Aliases for COMT Gene
External Ids for COMT Gene
Previous GeneCards Identifiers for COMT Gene
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
GeneCards Summary for COMT Gene
COMT (Catechol-O-Methyltransferase) is a Protein Coding gene. Diseases associated with COMT include Schizophrenia and Panic Disorder 1. Among its related pathways are Cytochrome P450 - arranged by substrate type and Neurotransmitter Clearance In The Synaptic Cleft. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and catechol O-methyltransferase activity. An important paralog of this gene is ENSG00000284922.
UniProtKB/Swiss-Prot Summary for COMT Gene
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Catechol O-Methyltransferase (COMT) (EC 188.8.131.52) catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to a catechol substrate, such as dopamine or levodopa, in the presence of magnesium (Mg2+) ions.