Aliases for COPS3 Gene
Aliases for COPS3 Gene
External Ids for COPS3 Gene
- HGNC: 2239
- Entrez Gene: 8533
- Ensembl: ENSG00000141030
- OMIM: 604665
- UniProtKB: Q9UNS2
Previous GeneCards Identifiers for COPS3 Gene
- GC17M017465
- GC17M018509
- GC17M017093
- GC17M017350
- GC17M017090
- GC17M016903
- GC17M017151
Summaries for COPS3 Gene
-
The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
GeneCards Summary for COPS3 Gene
COPS3 (COP9 Signalosome Subunit 3) is a Protein Coding gene. Diseases associated with COPS3 include Smith-Magenis Syndrome and Osteogenic Sarcoma. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Vesicle-mediated transport.
UniProtKB/Swiss-Prot for COPS3 Gene
-
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPS3 Gene
Genomics for COPS3 Gene
GeneHancer (GH) Regulatory Elements for COPS3 Gene
Promoters and enhancers for COPS3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around COPS3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for COPS3 Gene
Genomic Locations for COPS3 Gene
- chr17:17,246,624-17,281,303
- (GRCh38/hg38)
- Size:
- 34,680 bases
- Orientation:
- Minus strand
- chr17:17,149,938-17,184,617
- (GRCh37/hg19)
Genomic View for COPS3 Gene
Genes around COPS3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p11.2 by Ensembl
- 17p11.2 by Entrez Gene
- 17p11.2 by HGNC
COPS3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for COPS3 Gene
Proteins for COPS3 Gene
-
Protein details for COPS3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UNS2-CSN3_HUMAN
- Recommended name:
- COP9 signalosome complex subunit 3
- Protein Accession:
- Q9UNS2
- B2R683
- B4DY81
- O43191
- Q7LDR6
Protein attributes for COPS3 Gene
- Size:
- 423 amino acids
- Molecular mass:
- 47873 Da
- Quaternary structure:
-
- Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS1, COPS4, COPS8 and COPS9 isoform 1 (PubMed:18850735, PubMed:26456823). Interacts with CK2 and PKD (PubMed:12628923). Interacts with the translation initiation factor EIF3S6 and IKBKG (PubMed:11418127, PubMed:12220626).
- Miscellaneous:
-
- Amplified and overexpressed in some osteosarcomas (OS), suggesting that it may participate in TP53 degradation in OS.
- SequenceCaution:
-
- Sequence=AAC14197.1; Type=Frameshift; Positions=5; Evidence={ECO:0000305};
Protein Expression for COPS3 Gene
Post-translational modifications for COPS3 Gene
- Ubiquitination at Lys30, Lys125, posLast=243243, posLast=254254, posLast=281281, Lys296, Lys312, posLast=366366, Lys382, Lys391, and posLast=406406
Other Protein References for COPS3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
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Protein Products
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-
Abcam proteins for COPS3
Assay Products
No data available for DME Specific Peptides for COPS3 Gene
Domains & Families for COPS3 Gene
Gene Families for COPS3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for COPS3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for COPS3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UNS2- Family:
-
- Belongs to the CSN3 family.
Function for COPS3 Gene
Molecular function for COPS3 Gene
- GENATLAS Biochemistry:
- COP9 (constitutive photomorphogenic,Arabidopsis) homolog subunit 3,ubiquitously expressed,predominantly in cardiac and skeletal muscle,involved in signal transduction,within the Smith-Magenis critical region
- UniProtKB/Swiss-Prot Function:
- Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Phenotypes From GWAS Catalog for COPS3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 11418127 |
Phenotypes for COPS3 Gene
- MGI mutant phenotypes for COPS3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for COPS3:
Animal Model Products
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-
-
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-
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miRNA for COPS3 Gene
- miRTarBase miRNAs that target COPS3
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Inhibitory RNA Products
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- Overview of 117 available COPS3 gene related products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for COPS3
-
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Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for COPS3 Gene
Localization for COPS3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for COPS3 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Cytosol (3)
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005654 | nucleoplasm | TAS,IDA | -- |
| GO:0005737 | cytoplasm | TAS | 9535219 |
| GO:0005829 | cytosol | TAS,IDA | -- |
| GO:0008180 | COP9 signalosome | IDA,IEA | 18850735 |
Pathways & Interactions for COPS3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | ||
| 2 | Clathrin-mediated endocytosis | ||
| 3 | Vesicle-mediated transport | ||
| 4 | DNA Double-Strand Break Repair |
.53
|
|
Pathways by source for COPS3 Gene
Interacting Proteins for COPS3 Gene
Selected Interacting proteins:
ENSP00000268717
Q9UNS2-CSN3_HUMAN
for COPS3 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000338 | protein deneddylation | IDA | 19141280 |
| GO:0000715 | nucleotide-excision repair, DNA damage recognition | TAS | -- |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0006283 | transcription-coupled nucleotide-excision repair | TAS | -- |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IBA | -- |
Transcripts for COPS3 Gene
mRNA/cDNA for COPS3 Gene
- (11) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (405) Selected AceView cDNA sequences:
- (18) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for COPS3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for COPS3
- genomics-online: gRNA clones - Search results for 117 available COPS3 gene related products
- Overview of 117 available COPS3 gene related products
- Applied Biological Materials CRISPR for COPS3
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for COPS3
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miRNA Products
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Inhibitory RNA Products
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- Overview of 117 available COPS3 gene related products
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ViGene Biosciences ready-to-package AAV shRNAs for COPS3 gene
Clone Products
- Sino Biological Human cDNA Clone for COPS3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for COPS3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for COPS3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for COPS3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 14b | · | 14c | · | 14d |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: | |||||
| SP6: | |||||
| SP7: | |||||
| SP8: | |||||
| SP9: | |||||
| SP10: | |||||
| SP11: | |||||
| SP12: |
Expression for COPS3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for COPS3 Gene
This gene is overexpressed in Muscle - Skeletal (x4.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COPS3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of COPS3 Gene:
COPS3SOURCE GeneReport for Unigene cluster for COPS3 Gene:
Hs.6076mRNA Expression by UniProt/SwissProt for COPS3 Gene:
Q9UNS2-CSN3_HUMAN
Tissue specificity:
Widely expressed. Expressed at high level in heart and skeletal muscle.
Evidence on tissue expression from TISSUES for COPS3 Gene
- Nervous system(4.8)
- Liver(4.3)
- Blood(4.2)
- Lung(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for COPS3
-
OriGene qPCR primer pairs for COPS3
No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for COPS3 Gene
Orthologs for COPS3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | COPS3 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | COPS3 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | COPS3 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | COPS3 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Cops3 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cops3 33 |
|
||
| cow (Bos Taurus) |
Mammalia | COPS3 33 34 |
|
||
| chicken (Gallus gallus) |
Aves | COPS3 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | COPS3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cops3 33 |
|
||
| Str.11176 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | cops3-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cops3 33 34 |
|
||
| wufk59f01 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.684 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006445 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CSN3 35 33 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | csn-3 34 |
|
OneToOne | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | COP13 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7012 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os08g0119000 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.2898 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.1915 33 |
|
- Species where no ortholog for COPS3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for COPS3 Gene
Pseudogenes.org Pseudogenes for COPS3 Gene
No data available for Paralogs for COPS3 Gene
Variants for COPS3 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000022699 | -- | 17,279,982(-) | T/C | intron_variant | |
| rs1000181907 | -- | 17,249,486(-) | G/C | intron_variant | |
| rs1000292884 | -- | 17,276,413(-) | C/T | intron_variant | |
| rs1000385602 | -- | 17,255,237(-) | T/C | intron_variant | |
| rs1000406382 | -- | 17,276,130(-) | C/G | 5_prime_UTR_variant, coding_sequence_variant, intron_variant, missense_variant |
Residual Variation Intolerance Score:
21.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.53;
11.54% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for COPS3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- COPS3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COPS3 Gene
Disorders for COPS3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| smith-magenis syndrome |
|
|
| osteogenic sarcoma |
|
|
| xeroderma pigmentosum, complementation group e |
|
|
| kabuki syndrome 1 |
|
|
Search COPS3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for COPS3
No data available for UniProtKB/Swiss-Prot and Genatlas for COPS3 Gene
Publications for COPS3 Gene
- Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. (PMID: 12220626) Hoareau Alves K … Jalinot P (FEBS letters 2002) 3 4 22 58
- Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2. (PMID: 10191102) Potocki L … Lupski JR (Genomics 1999) 2 3 4 58
- A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PMID: 9535219) Seeger M … Dubiel W (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998) 2 3 4 58
- CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome. (PMID: 26456823) Rozen S … Sharon M (Cell reports 2015) 3 4 58
- Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PMID: 18850735) Fang L … Huang L (Journal of proteome research 2008) 3 4 58
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 56 available COPS3 Antibodies ranked by validation data
- Compare Top COPS3 Antibodies
- antibodies-online: Search results for 1 available COPS3 Elisa Kits ranked by validation data
- Compare Top COPS3 Elisa Kits
- antibodies-online: Search results for 13 available COPS3 Proteins ranked by validation data
- Compare Top COPS3 Proteins
- GeneTex COPS3 antibody for COPS3
- Search GeneTex for Proteins for COPS3
- ViGene Biosciences adenoviral particle packaged cDNA for COPS3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for COPS3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for COPS3 gene
- Search ViGene Biosciences for COPS3
- Santa Cruz Biotechnology (SCBT) Antibodies for COPS3
- Search Santa Cruz Biotechnology (SCBT) for COPS3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for COPS3
- genomics-online: cdna clones - Search results for 117 available COPS3 gene related products
- Overview of 117 available COPS3 gene related products
- orf clones - Search results for 117 available COPS3 gene related products
- Overview of 117 available COPS3 gene related products
- genomics-online: gRNA clones - Search results for 117 available COPS3 gene related products
- Overview of 117 available COPS3 gene related products
- genomics-online: primer clones - Search results for 117 available COPS3 gene related products
- Overview of 117 available COPS3 gene related products
- genomics-online: shRNA clones - Search results for 117 available COPS3 gene related products
- Overview of 117 available COPS3 gene related products
Sources for COPS3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew