Aliases for COMTD1 Gene

Aliases for COMTD1 Gene

  • Catechol-O-Methyltransferase Domain Containing 1 2 3 5
  • Catechol O-Methyltransferase Domain-Containing Protein 1 3 4
  • EC 2.1.1.- 4

External Ids for COMTD1 Gene

Previous GeneCards Identifiers for COMTD1 Gene

  • GC10M076339
  • GC10M076663
  • GC10M076993
  • GC10M070992

Summaries for COMTD1 Gene

GeneCards Summary for COMTD1 Gene

COMTD1 (Catechol-O-Methyltransferase Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include O-methyltransferase activity. An important paralog of this gene is LRTOMT.

UniProtKB/Swiss-Prot Summary for COMTD1 Gene

Additional gene information for COMTD1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for COMTD1 Gene

Genomics for COMTD1 Gene

GeneHancer (GH) Regulatory Elements for COMTD1 Gene

Promoters and enhancers for COMTD1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J075232 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 507.7 +1.3 1253 3.6 HNRNPK ZNF217 EP300 CTCF SIN3A NRF1 MYC POLR2G USF1 SP1 COMTD1 lnc-COMTD1-6 DUSP13 ZNF503-AS1 VDAC2
GH10J075207 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 6.7 +25.9 25924 6.1 RXRA HNRNPK ZBTB40 ZNF217 EP300 SIN3A NRF1 TCF12 POLR2G USF1 VDAC2 KAT6B ZNF503-AS1 COMTD1 HSALNG0078940
GH10J075191 Enhancer 1.3 Ensembl ENCODE dbSUPER 7.5 +42.9 42871 7.6 ZNF217 TCF12 JUND PHB2 FOS CTCF ZNF263 AFF1 REST HES1 piR-48772-004 DUSP13 ZNF503-AS1 COMTD1 PPIAP13 lnc-VDAC2-2 piR-45248
GH10J075222 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 7.4 +11.0 10966 5.3 TEAD4 TEAD1 POLR2A NR2F2 KLF9 FOXA2 ZBTB17 SAP130 NANOG TCF12 ZNF503-AS1 DUPD1 COMTD1 VDAC2 PPIAP13 lnc-COMTD1-6
GH10J075099 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 4.9 +135.1 135106 2.9 CTCF ZNF10 REST RAD21 CTBP1 TRIM22 SMC3 KDM4B RBM25 POLR2A DUSP13 SAMD8 ZNF503-AS1 KAT6B PPIAP13 COMTD1 lnc-DUPD1-3 LOC101929165
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around COMTD1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for COMTD1

Top Transcription factor binding sites by QIAGEN in the COMTD1 gene promoter:
  • CUTL1
  • E47
  • FOXD1
  • FOXJ2
  • FOXJ2 (long isoform)
  • Hand1
  • MRF-2
  • Roaz
  • SEF-1 (1)
  • ZID

Genomic Locations for COMTD1 Gene

Genomic Locations for COMTD1 Gene
2,417 bases
Minus strand
2,062 bases
Minus strand

Genomic View for COMTD1 Gene

Genes around COMTD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMTD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMTD1 Gene

Proteins for COMTD1 Gene

  • Protein details for COMTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Catechol O-methyltransferase domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q8TE79

    Protein attributes for COMTD1 Gene

    262 amino acids
    Molecular mass:
    28809 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for COMTD1 Gene

neXtProt entry for COMTD1 Gene

Post-translational modifications for COMTD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COMTD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COMTD1 Gene

Domains & Families for COMTD1 Gene

Gene Families for COMTD1 Gene

Protein Domains for COMTD1 Gene

  • O-methyltransferase, family 3

Suggested Antigen Peptide Sequences for COMTD1 Gene

GenScript: Design optimal peptide antigens:
  • Catechol O-methyltransferase domain-containing protein 1 (CMTD1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
genes like me logo Genes that share domains with COMTD1: view

Function for COMTD1 Gene

Molecular function for COMTD1 Gene

UniProtKB/Swiss-Prot Function:
Putative O-methyltransferase.

Enzyme Numbers (IUBMB) for COMTD1 Gene

Phenotypes From GWAS Catalog for COMTD1 Gene

Gene Ontology (GO) - Molecular Function for COMTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008168 methyltransferase activity IEA --
GO:0008171 O-methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with COMTD1: view
genes like me logo Genes that share phenotypes with COMTD1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COMTD1 Gene

Localization for COMTD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMTD1 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COMTD1 gene
Compartment Confidence
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COMTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with COMTD1: view

Pathways & Interactions for COMTD1 Gene

PathCards logo

SuperPathways for COMTD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with COMTD1: view

No data available for Pathways by source and SIGNOR curated interactions for COMTD1 Gene

Drugs & Compounds for COMTD1 Gene

(4) Drugs for COMTD1 Gene - From: DrugBank and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tolcapone Approved, Withdrawn Pharma COMT inhibitor, COMT inhibitor; also inhibits transthyretin aggregation 24
Feruloyl Coenzyme A Experimental Pharma Target 0
s-adenosylhomocysteine Experimental Pharma Target 0
Sinapoyl coenzyme A Experimental Pharma Target 0

(1) ApexBio Compounds for COMTD1 Gene

Compound Action Cas Number
Tolcapone COMT inhibitor 134308-13-7
genes like me logo Genes that share compounds with COMTD1: view

Drug Products

Transcripts for COMTD1 Gene

mRNA/cDNA for COMTD1 Gene

6 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COMTD1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - -
SP2: -
SP3: - - - - - - -
SP4: -

Relevant External Links for COMTD1 Gene

GeneLoc Exon Structure for

Expression for COMTD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for COMTD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COMTD1 Gene

This gene is overexpressed in Pancreas (x6.9) and Esophagus - Mucosa (x4.6).

Protein differential expression in normal tissues from HIPED for COMTD1 Gene

This gene is overexpressed in Islet of Langerhans (10.9) and Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for COMTD1 Gene

Protein tissue co-expression partners for COMTD1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for COMTD1

SOURCE GeneReport for Unigene cluster for COMTD1 Gene:


Evidence on tissue expression from TISSUES for COMTD1 Gene

  • Nervous system(4.2)
  • Liver(4.1)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with COMTD1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for COMTD1 Gene

Orthologs for COMTD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COMTD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COMTD1 31 30
  • 99.49 (n)
(Canis familiaris)
Mammalia COMTD1 31 30
  • 88.55 (n)
(Bos Taurus)
Mammalia COMTD1 31 30
  • 85.5 (n)
(Rattus norvegicus)
Mammalia Comtd1 30
  • 84.35 (n)
(Mus musculus)
Mammalia Comtd1 17 31 30
  • 84.22 (n)
(Monodelphis domestica)
Mammalia COMTD1 31
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia COMTD1 31
  • 62 (a)
(Gallus gallus)
Aves COMTD1 31 30
  • 54.56 (n)
(Anolis carolinensis)
Reptilia COMTD1 31
  • 43 (a)
(Danio rerio)
Actinopterygii comtd1 31 30
  • 55.13 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8831 30
(Caenorhabditis elegans)
Secernentea comt-5 31 30
  • 47.19 (n)
comt-2 31
  • 37 (a)
comt-4 31
  • 36 (a)
comt-3 31
  • 33 (a)
comt-1 31
  • 12 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G61990 30
  • 46.24 (n)
(Oryza sativa)
Liliopsida Os08g0154000 30
  • 46.51 (n)
(Triticum aestivum)
Liliopsida Ta.4917 30
(Hordeum vulgare)
Liliopsida Hv.6150 30
Species where no ortholog for COMTD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for COMTD1 Gene

Gene Tree for COMTD1 (if available)
Gene Tree for COMTD1 (if available)
Evolutionary constrained regions (ECRs) for COMTD1: view image

Paralogs for COMTD1 Gene

Paralogs for COMTD1 Gene

genes like me logo Genes that share paralogs with COMTD1: view

Variants for COMTD1 Gene

Additional dbSNP identifiers (rs#s) for COMTD1 Gene

Structural Variations from Database of Genomic Variants (DGV) for COMTD1 Gene

Variant ID Type Subtype PubMed ID
dgv927n100 CNV gain 25217958
dgv928n100 CNV gain 25217958
nsv831913 CNV loss 17160897

Variation tolerance for COMTD1 Gene

Gene Damage Index Score: 2.13; 38.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COMTD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for COMTD1 Gene

Disorders for COMTD1 Gene

Additional Disease Information for COMTD1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for COMTD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMTD1 Gene

Publications for COMTD1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 54
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41 54
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 41 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for COMTD1 Gene

Sources for COMTD1 Gene