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COQ5 (Coenzyme Q5, Methyltransferase) is a Protein Coding gene. Diseases associated with COQ5 include Coenzyme Q10 Deficiency, Primary, 4 and Coenzyme Q10 Deficiency Disease. Among its related pathways are Metabolism and Ubiquinol biosynthesis. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and S-adenosylmethionine-dependent methyltransferase activity. An important paralog of this gene is METTL7A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
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GO:0005515 | protein binding | IPI | 25152161 |
GO:0008168 | methyltransferase activity | IEA,IBA | 21873635 |
GO:0016740 | transferase activity | IEA | -- |
GO:0043333 | 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity | IEA,IDA | 25152161 |
GO:0043430 | 2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IEA | -- |
GO:0005743 | colocalizes_with mitochondrial inner membrane | IEA,IDA | 25152161 |
GO:0005759 | mitochondrial matrix | IDA | 25152161 |
GO:0016020 | membrane | IEA | -- |
GO:0031314 | extrinsic component of mitochondrial inner membrane | IEA | -- |
SuperPathway | Contained pathways | ||
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1 | Metabolism |
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2 | Ubiquinol biosynthesis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006744 | ubiquinone biosynthetic process | IEA,IGI | 25152161 |
GO:0032259 | methylation | IEA,IDA | 25152161 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
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s-adenosylhomocysteine | Experimental | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
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2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone |
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2-Hexaprenyl-6-methoxy-1,4-benzoquinone |
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2-Polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone |
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2-Polyprenyl-6-methoxy-1,4-benzoquinone |
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Difucosyllactohexaose |
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115236-57-2 |
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ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 |
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SP1: | - | - | - | ||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||
SP6: | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
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Chimpanzee (Pan troglodytes) |
Mammalia | COQ5 30 31 |
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OneToOne | |
Cow (Bos Taurus) |
Mammalia | COQ5 30 31 |
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OneToOne | |
Dog (Canis familiaris) |
Mammalia | COQ5 30 31 |
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OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Coq5 30 |
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Mouse (Mus musculus) |
Mammalia | Coq5 30 17 31 |
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OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | COQ5 31 |
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OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | COQ5 31 |
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OneToOne | |
Chicken (Gallus gallus) |
Aves | COQ5 30 31 |
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OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | COQ5 31 |
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OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | coq5 30 |
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African clawed frog (Xenopus laevis) |
Amphibia | Xl.25997 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | COQ5 31 |
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OneToOne | |
zgc:92445 30 |
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Fruit Fly (Drosophila melanogaster) |
Insecta | CG2453 30 31 |
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OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010488 30 |
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Worm (Caenorhabditis elegans) |
Secernentea | coq-5 30 31 |
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OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D01771g 30 |
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Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | COQ5 30 31 33 |
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OneToOne | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ABL132W 30 |
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Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT5G57300 30 |
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Soybean (Glycine max) |
eudicotyledons | Gma.12739 30 |
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Rice (Oryza sativa) |
Liliopsida | Os01g0976600 30 |
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Barley (Hordeum vulgare) |
Liliopsida | Hv.10592 30 |
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Wheat (Triticum aestivum) |
Liliopsida | Ta.3669 30 |
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Bread mold (Neurospora crassa) |
Ascomycetes | NCU09862 30 |
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Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | coq5 30 |
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SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
727118 | Likely Benign: not provided | 120,529,126(-) | T/C | MISSENSE_VARIANT | |
742153 | Likely Benign: not provided | 120,504,087(-) | C/T | INTRON_VARIANT | |
756765 | Benign: not provided | 120,503,982(-) | C/T | SYNONYMOUS_VARIANT | |
768593 | Benign: not provided | 120,510,130(-) | G/C | INTRON_VARIANT | |
790131 | Likely Benign: not provided | 120,516,746(-) | T/C | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
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coenzyme q10 deficiency, primary, 4 |
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coenzyme q10 deficiency disease |
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mitochondrial complex i deficiency, nuclear type 1 |
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mitochondrial metabolism disease |
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