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The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have be... See more...
Aliases for COPS3 Gene
Aliases for COPS3 Gene
External Ids for COPS3 Gene
- HGNC: 2239
- Entrez Gene: 8533
- Ensembl: ENSG00000141030
- OMIM: 604665
- UniProtKB: Q9UNS2
Previous GeneCards Identifiers for COPS3 Gene
- GC17M017465
- GC17M018509
- GC17M017093
- GC17M017350
- GC17M017090
- GC17M016903
- GC17M017151
Summaries for COPS3 Gene
-
The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
GeneCards Summary for COPS3 Gene
COPS3 (COP9 Signalosome Subunit 3) is a Protein Coding gene. Diseases associated with COPS3 include Bone Angioendothelial Sarcoma and Smith-Magenis Syndrome. Among its related pathways are Clathrin-mediated endocytosis and Transcription-Coupled Nucleotide Excision Repair (TC-NER). An important paralog of this gene is PSMD3.
UniProtKB/Swiss-Prot Summary for COPS3 Gene
-
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Additional gene information for COPS3 Gene
- HGNC(2239)
- Entrez Gene(8533)
- Ensembl(ENSG00000141030)
- OMIM(604665)
- UniProtKB(Q9UNS2)
- Open Targets Platform(ENSG00000141030)
- Search for COPS3 at DataMed
- Search for COPS3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for COPS3 Gene
Genomics for COPS3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for COPS3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around COPS3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for COPS3
- Top Transcription factor binding sites by QIAGEN in the COPS3 gene promoter:
-
- CBF(2)
- CBF-A
- CBF-B
- CBF-C
- CP1A
- CP1C
- CREB
- NRF-2
- p300
- p53
Genomic Locations for COPS3 Gene
Genomic Locations for COPS3 Gene
- chr17:17,246,616-17,281,303
- (GRCh38/hg38)
- Size:
- 34,688 bases
- Orientation:
- Minus strand
- chr17:17,149,938-17,184,617
- (GRCh37/hg19)
- Size:
- 34,680 bases
- Orientation:
- Minus strand
Genomic View for COPS3 Gene
Genes around COPS3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p11.2 by HGNC
- 17p11.2 by Entrez Gene
- 17p11.2 by Ensembl
COPS3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for COPS3 Gene
Proteins for COPS3 Gene
-
Protein details for COPS3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UNS2-CSN3_HUMAN
- Recommended name:
- COP9 signalosome complex subunit 3
- Protein Accession:
- Q9UNS2
- B2R683
- B4DY81
- O43191
- Q7LDR6
Protein attributes for COPS3 Gene
- Size:
- 423 amino acids
- Molecular mass:
- 47873 Da
- Quaternary structure:
-
- Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS1, COPS4, COPS8 and COPS9 isoform 1 (PubMed:18850735, PubMed:26456823). Interacts with CK2 and PKD (PubMed:12628923). Interacts with the translation initiation factor EIF3S6 and IKBKG (PubMed:11418127, PubMed:12220626). Interacts with ERCC6 (PubMed:26030138).
- SequenceCaution:
-
- Sequence=AAC14197.1; Type=Frameshift; Evidence={ECO:0000305};
- Miscellaneous:
-
- Amplified and overexpressed in some osteosarcomas (OS), suggesting that it may participate in TP53 degradation in OS.
Three dimensional structures from OCA and Proteopedia for COPS3 Gene
Protein Expression for COPS3 Gene
Post-translational modifications for COPS3 Gene
Other Protein References for COPS3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences COPS3 / CSN3 Antibody
- G Biosciences Immunotag™ COPS3 Antibody
- Creative Diagnostics Anti-COPS3 monoclonal antibody, clone MAAG2837
- Creative Biolabs Recombinant Mouse Anti-Human COPS3 Antibody
-
Custom Antibody ServicesOriGene Antibodies for COPS3
- Novus Biologicals Antibodies for COPS3
-
Abcam antibodies for COPS3
- Invitrogen Antibodies for COPS3 (AFLGC-Cops3)
-
Boster Bio Antibodies for COPS3
-
Santa Cruz Biotechnology (SCBT) Antibodies for COPS3
Protein Products
-
OriGene Purified Proteins for COPS3
- Search Origene for MassSpec and Protein Over-expression Lysates for COPS3
- Origene Custom Protein Services for COPS3
-
Signalway Proteins for COPS3
-
Abcam proteins for COPS3
Assay Products
-
Boster Bio ELISA Kits for COPS3
No data available for DME Specific Peptides for COPS3 Gene
Domains & Families for COPS3 Gene
Gene Families for COPS3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for COPS3 Gene
- InterPro:
- Blocks:
-
- Domain in components of the proteasome, COP9-complex and eIF3 (PCI)
- ProtoNet:
Suggested Antigen Peptide Sequences for COPS3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ79299, highly similar to COP9 signalosome complex subunit 3 (B4DY81_HUMAN)
- JAB1-containing signalosome subunit 3 (CSN3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UNS2- Family:
-
- Belongs to the CSN3 family.
Function for COPS3 Gene
Molecular function for COPS3 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
- GENATLAS Biochemistry:
- COP9 (constitutive photomorphogenic,Arabidopsis) homolog subunit 3,ubiquitously expressed,predominantly in cardiac and skeletal muscle,involved in signal transduction,within the Smith-Magenis critical region
Phenotypes From GWAS Catalog for COPS3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 11418127 |
Phenotypes for COPS3 Gene
- MGI mutant phenotypes for COPS3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for COPS3:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability
- Increased cell death HMECs cells
- Synthetic lethal with Ras
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased cell death in HCC-1954 cells
- Increased cell death in DLD-1 cells
- Reduced shRNA abundance in FBW7 KO line
- Increased cell death in HCT116 cells
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for COPS3 - Select products 50% OFF >
- * COPS3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for COPS3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for COPS3
-
Santa Cruz Biotechnology (SCBT) CRISPR for COPS3
miRNA for COPS3 Gene
- miRTarBase miRNAs that target COPS3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for COPS3
- Browse OriGene Inhibitory RNA Products For COPS3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COPS3
Clone Products
- Applied Biological Materials (abm): Clones for COPS3 - Select products 50% OFF >
- * COPS3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for COPS3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for COPS3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for COPS3 Gene
Localization for COPS3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for COPS3 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| lysosome | 1 |
| peroxisome | 0 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005737 | cytoplasm | IEA,TAS | 9535219 |
| GO:0005829 | cytosol | IDA,TAS | -- |
| GO:0008180 | COP9 signalosome | IEA,IDA | 18850735 |
Pathways & Interactions for COPS3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | ||
| 2 | Clathrin-mediated endocytosis | ||
| 3 | Vesicle-mediated transport | ||
| 4 | DNA Double-Strand Break Repair |
.53
|
|
Pathways by source for COPS3 Gene
Interacting Proteins for COPS3 Gene
Selected Interacting proteins:
Q9UNS2-CSN3_HUMAN
ENSP00000268717
for COPS3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for COPS3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000338 | protein deneddylation | IDA | 19141280 |
| GO:0000715 | nucleotide-excision repair, DNA damage recognition | TAS | -- |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0006283 | transcription-coupled nucleotide-excision repair | TAS | -- |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IBA | 21873635 |
Transcripts for COPS3 Gene
mRNA/cDNA for COPS3 Gene
- 7 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000539941 1699 nts (view in UCSC)
- ENST00000486032 725 nts (view in UCSC)
- ENST00000579716 419 nts (view in UCSC)
- ENST00000268717 1814 nts (view in UCSC)
- ENST00000578317 1625 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for COPS3 - Select products 50% OFF >
- * COPS3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for COPS3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for COPS3
-
Santa Cruz Biotechnology (SCBT) CRISPR for COPS3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for COPS3
- Browse OriGene Inhibitory RNA Products For COPS3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COPS3
Clone Products
- Applied Biological Materials (abm): Clones for COPS3 - Select products 50% OFF >
- * COPS3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for COPS3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for COPS3
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 14b | · | 14c | · | 14d |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: | |||||
| SP6: | |||||
| SP7: | |||||
| SP8: | |||||
| SP9: | |||||
| SP10: | |||||
| SP11: | |||||
| SP12: |
Relevant External Links for COPS3 Gene
- GeneLoc Exon Structure for
- COPS3
Expression for COPS3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for COPS3 Gene
This gene is overexpressed in Muscle - Skeletal (x4.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for COPS3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for COPS3
SOURCE GeneReport for Unigene cluster for COPS3 Gene:
Hs.6076mRNA Expression by UniProt/SwissProt for COPS3 Gene:
Q9UNS2-CSN3_HUMAN
Tissue specificity:
Widely expressed. Expressed at high level in heart and skeletal muscle.
Evidence on tissue expression from TISSUES for COPS3 Gene
- Nervous system(4.8)
- Blood(4.4)
- Lung(4.4)
- Liver(4.3)
- Skin(2.3)
- Bone marrow(2.2)
Primer Products
-
OriGene qPCR primer pairs for COPS3
-
OriGene qPCR primer pairs and template standards for COPS3
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for COPS3 Gene
Orthologs for COPS3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | COPS3 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | COPS3 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | COPS3 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | COPS3 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Cops3 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cops3 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | COPS3 30 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | COPS3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | COPS3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cops3 30 |
|
||
| Str.11176 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | cops3-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | cops3 30 31 |
|
OneToOne | |
| wufk59f01 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.684 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006445 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CSN3 30 31 32 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | csn-3 31 |
|
OneToOne | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | COP13 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7012 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os08g0119000 30 |
|
||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.2898 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.1915 30 |
|
- Species where no ortholog for COPS3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for COPS3 Gene
- ENSEMBL:
- Gene Tree for COPS3 (if available)
- TreeFam:
- Gene Tree for COPS3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for COPS3: view image
Paralogs for COPS3 Gene
Pseudogenes.org Pseudogenes for COPS3 Gene
Variants for COPS3 Gene
Residual Variation Intolerance Score:
21.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.53;
11.54% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for COPS3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- COPS3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COPS3 Gene
Disorders for COPS3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bone angioendothelial sarcoma |
|
|
| smith-magenis syndrome |
|
|
| episodic pain syndrome, familial, 3 |
|
|
| juxtacortical osteosarcoma |
|
|
| peripheral osteosarcoma |
|
|
Search COPS3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for COPS3
No data available for UniProtKB/Swiss-Prot and Genatlas for COPS3 Gene
Publications for COPS3 Gene
- Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. (PMID: 12220626) Hoareau Alves K … Jalinot P (FEBS letters 2002) 3 4 23
- Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2. (PMID: 10191102) Potocki L … Lupski JR (Genomics 1999) 2 3 4
- A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PMID: 9535219) Seeger M … Dubiel W (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998) 2 3 4
- Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics. (PMID: 26030138) Nicolai S … Proietti-De-Santis L (PloS one 2015) 3 4
- CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome. (PMID: 26456823) Rozen S … Sharon M (Cell reports 2015) 3 4
ExternalLinks
Products for COPS3 Gene
- Custom Antibody ServicesOriGene Antibodies for COPS3
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- Custom Assay Services
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- Origene Custom Protein Services for COPS3
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- Browse OriGene Inhibitory RNA Products For COPS3
- OriGene qPCR primer pairs for COPS3
- OriGene qPCR primer pairs and template standards for COPS3
- OriGene CRISPR knockouts for COPS3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For COPS3
- Sino Biological Human cDNA Clone for COPS3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for COPS3
- Novus Biologicals proteins and lysates for COPS3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for COPS3
- Abcam proteins for COPS3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for COPS3 (AFLGC-Cops3)
- VectorBuilder Custom and pre-made DNA vectors for COPS3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for COPS3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for COPS3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for COPS3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for COPS3
- antibodies-online: Show 21 available COPS3 Antibodies ranked by validation data
- Compare Top COPS3 Antibodies
- antibodies-online: Search results for available COPS3 related products ranked by validation data
- antibodies-online: Show 13 available COPS3 Proteins ranked by validation data
- Compare Top COPS3 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for COPS3
- Search Santa Cruz Biotechnology (SCBT) for COPS3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for COPS3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for COPS3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for COPS3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for COPS3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COPS3
- Signalway Proteins for COPS3
Sources for COPS3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB