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Aliases for COPG2 Gene

Aliases for COPG2 Gene

  • Coatomer Protein Complex Subunit Gamma 2 2 3 5
  • Coat Protein, Nonclathrin, Gamma-2-Cop 2 3
  • Gamma-2-Coat Protein 3 4
  • Gamma-2-COP 3 4
  • Coatomer Protein Complex, Subunit Gamma 2 2
  • Testicular Secretory Protein Li 12 3
  • Coatomer Subunit Gamma-2 3
  • 2-COP 3

External Ids for COPG2 Gene

Previous GeneCards Identifiers for COPG2 Gene

  • GC07M128622
  • GC07M129685
  • GC07M129700
  • GC07M129701
  • GC07M129741
  • GC07M129933
  • GC07M130146
  • GC07M124508

Summaries for COPG2 Gene

GeneCards Summary for COPG2 Gene

COPG2 (Coatomer Protein Complex Subunit Gamma 2) is a Protein Coding gene. Diseases associated with COPG2 include Silver-Russell Syndrome. Among its related pathways are wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF) and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include binding and structural molecule activity. An important paralog of this gene is COPG1.

UniProtKB/Swiss-Prot for COPG2 Gene

  • The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

Gene Wiki entry for COPG2 Gene

Additional gene information for COPG2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPG2 Gene

Genomics for COPG2 Gene

GeneHancer (GH) Regulatory Elements for COPG2 Gene

Promoters and enhancers for COPG2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J130667 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 694.4 +0.2 246 2.2 HDGF PKNOX1 ATF1 ARID4B SIN3A GLI4 ZNF2 POLR2B ZNF766 GLIS2 COPG2 ZC3HC1 MKLN1 CPA5 PIR53705 TSGA13
GH07J130485 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 34.8 +182.1 182123 2 ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 ZNF143 FOS DEK GC07M130482 MEST GC07P130490 ENSG00000278055 ENSG00000277269 COPG2 MESTIT1
GH07J130908 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 -247.3 -247267 15.2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 IRF4 GC07P130916 PIR43822 CEP41 COPG2 MIR29A RNU6-1010P LINC-PINT MKLN1-AS LINC00513 TMEM209
GH07J131104 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 -439.6 -439644 8.6 CLOCK DMAP1 IRF4 YY1 ZNF213 ZNF143 SP3 MEF2D SSRP1 GLIS1 MKLN1 LINC-PINT ENSG00000285106 COPG2 MKLN1-AS RNU6-1010P GC07M131055
GH07J130488 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 15.6 +177.0 177038 7.5 ATF1 ARNT SIN3A TCF12 GATA2 E2F8 ATF7 NCOA1 REST MBD2 ENSG00000274500 MESTIT1 MEST COPG2 CPA5 GC07P130498 GC07P130490 ENSG00000278055
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around COPG2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the COPG2 gene promoter:
  • E2F-1
  • E2F
  • STAT3
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • POU2F1a
  • POU2F1
  • MZF-1

Genomic Locations for COPG2 Gene

Genomic Locations for COPG2 Gene
chr7:130,506,238-130,668,758
(GRCh38/hg38)
Size:
162,521 bases
Orientation:
Minus strand
chr7:130,146,079-130,353,598
(GRCh37/hg19)
Size:
207,520 bases
Orientation:
Minus strand

Genomic View for COPG2 Gene

Genes around COPG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COPG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COPG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPG2 Gene

Proteins for COPG2 Gene

  • Protein details for COPG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBF2-COPG2_HUMAN
    Recommended name:
    Coatomer subunit gamma-2
    Protein Accession:
    Q9UBF2
    Secondary Accessions:
    • A6NH74
    • Q2NLA0
    • Q54AC3
    • Q8WVW8

    Protein attributes for COPG2 Gene

    Size:
    871 amino acids
    Molecular mass:
    97622 Da
    Quaternary structure:
    • Oligomeric complex. Binds to CDC42. Interacts with JAGN1.

    Alternative splice isoforms for COPG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COPG2 Gene

Post-translational modifications for COPG2 Gene

  • Ubiquitination at posLast=572572 and posLast=461461
  • Modification sites at PhosphoSitePlus

Other Protein References for COPG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COPG2 Gene

Domains & Families for COPG2 Gene

Gene Families for COPG2 Gene

Suggested Antigen Peptide Sequences for COPG2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBF2

UniProtKB/Swiss-Prot:

COPG2_HUMAN :
  • Belongs to the COPG family.
Family:
  • Belongs to the COPG family.
genes like me logo Genes that share domains with COPG2: view

Function for COPG2 Gene

Molecular function for COPG2 Gene

UniProtKB/Swiss-Prot Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
GENATLAS Biochemistry:
Golgi coatomer complex,gamma 2 subunit,component of the coat of non clathrin-coated vesicles,ubiquitously expressed from the paternal allele in most fetal tissues (maternally imprinted),expressed from both alleles in fetal brain,liver and adult peripheral blood,not likely to be involved in Silver-Russell syndrome

Phenotypes From GWAS Catalog for COPG2 Gene

Gene Ontology (GO) - Molecular Function for COPG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005488 binding IEA --
genes like me logo Genes that share ontologies with COPG2: view
genes like me logo Genes that share phenotypes with COPG2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COPG2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COPG2 Gene

Localization for COPG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPG2 Gene

Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Tends to be more abundant in the trans-Golgi network compared to the cis-Golgi. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COPG2 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
endoplasmic reticulum 4
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for COPG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IBA --
genes like me logo Genes that share ontologies with COPG2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for COPG2 Gene

Pathways & Interactions for COPG2 Gene

genes like me logo Genes that share pathways with COPG2: view

Interacting Proteins for COPG2 Gene

Gene Ontology (GO) - Biological Process for COPG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS 11030615
GO:0006891 intra-Golgi vesicle-mediated transport IDA 11056392
GO:0009306 protein secretion IBA --
genes like me logo Genes that share ontologies with COPG2: view

No data available for SIGNOR curated interactions for COPG2 Gene

Drugs & Compounds for COPG2 Gene

(1) Drugs for COPG2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with COPG2: view

Transcripts for COPG2 Gene

mRNA/cDNA for COPG2 Gene

Unigene Clusters for COPG2 Gene

Coatomer protein complex, subunit gamma 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for COPG2

Alternative Splicing Database (ASD) splice patterns (SP) for COPG2 Gene

No ASD Table

Relevant External Links for COPG2 Gene

GeneLoc Exon Structure for
COPG2
ECgene alternative splicing isoforms for
COPG2

Expression for COPG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COPG2 Gene

Protein differential expression in normal tissues from HIPED for COPG2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for COPG2 Gene



Protein tissue co-expression partners for COPG2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COPG2 Gene:

COPG2

SOURCE GeneReport for Unigene cluster for COPG2 Gene:

Hs.6421

Evidence on tissue expression from TISSUES for COPG2 Gene

  • Nervous system(4.6)
  • Eye(4.3)
genes like me logo Genes that share expression patterns with COPG2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for COPG2 Gene

Orthologs for COPG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COPG2 34 33
  • 99.89 (n)
OneToOne
cow
(Bos Taurus)
Mammalia COPG2 34 33
  • 93.03 (n)
OneToOne
dog
(Canis familiaris)
Mammalia COPG2 34 33
  • 93.03 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Copg2 33
  • 91.35 (n)
mouse
(Mus musculus)
Mammalia Copg2 16 34 33
  • 91.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia COPG2 34
  • 28 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COPG2 34
  • 28 (a)
OneToOne
chicken
(Gallus gallus)
Aves COPG2 34 33
  • 81.52 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COPG2 34
  • 27 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia copg2 33
  • 78.15 (n)
zebrafish
(Danio rerio)
Actinopterygii copg2 34 33
  • 76.5 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta gammaCop 34 35 33
  • 57.74 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009291 33
  • 57.72 (n)
worm
(Caenorhabditis elegans)
Secernentea T14G10.5 34 35 33
  • 57.22 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC21 34 33
  • 47.96 (n)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E13289g 33
  • 47.74 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL193W 33
  • 46.9 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G34450 33
  • 57.67 (n)
rice
(Oryza sativa)
Liliopsida Os03g0227000 33
  • 55.95 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.452 34
  • 57 (a)
ManyToMany
-- 34
  • 9 (a)
ManyToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU01992 33
  • 52.71 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec21 33
  • 50.78 (n)
Species where no ortholog for COPG2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COPG2 Gene

ENSEMBL:
Gene Tree for COPG2 (if available)
TreeFam:
Gene Tree for COPG2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for COPG2: view image

Paralogs for COPG2 Gene

Paralogs for COPG2 Gene

(3) SIMAP similar genes for COPG2 Gene using alignment to 5 proteins:

  • COPG2_HUMAN
  • F6X838_HUMAN
  • H7C1T7_HUMAN
  • Q2NLA0_HUMAN
  • Q96PK0_HUMAN
genes like me logo Genes that share paralogs with COPG2: view

Variants for COPG2 Gene

Sequence variations from dbSNP and Humsavar for COPG2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000001258 -- 130,626,583(-) C/T intron_variant
rs1000003477 -- 130,648,333(-) T/C intron_variant
rs1000087734 -- 130,551,157(-) A/G intron_variant
rs1000119418 -- 130,510,772(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000137422 -- 130,665,394(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for COPG2 Gene

Variant ID Type Subtype PubMed ID
esv3572141 CNV loss 25503493
nsv1119233 CNV duplication 24896259
nsv1126808 CNV deletion 24896259
nsv473631 CNV novel sequence insertion 20440878
nsv474006 CNV novel sequence insertion 20440878
nsv476703 CNV novel sequence insertion 20440878
nsv479683 CNV novel sequence insertion 20440878
nsv479698 CNV novel sequence insertion 20440878
nsv480568 CNV novel sequence insertion 20440878
nsv481352 CNV novel sequence insertion 20440878
nsv831130 CNV loss 17160897
nsv831131 CNV loss 17160897
nsv831132 CNV gain+loss 17160897

Variation tolerance for COPG2 Gene

Gene Damage Index Score: 0.88; 18.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COPG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COPG2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COPG2 Gene

Disorders for COPG2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for COPG2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
silver-russell syndrome
  • srs
- elite association - COSMIC cancer census association via MalaCards
Search COPG2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for COPG2

genes like me logo Genes that share disorders with COPG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for COPG2 Gene

Publications for COPG2 Gene

  1. The novel gene, gamma2-COP (COPG2), in the 7q32 imprinted domain escapes genomic imprinting. (PMID: 10995575) Yamasaki K … Kishino T (Genomics 2000) 2 3 22 58
  2. gamma2-COP, a novel imprinted gene on chromosome 7q32, defines a new imprinting cluster in the human genome. (PMID: 10556286) Blagitko N … Kalscheuer VM (Human molecular genetics 1999) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  5. Identification and characterization of novel isoforms of COP I subunits. (PMID: 11056392) Futatsumori M … Nakayama K (Journal of biochemistry 2000) 3 4 58

Products for COPG2 Gene

Sources for COPG2 Gene

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