Aliases for COPZ2 Gene
External Ids for COPZ2 Gene
Previous GeneCards Identifiers for COPZ2 Gene
This gene encodes a member of the adaptor complexes small subunit family. The encoded protein is a subunit of the coatomer protein complex, a seven-subunit complex that functions in the formation of COPI-type, non-clathrin-coated vesicles. COPI vesicles function in the retrograde Golgi-to-ER transport of dilysine-tagged proteins. [provided by RefSeq, Feb 2014]
GeneCards Summary for COPZ2 Gene
COPZ2 (COPI Coat Complex Subunit Zeta 2) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Delta508-CFTR traffic / ER-to-Golgi in CF. An important paralog of this gene is COPZ1.
UniProtKB/Swiss-Prot Summary for COPZ2 Gene
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.