Aliases for COPS9 Gene

Aliases for COPS9 Gene

  • COP9 Signalosome Subunit 9 2 3 5
  • CSN Acidic Protein 2 3 4
  • CSNAP 2 3 4
  • Myeloma-Overexpressed Gene 2 Protein 3 4
  • COP9 Signalosome Complex Subunit 9 3 4
  • Myeloma Overexpressed 2 2 3
  • MYEOV2 3 4
  • Helicase/Primase Complex Protein 3
  • COPS9 5

External Ids for COPS9 Gene

Previous HGNC Symbols for COPS9 Gene

  • MYEOV2

Summaries for COPS9 Gene

GeneCards Summary for COPS9 Gene

COPS9 (COP9 Signalosome Subunit 9) is a Protein Coding gene. Diseases associated with COPS9 include Balo Concentric Sclerosis and Photoparoxysmal Response 1.

UniProtKB/Swiss-Prot Summary for COPS9 Gene

  • [Isoform 1]: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation.
  • [Isoform 2]: Negatively regulates neddylation of proteins, including ribosoaml protein RPL11.

Additional gene information for COPS9 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for COPS9 Gene

Genomics for COPS9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for COPS9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J240134 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 605.7 +1.0 1006 3.2 POLR2A LARP7 GABPA ZNF143 ZIC2 RBFOX2 IRF2 REST ZNF501 RELA COPS9 lnc-OTOS-2 ANKMY1 CAPN10 OR6B3 NDUFA10 OR5S1P
GH02J240194 Enhancer 0.6 Ensembl 10.7 -57.8 -57794 0.8 CTCF ZHX2 CEBPA SOX13 ZNF140 RAD21 CEBPB NR2F6 GLIS1 TRIM28 ENSG00000286183 MTERF4 COPS9 GPC1 ANKMY1 NDUFA10 LOC107985836 OTOS
GH02J240170 Enhancer 0.4 Ensembl 11.4 -33.8 -33795 0.4 KLF9 BHLHE40 FOXA1 OTOS COPS9 FR772910-004 ENSG00000286325 GPC1
GH02J240200 Enhancer 0.3 Ensembl ENCODE 10.7 -64.0 -63972 1.2 COPS9 GPC1 NDUFA10 ENSG00000286183 LOC107985836 OTOS
GH02J240087 Enhancer 0.2 Ensembl 11.8 +47.5 47506 0.2 piR-60794-010 COPS9 NDUFA10 OR5S1P OR6B3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around COPS9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for COPS9

Genomic Locations for COPS9 Gene

Genomic Locations for COPS9 Gene
chr2:240,126,548-240,136,807
(GRCh38/hg38)
Size:
10,260 bases
Orientation:
Minus strand
chr2:241,065,980-241,076,224
(GRCh37/hg19)
Size:
10,245 bases
Orientation:
Minus strand

Genomic View for COPS9 Gene

Genes around COPS9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COPS9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COPS9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPS9 Gene

Proteins for COPS9 Gene

  • Protein details for COPS9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXC6-CSN9_HUMAN
    Recommended name:
    COP9 signalosome complex subunit 9
    Protein Accession:
    Q8WXC6
    Secondary Accessions:
    • Q8N110

    Protein attributes for COPS9 Gene

    Size:
    57 amino acids
    Molecular mass:
    6211 Da
    Quaternary structure:
    • Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1. In the complex, it interacts directly with COPS3, COPS5 and COPS6 (PubMed:26456823). Isoform 2 associates with CSN complex (PubMed:23776465). Isoform 2 interacts with COPS5, CUL1, CUL3 and RPL11 (PubMed:23776465). According to PubMed:26456823, does not associate with CSN complex.

    Alternative splice isoforms for COPS9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COPS9 Gene

Post-translational modifications for COPS9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COPS9 Gene

No data available for DME Specific Peptides for COPS9 Gene

Domains & Families for COPS9 Gene

Gene Families for COPS9 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for COPS9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for COPS9 Gene

GenScript: Design optimal peptide antigens:
  • Myeloma-overexpressed gene 2 protein (MYOV2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WXC6

UniProtKB/Swiss-Prot:

CSN9_HUMAN :
  • [Isoform 1]: The Phe/Asp-rich domain at the C-terminus is necessary for its incorporation into the CSN complex.
  • Belongs to the CSN9 family.
Domain:
  • [Isoform 1]: The Phe/Asp-rich domain at the C-terminus is necessary for its incorporation into the CSN complex.
  • [Isoform 2]: Amino acids 60-89 in isoform 2 are necessary for interaction with COPS5, CUL1, CUL3.
Family:
  • Belongs to the CSN9 family.
genes like me logo Genes that share domains with COPS9: view

Function for COPS9 Gene

Molecular function for COPS9 Gene

UniProtKB/Swiss-Prot Function:
[Isoform 1]: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation.
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Negatively regulates neddylation of proteins, including ribosoaml protein RPL11.

Phenotypes From GWAS Catalog for COPS9 Gene

Gene Ontology (GO) - Molecular Function for COPS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26456823
genes like me logo Genes that share ontologies with COPS9: view
genes like me logo Genes that share phenotypes with COPS9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COPS9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COPS9 Gene

Localization for COPS9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPS9 Gene

[Isoform 1]: Nucleus. Cytoplasm. Nucleus, nucleoplasm. Note=Excluded from the nucleolus. Recruited to the nucleoplasm and chromatin following DNA damage induction. {ECO:0000269 PubMed:26456823}.
[Isoform 2]: Nucleus, nucleoplasm. Note=Excluded from the nucleolus. {ECO:0000269 PubMed:23776465}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COPS9 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COPS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 26456823
GO:0005634 nucleus IEA,IDA 26456823
GO:0005654 nucleoplasm IEA,IDA 23776465
GO:0005737 cytoplasm IEA,IDA 26456823
GO:0008180 COP9 signalosome IBA,IDA 26456823
genes like me logo Genes that share ontologies with COPS9: view

Pathways & Interactions for COPS9 Gene

PathCards logo

SuperPathways for COPS9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COPS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IMP 26456823
GO:0034644 cellular response to UV IDA 26456823
GO:2000435 negative regulation of protein neddylation IBA 21873635
genes like me logo Genes that share ontologies with COPS9: view

No data available for Pathways by source and SIGNOR curated interactions for COPS9 Gene

Drugs & Compounds for COPS9 Gene

No Compound Related Data Available

Transcripts for COPS9 Gene

mRNA/cDNA for COPS9 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COPS9

Alternative Splicing Database (ASD) splice patterns (SP) for COPS9 Gene

No ASD Table

Relevant External Links for COPS9 Gene

GeneLoc Exon Structure for
COPS9

Expression for COPS9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for COPS9

Evidence on tissue expression from TISSUES for COPS9 Gene

  • Liver(4.3)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for COPS9 Gene

Orthologs for COPS9 Gene

This gene was present in the common ancestor of animals.

Orthologs for COPS9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MYEOV2 30 31
  • 98.83 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MYEOV2 30 31
  • 94.15 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MYEOV2 30 31
  • 93.57 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Myeov2 30 31
  • 90.64 (n)
OneToOne
Cops9 17
Rat
(Rattus norvegicus)
Mammalia Myeov2 30
  • 89.47 (n)
Oppossum
(Monodelphis domestica)
Mammalia MYEOV2 31
  • 48 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MYEOV2 30 31
  • 87.13 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MYEOV2 31
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia myeov2 30
  • 83.04 (n)
Zebrafish
(Danio rerio)
Actinopterygii myeov2 31
  • 95 (a)
OneToOne
zgc77808 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG17059 31
  • 46 (a)
OneToOne
Species where no ortholog for COPS9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for COPS9 Gene

ENSEMBL:
Gene Tree for COPS9 (if available)
TreeFam:
Gene Tree for COPS9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for COPS9: view image

Paralogs for COPS9 Gene

Pseudogenes.org Pseudogenes for COPS9 Gene

genes like me logo Genes that share paralogs with COPS9: view

No data available for Paralogs for COPS9 Gene

Variants for COPS9 Gene

Additional dbSNP identifiers (rs#s) for COPS9 Gene

Structural Variations from Database of Genomic Variants (DGV) for COPS9 Gene

Variant ID Type Subtype PubMed ID
nsv997288 CNV gain 25217958

Variation tolerance for COPS9 Gene

Residual Variation Intolerance Score: 50.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COPS9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COPS9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for COPS9 Gene

Disorders for COPS9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for COPS9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
balo concentric sclerosis
  • balo's concentric sclerosis
photoparoxysmal response 1
  • ppr1
- elite association - COSMIC cancer census association via MalaCards
Search COPS9 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with COPS9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for COPS9 Gene

Publications for COPS9 Gene

  1. CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome. (PMID: 26456823) Rozen S … Sharon M (Cell reports 2015) 2 3 4
  2. Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification. (PMID: 23776465) Ebina M … Chiba T (PloS one 2013) 2 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II. (PMID: 30349055) Li Y … Lu X (Nature communications 2018) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for COPS9 Gene

Sources for COPS9 Gene