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Aliases for COMMD8 Gene

Aliases for COMMD8 Gene

  • COMM Domain Containing 8 2 3 5
  • COMM Domain-Containing Protein 8 3

External Ids for COMMD8 Gene

Previous GeneCards Identifiers for COMMD8 Gene

  • GC04M047293
  • GC04M047147
  • GC04M046772

Summaries for COMMD8 Gene

Entrez Gene Summary for COMMD8 Gene

  • The protein encoded by this gene binds coiled-coil domain-containing protein 22 (CCDC22), and this complex can regulate the turnover of I-kappa-B and the activation of NF-kappa-B. [provided by RefSeq, Jul 2016]

GeneCards Summary for COMMD8 Gene

COMMD8 (COMM Domain Containing 8) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COMMD8 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).

Additional gene information for COMMD8 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD8 Gene

Genomics for COMMD8 Gene

GeneHancer (GH) Regulatory Elements for COMMD8 Gene

Promoters and enhancers for COMMD8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J047462 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 658.6 +0.0 39 2.5 HDGF PKNOX1 CLOCK MLX ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B COMMD8 ENSG00000282904 CNGA1 ATP10D GC04M047447
GH04J047465 Enhancer 0.6 FANTOM5 656.1 -1.5 -1464 0.3 SRF NR2F1 JUNB ZFP36 NBN ZBTB33 ATF7 CREM SPI1 COMMD8 ENSG00000282904 CNGA1 ATP10D
GH04J047493 Promoter/Enhancer 1.3 EPDnew FANTOM5 dbSUPER 13.8 -30.0 -29981 0.3 ZNF687 SMAD5 CBFB ZBED1 JUNB TRIM22 BMI1 IKZF1 NBN ATP10D COMMD8 RPL21P52 GC04P047550
GH04J047498 Enhancer 1 Ensembl ENCODE dbSUPER 11.8 -35.9 -35937 2.8 EBF1 MEF2B RELA YY1 SP1 IKZF1 EED NFATC1 NBN IKZF2 COMMD8 ATP10D RPL21P52 GC04P047550
GH04J047471 Enhancer 0.6 FANTOM5 ENCODE 8.3 -8.2 -8232 1.6 FOXA2 COMMD8 ENSG00000282904 ATP10D
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around COMMD8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the COMMD8 gene promoter:

Genomic Locations for COMMD8 Gene

Genomic Locations for COMMD8 Gene
12,927 bases
Minus strand

Genomic View for COMMD8 Gene

Genes around COMMD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMMD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMMD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD8 Gene

Proteins for COMMD8 Gene

  • Protein details for COMMD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    COMM domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • Q8WUR4
    • Q9HC15

    Protein attributes for COMMD8 Gene

    183 amino acids
    Molecular mass:
    21090 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5.
    • Sequence=AAG14957.1; Type=Frameshift; Positions=11; Evidence={ECO:0000305};

neXtProt entry for COMMD8 Gene

Post-translational modifications for COMMD8 Gene

  • Ubiquitination at Lys132
  • Modification sites at PhosphoSitePlus

Other Protein References for COMMD8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for COMMD8
  • Santa Cruz Biotechnology (SCBT) Antibodies for COMMD8

No data available for DME Specific Peptides for COMMD8 Gene

Domains & Families for COMMD8 Gene

Gene Families for COMMD8 Gene

Protein Domains for COMMD8 Gene


Suggested Antigen Peptide Sequences for COMMD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with COMMD8: view

No data available for UniProtKB/Swiss-Prot for COMMD8 Gene

Function for COMMD8 Gene

Molecular function for COMMD8 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).

Phenotypes From GWAS Catalog for COMMD8 Gene

Gene Ontology (GO) - Molecular Function for COMMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15799966
genes like me logo Genes that share ontologies with COMMD8: view
genes like me logo Genes that share phenotypes with COMMD8: view

Animal Model Products

miRNA for COMMD8 Gene

miRTarBase miRNAs that target COMMD8

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COMMD8 Gene

Localization for COMMD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COMMD8 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
peroxisome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COMMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with COMMD8: view

Pathways & Interactions for COMMD8 Gene

SuperPathways for COMMD8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with COMMD8: view

No data available for Pathways by source and SIGNOR curated interactions for COMMD8 Gene

Drugs & Compounds for COMMD8 Gene

No Compound Related Data Available

Transcripts for COMMD8 Gene

mRNA/cDNA for COMMD8 Gene

Unigene Clusters for COMMD8 Gene

COMM domain containing 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for COMMD8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COMMD8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COMMD8 Gene

Protein differential expression in normal tissues from HIPED for COMMD8 Gene

This gene is overexpressed in Rectum (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for COMMD8 Gene

Protein tissue co-expression partners for COMMD8 Gene

NURSA nuclear receptor signaling pathways regulating expression of COMMD8 Gene:


SOURCE GeneReport for Unigene cluster for COMMD8 Gene:


mRNA Expression by UniProt/SwissProt for COMMD8 Gene:

Tissue specificity: Widely expressed with highest expression in thyroid.

Evidence on tissue expression from TISSUES for COMMD8 Gene

  • Kidney(4.4)
genes like me logo Genes that share expression patterns with COMMD8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for COMMD8 Gene

Orthologs for COMMD8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COMMD8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COMMD8 34 33
  • 99.82 (n)
(Canis familiaris)
Mammalia COMMD8 34 33
  • 89.25 (n)
(Bos Taurus)
Mammalia COMMD8 34 33
  • 88.89 (n)
(Rattus norvegicus)
Mammalia Commd8 33
  • 80.69 (n)
(Mus musculus)
Mammalia Commd8 16 34 33
  • 79.05 (n)
(Monodelphis domestica)
Mammalia COMMD8 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia COMMD8 34
  • 57 (a)
(Gallus gallus)
Aves COMMD8 34 33
  • 71.12 (n)
(Anolis carolinensis)
Reptilia COMMD8 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia commd8 33
  • 63.75 (n)
Str.15114 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24752 33
(Danio rerio)
Actinopterygii commd8 34 33
  • 53.68 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9137 33
Species where no ortholog for COMMD8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD8 Gene

Gene Tree for COMMD8 (if available)
Gene Tree for COMMD8 (if available)
Evolutionary constrained regions (ECRs) for COMMD8: view image

Paralogs for COMMD8 Gene Pseudogenes for COMMD8 Gene

genes like me logo Genes that share paralogs with COMMD8: view

No data available for Paralogs for COMMD8 Gene

Variants for COMMD8 Gene

Sequence variations from dbSNP and Humsavar for COMMD8 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000144504 -- 47,455,235(-) C/T intron_variant
rs1000145396 -- 47,465,548(-) A/T upstream_transcript_variant
rs1000405067 -- 47,457,341(-) T/C intron_variant
rs1000499592 -- 47,452,444(-) T/C 3_prime_UTR_variant, intron_variant
rs10005092 -- 47,450,383(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for COMMD8 Gene

Variant ID Type Subtype PubMed ID
nsv829923 CNV gain 17160897
nsv998919 CNV gain 25217958

Variation tolerance for COMMD8 Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for COMMD8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD8 Gene

Disorders for COMMD8 Gene

Additional Disease Information for COMMD8

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for COMMD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMMD8 Gene

Publications for COMMD8 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E … Duckett CS (The Journal of biological chemistry 2005) 2 3 4 58
  2. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak CA … Burstein E (Molecular biology of the cell 2015) 3 4 58
  3. CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling. (PMID: 23563313) Starokadomskyy P … Burstein E (The Journal of clinical investigation 2013) 3 4 58
  4. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. (PMID: 21778237) Mao X … Burstein E (The Journal of biological chemistry 2011) 3 4 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for COMMD8 Gene

Sources for COMMD8 Gene

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