Aliases for CORO1A Gene
External Ids for CORO1A Gene
Previous GeneCards Identifiers for CORO1A Gene
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]
GeneCards Summary for CORO1A Gene
CORO1A (Coronin 1A) is a Protein Coding gene. Diseases associated with CORO1A include Immunodeficiency 8 and Coronin-1A Deficiency. Among its related pathways are Phagosome and Tuberculosis. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is CORO1B.
UniProtKB/Swiss-Prot Summary for CORO1A Gene
May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.