This gene encodes a member of the adaptor complexes small subunit family. The encoded protein is a subunit of the coatomer protein complex, a seven-subunit complex that functions in the formation of COPI-type, non-clathrin-coated vesicles. COPI vesicles function in the retrograde Golgi-to-ER transport of dilysine-tagged proteins. [provided by RefSeq, Feb 2014] See more...

Aliases for COPZ2 Gene

Aliases for COPZ2 Gene

  • COPI Coat Complex Subunit Zeta 2 2 3 5
  • Nonclathrin Coat Protein Zeta-COP 2 3
  • Coatomer Subunit Zeta-2 3 4
  • Zeta-2-Coat Protein 3 4
  • Zeta-2 COP 3 4
  • Zeta2-COP 2 3
  • Coatomer Protein Complex, Subunit Zeta 2 2
  • Coatomer Protein Complex Subunit Zeta 2 3
  • Zeta-2 Coat Protein 2
  • MGC23008 2
  • COPZ2 5

External Ids for COPZ2 Gene

Previous GeneCards Identifiers for COPZ2 Gene

  • GC17M045809
  • GC17M048584
  • GC17M046445
  • GC17M046578
  • GC17M043459
  • GC17M046103
  • GC17M041472

Summaries for COPZ2 Gene

Entrez Gene Summary for COPZ2 Gene

  • This gene encodes a member of the adaptor complexes small subunit family. The encoded protein is a subunit of the coatomer protein complex, a seven-subunit complex that functions in the formation of COPI-type, non-clathrin-coated vesicles. COPI vesicles function in the retrograde Golgi-to-ER transport of dilysine-tagged proteins. [provided by RefSeq, Feb 2014]

GeneCards Summary for COPZ2 Gene

COPZ2 (COPI Coat Complex Subunit Zeta 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. An important paralog of this gene is COPZ1.

UniProtKB/Swiss-Prot Summary for COPZ2 Gene

  • The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for COPZ2 Gene

Genomics for COPZ2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for COPZ2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around COPZ2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for COPZ2

Top Transcription factor binding sites by QIAGEN in the COPZ2 gene promoter:
  • AREB6
  • Bach1
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • HEN1
  • Nkx2-5

Genomic Locations for COPZ2 Gene

Genomic Locations for COPZ2 Gene
chr17:48,026,167-48,048,086
(GRCh38/hg38)
Size:
21,920 bases
Orientation:
Minus strand
chr17:46,103,533-46,115,392
(GRCh37/hg19)
Size:
11,860 bases
Orientation:
Minus strand

Genomic View for COPZ2 Gene

Genes around COPZ2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COPZ2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COPZ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPZ2 Gene

Proteins for COPZ2 Gene

  • Protein details for COPZ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P299-COPZ2_HUMAN
    Recommended name:
    Coatomer subunit zeta-2
    Protein Accession:
    Q9P299

    Protein attributes for COPZ2 Gene

    Size:
    210 amino acids
    Molecular mass:
    23548 Da
    Quaternary structure:
    • Oligomeric complex.

neXtProt entry for COPZ2 Gene

Post-translational modifications for COPZ2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for COPZ2 Gene

Domains & Families for COPZ2 Gene

Gene Families for COPZ2 Gene

Protein Domains for COPZ2 Gene

InterPro:
Blocks:
  • Clathrin adaptor complex, small chain
ProtoNet:

Suggested Antigen Peptide Sequences for COPZ2 Gene

GenScript: Design optimal peptide antigens:
  • Zeta-2-coat protein (COPZ2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9P299

UniProtKB/Swiss-Prot:

COPZ2_HUMAN :
  • Belongs to the adaptor complexes small subunit family.
Family:
  • Belongs to the adaptor complexes small subunit family.
genes like me logo Genes that share domains with COPZ2: view

Function for COPZ2 Gene

Molecular function for COPZ2 Gene

UniProtKB/Swiss-Prot Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

Phenotypes From GWAS Catalog for COPZ2 Gene

genes like me logo Genes that share phenotypes with COPZ2: view

Animal Model Products

CRISPR Products

miRNA for COPZ2 Gene

miRTarBase miRNAs that target COPZ2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COPZ2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COPZ2 Gene

Localization for COPZ2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPZ2 Gene

Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment membrane. Peripheral membrane protein. Cytoplasmic side. Golgi apparatus membrane. Peripheral membrane protein. Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane. Peripheral membrane protein. Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Shows a significant preference for ERGIC and cis-Golgi apparatus compared with trans-Golgi network. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COPZ2 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
endoplasmic reticulum 4
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for COPZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA,TAS --
GO:0005737 cytoplasm IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0005801 cis-Golgi network NAS 11056392
genes like me logo Genes that share ontologies with COPZ2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for COPZ2 Gene

Pathways & Interactions for COPZ2 Gene

genes like me logo Genes that share pathways with COPZ2: view

Pathways by source for COPZ2 Gene

5 GeneGo (Thomson Reuters) pathways for COPZ2 Gene
  • Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)
  • Delta508-CFTR traffic / ER-to-Golgi in CF
  • Normal wtCFTR traffic / ER-to-Golgi
  • Transport Clathrin-coated vesicle cycle
  • wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)

Gene Ontology (GO) - Biological Process for COPZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA,NAS 11056392
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IEA,TAS --
GO:0006891 intra-Golgi vesicle-mediated transport IBA 21873635
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with COPZ2: view

No data available for SIGNOR curated interactions for COPZ2 Gene

Drugs & Compounds for COPZ2 Gene

No Compound Related Data Available

Transcripts for COPZ2 Gene

mRNA/cDNA for COPZ2 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COPZ2

Alternative Splicing Database (ASD) splice patterns (SP) for COPZ2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: -

Relevant External Links for COPZ2 Gene

GeneLoc Exon Structure for
COPZ2

Expression for COPZ2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for COPZ2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for COPZ2 Gene

This gene is overexpressed in Bone marrow stromal cell (43.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for COPZ2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for COPZ2

SOURCE GeneReport for Unigene cluster for COPZ2 Gene:

Hs.408434
genes like me logo Genes that share expression patterns with COPZ2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for COPZ2 Gene

Orthologs for COPZ2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for COPZ2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia COPZ2 30 31
  • 96.82 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia COPZ2 30 31
  • 93.02 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Copz2 30 17 31
  • 89.76 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Copz2 30
  • 89.05 (n)
Dog
(Canis familiaris)
Mammalia COPZ2 30 31
  • 84.95 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia COPZ2 31
  • 71 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia COPZ2 31
  • 71 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii copz2 30 31
  • 71.35 (n)
OneToOne
-- 30
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RET3 31
  • 31 (a)
OneToMany
Species where no ortholog for COPZ2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for COPZ2 Gene

ENSEMBL:
Gene Tree for COPZ2 (if available)
TreeFam:
Gene Tree for COPZ2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for COPZ2: view image

Paralogs for COPZ2 Gene

Paralogs for COPZ2 Gene

(1) SIMAP similar genes for COPZ2 Gene using alignment to 6 proteins:

  • COPZ2_HUMAN
  • J3KRJ9_HUMAN
  • J3QL73_HUMAN
  • J3QLS7_HUMAN
  • J3QQQ5_HUMAN
  • J3QS21_HUMAN
genes like me logo Genes that share paralogs with COPZ2: view

Variants for COPZ2 Gene

Additional dbSNP identifiers (rs#s) for COPZ2 Gene

Structural Variations from Database of Genomic Variants (DGV) for COPZ2 Gene

Variant ID Type Subtype PubMed ID
nsv469808 CNV loss 16826518

Variation tolerance for COPZ2 Gene

Gene Damage Index Score: 0.87; 18.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COPZ2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COPZ2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for COPZ2 Gene

Disorders for COPZ2 Gene

No disorders were found for COPZ2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COPZ2 Gene

Publications for COPZ2 Gene

  1. Identification and characterization of novel isoforms of COP I subunits. (PMID: 11056392) Futatsumori M … Nakayama K (Journal of biochemistry 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32. (PMID: 22949513) EPICURE Consortium … Sander T (Human molecular genetics 2012) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ζ 2 renders tumor cells dependent on its paralogous gene COPZ1. (PMID: 21746916) Shtutman M … Roninson IB (Proceedings of the National Academy of Sciences of the United States of America 2011) 3

Products for COPZ2 Gene

Sources for COPZ2 Gene