Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM, Mar 2008] See more...

Aliases for CORO1B Gene

Aliases for CORO1B Gene

  • Coronin 1B 2 3 5
  • Coronin-1B 3 4
  • Coronin, Actin Binding Protein, 1B 3
  • Coronin, Actin-Binding Protein, 1B 2
  • CORONIN-2 3
  • Coronin-2 4

External Ids for CORO1B Gene

Previous GeneCards Identifiers for CORO1B Gene

  • GC11P069657
  • GC11M068901
  • GC11M067455
  • GC11M066980
  • GC11M066962
  • GC11M067205
  • GC11M063533

Summaries for CORO1B Gene

Entrez Gene Summary for CORO1B Gene

  • Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CORO1B Gene

CORO1B (Coronin 1B) is a Protein Coding gene. Diseases associated with CORO1B include Coronin-1A Deficiency. Gene Ontology (GO) annotations related to this gene include identical protein binding and Arp2/3 complex binding. An important paralog of this gene is CORO1C.

UniProtKB/Swiss-Prot Summary for CORO1B Gene

  • Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).

Additional gene information for CORO1B Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CORO1B Gene

Genomics for CORO1B Gene

GeneHancer (GH) Regulatory Elements for CORO1B Gene

Promoters and enhancers for CORO1B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CORO1B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CORO1B

Top Transcription factor binding sites by QIAGEN in the CORO1B gene promoter:
  • Bach2
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4

Genomic Locations for CORO1B Gene

Genomic Locations for CORO1B Gene
chr11:67,435,510-67,443,821
(GRCh38/hg38)
Size:
8,312 bases
Orientation:
Minus strand
chr11:67,205,518-67,211,292
(GRCh37/hg19)
Size:
5,775 bases
Orientation:
Minus strand

Genomic View for CORO1B Gene

Genes around CORO1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO1B Gene

Proteins for CORO1B Gene

  • Protein details for CORO1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BR76-COR1B_HUMAN
    Recommended name:
    Coronin-1B
    Protein Accession:
    Q9BR76
    Secondary Accessions:
    • B2RD45

    Protein attributes for CORO1B Gene

    Size:
    489 amino acids
    Molecular mass:
    54235 Da
    Quaternary structure:
    • Forms homooligomers, but does not form complexes with the other coronins. Interacts with Arp2/3 complex components, including ACTR2, ARPC1B and ARPC2. Binds actin (By similarity).

neXtProt entry for CORO1B Gene

Post-translational modifications for CORO1B Gene

  • Phosphorylation by PKC on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts. Phosphorylation does not seem to affect subcellular location.
  • Ubiquitination at Lys233 and Lys344
  • Modification sites at PhosphoSitePlus

Other Protein References for CORO1B Gene

No data available for DME Specific Peptides for CORO1B Gene

Domains & Families for CORO1B Gene

Gene Families for CORO1B Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CORO1B Gene

GenScript: Design optimal peptide antigens:
  • Coronin-2 (COR1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BR76

UniProtKB/Swiss-Prot:

COR1B_HUMAN :
  • Belongs to the WD repeat coronin family.
Family:
  • Belongs to the WD repeat coronin family.
genes like me logo Genes that share domains with CORO1B: view

Function for CORO1B Gene

Molecular function for CORO1B Gene

UniProtKB/Swiss-Prot Function:
Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).

Phenotypes From GWAS Catalog for CORO1B Gene

Gene Ontology (GO) - Molecular Function for CORO1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI,IEA 16027158
GO:0042802 identical protein binding IDA 16027158
GO:0045296 cadherin binding HDA 25468996
GO:0051015 actin filament binding IMP 22364218
genes like me logo Genes that share ontologies with CORO1B: view
genes like me logo Genes that share phenotypes with CORO1B: view

Animal Models for CORO1B Gene

MGI Knock Outs for CORO1B:

Animal Model Products

CRISPR Products

miRNA for CORO1B Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CORO1B Gene

Localization for CORO1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORO1B Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Note=Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers. {ECO:0000269 PubMed:16027158}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CORO1B gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 5
mitochondrion 2
nucleus 2
extracellular 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CORO1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 16027158
GO:0005737 cytoplasm IDA,IEA 23667561
GO:0005829 cytosol IDA 22619279
GO:0005856 cytoskeleton IEA --
GO:0005884 actin filament IDA 18775315
genes like me logo Genes that share ontologies with CORO1B: view

Pathways & Interactions for CORO1B Gene

PathCards logo

SuperPathways for CORO1B Gene

No Data Available

SIGNOR curated interactions for CORO1B Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CORO1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IBA 21873635
GO:0016477 cell migration IDA 16027158
GO:0030036 actin cytoskeleton organization IDA 18775315
GO:0031529 ruffle organization IDA 16027158
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation IC 22619279
genes like me logo Genes that share ontologies with CORO1B: view

No data available for Pathways by source for CORO1B Gene

Drugs & Compounds for CORO1B Gene

No Compound Related Data Available

Transcripts for CORO1B Gene

mRNA/cDNA for CORO1B Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORO1B Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12
SP1: - -
SP2: -
SP3: -
SP4:
SP5: -
SP6:

Relevant External Links for CORO1B Gene

GeneLoc Exon Structure for
CORO1B

Expression for CORO1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CORO1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CORO1B Gene



Protein tissue co-expression partners for CORO1B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CORO1B

SOURCE GeneReport for Unigene cluster for CORO1B Gene:

Hs.6191

Evidence on tissue expression from TISSUES for CORO1B Gene

  • Nervous system(4.8)
  • Liver(4.2)
  • Intestine(2.8)
  • Lung(2.7)
  • Stomach(2)
genes like me logo Genes that share expression patterns with CORO1B: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CORO1B Gene

Orthologs for CORO1B Gene

This gene was present in the common ancestor of animals.

Orthologs for CORO1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CORO1B 31 30
  • 99.39 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1CA 31
  • 94 (a)
OneToOne
LOC476007 30
  • 89.71 (n)
cow
(Bos Taurus)
Mammalia CORO1B 31 30
  • 89.12 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Coro1b 17 31 30
  • 87.19 (n)
rat
(Rattus norvegicus)
Mammalia Coro1b 30
  • 86.57 (n)
oppossum
(Monodelphis domestica)
Mammalia CORO1B 31
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-6579-2 31
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CORO1B 31
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii coro1b 31
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta coro 32
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea cor-1 32
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.313 31
  • 41 (a)
OneToMany
Species where no ortholog for CORO1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CORO1B Gene

ENSEMBL:
Gene Tree for CORO1B (if available)
TreeFam:
Gene Tree for CORO1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CORO1B: view image

Paralogs for CORO1B Gene

Paralogs for CORO1B Gene

(9) SIMAP similar genes for CORO1B Gene using alignment to 4 proteins:

  • COR1B_HUMAN
  • E7EW44_HUMAN
  • F5H0D2_HUMAN
  • F5H390_HUMAN
genes like me logo Genes that share paralogs with CORO1B: view

Variants for CORO1B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CORO1B Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs756117196 A colorectal cancer sample p.Val411Met
rs2286624 - p.Arg476Leu

Additional dbSNP identifiers (rs#s) for CORO1B Gene

Structural Variations from Database of Genomic Variants (DGV) for CORO1B Gene

Variant ID Type Subtype PubMed ID
dgv1977n54 CNV loss 21841781
dgv52n111 CNV deletion 26073780
nsv468604 CNV loss 19166990
nsv521723 CNV loss 19592680
nsv524096 CNV loss 19592680
nsv527056 CNV loss 19592680

Variation tolerance for CORO1B Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CORO1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CORO1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORO1B Gene

Disorders for CORO1B Gene

MalaCards: The human disease database

(1) MalaCards diseases for CORO1B Gene - From: DISEASES

Disorder Aliases PubMed IDs
coronin-1a deficiency
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CORO1B

genes like me logo Genes that share disorders with CORO1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CORO1B Gene

Publications for CORO1B Gene

  1. Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility. (PMID: 16027158) Cai L … Bear JE (The Journal of biological chemistry 2005) 3 4 23 54
  2. Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein. (PMID: 9778037) Okumura M … Thomas ML (DNA and cell biology 1998) 2 3 23 54
  3. Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia. (PMID: 18775315) Cai L … Bear JE (Cell 2008) 3 23 54
  4. Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. (PMID: 17350576) Cai L … Bear JE (Cell 2007) 3 23 54
  5. F-actin binding is essential for coronin 1B function in vivo. (PMID: 17456547) Cai L … Bear JE (Journal of cell science 2007) 3 23 54

Products for CORO1B Gene

Sources for CORO1B Gene