Aliases for COQ7 Gene
External Ids for COQ7 Gene
Previous GeneCards Identifiers for COQ7 Gene
The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for COQ7 Gene
COQ7 (Coenzyme Q7, Hydroxylase) is a Protein Coding gene. Diseases associated with COQ7 include Coenzyme Q10 Deficiency, Primary, 8 and Coenzyme Q10 Deficiency, Primary, 7. Among its related pathways are Ubiquinol biosynthesis and Biosynthesis of cofactors.
UniProtKB/Swiss-Prot Summary for COQ7 Gene
Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.