Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CORO1A Gene

Aliases for CORO1A Gene

  • Coronin 1A 2 3 5
  • Tryptophan Aspartate-Containing Coat Protein 3 4
  • Coronin-Like Protein P57 3 4
  • Coronin-Like Protein A 3 4
  • Clipin-A 3 4
  • TACO 3 4
  • Coronin, Actin-Binding Protein, 1A 2
  • Coronin, Actin Binding Protein, 1A 3
  • Clabp TACO 2
  • Coronin-1A 3
  • Coronin-1 3
  • HCORO1 3
  • CLABP 3
  • CORO1 4
  • IMD8 3
  • P57 3

External Ids for CORO1A Gene

Previous GeneCards Identifiers for CORO1A Gene

  • GC16M028961
  • GC16P030516
  • GC16P030193
  • GC16P030231
  • GC16P030103
  • GC16P027857

Summaries for CORO1A Gene

Entrez Gene Summary for CORO1A Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]

GeneCards Summary for CORO1A Gene

CORO1A (Coronin 1A) is a Protein Coding gene. Diseases associated with CORO1A include Immunodeficiency 8 and Coronin-1A Deficiency. Among its related pathways are Phagosome and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is CORO1B.

UniProtKB/Swiss-Prot for CORO1A Gene

  • May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.

Gene Wiki entry for CORO1A Gene

Additional gene information for CORO1A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO1A Gene

Genomics for CORO1A Gene

GeneHancer (GH) Regulatory Elements for CORO1A Gene

Promoters and enhancers for CORO1A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I030182 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +2.4 2428 6.4 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 E2F8 CORO1A ENSG00000261416 SMG1P5 SETD1A ZNF689 ZNF688 FBRS ZNF646 INO80E PRRT2
GH16I030119 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.6 -60.7 -60656 5.8 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF207 MAPK3 YPEL3 SETD1A NPIPB13 NPIPB12 SRCAP ZNF747 INO80E CORO1A BOLA2B
GH16I030112 Promoter/Enhancer 1.5 EPDnew ENCODE 12.3 -68.0 -67979 5.5 HDGF ARID4B SIN3A GLI4 ZNF2 ZBTB7B ZNF48 YY1 ZNF121 ZNF143 GDPD3 GC16P030116 TBX6 MAPK3 CORO1A SLX1A SLX1A-SULT1A3 BOLA2B CD2BP2 DOC2A
GH16I030566 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 3.6 +387.0 387047 6 ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 SETD1A SRCAP ENSG00000260267 FUS INO80E ZNF747 NPIPB13 ZNF764 SMG1P5 SMG1P2
GH16I029742 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.1 -437.7 -437695 5.4 HDGF BMI1 BATF KLF5 IRF4 ZNF207 ETV6 BCLAF1 IKZF2 RUNX3 C16orf54 ENSG00000260719 RN7SKP127 TBX6 YPEL3 MYLPF CORO1A PPP4C GC16M029747
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CORO1A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CORO1A gene promoter:

Genomic Locations for CORO1A Gene

Genomic Locations for CORO1A Gene
6,250 bases
Plus strand

Genomic View for CORO1A Gene

Genes around CORO1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO1A Gene

Proteins for CORO1A Gene

  • Protein details for CORO1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2RBL1
    • Q2YD73

    Protein attributes for CORO1A Gene

    461 amino acids
    Molecular mass:
    51026 Da
    Quaternary structure:
    • Binds actin.

neXtProt entry for CORO1A Gene

Post-translational modifications for CORO1A Gene

  • phosphorylation at Thr-412 by PKC strongly down-regulates the association with actin.
  • Polyubiquitinated by RNF128 with Lys-48-linked chains, leading to proteasomal degradation.
  • Ubiquitination at Lys20, posLast=6666, Lys233, posLast=313313, Lys331, Lys355, and posLast=393393
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CORO1A Gene

Domains & Families for CORO1A Gene

Gene Families for CORO1A Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CORO1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat coronin family.
  • Belongs to the WD repeat coronin family.
genes like me logo Genes that share domains with CORO1A: view

Function for CORO1A Gene

Molecular function for CORO1A Gene

UniProtKB/Swiss-Prot Function:
May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.

Phenotypes From GWAS Catalog for CORO1A Gene

Gene Ontology (GO) - Molecular Function for CORO1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,HDA 22658674
GO:0003779 actin binding IPI 23100250
GO:0003785 actin monomer binding IMP 23100250
GO:0005515 protein binding IPI 11094157
GO:0008022 protein C-terminus binding IPI 9365277
genes like me logo Genes that share ontologies with CORO1A: view
genes like me logo Genes that share phenotypes with CORO1A: view

Human Phenotype Ontology for CORO1A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CORO1A Gene

MGI Knock Outs for CORO1A:

Animal Model Products

miRNA for CORO1A Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CORO1A Gene

Localization for CORO1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORO1A Gene

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle, phagosome membrane. Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity). {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CORO1A gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
cytosol 4
mitochondrion 2
lysosome 2
endosome 2
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CORO1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 24760828
GO:0001891 phagocytic cup IDA 17442961
GO:0005634 NOT nucleus IDA 17341475
GO:0005737 cytoplasm IDA,IEA 17341475
GO:0005769 early endosome IEA --
genes like me logo Genes that share ontologies with CORO1A: view

Pathways & Interactions for CORO1A Gene

genes like me logo Genes that share pathways with CORO1A: view

Pathways by source for CORO1A Gene

2 KEGG pathways for CORO1A Gene
1 Cell Signaling Technology pathway for CORO1A Gene

Gene Ontology (GO) - Biological Process for CORO1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001771 NOT immunological synapse formation IMP 24760828
GO:0001845 phagolysosome assembly IEA,IMP 12132654
GO:0006816 calcium ion transport IEA --
GO:0006909 phagocytosis IMP 17442961
GO:0006928 movement of cell or subcellular component NAS 17341475
genes like me logo Genes that share ontologies with CORO1A: view

No data available for SIGNOR curated interactions for CORO1A Gene

Drugs & Compounds for CORO1A Gene

(1) Drugs for CORO1A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CORO1A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CORO1A: view

Transcripts for CORO1A Gene

Unigene Clusters for CORO1A Gene

Coronin, actin binding protein, 1A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORO1A Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^
SP1: - - - - - - -
SP2: -
SP3: -
SP4: - - -
SP5: -
SP6: - - - - - - - - - -
SP7: - -
SP8: - - - - -
SP9: - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - -
SP13: -

ExUns: 13 ^ 14a · 14b ^ 15

Relevant External Links for CORO1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CORO1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CORO1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CORO1A Gene

This gene is overexpressed in Whole Blood (x25.8) and Spleen (x5.0).

Protein differential expression in normal tissues from HIPED for CORO1A Gene

This gene is overexpressed in Lymph node (13.6), NK cells (9.5), and Tlymphocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CORO1A Gene

Protein tissue co-expression partners for CORO1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CORO1A Gene:


SOURCE GeneReport for Unigene cluster for CORO1A Gene:


mRNA Expression by UniProt/SwissProt for CORO1A Gene:

Tissue specificity: Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.

Evidence on tissue expression from TISSUES for CORO1A Gene

  • Blood(4.9)
  • Nervous system(4.9)
  • Kidney(4.3)
  • Liver(4.3)
  • Skin(4.2)
  • Spleen(4)
  • Intestine(2.8)
  • Bone marrow(2.6)
  • Lymph node(2.6)
  • Pancreas(2.4)
  • Lung(2.3)
  • Eye(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CORO1A Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • immune
  • lymphatic
  • nervous
  • respiratory
Head and neck:
  • brain
  • head
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with CORO1A: view

Orthologs for CORO1A Gene

This gene was present in the common ancestor of animals.

Orthologs for CORO1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CORO1A 33 34
  • 99.86 (n)
(Canis familiaris)
Mammalia CORO1A 34 33
  • 92.26 (n)
(Bos Taurus)
Mammalia CORO1A 33 34
  • 92.12 (n)
(Monodelphis domestica)
Mammalia CORO1A 34
  • 90 (a)
(Mus musculus)
Mammalia Coro1a 33 16 34
  • 89.08 (n)
(Rattus norvegicus)
Mammalia Coro1a 33
  • 88.65 (n)
(Ornithorhynchus anatinus)
Mammalia CORO1A 34
  • 54 (a)
(Anolis carolinensis)
Reptilia CORO1A 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia coro2b 33
  • 72.48 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC69077 33
(Danio rerio)
Actinopterygii coro1a 33 34
  • 69.4 (n)
zgc63766 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6309 33
fruit fly
(Drosophila melanogaster)
Insecta coro 35
  • 57 (a)
(Caenorhabditis elegans)
Secernentea cor-1 35
  • 51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.313 34
  • 40 (a)
Species where no ortholog for CORO1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CORO1A Gene

Gene Tree for CORO1A (if available)
Gene Tree for CORO1A (if available)

Paralogs for CORO1A Gene

Paralogs for CORO1A Gene Pseudogenes for CORO1A Gene

genes like me logo Genes that share paralogs with CORO1A: view

Variants for CORO1A Gene

Sequence variations from dbSNP and Humsavar for CORO1A Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs117288362 benign, Immunodeficiency 8 30,188,258(+) C/T intron_variant
rs139282852 benign, Immunodeficiency 8 30,188,396(+) C/T coding_sequence_variant, synonymous_variant
rs139989282 likely-benign, Immunodeficiency 8 30,187,217(+) C/G/T coding_sequence_variant, synonymous_variant
rs397514755 pathogenic, Immunodeficiency 8, Immunodeficiency 8 (IMD8) [MIM:615401] 30,186,894(+) G/A coding_sequence_variant, missense_variant
rs606231246 pathogenic, Immunodeficiency 8 30,186,647(+) CT/ coding_sequence_variant, frameshift

Structural Variations from Database of Genomic Variants (DGV) for CORO1A Gene

Variant ID Type Subtype PubMed ID
esv22245 CNV gain 19812545
esv2758642 CNV gain 17122850
esv3364056 CNV duplication 20981092
nsv571819 CNV gain 21841781
nsv821543 CNV duplication 20802225
nsv9431 CNV gain+loss 18304495
nsv978130 CNV duplication 23825009

Variation tolerance for CORO1A Gene

Residual Variation Intolerance Score: 10.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CORO1A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORO1A Gene

Disorders for CORO1A Gene

MalaCards: The human disease database

(8) MalaCards diseases for CORO1A Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards


  • Immunodeficiency 8 (IMD8) [MIM:615401]: A disease of the immune system leading to recurrent infections, and characterized by CD4+ T-cells lymphopenia. Patients can develop B-cell lymphoproliferation associated with Epstein-Barr virus infection. {ECO:0000269 PubMed:19097825, ECO:0000269 PubMed:23522482}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for CORO1A

genes like me logo Genes that share disorders with CORO1A: view

No data available for Genatlas for CORO1A Gene

Publications for CORO1A Gene

  1. Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein. (PMID: 9778037) Okumura M … Thomas ML (DNA and cell biology 1998) 2 3 22 58
  2. Molecular cloning of a novel actin-binding protein, p57, with a WD repeat and a leucine zipper motif. (PMID: 7758584) Suzuki K … Toyoshima S (FEBS letters 1995) 3 4 22 58
  3. Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation. (PMID: 23522482) Moshous D … de Villartay JP (The Journal of allergy and clinical immunology 2013) 3 4 58
  4. Constitutive turnover of phosphorylation at Thr-412 of human p57/coronin-1 regulates the interaction with actin. (PMID: 23100250) Oku T … Tsuji T (The Journal of biological chemistry 2012) 3 4 58
  5. Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a Coronin-1A mutation and a chromosome 16p11.2 deletion. (PMID: 19097825) Shiow LR … Puck JM (Clinical immunology (Orlando, Fla.) 2009) 4 22 58

Products for CORO1A Gene

Sources for CORO1A Gene

Loading form....