COPS7A Gene (Protein Coding)

COP9 Signalosome Subunit 7A

GC12P008165
GIFtS:
37
This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Mar 2014] See more...

Aliases for COPS7A Gene

Aliases for COPS7A Gene

  • COP9 Signalosome Subunit 7A 2 3 5
  • CSN7A 2 3 4
  • JAB1-Containing Signalosome Subunit 7a 3 4
  • COP9 Signalosome Complex Subunit 7a 3 4
  • Dermal Papilla-Derived Protein 10 3 4
  • SGN7a 3 4
  • COP9 (Constitutive Photomorphogenic, Arabidopsis, Homolog) Subunit 7A 2
  • COP9 Constitutive Photomorphogenic Homolog Subunit 7A (Arabidopsis) 2
  • COP9 Constitutive Photomorphogenic Homolog Subunit 7A 3
  • COP9 Complex Subunit 7a 3
  • Signalosome Subunit 7a 4
  • COPS7A 5
  • DERP10 4
  • CSN7 3

External Ids for COPS7A Gene

Previous GeneCards Identifiers for COPS7A Gene

  • GC12M006747
  • GC12M006872
  • GC12P006712
  • GC12P006703
  • GC12P006833
  • GC12P006723

Summaries for COPS7A Gene

Entrez Gene Summary for COPS7A Gene

  • This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Mar 2014]

GeneCards Summary for COPS7A Gene

COPS7A (COP9 Signalosome Subunit 7A) is a Protein Coding gene. Diseases associated with COPS7A include Snail Allergy and Shrimp Allergy. Among its related pathways are Clathrin-mediated endocytosis and Transcription-Coupled Nucleotide Excision Repair (TC-NER). An important paralog of this gene is COPS7B.

UniProtKB/Swiss-Prot Summary for COPS7A Gene

  • Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene Wiki entry for COPS7A Gene

Additional gene information for COPS7A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for COPS7A Gene

Genomics for COPS7A Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for COPS7A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around COPS7A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for COPS7A

Top Transcription factor binding sites by QIAGEN in the COPS7A gene promoter:
  • ATF-2
  • ATF6
  • c-Myc
  • CREB
  • deltaCREB
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO4
  • Max1
  • RORalpha1

Genomic Locations for COPS7A Gene

Genomic Locations for COPS7A Gene
chr12:6,724,014-6,731,875
(GRCh38/hg38)
Size:
7,862 bases
Orientation:
Plus strand
chr12:6,832,907-6,841,041
(GRCh37/hg19)
Size:
8,135 bases
Orientation:
Plus strand

Genomic View for COPS7A Gene

Genes around COPS7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COPS7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COPS7A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for COPS7A Gene

Proteins for COPS7A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for COPS7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBW8-CSN7A_HUMAN
    Recommended name:
    COP9 signalosome complex subunit 7a
    Protein Accession:
    Q9UBW8
    Secondary Accessions:
    • A8K9A6
    • Q9NVX3
    • Q9UJW4

    Protein attributes for COPS7A Gene

    Size:
    275 amino acids
    Molecular mass:
    30277 Da
    Quaternary structure:
    • Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:11337588, PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8. Interacts with PMF1 (PubMed:12020345). Interacts with the translation initiation factor EIF3S6 (PubMed:12220626). Interacts with CK2 and PKD (PubMed:12628923). Interacts directly with ID3 (By similarity).
    • (Microbial infection) Interacts with vaccinia virus protein C9L.

    Three dimensional structures from OCA and Proteopedia for COPS7A Gene

neXtProt entry for COPS7A Gene

Protein Expression for COPS7A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for COPS7A Gene

Other Protein References for COPS7A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COPS7A Gene

Domains & Families for COPS7A Gene

Gene Families for COPS7A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for COPS7A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for COPS7A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ78300, highly similar to Homo sapiens COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) (COPS7A), mRNA (A8K9A6_HUMAN)
  • JAB1-containing signalosome subunit 7a (CSN7A_HUMAN)
  • COPS7A protein (Q567U8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UBW8

UniProtKB/Swiss-Prot:

CSN7A_HUMAN :
  • Belongs to the CSN7/EIF3M family. CSN7 subfamily.
Family:
  • Belongs to the CSN7/EIF3M family. CSN7 subfamily.
genes like me logo Genes that share domains with COPS7A: view

Function for COPS7A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for COPS7A Gene

UniProtKB/Swiss-Prot Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Phenotypes From GWAS Catalog for COPS7A Gene

Gene Ontology (GO) - Molecular Function for COPS7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20399188
genes like me logo Genes that share ontologies with COPS7A: view
genes like me logo Genes that share phenotypes with COPS7A: view

Animal Models for COPS7A Gene

MGI Knock Outs for COPS7A:
  • Cops7a Cops7a<tm1b(KOMP)Mbp>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COPS7A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for COPS7A Gene

Localization for COPS7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPS7A Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COPS7A gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COPS7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,TAS --
GO:0008180 COP9 signalosome IEA,IDA 18850735
genes like me logo Genes that share ontologies with COPS7A: view

Pathways & Interactions for COPS7A Gene

genes like me logo Genes that share pathways with COPS7A: view

Gene Ontology (GO) - Biological Process for COPS7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000338 protein deneddylation IDA 19141280
GO:0000715 nucleotide-excision repair, DNA damage recognition TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0010387 COP9 signalosome assembly IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with COPS7A: view

No data available for SIGNOR curated interactions for COPS7A Gene

Drugs & Compounds for COPS7A Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for COPS7A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for COPS7A Gene

4 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COPS7A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COPS7A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13a · 13b · 13c ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - -
SP13: - - - - - - -
SP14: - - - -
SP15: - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - -
SP17: - - - - -
SP18:
SP19:

ExUns: 13d · 13e ^ 14a · 14b
SP1:
SP2:
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for COPS7A Gene

GeneLoc Exon Structure for
COPS7A

Expression for COPS7A Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for COPS7A Gene

mRNA expression in normal human tissues for COPS7A Gene
mRNA expression by GTEx for COPS7A GenemRNA expression by BioGPS for COPS7A Gene

Protein differential expression in normal tissues from HIPED for COPS7A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for COPS7A Gene



Protein tissue co-expression partners for COPS7A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for COPS7A

SOURCE GeneReport for Unigene cluster for COPS7A Gene:

Hs.530823

mRNA Expression by UniProt/SwissProt for COPS7A Gene:

Q9UBW8-CSN7A_HUMAN
Tissue specificity: Widely expressed. Expressed at high level in brain, heart and skeletal muscle.

Evidence on tissue expression from TISSUES for COPS7A Gene

  • Skin(4.8)
  • Nervous system(4.5)
  • Liver(4.4)
  • Lung(3.2)
  • Muscle(2.8)
  • Kidney(2.2)
  • Blood(2.1)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with COPS7A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for COPS7A Gene

Orthologs for COPS7A Gene

This gene was present in the common ancestor of animals.

Orthologs for COPS7A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia COPS7A 30 31
  • 99.52 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia COPS7A 31
  • 98 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia COPS7A 30 31
  • 92.36 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Cops7a 30
  • 91.39 (n)
Mouse
(Mus musculus)
 Mammalia Cops7a 30 17 31
  • 91.27 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia COPS7A 30 31
  • 90.91 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia COPS7A 31
  • 80 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves COPS7A 30 31
  • 76.85 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia COPS7A 31
  • 81 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii cops7a 30 31
  • 61.42 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta CSN7b 32
  • 43 (a)
CSN7 31
  • 40 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.9499 31
  • 43 (a)
 OneToMany
Species where no ortholog for COPS7A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for COPS7A Gene

ENSEMBL:
Gene Tree for COPS7A (if available)
TreeFam:
Gene Tree for COPS7A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for COPS7A: view image

Paralogs for COPS7A Gene

Paralogs for COPS7A Gene

(1) SIMAP similar genes for COPS7A Gene using alignment to 10 proteins:

  • CSN7A_HUMAN
  • F5GXT7_HUMAN
  • F5GYF7_HUMAN
  • F5H248_HUMAN
  • F5H3M6_HUMAN
  • F5H4U8_HUMAN
  • F5H4Z0_HUMAN
  • F5H7C6_HUMAN
  • G3XAP1_HUMAN
  • Q567U8_HUMAN
genes like me logo Genes that share paralogs with COPS7A: view

Variants for COPS7A Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for COPS7A Gene

Structural Variations from Database of Genomic Variants (DGV) for COPS7A Gene

Variant ID Type Subtype PubMed ID
esv2761725 CNV gain 21179565
esv3580394 CNV gain 25503493
nsv524621 CNV loss 19592680
nsv525884 CNV loss 19592680
nsv557257 CNV loss 21841781
nsv832322 CNV loss 17160897
nsv832323 CNV loss 17160897

Variation tolerance for COPS7A Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COPS7A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COPS7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for COPS7A Gene

Disorders for COPS7A Gene

MalaCards: The human disease database

(14) MalaCards diseases for COPS7A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
snail allergy
shrimp allergy
crustacean allergy
tomato allergy
  • solanum lycopersicum fruit allergy
melon allergy
  • cucumis melo fruit allergy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for COPS7A

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with COPS7A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for COPS7A Gene

Publications for COPS7A Gene

  1. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PMID: 18850735) Fang L … Huang L (Journal of proteome research 2008) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PMID: 12732143) Groisman R … Nakatani Y (Cell 2003) 3 4
  5. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. (PMID: 12628923) Uhle S … Dubiel W (The EMBO journal 2003) 3 4

ExternalLinks

View latest publications for COPS7A gene in Mastermind

Products for COPS7A Gene

Sources for COPS7A Gene