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Aliases for COQ10B Gene

Aliases for COQ10B Gene

  • Coenzyme Q10B 2 3 5
  • Coenzyme Q10 Homolog B (S. Cerevisiae) 2
  • Coenzyme Q10 Homolog B (Yeast) 2

External Ids for COQ10B Gene

Previous GeneCards Identifiers for COQ10B Gene

  • GC02P198144
  • GC02P198026
  • GC02P198318
  • GC02P190170

Summaries for COQ10B Gene

GeneCards Summary for COQ10B Gene

COQ10B (Coenzyme Q10B) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. An important paralog of this gene is COQ10A.

UniProtKB/Swiss-Prot for COQ10B Gene

  • Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).

Additional gene information for COQ10B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COQ10B Gene

Genomics for COQ10B Gene

GeneHancer (GH) Regulatory Elements for COQ10B Gene

Promoters and enhancers for COQ10B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I197451 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 555.6 0.0 -45 4.2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 COQ10B HSPE1 HSPD1 ENSG00000202434 BOLL ANKRD44 PLCL1 RNU6-1029P
GH02I197203 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 8.9 -242.1 -242138 15.7 HDGF PKNOX1 FOXA2 SMAD1 IRF4 YY1 TCF12 ATF7 RUNX3 RXRA ANKRD44 ANKRD44-IT1 LOC105373824 MOB4 COQ10B SF3B1 MARS2 HSPD1 LOC105373826 LOC101927596
GH02I197495 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 4.3 +46.1 46086 7.5 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 GC02P197502 HSPE1-MOB4 HSPE1 HSPD1 SF3B1 NPM1P46 GTF3C3 RNU6-1029P ANKRD44 ENSG00000202434
GH02I197292 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 6.4 -157.8 -157773 6.7 HDGF PKNOX1 EBF1 CEBPG BMI1 BATF GATA3 POLR2A ZNF207 ATF7 ANKRD44 LOC101927596 COQ10B SF3B1 MOB4 ANKRD44-IT1 GC02P197265
GH02I197252 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 4.8 -197.0 -197017 7.4 HDGF PKNOX1 SMAD1 RB1 BATF KLF5 IRF4 ZNF207 ZNF143 ATF7 ANKRD44 ANKRD44-IT1 LOC105373824 LOC101927596 COQ10B SF3B1 ATP5MC2P3 GC02P197242
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around COQ10B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the COQ10B gene promoter:

Genomic Locations for COQ10B Gene

Genomic Locations for COQ10B Gene
chr2:197,453,423-197,475,308
(GRCh38/hg38)
Size:
21,886 bases
Orientation:
Plus strand
chr2:198,318,147-198,340,032
(GRCh37/hg19)

Genomic View for COQ10B Gene

Genes around COQ10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COQ10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COQ10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COQ10B Gene

Proteins for COQ10B Gene

  • Protein details for COQ10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8M1-CQ10B_HUMAN
    Recommended name:
    Coenzyme Q-binding protein COQ10 homolog B, mitochondrial
    Protein Accession:
    Q9H8M1
    Secondary Accessions:
    • B7Z1Y4

    Protein attributes for COQ10B Gene

    Size:
    238 amino acids
    Molecular mass:
    27071 Da
    Quaternary structure:
    • Interacts with coenzyme Q.

    Alternative splice isoforms for COQ10B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COQ10B Gene

Post-translational modifications for COQ10B Gene

  • Ubiquitination at posLast=144144
  • Modification sites at PhosphoSitePlus

Other Protein References for COQ10B Gene

No data available for DME Specific Peptides for COQ10B Gene

Domains & Families for COQ10B Gene

Gene Families for COQ10B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for COQ10B Gene

Graphical View of Domain Structure for InterPro Entry

Q9H8M1

UniProtKB/Swiss-Prot:

CQ10B_HUMAN :
  • Belongs to the COQ10 family.
Family:
  • Belongs to the COQ10 family.
genes like me logo Genes that share domains with COQ10B: view

Function for COQ10B Gene

Molecular function for COQ10B Gene

UniProtKB/Swiss-Prot Function:
Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).

Phenotypes From GWAS Catalog for COQ10B Gene

Gene Ontology (GO) - Molecular Function for COQ10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048039 ubiquinone binding IBA --
genes like me logo Genes that share ontologies with COQ10B: view
genes like me logo Genes that share phenotypes with COQ10B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COQ10B Gene

Localization for COQ10B Gene

Subcellular locations from UniProtKB/Swiss-Prot for COQ10B Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COQ10B gene
Compartment Confidence
mitochondrion 4
cytosol 3
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for COQ10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with COQ10B: view

Pathways & Interactions for COQ10B Gene

genes like me logo Genes that share pathways with COQ10B: view

Interacting Proteins for COQ10B Gene

Gene Ontology (GO) - Biological Process for COQ10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006744 ubiquinone biosynthetic process IBA --
GO:0045333 cellular respiration IBA --
genes like me logo Genes that share ontologies with COQ10B: view

No data available for SIGNOR curated interactions for COQ10B Gene

Drugs & Compounds for COQ10B Gene

No Compound Related Data Available

Transcripts for COQ10B Gene

Unigene Clusters for COQ10B Gene

Coenzyme Q10 homolog B (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COQ10B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for COQ10B Gene

GeneLoc Exon Structure for
COQ10B
ECgene alternative splicing isoforms for
COQ10B

Expression for COQ10B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COQ10B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for COQ10B Gene

This gene is overexpressed in Frontal cortex (12.2), Heart (8.5), and Bone (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COQ10B Gene



NURSA nuclear receptor signaling pathways regulating expression of COQ10B Gene:

COQ10B

SOURCE GeneReport for Unigene cluster for COQ10B Gene:

Hs.606592

Evidence on tissue expression from TISSUES for COQ10B Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with COQ10B: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for COQ10B Gene

Orthologs for COQ10B Gene

This gene was present in the common ancestor of animals.

Orthologs for COQ10B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COQ10B 33 34
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia COQ10B 33
  • 90.62 (n)
cow
(Bos Taurus)
Mammalia COQ10B 33 34
  • 88.94 (n)
oppossum
(Monodelphis domestica)
Mammalia COQ10B 34
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Coq10b 33
  • 84.31 (n)
mouse
(Mus musculus)
Mammalia Coq10b 33 16 34
  • 83.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia COQ10B 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves COQ10B 33 34
  • 73.94 (n)
lizard
(Anolis carolinensis)
Reptilia COQ10B 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia coq10a 33
  • 68.63 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14965 33
zebrafish
(Danio rerio)
Actinopterygii coq10b 33 34
  • 64.22 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007391 33
  • 50.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9410 33 34
  • 49.44 (n)
worm
(Caenorhabditis elegans)
Secernentea R144.13 34
  • 45 (a)
OneToMany
Species where no ortholog for COQ10B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COQ10B Gene

ENSEMBL:
Gene Tree for COQ10B (if available)
TreeFam:
Gene Tree for COQ10B (if available)

Paralogs for COQ10B Gene

Paralogs for COQ10B Gene

(1) SIMAP similar genes for COQ10B Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for COQ10B Gene

genes like me logo Genes that share paralogs with COQ10B: view

Variants for COQ10B Gene

Sequence variations from dbSNP and Humsavar for COQ10B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000169732 -- 197,464,876(+) T/C intron_variant
rs1000222941 -- 197,461,161(+) G/C intron_variant
rs1000455801 -- 197,468,163(+) GGG/G intron_variant
rs1000493945 -- 197,463,417(+) G/T intron_variant
rs1000831245 -- 197,467,882(+) AGAGAG/AGAG intron_variant

Structural Variations from Database of Genomic Variants (DGV) for COQ10B Gene

Variant ID Type Subtype PubMed ID
nsv1014881 CNV gain 25217958

Variation tolerance for COQ10B Gene

Residual Variation Intolerance Score: 45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COQ10B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COQ10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COQ10B Gene

Disorders for COQ10B Gene

Additional Disease Information for COQ10B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for COQ10B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COQ10B Gene

Publications for COQ10B Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 58
  5. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 58

Products for COQ10B Gene

Sources for COQ10B Gene

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