This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal tran... See more...

Aliases for CORO1C Gene

Aliases for CORO1C Gene

  • Coronin 1C 2 3 5
  • Coronin-1C 3 4
  • Coronin-3 3 4
  • HCRNN4 3 4
  • Coronin, Actin Binding Protein, 1C 3
  • Coronin, Actin-Binding Protein, 1C 2
  • CRNN4 4
  • CRN2 4

External Ids for CORO1C Gene

Previous GeneCards Identifiers for CORO1C Gene

  • GC12M108144
  • GC12M108919
  • GC12M108971
  • GC12M107541
  • GC12M109038
  • GC12M106103

Summaries for CORO1C Gene

Entrez Gene Summary for CORO1C Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

GeneCards Summary for CORO1C Gene

CORO1C (Coronin 1C) is a Protein Coding gene. Diseases associated with CORO1C include Coronin-1A Deficiency and Lung Squamous Cell Carcinoma. Gene Ontology (GO) annotations related to this gene include actin filament binding. An important paralog of this gene is CORO1B.

UniProtKB/Swiss-Prot Summary for CORO1C Gene

  • Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity).
  • [Isoform 3]: Involved in myogenic differentiation.

Gene Wiki entry for CORO1C Gene

Additional gene information for CORO1C Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CORO1C Gene

Genomics for CORO1C Gene

GeneHancer (GH) Regulatory Elements for CORO1C Gene

Promoters and enhancers for CORO1C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CORO1C on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CORO1C

Top Transcription factor binding sites by QIAGEN in the CORO1C gene promoter:
  • AML1a
  • GATA-1
  • MRF-2
  • Pax-2
  • Pax-2a
  • POU2F1
  • POU2F1a
  • POU2F1b
  • RSRFC4

Genomic Locations for CORO1C Gene

Genomic Locations for CORO1C Gene
chr12:108,645,109-108,731,596
(GRCh38/hg38)
Size:
86,488 bases
Orientation:
Minus strand
chr12:109,038,885-109,125,372
(GRCh37/hg19)
Size:
86,488 bases
Orientation:
Minus strand

Genomic View for CORO1C Gene

Genes around CORO1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO1C Gene

Proteins for CORO1C Gene

  • Protein details for CORO1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULV4-COR1C_HUMAN
    Recommended name:
    Coronin-1C
    Protein Accession:
    Q9ULV4
    Secondary Accessions:
    • A7MAP0
    • A7MAP1
    • B3KU12
    • Q9NSK5

    Protein attributes for CORO1C Gene

    Size:
    474 amino acids
    Molecular mass:
    53249 Da
    Quaternary structure:
    • Binds F-actin (PubMed:12377779, PubMed:22364218). Interacts with RCC2 (PubMed:25074804). Interacts preferentially with nucleotide-free and GDP-bound RAC1 (PubMed:25074804). Interacts with VIM (via head domain) (By similarity). Isoform 1 and isoform 2 appear as homotrimers, while isoform 3 seems to exist as monomers (PubMed:19651142).
    Miscellaneous:
    • [Isoform 3]: Exclusively expressed in well-differentiated myoblasts as well as in mature skeletal muscle.
    SequenceCaution:
    • Sequence=CAB82406.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CORO1C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CORO1C Gene

Post-translational modifications for CORO1C Gene

  • Glycosylation at Asn185
  • Ubiquitination at Lys311 and Lys391
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • COR1C_HUMAN (1157)

No data available for DME Specific Peptides for CORO1C Gene

Domains & Families for CORO1C Gene

Gene Families for CORO1C Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CORO1C Gene

GenScript: Design optimal peptide antigens:
  • Coronin-1C_i3 protein (A7MAP1_HUMAN)
  • cDNA, FLJ79403, highly similar to Coronin-1C (B4E3S0_HUMAN)
  • hCRNN4 (COR1C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9ULV4

UniProtKB/Swiss-Prot:

COR1C_HUMAN :
  • The C-terminal coiled-coil domain is essential for cortical membrane localization and oligomerization.
  • Belongs to the WD repeat coronin family.
Domain:
  • The C-terminal coiled-coil domain is essential for cortical membrane localization and oligomerization.
Family:
  • Belongs to the WD repeat coronin family.
genes like me logo Genes that share domains with CORO1C: view

Function for CORO1C Gene

Molecular function for CORO1C Gene

UniProtKB/Swiss-Prot Function:
Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity).
UniProtKB/Swiss-Prot Function:
[Isoform 3]: Involved in myogenic differentiation.

Phenotypes From GWAS Catalog for CORO1C Gene

Gene Ontology (GO) - Molecular Function for CORO1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IEA,IPI 25074804
GO:0048365 Rac GTPase binding IEA --
GO:0051015 actin filament binding IMP 22364218
genes like me logo Genes that share ontologies with CORO1C: view
genes like me logo Genes that share phenotypes with CORO1C: view

Animal Models for CORO1C Gene

MGI Knock Outs for CORO1C:
  • Coro1c Coro1c<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CORO1C Gene

Localization for CORO1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORO1C Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Endosome membrane. Note=All isoforms colocalize with the actin cytoskeleton in the cytosol, and especially in the cell cortex (PubMed:10828594, PubMed:19651142, PubMed:25074804). Colocalizes with F-actin at the leading edge of lamellipodia. Partially colocalizes with microtubules and vimentin intermediate filaments (PubMed:10828594, PubMed:19651142, PubMed:25074804). Localizes to endosome membrane tubules/buds (PubMed:30220460). {ECO:0000269 PubMed:10828594, ECO:0000269 PubMed:19651142, ECO:0000269 PubMed:25074804, ECO:0000269 PubMed:30220460}.
[Isoform 3]: Cell membrane, sarcolemma. Cytoplasm, myofibril, sarcomere. Cell junction, synapse. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Colocalizes with the thin filaments of the sarcomere and with the postsynaptic area and the junctional sarcoplasm of motor end plates. Colocalizes with the actin cytoskeleton in the cytosol, and especially in the cell cortex. {ECO:0000269 PubMed:19651142}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CORO1C gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
endosome 5
cytosol 3
mitochondrion 2
nucleus 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CORO1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0005925 NOT colocalizes_with focal adhesion HDA,IDA 19913511
genes like me logo Genes that share ontologies with CORO1C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CORO1C Gene

Pathways & Interactions for CORO1C Gene

PathCards logo

SuperPathways for CORO1C Gene

No Data Available

SIGNOR curated interactions for CORO1C Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CORO1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001755 neural crest cell migration IMP 25074804
GO:0001932 regulation of protein phosphorylation IGI 19913511
GO:0001933 negative regulation of protein phosphorylation IMP 19913511
GO:0006909 phagocytosis TAS 9778037
GO:0007015 actin filament organization IBA 21873635
genes like me logo Genes that share ontologies with CORO1C: view

No data available for Pathways by source for CORO1C Gene

Drugs & Compounds for CORO1C Gene

No Compound Related Data Available

Transcripts for CORO1C Gene

mRNA/cDNA for CORO1C Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORO1C Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6: - - - - -
SP7:

Relevant External Links for CORO1C Gene

GeneLoc Exon Structure for
CORO1C

Expression for CORO1C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CORO1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CORO1C Gene

This gene is overexpressed in Platelet (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CORO1C Gene



Protein tissue co-expression partners for CORO1C Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CORO1C

SOURCE GeneReport for Unigene cluster for CORO1C Gene:

Hs.330384

mRNA Expression by UniProt/SwissProt for CORO1C Gene:

Q9ULV4-COR1C_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for CORO1C Gene

  • Lung(4.6)
  • Nervous system(4.5)
  • Liver(4.3)
  • Skin(3.5)
  • Intestine(2.3)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with CORO1C: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CORO1C Gene

Orthologs for CORO1C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CORO1C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CORO1C 31 30
  • 99.43 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CORO1C 31
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CORO1C 31 30
  • 93.82 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CORO1C 31 30
  • 92.12 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Coro1c 30
  • 89.59 (n)
mouse
(Mus musculus)
Mammalia Coro1c 17 31 30
  • 88.68 (n)
oppossum
(Monodelphis domestica)
Mammalia CORO1C 31
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves CORO1C 31 30
  • 82.1 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CORO1C 31
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia coro1c 30
  • 76.27 (n)
MGC76199 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.908 30
zebrafish
(Danio rerio)
Actinopterygii coro1ca 31
  • 81 (a)
OneToMany
coro1cb 31 30
  • 76.15 (n)
OneToMany
coro1c 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005891 30
  • 58.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta coro 32 30
  • 57.69 (n)
worm
(Caenorhabditis elegans)
Secernentea cor-1 32 30
  • 55.85 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRN1 33 30
  • 49.83 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D02530g 30
  • 48.94 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER114W 30
  • 48.7 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00202 30
  • 51.64 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes crn1 30
  • 47.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.313 31
  • 42 (a)
OneToMany
Species where no ortholog for CORO1C was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CORO1C Gene

ENSEMBL:
Gene Tree for CORO1C (if available)
TreeFam:
Gene Tree for CORO1C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CORO1C: view image

Paralogs for CORO1C Gene

Paralogs for CORO1C Gene

(12) SIMAP similar genes for CORO1C Gene using alignment to 10 proteins:

  • COR1C_HUMAN
  • B4E3S0_HUMAN
  • F8VRE9_HUMAN
  • F8VSA4_HUMAN
  • F8VTT6_HUMAN
  • F8VUX3_HUMAN
  • F8VV53_HUMAN
  • F8VVB7_HUMAN
  • F8W1H8_HUMAN
  • H0YHL7_HUMAN

Pseudogenes.org Pseudogenes for CORO1C Gene

genes like me logo Genes that share paralogs with CORO1C: view

Variants for CORO1C Gene

Additional dbSNP identifiers (rs#s) for CORO1C Gene

Structural Variations from Database of Genomic Variants (DGV) for CORO1C Gene

Variant ID Type Subtype PubMed ID
esv3549756 CNV deletion 23714750

Variation tolerance for CORO1C Gene

Residual Variation Intolerance Score: 21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CORO1C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CORO1C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CORO1C Gene

Disorders for CORO1C Gene

MalaCards: The human disease database

(2) MalaCards diseases for CORO1C Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
coronin-1a deficiency
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CORO1C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CORO1C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CORO1C Gene

Publications for CORO1C Gene

  1. Structural and functional diversity of novel coronin 1C (CRN2) isoforms in muscle. (PMID: 19651142) Xavier CP … Clemen CS (Journal of molecular biology 2009) 3 4 23 54
  2. Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus. (PMID: 12377779) Spoerl Z … Hasse A (The Journal of biological chemistry 2002) 3 4 23 54
  3. Isolation and chromosomal assignment of a novel human gene, CORO1C, homologous to coronin-like actin-binding proteins. (PMID: 10828594) Iizaka M … Nakamura Y (Cytogenetics and cell genetics 2000) 3 4 23 54
  4. A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission. (PMID: 30220460) Hoyer MJ … Voeltz GK (Cell 2018) 3 4 54
  5. Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure. (PMID: 25074804) Williamson RC … Bass MD (Journal of cell science 2014) 3 4 54

Products for CORO1C Gene