Aliases for COPB2 Gene
External Ids for COPB2 Gene
Previous GeneCards Identifiers for COPB2 Gene
The Golgi coatomer complex (see MIM 601924) constitutes the coat of nonclathrin-coated vesicles and is essential for Golgi budding and vesicular trafficking. It consists of 7 protein subunits, including COPB2.[supplied by OMIM, Jul 2002]
GeneCards Summary for COPB2 Gene
COPB2 (COPI Coat Complex Subunit Beta 2) is a Protein Coding gene. Diseases associated with COPB2 include Microcephaly 19, Primary, Autosomal Recessive and Primary Autosomal Recessive Microcephaly. Among its related pathways are Golgi-to-ER retrograde transport and Delta508-CFTR traffic / ER-to-Golgi in CF. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is COPA.
UniProtKB/Swiss-Prot Summary for COPB2 Gene
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity).