CORO1C Gene

MGI Knock Outs for CORO1C:
  • Coro1c Coro1c<tm1a(KOMP)Wtsi>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CORO1C Gene

Localization for CORO1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORO1C Gene

Cell membrane. Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Note=All isoforms localize in a diffuse and punctate pattern in the cytosol and are highly enriched in F-actin-rich areas. Isoform 3 colocalizes with the thin filaments of the sarcomere and with the postsynaptic area and the junctional sarcoplasm of motor end plates.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CORO1C gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 3
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for CORO1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0005925 NOT colocalizes_with focal adhesion IDA,HDA 19913511
GO:0015629 actin cytoskeleton IDA 22364218
genes like me logo Genes that share ontologies with CORO1C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CORO1C Gene

Pathways & Interactions for CORO1C Gene

SuperPathways for CORO1C Gene

No Data Available

SIGNOR curated interactions for CORO1C Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CORO1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001755 neural crest cell migration IMP 25074804
GO:0001932 regulation of protein phosphorylation IGI 19913511
GO:0001933 negative regulation of protein phosphorylation IMP 19913511
GO:0006909 phagocytosis TAS 9778037
GO:0007165 signal transduction TAS 9778037
genes like me logo Genes that share ontologies with CORO1C: view

No data available for Pathways by source for CORO1C Gene

Drugs & Compounds for CORO1C Gene

No Compound Related Data Available

Transcripts for CORO1C Gene

Unigene Clusters for CORO1C Gene

Coronin, actin binding protein, 1C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORO1C Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6: - - - - -

Relevant External Links for CORO1C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CORO1C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CORO1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CORO1C Gene

This gene is overexpressed in Platelet (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CORO1C Gene

Protein tissue co-expression partners for CORO1C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CORO1C Gene:


SOURCE GeneReport for Unigene cluster for CORO1C Gene:


mRNA Expression by UniProt/SwissProt for CORO1C Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for CORO1C Gene

  • Lung(4.6)
  • Nervous system(4.5)
  • Liver(4.3)
  • Skin(3.5)
  • Intestine(2.3)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with CORO1C: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CORO1C Gene

Orthologs for CORO1C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CORO1C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CORO1C 34 33
  • 99.43 (n)
(Ornithorhynchus anatinus)
Mammalia CORO1C 34
  • 95 (a)
(Canis familiaris)
Mammalia CORO1C 34 33
  • 93.82 (n)
(Bos Taurus)
Mammalia CORO1C 34 33
  • 92.12 (n)
(Rattus norvegicus)
Mammalia Coro1c 33
  • 89.59 (n)
(Mus musculus)
Mammalia Coro1c 16 34 33
  • 88.68 (n)
(Monodelphis domestica)
Mammalia CORO1C 34
  • 60 (a)
(Gallus gallus)
Aves CORO1C 34 33
  • 82.1 (n)
(Anolis carolinensis)
Reptilia CORO1C 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia coro1c 33
  • 76.27 (n)
MGC76199 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.908 33
(Danio rerio)
Actinopterygii coro1ca 34
  • 81 (a)
coro1cb 34 33
  • 76.15 (n)
coro1c 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005891 33
  • 58.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta coro 35 33
  • 57.69 (n)
(Caenorhabditis elegans)
Secernentea cor-1 35 33
  • 55.85 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRN1 36 33
  • 49.83 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D02530g 33
  • 48.94 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER114W 33
  • 48.7 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00202 33
  • 51.64 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes crn1 33
  • 47.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.313 34
  • 42 (a)
Species where no ortholog for CORO1C was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CORO1C Gene

Gene Tree for CORO1C (if available)
Gene Tree for CORO1C (if available)
Evolutionary constrained regions (ECRs) for CORO1C: view image

Paralogs for CORO1C Gene

Paralogs for CORO1C Gene

(12) SIMAP similar genes for CORO1C Gene using alignment to 10 proteins:

  • B4E3S0_HUMAN
  • F8VV53_HUMAN
  • F8W1H8_HUMAN
  • H0YHL7_HUMAN Pseudogenes for CORO1C Gene

genes like me logo Genes that share paralogs with CORO1C: view

Variants for CORO1C Gene

Sequence variations from dbSNP and Humsavar for CORO1C Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000004618 -- 108,728,119(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000015425 -- 108,708,557(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000048968 -- 108,687,456(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000054860 -- 108,671,333(-) AAAGAAAAG/AAAG genic_upstream_transcript_variant, intron_variant
rs1000069126 -- 108,708,933(-) A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CORO1C Gene

Variant ID Type Subtype PubMed ID
esv3549756 CNV deletion 23714750

Variation tolerance for CORO1C Gene

Residual Variation Intolerance Score: 21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CORO1C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORO1C Gene

Disorders for CORO1C Gene

MalaCards: The human disease database

(2) MalaCards diseases for CORO1C Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
coronin-1a deficiency
  • coronin 1a
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CORO1C

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CORO1C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CORO1C Gene

Publications for CORO1C Gene

  1. Structural and functional diversity of novel coronin 1C (CRN2) isoforms in muscle. (PMID: 19651142) Xavier CP … Clemen CS (Journal of molecular biology 2009) 3 4 22 58
  2. Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus. (PMID: 12377779) Spoerl Z … Hasse A (The Journal of biological chemistry 2002) 3 4 22 58
  3. Isolation and chromosomal assignment of a novel human gene, CORO1C, homologous to coronin-like actin-binding proteins. (PMID: 10828594) Iizaka M … Nakamura Y (Cytogenetics and cell genetics 2000) 3 4 22 58
  4. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
  5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 44 58

Products for CORO1C Gene

Sources for CORO1C Gene

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